{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:23:16Z","timestamp":1790630596170,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1038\/ncpneph0228","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T21:16:23Z","timestamp":1154466983000},"page":"424-431","source":"Crossref","is-referenced-by-count":95,"title":["Orthostatic hypertension: when pressor reflexes overcompensate"],"prefix":"10.1038","volume":"2","author":[{"given":"Joshua","family":"Fessel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFncpneph0228_CR1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s11906-999-0030-9","volume":"1","author":"JL Izzo Jr","year":"1999","unstructured":"Izzo JL Jr and Taylor AA (1999) The sympathetic nervous system and baroreflexes in hypertension and hypotension. Curr Hypertens Rep 1: 254\u2013263","journal-title":"Curr Hypertens Rep"},{"key":"BFncpneph0228_CR2","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1152\/jappl.1998.84.3.914","volume":"84","author":"G Jacob","year":"1998","unstructured":"Jacob G  et al. (1998) Effect of standing on neurohumoral responses and plasma volume in healthy subjects. J Appl Physiol 84: 914\u2013921","journal-title":"J Appl Physiol"},{"key":"BFncpneph0228_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1097\/00000441-199805000-00001","volume":"315","author":"D Robertson","year":"1998","unstructured":"Robertson D  et al. (1998) Distribution and observed associations of orthostatic blood pressure changes in elderly general medicine outpatients. Am J Med Sci 315: 287\u2013295","journal-title":"Am J Med Sci"},{"key":"BFncpneph0228_CR4","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/00041552-199509000-00014","volume":"4","author":"G Jacob","year":"1995","unstructured":"Jacob G and Robertson D (1995) Orthostatic hypotension: epidemiology, pathophysiology and management. Curr Opin Nephrol Hypertens 4: 452\u2013454","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"BFncpneph0228_CR5","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1212\/WNL.45.12_Suppl_9.S26","volume":"45","author":"D Robertson","year":"1995","unstructured":"Robertson D and Davis TL (1995) Recent advances in the treatment of orthostatic hypotension. Neurology 45: S26\u201332","journal-title":"Neurology"},{"key":"BFncpneph0228_CR6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1161\/01.HYP.0000081216.11623.C3","volume":"42","author":"DS Goldstein","year":"2003","unstructured":"Goldstein DS  et al. (2003) Association between supine hypertension and orthostatic hypotension in autonomic failure. Hypertension 42: 136\u2013142","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0165-1838(83)90075-9","volume":"7","author":"RH Johnson","year":"1983","unstructured":"Johnson RH (1983) Autonomic dysfunction in clinical disorders with particular reference to catecholamine release. J Auton Nerv Syst 7: 219\u2013232","journal-title":"J Auton Nerv Syst"},{"key":"BFncpneph0228_CR8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2165\/00002018-199411010-00003","volume":"11","author":"SG Carruthers","year":"1994","unstructured":"Carruthers SG (1994) Adverse effects of alpha 1-adrenergic blocking drugs. Drug Saf 11: 12\u201320","journal-title":"Drug Saf"},{"key":"BFncpneph0228_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3949\/ccjm.61.1.59","volume":"61","author":"CJ Pearce","year":"1994","unstructured":"Pearce CJ and Wallin JD (1994) Labetalol and other agents that block both alpha- and beta-adrenergic receptors. Cleve Clin J Med 61: 59\u201369","journal-title":"Cleve Clin J Med"},{"key":"BFncpneph0228_CR10","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1161\/01.HYP.0000160355.93303.72","volume":"45","author":"K Heusser","year":"2005","unstructured":"Heusser K  et al. (2005) Baroreflex failure. Hypertension 45: 834\u2013839","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR11","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1056\/NEJM199311113292003","volume":"329","author":"D Robertson","year":"1993","unstructured":"Robertson D  et al. (1993) The diagnosis and treatment of baroreflex failure. N Engl J Med 329: 1449\u20131455","journal-title":"N Engl J Med"},{"key":"BFncpneph0228_CR12","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1161\/01.CIR.0000017186.52382.F4","volume":"105","author":"T Ketch","year":"2002","unstructured":"Ketch