{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:53:08Z","timestamp":1772794388175,"version":"3.50.1"},"reference-count":172,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T00:00:00Z","timestamp":1213056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1038\/ncpneph0848","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T11:45:15Z","timestamp":1213098315000},"page":"378-392","source":"Crossref","is-referenced-by-count":100,"title":["Endogenous digitalis: pathophysiologic roles and therapeutic applications"],"prefix":"10.1038","volume":"4","author":[{"given":"Alexei Y","family":"Bagrov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph I","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,6,10]]},"reference":[{"key":"BFncpneph0848_CR1","first-page":"969","volume":"11","author":"E Ritz","year":"1996","unstructured":"Ritz E (1996) The history of salt\u2014aspects of interest to the nephrologist. Nephrol Dial Transplant 11: 969\u2013975","journal-title":"Nephrol Dial Transplant"},{"key":"BFncpneph0848_CR2","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1152\/physrev.00056.2003","volume":"85","author":"P Meneton","year":"2005","unstructured":"Meneton P et al. (2005) Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev 85: 679\u2013715","journal-title":"Physiol Rev"},{"key":"BFncpneph0848_CR3","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1126\/science.281.5379.898","volume":"281","author":"G Taubes","year":"1998","unstructured":"Taubes G (1998) The (political) science of salt. Science 281: 898\u2013901","journal-title":"Science"},{"key":"BFncpneph0848_CR4","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/00001573-200207000-00007","volume":"17","author":"HE De Wardener","year":"2002","unstructured":"De Wardener HE and MacGregor GA (2002) Sodium and blood pressure. Curr Opin Cardiol 17: 360\u2013367","journal-title":"Curr Opin Cardiol"},{"key":"BFncpneph0848_CR5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s11906-006-0014-y","volume":"8","author":"MH Weinberger","year":"2006","unstructured":"Weinberger MH (2006) Pathogenesis of salt sensitivity of blood pressure. Curr Hypertens Rep 8: 166\u2013170","journal-title":"Curr Hypertens Rep"},{"key":"BFncpneph0848_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000089439","volume":"24","author":"E Ritz","year":"2006","unstructured":"Ritz E et al. (2006) Salt\u2014a potential 'uremic toxin'? Blood Purif 24: 63\u201366","journal-title":"Blood Purif"},{"issue":"Suppl 1","key":"BFncpneph0848_CR7","first-page":"19","volume":"17","author":"J Stamler","year":"1991","unstructured":"Stamler J et al. (1991) Findings of the international cooperative INTERSALT study. Hypertension 17 (Suppl 1): 19\u201315","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR8","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","volume":"336","author":"LJ Appel","year":"1997","unstructured":"Appel LJ et al. for the DASH Collaborative Research Group (1997) A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 336: 1117\u20131124","journal-title":"N Engl J Med"},{"key":"BFncpneph0848_CR9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1152\/physrev.1985.65.3.658","volume":"65","author":"HE de Wardener","year":"1985","unstructured":"de Wardener HE and Clarkson EM (1985) Concept of natriuretic hormone. Physiol Rev 65: 658\u2013759","journal-title":"Physiol Rev"},{"key":"BFncpneph0848_CR10","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1161\/01.CIR.86.2.694","volume":"86","author":"RA Kelly","year":"1992","unstructured":"Kelly RA and Smith TW (1992) Is ouabain the endogenous digitalis? Circulation 86: 694\u2013697","journal-title":"Circulation"},{"key":"BFncpneph0848_CR11","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1046\/j.1432-1033.2003.03554.x","volume":"270","author":"O Hansen","year":"2003","unstructured":"Hansen O (2003) No evidence for a role in signal-transduction of Na+\/K+-ATPase interaction with putative endogenous ouabain. Eur J Biochem 270: 1916\u20131919","journal-title":"Eur J Biochem"},{"key":"BFncpneph0848_CR12","doi-asserted-by":"publisher","first-page":"6259","DOI":"10.1073\/pnas.88.14.6259","volume":"88","author":"JM Hamlyn","year":"1991","unstructured":"Hamlyn JM et al. (1991) Identification and characterization of an ouabain-like compound from human plasma. Proc Natl Acad Sci USA 88: 6259\u20136263","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFncpneph0848_CR13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1432-1033.1993.tb18141.x","volume":"216","author":"D Lichtstein","year":"1993","unstructured":"Lichtstein D et al. (1993) Identification of digitalis-like compounds in human cataractous lenses. Eur J Biochem 216: 261\u2013268","journal-title":"Eur J Biochem"},{"key":"BFncpneph0848_CR14","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1161\/01.HYP.31.5.1097","volume":"31","author":"AY Bagrov","year":"1998","unstructured":"Bagrov AY et al. (1998) Characterization of a urinary bufodienolide Na+,K+-ATPase inhibitor in patients after acute myocardial infarction. Hypertension 31: 1097\u20131103","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.clinbiochem.2004.08.005","volume":"38","author":"Y Komiyama","year":"2005","unstructured":"Komiyama Y et al. (2005) A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clin Biochem 38: 36\u201345","journal-title":"Clin Biochem"},{"key":"BFncpneph0848_CR16","doi-asserted-by":"publisher","first-page":"C509","DOI":"10.1152\/ajpcell.00098.2007","volume":"293","author":"W Schoner","year":"2007","unstructured":"Schoner W and Scheiner-Bobis G (2007) Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. Am J Physiol Cell Physiol 293: C509\u2013C536","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFncpneph0848_CR17","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.lfs.2006.05.017","volume":"79","author":"FJ Haddy","year":"2006","unstructured":"Haddy FJ (2006) Role of dietary salt in hypertension. Life Sci 79: 1585\u20131592","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1748-1716.2006.01546.x","volume":"187","author":"SN Orlov","year":"2006","unstructured":"Orlov SN and Hamet P (2006) The death of cardiotonic steroid-treated cells: evidence of Na+i,K+i-independent H+i-sensitive