{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:50:52Z","timestamp":1790470252767,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1038\/ncpneph0309","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T05:02:56Z","timestamp":1161838976000},"page":"624-630","source":"Crossref","is-referenced-by-count":36,"title":["Monogenic forms of low-renin hypertension"],"prefix":"10.1038","volume":"2","author":[{"given":"Vesna D","family":"Garovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen T","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFncpneph0309_CR1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0895-7061(02)03201-6","volume":"16","author":"JM Lalouel","year":"2003","unstructured":"Lalouel JM (2003) Large-scale search for genes predisposing to essential hypertension. Am J Hypertens 16: 163\u2013166","journal-title":"Am J Hypertens"},{"key":"BFncpneph0309_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0895-7061(02)03244-2","volume":"16","author":"NJ Samani","year":"2003","unstructured":"Samani NJ (2003) Genome scans for hypertension and blood pressure regulation. Am J Hypertens 16: 167\u2013171","journal-title":"Am J Hypertens"},{"key":"BFncpneph0309_CR3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1161\/01.HYP.0000079505.25750.11","volume":"42","author":"L Mosso","year":"2003","unstructured":"Mosso L  et al. (2003) Primary aldosteronism and hypertensive disease. Hypertension 42: 161\u2013165","journal-title":"Hypertension"},{"key":"BFncpneph0309_CR4","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.tem.2005.02.007","volume":"16","author":"P Mulatero","year":"2005","unstructured":"Mulatero P  et al. (2005) Diagnosis of primary aldosteronism: from screening to subtype differentiation. Trends Endocrinol Metab 16: 114\u2013119","journal-title":"Trends Endocrinol Metab"},{"key":"BFncpneph0309_CR5","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1373\/clinchem.2004.041780","volume":"51","author":"GL Schwartz","year":"2005","unstructured":"Schwartz GL and Turner ST (2005) Screening for primary aldosteronism in essential hypertension: diagnostic accuracy of the ratio of plasma aldosterone concentration to plasma renin activity. Clin Chem 51: 386\u2013394","journal-title":"Clin Chem"},{"key":"BFncpneph0309_CR6","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.amjhyper.2005.01.002","volume":"18","author":"MK Nishizaka","year":"2005","unstructured":"Nishizaka MK  et al. (2005) Validity of plasma aldosterone-to-renin activity ratio in African American and white subjects with resistant hypertension. Am J Hypertens 18: 805\u2013812","journal-title":"Am J Hypertens"},{"key":"BFncpneph0309_CR7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ng0992-66","volume":"2","author":"RP Lifton","year":"1992","unstructured":"Lifton RP  et al. (1992) Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet 2: 66\u201374","journal-title":"Nat Genet"},{"key":"BFncpneph0309_CR8","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1136\/adc.81.5.452","volume":"81","author":"DV Milford","year":"1999","unstructured":"Milford DV (1999) Investigation of hypertension and the recognition of monogenic hypertension. Arch Dis Child 81: 452\u2013455","journal-title":"Arch Dis Child"},{"key":"BFncpneph0309_CR9","doi-asserted-by":"publisher","first-page":"813","DOI":"10.7326\/0003-4819-116-10-813","volume":"116","author":"GM Rich","year":"1992","unstructured":"Rich GM  et al. (1992) Glucocorticoid-remediable aldosteronism in a large kindred: clinical spectrum and diagnosis using a characteristic biochemical phenotype. Ann Intern Med 116: 813\u2013820","journal-title":"Ann Intern Med"},{"key":"BFncpneph0309_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1440-1681.1992.tb00462.x","volume":"19","author":"M Stowasser","year":"1992","unstructured":"Stowasser M  et al. (1992) Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism. Clin Exp Pharmacol Physiol 19: 319\u2013322","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFncpneph0309_CR11","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1136\/jmg.37.11.831","volume":"37","author":"AR Lafferty","year":"2000","unstructured":"Lafferty AR  et al. (2000) A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22). J Med Genet 37: 831\u2013835","journal-title":"J Med Genet"},{"key":"BFncpneph0309_CR12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.tem.2005.02.011","volume":"16","author":"MI New","year":"2005","unstructured":"New MI  et al. (2005) Monogenic low renin hypertension. Trends Endocrinol Metab 