T  et al. (2002) Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia. Circulation 105: 2518\u20132523","journal-title":"Circulation"},{"key":"BFncpneph0228_CR13","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1056\/NEJM199311113292011","volume":"329","author":"WM Manger","year":"1993","unstructured":"Manger WM (1993) Baroreflex failure\u2014a diagnostic challenge. N Engl J Med 329: 1494\u20131495","journal-title":"N Engl J Med"},{"key":"BFncpneph0228_CR14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1161\/01.HYP.32.4.699","volume":"32","author":"J Jordan","year":"1998","unstructured":"Jordan J  et al. (1998) Raised cerebrovascular resistance in idiopathic orthostatic intolerance: evidence for sympathetic vasoconstriction. Hypertension 32: 699\u2013704","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0002-9343(98)00364-7","volume":"106","author":"G Jacob","year":"1999","unstructured":"Jacob G  et al. (1999) Effects of standing on cerebrovascular resistance in patients with idiopathic orthostatic intolerance. Am J Med 106: 59\u201364","journal-title":"Am J Med"},{"key":"BFncpneph0228_CR16","first-page":"A242","volume":"28","author":"RM Robertson","year":"1980","unstructured":"Robertson RM  et al. (1980) Ergonovine-induced discrepancy between direct and indirect arterial-pressure recording. Clin Res 28: A242","journal-title":"Clin Res"},{"key":"BFncpneph0228_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.7326\/0003-4819-99-4-477","volume":"99","author":"JP Nicholson Jr","year":"1983","unstructured":"Nicholson JP Jr  et al. (1983) Pheochromocytoma and prazosin. Ann Intern Med 99: 477\u2013479","journal-title":"Ann Intern Med"},{"key":"BFncpneph0228_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0146-2806(79)80003-1","volume":"4","author":"CV Ram","year":"1979","unstructured":"Ram CV and Engelman K (1979) Pheochromocytoma\u2014recognition and management. Curr Probl Cardiol 4: 1\u201337","journal-title":"Curr Probl Cardiol"},{"key":"BFncpneph0228_CR19","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1161\/01.HYP.0000158259.68614.40","volume":"45","author":"C Shibao","year":"2005","unstructured":"Shibao C  et al. (2005) Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension 45: 385\u2013390","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1291\/hypres.27.235","volume":"27","author":"K Eguchi","year":"2004","unstructured":"Eguchi K  et al. (2004) Greater change of orthostatic blood pressure is related to silent cerebral infarct and cardiac overload in hypertensive subjects. Hypertens Res 27: 235\u2013241","journal-title":"Hypertens Res"},{"key":"BFncpneph0228_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0735-1097(02)01923-X","volume":"40","author":"K Kario","year":"2002","unstructured":"Kario K  et al. (2002) U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: orthostatic hypertension as a new cardiovascular risk factor. J Am Coll Cardiol 40: 133\u2013141","journal-title":"J Am Coll Cardiol"},{"key":"BFncpneph0228_CR22","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1161\/01.HYP.7.2.196","volume":"7","author":"DH Streeten","year":"1985","unstructured":"Streeten DH  et al. (1985) Orthostatic hypertension: pathogenetic studies. Hypertension 7: 196\u2013203","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1161\/01.HYP.31.1.77","volume":"31","author":"K Kario","year":"1998","unstructured":"Kario K  et al. (1998) Relationship between extreme dippers and orthostatic hypertension in elderly hypertensive patients. Hypertension 31: 77\u201382","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1081\/CEH-120028556","volume":"26","author":"K Kario","year":"2004","unstructured":"Kario K and Shimada K (2004) Risers and extreme-dippers of nocturnal blood pressure in hypertension: antihypertensive strategy for nocturnal blood pressure. Clin Exp Hypertens 26: 177\u2013189","journal-title":"Clin Exp Hypertens"},{"key":"BFncpneph0228_CR25","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1161\/01.STR.28.11.2169","volume":"28","author":"K Matsubayashi","year":"1997","unstructured":"Matsubayashi K  et al. (1997) Postural dysregulation in systolic blood pressure is associated with worsened scoring on neurobehavioral function tests and leukoaraiosis in the older elderly living in a community. Stroke 28: 