signalling. Acta Physiol (Oxf) 187: 231\u2013240","journal-title":"Acta Physiol (Oxf)"},{"key":"BFncpneph0848_CR19","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1385\/CBB:46:3:303","volume":"46","author":"SV Pierre","year":"2006","unstructured":"Pierre SV and Xie Z (2006) The Na,K-ATPase receptor complex: its organization and membership. Cell Biochem Biophys 46: 303\u2013316","journal-title":"Cell Biochem Biophys"},{"key":"BFncpneph0848_CR20","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.lfs.2007.03.013","volume":"80","author":"M Nesher","year":"2007","unstructured":"Nesher M et al. (2007) The digitalis-like steroid hormones: new mechanisms of action and biological significance. Life Sci 80: 2093\u20132107","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR21","doi-asserted-by":"publisher","first-page":"H1781","DOI":"10.1152\/ajpheart.00707.2004","volume":"289","author":"JA Wasserstrom","year":"2005","unstructured":"Wasserstrom JA and Aistrup GL (2005) Digitalis: new actions for an old drug. Am J Physiol Heart Circ Physiol 289: H1781\u2013H1793","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFncpneph0848_CR22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/01.hco.0000231398.64362.94","volume":"21","author":"BS Huang","year":"2006","unstructured":"Huang BS et al. (2006) The central role of the brain in salt-sensitive hypertension. Curr Opin Cardiol 21: 295\u2013304","journal-title":"Curr Opin Cardiol"},{"key":"BFncpneph0848_CR23","doi-asserted-by":"publisher","first-page":"R514","DOI":"10.1152\/ajpregu.00819.2005","volume":"290","author":"MP Blaustein","year":"2006","unstructured":"Blaustein MP et al. (2006) How does salt retention raise blood pressure? Am J Physiol Regul Integr Comp Physiol 290: R514\u2013R523","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFncpneph0848_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1056\/NEJM197501092920207","volume":"292","author":"RW Schrier","year":"1975","unstructured":"Schrier RW and Berl T (1975) Nonosmolar factors affecting renal water excretion (first of two parts). N Engl J Med 292: 81\u201388","journal-title":"N Engl J Med"},{"key":"BFncpneph0848_CR25","doi-asserted-by":"publisher","first-page":"155","DOI":"10.7326\/0003-4819-113-2-155","volume":"113","author":"RW Schrier","year":"1990","unstructured":"Schrier RW (1990) Body fluid volume regulation in health and disease: a unifying hypothesis. Ann Intern Med 113: 155\u2013159","journal-title":"Ann Intern Med"},{"key":"BFncpneph0848_CR26","first-page":"249","volume":"21","author":"H de Wardener","year":"1961","unstructured":"de Wardener H et al. (1961) Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin Sci 21: 249\u2013258","journal-title":"Clin Sci"},{"key":"BFncpneph0848_CR27","first-page":"497","volume":"12","author":"JH Cort","year":"1963","unstructured":"Cort JH and Lichardus B (1963) The natriuretic activity of jugular vein blood during carotid occlusion. Physiol Bohemoslov 12: 497\u2013501","journal-title":"Physiol Bohemoslov"},{"key":"BFncpneph0848_CR28","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1172\/JCI106312","volume":"49","author":"VM Buckalew Jr","year":"1970","unstructured":"Buckalew VM Jr et al. (1970) The effect of dialysates and ultrafiltrates of plasma of saline-loaded dogs on toad bladder sodium transport. J Clin Invest 49: 926\u2013935","journal-title":"J Clin Invest"},{"key":"BFncpneph0848_CR29","first-page":"57","volume":"34","author":"RW Schrier","year":"1968","unstructured":"Schrier RW et al. (1968) Absence of natriuretic response to acute hypotonic intravascular volume expansion in dogs. Clin Sci 34: 57\u201372","journal-title":"Clin Sci"},{"key":"BFncpneph0848_CR30","first-page":"433","volume":"35","author":"RW Schrier","year":"1968","unstructured":"Schrier RW et al. (1968) Effect of isotonic saline infusion and acute haemorrhage on plasma oxytocin and vasopressin concentrations in dogs. Clin Sci 35: 433\u2013443","journal-title":"Clin Sci"},{"key":"BFncpneph0848_CR31","first-page":"97","volume":"1","author":"HE de Wardener","year":"1971","unstructured":"de Wardener HE et al. (1971) Evidence for a hormone other than aldosterone which controls urinary sodium excretion. Adv Nephrol Necker Hosp 1: 97\u2013111","journal-title":"Adv Nephrol Necker Hosp"},{"key":"BFncpneph0848_CR32","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1159\/000180341","volume":"12","author":"HJ Kramer","year":"1974","unstructured":"Kramer HJ and Gonick HC (1974) Effect of extracellular volume expansion on renal Na-K-ATPase and cell metabolism. Nephron 12: 281\u2013296","journal-title":"Nephron"},{"key":"BFncpneph0848_CR33","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1172\/JCI107707","volume":"53","author":"MA Kaplan","year":"1974","unstructured":"Kaplan MA et al. (1974) The effects of the natriuretic factor from uremic urine on sodium transport, water and electrolyte content, and pyruvate oxidation by the isolated toad bladder. J Clin Invest 53: 1568\u20131577","journal-title":"J Clin Invest"},{"key":"BFncpneph0848_CR34","first-page":"293","volume":"48","author":"NS Bricker","year":"1975","unstructured":"Bricker NS et al. (1975) On the biology of sodium excretion: the search for a natriuretic hormone. Yale J Biol Med 48: 293\u2013303","journal-title":"Yale J Biol Med"},{"key":"BFncpneph0848_CR35","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/287743a0","volume":"287","author":"KA Gruber","year":"1980","unstructured":"Gruber KA et al. (1980) Endogenous digitalis-like substance in plasma of volume-expanded dogs. Nature 287: 743\u2013745","journal-title":"Nature"},{"key":"BFncpneph0848_CR36","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/300650a0","volume":"300","author":"JM Hamlyn","year":"1982","unstructured":"Hamlyn JM et al. (1982) A circulating inhibitor of (Na+ + K+)ATPase associated with essential hypertension. Nature 300: 650\u2013652","journal-title":"Nature"},{"key":"BFncpneph0848_CR37","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1016\/0024-3205(82)90313-7","volume":"30","author":"I Kojima","year":"1982","unstructured":"Kojima I et al. (1982) Involvement of endogenous digitalis-like substance in genesis of deoxycorticosterone-salt hypertension. Life Sci 30: 