16: 92\u201397","journal-title":"Trends Endocrinol Metab"},{"key":"BFncpneph0309_CR13","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0960-0760(91)90268-A","volume":"40","author":"EG Biglieri","year":"1991","unstructured":"Biglieri EG and Kater CE (1991) Mineralocorticoids in congenital adrenal hyperplasia. J Steroid Biochem Mol Biol 40: 493\u2013499","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BFncpneph0309_CR14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1126\/science.289.5476.119","volume":"289","author":"DS Geller","year":"2000","unstructured":"Geller DS  et al. (2000) Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289: 119\u2013123","journal-title":"Science"},{"key":"BFncpneph0309_CR15","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1210\/en.2002-220708","volume":"144","author":"ME Rafestin-Oblin","year":"2003","unstructured":"Rafestin-Oblin ME  et al. (2003) The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related. Endocrinology 144: 528\u2013533","journal-title":"Endocrinology"},{"key":"BFncpneph0309_CR16","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/ng0895-394","volume":"10","author":"T Mune","year":"1995","unstructured":"Mune T  et al. (1995) Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet 10: 394\u2013399","journal-title":"Nat Genet"},{"key":"BFncpneph0309_CR17","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1210\/endo.132.6.8504732","volume":"132","author":"CB Whorwood","year":"1993","unstructured":"Whorwood CB  et al. (1993) Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology 132: 2287\u20132292","journal-title":"Endocrinology"},{"key":"BFncpneph0309_CR18","first-page":"963","volume":"74","author":"S Ulick","year":"1992","unstructured":"Ulick S  et al. (1992) Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab 74: 963\u2013967","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpneph0309_CR19","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0092-8674(94)90250-X","volume":"79","author":"RA Shimkets","year":"1994","unstructured":"Shimkets RA  et al. (1994) Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407\u2013414","journal-title":"Cell"},{"key":"BFncpneph0309_CR20","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ng0995-76","volume":"11","author":"JH Hansson","year":"1995","unstructured":"Hansson JH  et al. (1995) Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 11: 76\u201382","journal-title":"Nat Genet"},{"key":"BFncpneph0309_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0002-9343(98)00018-7","volume":"104","author":"BF Palmer","year":"1998","unstructured":"Palmer BF and Alpern RJ (1998) Liddle's syndrome. Am J Med 104: 301\u2013309","journal-title":"Am J Med"},{"key":"BFncpneph0309_CR22","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1126\/science.1062844","volume":"293","author":"FH Wilson","year":"2001","unstructured":"Wilson FH  et al. (2001) Human hypertension caused by mutations in WNK kinases. Science 293: 1107\u20131112","journal-title":"Science"},{"key":"BFncpneph0309_CR23","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1073\/pnas.242728499","volume":"100","author":"KA Choate","year":"2003","unstructured":"Choate KA  et al. (2003) WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl\u2212-transporting epithelia. Proc Natl Acad Sci USA 100: 663\u2013668","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFncpneph0309_CR24","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/ng1271","volume":"35","author":"KT Kahle","year":"2003","unstructured":"Kahle KT  et al. (2003) WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet 35: 372\u2013376","journal-title":"Nat Genet"},{"key":"BFncpneph0309_CR25","doi-asserted-by":"publisher","first-page":"5739","DOI":"10.1210\/jc.2003-030988","volume":"88","author":"RM Martin","year":"2003","unstructured":"Martin RM  et al. (2003) P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping. J Clin Endocrinol Metab 88: 5739\u20135746","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Nature Clinical Practice Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0309","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:14:22Z","timestamp":1684426462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpneph0309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["BFncpneph0309"],"URL":"https:\/\/doi.org\/10.1038\/ncpneph0309","relation":{},"ISSN":["1745-8323","1745-8331"],"issn-type":[{"value":"1745-8323","type":"print"},{"value":"1745-8331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}