2169\u20132173","journal-title":"Stroke"},{"key":"BFncpneph0228_CR26","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1161\/01.HYP.30.5.1072","volume":"30","author":"J Jordan","year":"1997","unstructured":"Jordan J  et al. (1997) Malignant vagotonia due to selective baroreflex failure. Hypertension 30: 1072\u20131077","journal-title":"Hypertension"},{"key":"BFncpneph0228_CR27","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1161\/01.CIR.102.21.2611","volume":"102","author":"J Jordan","year":"2000","unstructured":"Jordan J  et al. (2000) Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact. Circulation 102: 2611\u20132618","journal-title":"Circulation"},{"key":"BFncpneph0228_CR28","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1161\/hc1102.105744","volume":"105","author":"AA Smit","year":"2002","unstructured":"Smit AA  et al. (2002) Long-term effects of carotid sinus denervation on arterial blood pressure in humans. Circulation 105: 1329\u20131335","journal-title":"Circulation"},{"key":"BFncpneph0228_CR29","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1196\/annals.1296.063","volume":"1018","author":"HJ Timmers","year":"2004","unstructured":"Timmers HJ  et al. (2004) Cardiovascular responses to stress after carotid baroreceptor denervation in humans. Ann N Y Acad Sci 1018: 515\u2013519","journal-title":"Ann N Y Acad Sci"},{"key":"BFncpneph0228_CR30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1056\/NEJM200002243420803","volume":"342","author":"JR Shannon","year":"2000","unstructured":"Shannon JR  et al. (2000) Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 342: 541\u2013549","journal-title":"N Engl J Med"},{"key":"BFncpneph0228_CR31","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.2337\/diacare.24.10.1783","volume":"24","author":"M Yoshinari","year":"2001","unstructured":"Yoshinari M  et al. (2001) Orthostatic hypertension in patients with type 2 diabetes. Diabetes Care 24: 1783\u20131786","journal-title":"Diabetes Care"},{"key":"BFncpneph0228_CR32","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/00000658-198503000-00023","volume":"201","author":"PJ Jannetta","year":"1985","unstructured":"Jannetta PJ  et al. (1985) Neurogenic hypertension: etiology and surgical treatment. I: observations in 53 patients. Ann Surg 201: 391\u2013398","journal-title":"Ann Surg"},{"key":"BFncpneph0228_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00006123-199807000-00001","volume":"43","author":"EI Levy","year":"1998","unstructured":"Levy EI  et al. (1998) Microvascular decompression of the left lateral medulla oblongata for severe refractory neurogenic hypertension. Neurosurgery 43: 1\u20136","journal-title":"Neurosurgery"},{"key":"BFncpneph0228_CR34","first-page":"326","volume":"111","author":"DH Streeten","year":"1988","unstructured":"Streeten DH  et al. (1988) Abnormal orthostatic changes in blood pressure and heart rate in subjects with intact sympathetic nervous function: evidence for excessive venous pooling. J Lab Clin Med 111: 326\u2013335","journal-title":"J Lab Clin Med"},{"key":"BFncpneph0228_CR35","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1056\/NEJM200010053431404","volume":"343","author":"G Jacob","year":"2000","unstructured":"Jacob G  et al. (2000) The neuropathic postural tachycardia syndrome. N Engl J Med 343: 1008\u20131014","journal-title":"N Engl J Med"},{"key":"BFncpneph0228_CR36","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/01.fjc.0000157440.57236.58","volume":"45","author":"G Raffai","year":"2005","unstructured":"Raffai G  et al. (2005) Experimental orthostasis elicits sustained hypertension, which can be prevented by sympathetic blockade in the rat. J Cardiovasc Pharmacol 45: 354\u2013361","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["Nature Clinical Practice Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0228","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ncpneph0228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:12:59Z","timestamp":1684440779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpneph0228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["BFncpneph0228"],"URL":"https:\/\/doi.org\/10.1038\/ncpneph0228","relation":{},"ISSN":["1745-8323","1745-8331"],"issn-type":[{"value":"1745-8323","type":"print"},{"value":"1745-8331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}