1775\u20131781","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR38","first-page":"377","volume":"44","author":"A Goto","year":"1992","unstructured":"Goto A et al. (1992) Physiology and pharmacology of endogenous digitalis-like factors. Pharmacol Rev 44: 377\u2013399","journal-title":"Pharmacol Rev"},{"key":"BFncpneph0848_CR39","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0009-9120(81)90704-9","volume":"14","author":"B Bergdahl","year":"1981","unstructured":"Bergdahl B and Molin L (1981) Precision of digoxin radioimmunoassays and matrix effects: four kits compared. Clin Biochem 14: 67\u201371","journal-title":"Clin Biochem"},{"key":"BFncpneph0848_CR40","first-page":"810","volume":"5","author":"RA Pleasants","year":"1986","unstructured":"Pleasants RA et al. (1986) Interference of digoxin-like immunoreactive substances with three digoxin immunoassays in patients with various degrees of renal function. Clin Pharm 5: 810\u2013816","journal-title":"Clin Pharm"},{"key":"BFncpneph0848_CR41","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1161\/01.CIR.99.9.1265","volume":"99","author":"PJ Hauptman","year":"1999","unstructured":"Hauptman PJ and Kelly RA (1999) Digitalis. Circulation 99: 1265\u20131270","journal-title":"Circulation"},{"key":"BFncpneph0848_CR42","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1074\/jbc.273.2.784","volume":"273","author":"R Schneider","year":"1998","unstructured":"Schneider R et al. (1998) Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. J Biol Chem 273: 784\u2013792","journal-title":"J Biol Chem"},{"key":"BFncpneph0848_CR43","doi-asserted-by":"publisher","first-page":"6654","DOI":"10.1073\/pnas.96.12.6654","volume":"96","author":"A Kawamura","year":"1999","unstructured":"Kawamura A et al. (1999) On the structure of endogenous ouabain. Proc Natl Acad Sci USA 96: 6654\u20136659","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFncpneph0848_CR44","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1046\/j.1432-1033.2002.02910.x","volume":"269","author":"Z Xie","year":"2002","unstructured":"Xie Z and Askari A (2002) Na(+)\/K(+)-ATPase as a signal transducer. Eur J Biochem 269: 2434\u20132439","journal-title":"Eur J Biochem"},{"key":"BFncpneph0848_CR45","doi-asserted-by":"publisher","first-page":"C1550","DOI":"10.1152\/ajpcell.00555.2002","volume":"284","author":"L Liu","year":"2003","unstructured":"Liu L et al. (2003) Role of caveolae in signal-transducing function of cardiac Na+\/K+-ATPase. Am J Physiol Cell Physiol 284: C1550\u2013C1560","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFncpneph0848_CR46","doi-asserted-by":"publisher","first-page":"17250","DOI":"10.1074\/jbc.M313239200","volume":"279","author":"H Wang","year":"2004","unstructured":"Wang H et al. (2004) Ouabain assembles signaling cascades through the caveolar Na+\/K+-ATPase. J Biol Chem 279: 17250\u201317259","journal-title":"J Biol Chem"},{"key":"BFncpneph0848_CR47","doi-asserted-by":"publisher","first-page":"10585","DOI":"10.1074\/jbc.M609181200","volume":"282","author":"M Liang","year":"2007","unstructured":"Liang M et al. (2007) Identification of a pool of non-pumping Na\/K-ATPase. J Biol Chem 282: 10585\u201310593","journal-title":"J Biol Chem"},{"key":"BFncpneph0848_CR48","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1161\/01.HYP.38.2.198","volume":"38","author":"P Manunta","year":"2001","unstructured":"Manunta P et al. (2001) Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension. Hypertension 38: 198\u2013203","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR49","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.amjhyper.2005.01.007","volume":"18","author":"S Balzan","year":"2005","unstructured":"Balzan S et al. (2005) Endogenous ouabain and acute salt loading in low-renin hypertension. Am J Hypertens 18: 906\u2013909","journal-title":"Am J Hypertens"},{"key":"BFncpneph0848_CR50","doi-asserted-by":"publisher","first-page":"R553","DOI":"10.1152\/ajpregu.00648.2005","volume":"290","author":"P Manunta","year":"2006","unstructured":"Manunta P et al. (2006) Salt intake and depletion increase circulating levels of endogenous ouabain in normal men. Am J Physiol Regul Integr Comp Physiol 290: R553\u2013R559","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFncpneph0848_CR51","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1161\/01.HYP.26.5.781","volume":"26","author":"AY Bagrov","year":"1995","unstructured":"Bagrov AY et al. (1995) Endogenous marinobufagenin-like immunoreactive factor and Na,K-ATPase inhibition during voluntary hypoventilation. Hypertension 26: 781\u2013788","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR52","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1097\/00004872-199917080-00018","volume":"17","author":"DA Lopatin","year":"1999","unstructured":"Lopatin DA et al. (1999) Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia. J Hypertens 17: 1179\u20131187","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR53","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3109\/10641969809053240","volume":"20","author":"HC Gonick","year":"1998","unstructured":"Gonick HC et al. (1998) Simultaneous measurement of marinobufagenin, ouabain and hypertension-associated protein in various disease states. Clin Exp Hypertens 20: 617\u2013627","journal-title":"Clin Exp Hypertens"},{"key":"BFncpneph0848_CR54","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1097\/00004872-200206000-00032","volume":"20","author":"AI Fridman","year":"2002","unstructured":"Fridman AI et al. (2002) Marinobufagenin, an endogenous ligand of alpha-1 Na\/K-ATPase, is a marker of congestive heart failure severity. J Hypertens 20: 1189\u20131194","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR55","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/00004872-200102000-00009","volume":"19","author":"Y Komiyama","year":"2001","unstructured":"Komiyama Y et al. (2001) Identification of endogenous ouabain in culture supernatant of PC12 cells. J Hypertens 19: 229\u2013236","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR56","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1161\/CIRCULATIONAHA.105.554071","volume":"112","author":"JR Murrell","year":"2005","unstructured":"Murrell JR et al. (2005) Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Circulation 112: 1301\u20131308","journal-title":"Circulation"},{"key":"BFncpneph0848_CR57","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/clinchem\/48.10.1720","volume":"48","author":"MA el-Masri","year":"2002","unstructured":"el-Masri MA et al. (2002) Human adrenal cells in culture produce both ouabain-like and dihydroouabain-like factors. Clin Chem 48: 1720\u20131730","journal-title":"Clin Chem"},{"key":"BFncpneph0848_CR58","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1161\/01.HYP.29.1.401","volume":"29","author":"J Laredo","year":"1997","unstructured":"Laredo J et al. (1997) Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors. Hypertension 29: 401\u2013407","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR59","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1161\/01.HYP.33.1.373","volume":"33","author":"JR Shah","year":"1999","unstructured":"Shah JR et al. (1999) Effects of angiotensin II on sodium potassium pumps, endogenous ouabain, and aldosterone in bovine zona glomerulosa cells. Hypertension 33: 373\u2013377","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR60","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/S0006-291X(05)80898-8","volume":"173","author":"A Goto","year":"1990","unstructured":"Goto A et al. (1990) Isolation of a urinary digitalis-like factor indistinguishable from digoxin. Biochem Biophys Res Commun 173: 1093\u20131101","journal-title":"Biochem Biophys Res Commun"},{"key":"BFncpneph0848_CR61","doi-asserted-by":"publisher","first-page":"8731","DOI":"10.1074\/jbc.271.15.8731","volume":"271","author":"HM Qazzaz","year":"1996","unstructured":"Qazzaz HM et al. (1996) Deglycosylated products of endogenous digoxin-like immunoreactive factor in mammalian tissue. J Biol Chem 271: 8731\u20138737","journal-title":"J Biol Chem"},{"key":"BFncpneph0848_CR62","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1161\/01.HYP.34.4.733","volume":"34","author":"BS Huang","year":"1999","unstructured":"Huang BS et al. (1999) Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation. Hypertension 34: 733\u2013738","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR63","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/0024-3205(91)90309-Y","volume":"49","author":"A Goto","year":"1991","unstructured":"Goto A et al. (1991) Digoxin-like immunoreactivity: is it still worth measuring? Life Sci 49: 1667\u20131678","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR64","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/B978-0-12-138902-4.50027-1","volume-title":"Venomous animals and their venoms","author":"K Meyer","year":"1971","unstructured":"Meyer K and Linde H (1971) Collection of toad venoms and chemistry of the toad venom steroids. In Venomous animals and their venoms, 521\u2013556 (Eds Bucherl W and Buckley E) London: Academic Press"},{"key":"BFncpneph0848_CR65","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/jps.2600561202","volume":"56","author":"KK Chen","year":"1967","unstructured":"Chen KK and Kowarikowa A (1967) Pharmacology and toxicology of toad venom. J Pharmacol Sci 56: 1535\u20131542","journal-title":"J Pharmacol Sci"},{"key":"BFncpneph0848_CR66","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1126\/science.6245447","volume":"208","author":"J Flier","year":"1980","unstructured":"Flier J et al. (1980) Widespread occurrence in frogs and toads of skin compounds interacting with the ouabain site of Na+,K+-ATPase. Science 208: 503\u2013505","journal-title":"Science"},{"key":"BFncpneph0848_CR67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0304-4165(91)90183-H","volume":"1073","author":"D Lichtstein","year":"1981","unstructured":"Lichtstein D et al. (1981) Effect of salt acclimation on digitalis-like compounds in the toad. Biochim Biophys Acta 1073: 65\u201368","journal-title":"Biochim Biophys Acta"},{"key":"BFncpneph0848_CR68","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/0735-1097(88)91543-4","volume":"11","author":"RS Kieval","year":"1988","unstructured":"Kieval RS et al. (1988) Cellular electrophysiologic effects of vertebrate digitalis-like substances. J Am Col Cardiol 11: 637\u2013643","journal-title":"J Am Col Cardiol"},{"key":"BFncpneph0848_CR69","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/0006-2952(91)90668-U","volume":"41","author":"A Goto","year":"1991","unstructured":"Goto A et al. (1991) Immunoreactivity of endogenous digitalis-like factors. Biochem Pharmacol 41: 1261\u20131263","journal-title":"Biochem Pharmacol"},{"key":"BFncpneph0848_CR70","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/0145-2126(95)00081-X","volume":"19","author":"S Numazawa","year":"1995","unstructured":"Numazawa S et al. (1995) A cardiotonic steroid bufalin-like factor in human plasma induces leukemia cell differentiation. Leuk Res 19: 945\u2013953","journal-title":"Leuk Res"},{"key":"BFncpneph0848_CR71","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/S0024-3205(00)01013-4","volume":"68","author":"M Oda","year":"2001","unstructured":"Oda M et al. (2001) Determination of bufalin-like immunoreactivity in serum of humans and rats by time-resolved fluoroimmunoassay for using a monoclonal antibody. Life Sci 68: 1107\u20131117","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR72","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1161\/01.HYP.27.5.1073","volume":"27","author":"B Sich","year":"1996","unstructured":"Sich B et al. (1996) Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound. Hypertension 27: 1073\u20131078","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR73","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0140-6736(96)02257-X","volume":"348","author":"PJ Hilton","year":"1996","unstructured":"Hilton PJ et al. (1996) An inhibitor of the sodium pump obtained from human placenta. Lancet 348: 303\u2013305","journal-title":"Lancet"},{"key":"BFncpneph0848_CR74","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0014-2999(93)90950-M","volume":"234","author":"AY Bagrov","year":"1993","unstructured":"Bagrov AY et al. (1993) Digitalis-Like and vasoconstrictor properties of endogenous digoxin-like factor from Bufo marinus toad. Eur J Pharmacol 234: 165\u2013172","journal-title":"Eur J Pharmacol"},{"key":"BFncpneph0848_CR75","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0014-2999(94)00735-P","volume":"274","author":"AY Bagrov","year":"1995","unstructured":"Bagrov AY et al. (1995) Effects of two endogenous digitalis-like factors, ouabain and marinobufagenin in isolated rat aorta. Eur J Pharmacol 274: 151\u2013158","journal-title":"Eur J Pharmacol"},{"key":"BFncpneph0848_CR76","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/0895-7061(96)00148-3","volume":"9","author":"AY Bagrov","year":"1996","unstructured":"Bagrov AY et al. (1996) Endogenous marinobufagenin-like immunoreactive substance: a possible endogenous Na,K-ATPase inhibitor with vasoconstrictor activity. Am J Hypertens 9: 982\u2013990","journal-title":"Am J Hypertens"},{"key":"BFncpneph0848_CR77","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1161\/01.HYP.30.6.1544","volume":"30","author":"CS Ho","year":"1997","unstructured":"Ho CS et al. (1997) Effect of carbidopa on the excretion of sodium, dopamine, and ouabain-like substance in the rat. Hypertension 30: 1544\u20131548","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR78","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1016\/S0024-3205(97)00953-3","volume":"61","author":"AN Butt","year":"1997","unstructured":"Butt AN et al. (1997) Effect of high salt intake on plasma and tissue concentration of endogenous ouabain-like substance in the rat. Life Sci 61: 2367\u20137233","journal-title":"Life Sci"},{"issue":"Suppl 2","key":"BFncpneph0848_CR79","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1097\/00005344-199322002-00014","volume":"22","author":"JH Ludens","year":"1993","unstructured":"Ludens JH et al. (1993) Digitalis-like factor and ouabain-like compound in plasma of volume-expanded dogs. J Cardiovasc Pharmacol 22 (Suppl 2): S38\u2013S41","journal-title":"J Cardiovasc Pharmacol"},{"key":"BFncpneph0848_CR80","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S0008-6363(95)00208-1","volume":"206","author":"AY Bagrov","year":"1996","unstructured":"Bagrov AY et al. (1996) Plasma marinobufagenin-like and ouabain-like immunorecativity during acute saline volume expansion in anesthetized dogs. Cardiovasc Res 206: 296\u2013305","journal-title":"Cardiovasc Res"},{"key":"BFncpneph0848_CR81","first-page":"R352","volume":"281","author":"OV Fedorova","year":"2001","unstructured":"Fedorova OV et al. (2001) Interaction of high sodium chloride intake and psychosocial stress on endogenous ligands of the sodium pump and blood pressure in normotensive rats. Am J Physiol 281: R352\u2013R358","journal-title":"Am J Physiol"},{"key":"BFncpneph0848_CR82","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1161\/01.CIR.102.24.3009","volume":"102","author":"OV Fedorova","year":"2000","unstructured":"Fedorova OV et al. (2000) Differential effects of acute NaCl loading on endogenous ouabain-like and marinobufagenin-like ligands of the sodium pump in Dahl hypertensive rats. Circulation 102: 3009\u20133014","journal-title":"Circulation"},{"key":"BFncpneph0848_CR83","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1161\/hc0902.104710","volume":"105","author":"OV Fedorova","year":"2002","unstructured":"Fedorova OV et al. (2002) An endogenous ligand of \u03b1-1 sodium pump, marinobufagenin, is a novel mediator of sodium chloride dependent hypertension. Circulation 105: 1122\u20131127","journal-title":"Circulation"},{"key":"BFncpneph0848_CR84","doi-asserted-by":"publisher","first-page":"R1248","DOI":"10.1152\/ajpregu.00782.2007","volume":"294","author":"DE Anderson","year":"2008","unstructured":"Anderson DE et al. (2008) Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. Am J Physiol Regul Integr Comp Physiol 294: R1248\u2013R1254","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFncpneph0848_CR85","doi-asserted-by":"publisher","first-page":"R529","DOI":"10.1152\/ajpregu.00518.2005","volume":"290","author":"P Ferrari","year":"2006","unstructured":"Ferrari P et al. (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+-ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 290: R529\u2013R535","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFncpneph0848_CR86","doi-asserted-by":"publisher","first-page":"H2110","DOI":"10.1152\/ajpheart.00454.2002","volume":"283","author":"LV Rossoni","year":"2002","unstructured":"Rossoni LV et al. (2002) Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors. Am J Physiol Heart Circ Physiol 283: H2110\u2013H2118","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFncpneph0848_CR87","doi-asserted-by":"publisher","first-page":"33306","DOI":"10.1074\/jbc.M402187200","volume":"279","author":"M Ferrandi","year":"2004","unstructured":"Ferrandi M et al. (2004) Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238. J Biol Chem 279: 33306\u201333314","journal-title":"J Biol Chem"},{"key":"BFncpneph0848_CR88","doi-asserted-by":"publisher","first-page":"15845","DOI":"10.1073\/pnas.0507358102","volume":"102","author":"I Dostanic-Larson","year":"2005","unstructured":"Dostanic-Larson I et al. (2005) The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci USA 102: 15845\u201315850","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFncpneph0848_CR89","doi-asserted-by":"publisher","first-page":"H193","DOI":"10.1152\/ajpheart.00802.2005","volume":"291","author":"Briones","year":"2006","unstructured":"Briones et al. (2006) Alterations in structure and mechanics of resistance arteries from ouabain-induced hypertensive rats. Am J Physiol Heart Circ Physiol 291: H193\u2013H201","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFncpneph0848_CR90","doi-asserted-by":"publisher","first-page":"H624","DOI":"10.1152\/ajpheart.01148.2005","volume":"291","author":"WJ Cheung","year":"2006","unstructured":"Cheung WJ et al. (2006) Central and peripheral renin-angiotensin systems in ouabain-induced hypertension. Am J Physiol Heart Circ Physiol 291: H624\u2013H630","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFncpneph0848_CR91","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.lfs.2006.04.017","volume":"79","author":"LV Rossoni","year":"2006","unstructured":"Rossoni LV et al. (2006) Ouabain-induced hypertension enhances left ventricular contractility in rats. Life Sci 79: 1537\u20131545","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR92","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.1073\/pnas.91.9.3999","volume":"91","author":"G Bianchi","year":"1994","unstructured":"Bianchi G et al. (1994) Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 91: 3999\u20134003","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFncpneph0848_CR93","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1161\/01.RES.0000149570.20845.89","volume":"95","author":"R Efendiev","year":"2004","unstructured":"Efendiev R et al. (2004) Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+K+-ATPase trafficking in response to GPCR signals and intracellular sodium. Circ Res 95: 1100\u20131108","journal-title":"Circ Res"},{"key":"BFncpneph0848_CR94","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1113\/jphysiol.2005.091801","volume":"569","author":"J Zhang","year":"2005","unstructured":"Zhang J et al. (2005) Sodium pump \u03b12 subunits control myogenic tone and blood pressure in mice. J Physiol 569: 243\u2013256","journal-title":"J Physiol"},{"key":"BFncpneph0848_CR95","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1523-1755.2004.00723.x","volume":"66","author":"J Liu","year":"2004","unstructured":"Liu J et al. (2004) Ouabain induces endocytosis of plasmalemmal Na\/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int 66: 227\u2013241","journal-title":"Kidney Int"},{"key":"BFncpneph0848_CR96","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1111\/j.1523-1755.2005.00283.x","volume":"67","author":"J Liu","year":"2005","unstructured":"Liu J et al. (2005) Ouabain-induced endocytosis of the plasmalemmal Na\/K-ATPase in LLC-PK1 cells requires caveolin-1. Kidney Int 67: 1844\u20131854","journal-title":"Kidney Int"},{"key":"BFncpneph0848_CR97","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1681\/ASN.2006010086","volume":"18","author":"AN Nguyen","year":"2007","unstructured":"Nguyen AN et al. (2007) Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation. J Am Soc Nephrol 18: 46\u201357","journal-title":"J Am Soc Nephrol"},{"key":"BFncpneph0848_CR98","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1097\/00004872-200308000-00010","volume":"21","author":"JG Wang","year":"2003","unstructured":"Wang JG et al. (2003) Salt, endogenous ouabain and blood pressure interactions in the general population. J Hypertens 21: 1475\u20131481","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR99","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0022-3565(24)38059-0","volume":"288","author":"P Ferrari","year":"1999","unstructured":"Ferrari P et al. (1999) PST 2238: a new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther 288: 1074\u20131083","journal-title":"J Pharmacol Exp Ther"},{"key":"BFncpneph0848_CR100","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1161\/01.HYP.28.6.1005","volume":"28","author":"BS Huang","year":"1996","unstructured":"Huang BS and Leenen FH (1996) Brain 'ouabain' and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive rats. Hypertension 28: 1005\u20131012","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR101","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1161\/01.HYP.32.6.1028","volume":"32","author":"BS Huang","year":"1998","unstructured":"Huang BS and Leenen FH (1998) Both brain angiotensin II and 'ouabain' contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake. Hypertension 32: 1028\u20131033","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR102","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1097\/HJH.0b013e328200497a","volume":"25","author":"OV Fedorova","year":"2007","unstructured":"Fedorova OV et al. (2007) Intrahippocampal microinjection of an exquisitely low dose of ouabain mimics NaCl loading and stimulates a bufadienolide Na\/K-ATPase inhibitor. J Hypertens 25: 1834\u20131844","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR103","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1097\/01.hjh.0000174969.79836.8b","volume":"23","author":"OV Fedorova","year":"2005","unstructured":"Fedorova OV et al. (2005) Brain ouabain stimulates peripheral marinobufagenin via angiotensin II signalling in NaCl loaded Dahl-S rats. J Hypertens 23: 1515\u20131523","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR104","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1253\/jcj.48.1243","volume":"48","author":"H Takahashi","year":"1984","unstructured":"Takahashi H et al. (1984) Centrally-induced vasopressor responses to sodium-potassium adenosine triphosphatase inhibitor, ouabain, may be mediated via angiotensin II in the anteroventral third ventricle in the brain. Jpn Circ J 48: 1243\u20131250","journal-title":"Jpn Circ J"},{"key":"BFncpneph0848_CR105","first-page":"H275","volume":"270","author":"BS Huang","year":"1996","unstructured":"Huang BS and Leenen FHH (1996) Sympathoexcitatory and pressor responses to increased brain sodium and ouabain are mediated via brain ANGII. Am J Physiol 270: H275\u2013H280","journal-title":"Am J Physiol"},{"key":"BFncpneph0848_CR106","doi-asserted-by":"publisher","first-page":"H1160","DOI":"10.1152\/ajpheart.00126.2004","volume":"287","author":"BS Huang","year":"2004","unstructured":"Huang BS et al. (2004) Increases in CSF [Na+] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet. Am J Physiol Heart Circ Physiol 287: H1160\u2013H1166","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFncpneph0848_CR107","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1097\/00004872-200308000-00016","volume":"21","author":"H Wang","year":"2003","unstructured":"Wang H and Leenen FH (2003) Brain sodium channels and central sodium-induced increases in brain ouabain-like compound and blood pressure. J Hypertens 21: 1519\u20131524","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR108","doi-asserted-by":"publisher","first-page":"R1787","DOI":"10.1152\/ajpregu.00063.2005","volume":"289","author":"MS Amin","year":"2005","unstructured":"Amin MS et al. (2005) Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain. Am J Physiol Regul Integr Comp Physiol 289: R1787\u2013R1797","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFncpneph0848_CR109","doi-asserted-by":"publisher","first-page":"H2039","DOI":"10.1152\/ajpheart.00325.2007","volume":"293","author":"SN Orlov","year":"2007","unstructured":"Orlov SN and Mongin AA (2007) Salt-sensing mechanisms in blood pressure regulation and hypertension. Am J Physiol Heart Circ Physiol 293: H2039\u2013H2053","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFncpneph0848_CR110","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3109\/10641969809053236","volume":"20","author":"OV Fedorova","year":"1998","unstructured":"Fedorova OV et al. (1998) Endogenous marinobufagenin-like factor in acute plasma volume expansion. Clin Exp Hypertens 20: 581\u2013591","journal-title":"Clin Exp Hypertens"},{"key":"BFncpneph0848_CR111","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1111\/j.1523-1755.2005.00285.x","volume":"67","author":"SM Periyasamy","year":"2005","unstructured":"Periyasamy SM et al. (2005) Salt loading induces redistribution of the plasmalemmal Na\/K-ATPase in proximal tubule cells. Kidney Int 67: 1868\u20131877","journal-title":"Kidney Int"},{"key":"BFncpneph0848_CR112","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0895-7061(97)00096-4","volume":"10","author":"OV Fedorova","year":"1997","unstructured":"Fedorova OV and Bagrov AY (1997) Inhibition of Na\/K ATPase from rat aorta by two Na\/K pump inhibitors, ouabain and marinobufagenin: evidence of interaction with different alpha-subunit isoforms. Am J Hypertens 10: 929\u2013935","journal-title":"Am J Hypertens"},{"issue":"Suppl","key":"BFncpneph0848_CR113","first-page":"S21","volume":"24","author":"LK Dahl","year":"1969","unstructured":"Dahl LK et al. (1969) Humoral transmission of hypertension: evidence from parabiosis. Circ Res 24 (Suppl): S21\u2013S33","journal-title":"Circ Res"},{"key":"BFncpneph0848_CR114","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pathophys.2007.09.008","volume":"14","author":"J Liu","year":"2007","unstructured":"Liu J and Shapiro JI (2007) Regulation of sodium pump endocytosis by cardiotonic steroids: Molecular mechanisms and physiological implications. Pathophysiology 14: 171\u2013181","journal-title":"Pathophysiology"},{"key":"BFncpneph0848_CR115","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1046\/j.1523-1755.2002.00672.x","volume":"62","author":"J Liu","year":"2002","unstructured":"Liu J et al. (2002) Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells. Kidney Int 62: 2118\u20132125","journal-title":"Kidney Int"},{"key":"BFncpneph0848_CR116","doi-asserted-by":"publisher","first-page":"F997","DOI":"10.1152\/ajprenal.00322.2005","volume":"290","author":"S Oweis","year":"2006","unstructured":"Oweis S et al. (2006) Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells. Am J Physiol Renal Physiol 290: F997\u2013F1008","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFncpneph0848_CR117","doi-asserted-by":"publisher","first-page":"C555","DOI":"10.1152\/ajpcell.00475.2007","volume":"294","author":"H Cai","year":"2008","unstructured":"Cai H et al. (2008) Regulation of apical NHE3 trafficking by ouabain-induced activation of basolateral Na\/K-ATPase receptor complex. Am J Physiol Cell Physiol 294: C555\u2013C563","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFncpneph0848_CR118","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1056\/NEJM199908193410806","volume":"341","author":"RW Schrier","year":"1999","unstructured":"Schrier RW and Abraham WT (1999) Hormones and hemodynamics in heart failure. N Engl J Med 341: 577\u2013585","journal-title":"N Engl J Med"},{"key":"BFncpneph0848_CR119","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0022-2828(81)90232-7","volume":"13","author":"V Schreiber","year":"1981","unstructured":"Schreiber V et al. (1981) Digoxin-like immunoreactivity in the serum of rats with cardiac overload. J Mol Cell Cardiol 13: 107\u2013110","journal-title":"J Mol Cell Cardiol"},{"key":"BFncpneph0848_CR120","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1253\/jcj.52.1309","volume":"52","author":"T Morise","year":"1988","unstructured":"Morise T et al. (1988) Biological activity of partially purified digitalis-like substance and Na-K-ATPase inhibitor in rats. Jpn Circ J 52: 1309\u20131316","journal-title":"Jpn Circ J"},{"key":"BFncpneph0848_CR121","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0167-5273(90)90190-G","volume":"27","author":"ZQ Liu","year":"1990","unstructured":"Liu ZQ et al. (1990) Intra-cellular electrolyte changes and levels of endogenous digoxin-like substance within the plasma in patients with congestive heart failure. Int J Cardiol 27: 47\u201353","journal-title":"Int J Cardiol"},{"key":"BFncpneph0848_CR122","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1161\/01.CIR.86.2.420","volume":"86","author":"SS Gottlieb","year":"1992","unstructured":"Gottlieb SS et al. (1992) Elevated concentrations of endogenous ouabain in patients with congestive heart failure. Circulation 86: 420\u2013425","journal-title":"Circulation"},{"key":"BFncpneph0848_CR123","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1161\/01.HYP.34.3.450","volume":"34","author":"P Manunta","year":"1999","unstructured":"Manunta P et al. (1999) Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension. Hypertension 34: 450\u2013456","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR124","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0895-7061(00)01225-5","volume":"14","author":"SD Pierdomenico","year":"2001","unstructured":"Pierdomenico SD et al. (2001) Endogenous ouabain and hemodynamic and left ventricular geometric patterns in essential hypertension. Am J Hypertens 14: 44\u201350","journal-title":"Am J Hypertens"},{"key":"BFncpneph0848_CR125","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S1388-9842(00)00132-X","volume":"3","author":"S Balzan","year":"2001","unstructured":"Balzan S et al. (2001) Increased circulating levels of ouabain-like factor in patients with asymptomatic left ventricular dysfunction. Eur J Heart Fail 3: 165\u2013171","journal-title":"Eur J Heart Fail"},{"key":"BFncpneph0848_CR126","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ejheart.2005.07.010","volume":"8","author":"MV Pitzalis","year":"2006","unstructured":"Pitzalis MV et al. (2006) Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy. Eur J Heart Fail 8: 179\u2013186","journal-title":"Eur J Heart Fail"},{"key":"BFncpneph0848_CR127","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1365-2796.2007.01883.x","volume":"263","author":"P Stella","year":"2008","unstructured":"Stella P et al. (2008) Endogenous ouabain and cardiomyopathy in dialysis patients. J Intern Med 263: 274\u2013280","journal-title":"J Intern Med"},{"key":"BFncpneph0848_CR128","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1097\/00004872-200402000-00025","volume":"22","author":"OV Fedorova","year":"2004","unstructured":"Fedorova OV et al. (2004) Coordinated shifts in Na\/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension. J Hypertens 22: 389\u2013397","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR129","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1074\/jbc.M411011200","volume":"280","author":"OA Akimova","year":"2005","unstructured":"Akimova OA et al. (2005) Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i\/[K+]i-independent signaling in C7-MDCK cells. J Biol Chem 280: 832\u2013839","journal-title":"J Biol Chem"},{"key":"BFncpneph0848_CR130","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1023\/A:1013715704835","volume":"15","author":"M Neuss","year":"2001","unstructured":"Neuss M et al. (2001) Apoptosis in cardiac disease-what is it-how does it occur. Cardiovasc Drugs Ther 15: 507\u2013523","journal-title":"Cardiovasc Drugs Ther"},{"key":"BFncpneph0848_CR131","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.2741\/1679","volume":"10","author":"B Mohmand","year":"2005","unstructured":"Mohmand B et al. (2005) Uremic cardiomyopathy: role of circulating digitalis like substances. Front Biosci 10: 2036\u20132044","journal-title":"Front Biosci"},{"key":"BFncpneph0848_CR132","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1681\/ASN.V1251079","volume":"12","author":"RJ Middleton","year":"2001","unstructured":"Middleton RJ et al. (2001) Left ventricular hypertrophy in the renal patient. J Am Soc Nephrol 12: 1079\u20131084","journal-title":"J Am Soc Nephrol"},{"key":"BFncpneph0848_CR133","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/01.ASN.0000037403.95126.03","volume":"14","author":"DJ Kennedy","year":"2003","unstructured":"Kennedy DJ et al. (2003) Effect of chronic renal failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat. J Am Soc Nephrol 14: 90\u201397","journal-title":"J Am Soc Nephrol"},{"key":"BFncpneph0848_CR134","doi-asserted-by":"publisher","first-page":"F450","DOI":"10.1152\/ajprenal.00472.2007","volume":"294","author":"DJ Kennedy","year":"2008","unstructured":"Kennedy DJ et al. (2008) Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am J Physiol Renal Physiol 294: F450\u2013F454","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFncpneph0848_CR135","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1161\/01.HYP.0000252409.36927.05","volume":"49","author":"J Elkareh","year":"2007","unstructured":"Elkareh J et al. (2007) Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension 49: 215\u2013224","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR136","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1161\/01.HYP.0000202594.82271.92","volume":"47","author":"DJ Kennedy","year":"2006","unstructured":"Kennedy DJ et al. (2006) Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47: 488\u2013495","journal-title":"Hypertension"},{"issue":"Suppl 1","key":"BFncpneph0848_CR137","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1093\/ndt\/17.suppl_1.29","volume":"17","author":"GM London","year":"2002","unstructured":"London GM (2002) Left ventricular alterations and end-stage renal disease. Nephrol Dial Transplant 17 (Suppl 1): S29\u2013S36","journal-title":"Nephrol Dial Transplant"},{"key":"BFncpneph0848_CR138","first-page":"593","volume":"192","author":"ED Gallery","year":"1979","unstructured":"Gallery ED et al. (1979) Plasma volume contraction: a significant factor in both pregnancy-associated hypertension (pre-eclampsia) and chronic hypertension in pregnancy. Q J Med 192: 593\u2013602","journal-title":"Q J Med"},{"key":"BFncpneph0848_CR139","first-page":"R1611","volume":"267","author":"S Masilamani","year":"1994","unstructured":"Masilamani S and Baylis C (1994) Pregnant rats are refractory to the natriuretic actions of ANP. Am J Physiol 267: R1611\u2013R1616","journal-title":"Am J Physiol"},{"key":"BFncpneph0848_CR140","doi-asserted-by":"publisher","first-page":"I84","DOI":"10.1161\/01.HYP.10.5_Pt_2.I84","volume":"10","author":"SW Graves","year":"1987","unstructured":"Graves SW (1987) The possible role of digitalislike factors in pregnancy-induced hypertension. Hypertension 10: I84\u2013I86","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR141","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1210\/jcem-58-4-748","volume":"58","author":"SW Graves","year":"1984","unstructured":"Graves SW et al. (1984) Endogenous digoxin-immunoreactive substance in human pregnancies. J Clin Endocrinol Metab 58: 748\u2013751","journal-title":"J Clin Endocrinol Metab"},{"key":"BFncpneph0848_CR142","first-page":"19","volume":"52","author":"IV Averina","year":"2006","unstructured":"Averina IV et al. (2006) Endogenous Na\/K-ATPase inhibitors in patients with preeclampsia. Cell Mol Biol (Noisy-le-grand) 52: 19\u201323","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"BFncpneph0848_CR143","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1056\/NEJM198802253180815","volume":"318","author":"RC Goodlin","year":"1988","unstructured":"Goodlin RC (1988) Antidigoxin antibodies in eclampsia. N Engl J Med 318: 518\u2013519","journal-title":"N Engl J Med"},{"key":"BFncpneph0848_CR144","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1159\/000169054","volume":"16","author":"CD Adair","year":"1996","unstructured":"Adair CD et al. (1996) Elevated endoxin-like factor complicating a multifetal second trimester pregnancy: treatment with digoxin-binding immunoglobulin. Am J Nephrol 16: 529\u2013531","journal-title":"Am J Nephrol"},{"key":"BFncpneph0848_CR145","doi-asserted-by":"publisher","first-page":"11A","DOI":"10.1016\/S0895-7061(97)88679-7","volume":"10","author":"D Adair","year":"1997","unstructured":"Adair D et al. (1997) Effects of Fab digoxin-specific antibodies on mean arterial pressure in severe preeclampsia [abstract]. Am J Hypertens 10: 11A","journal-title":"Am J Hypertens"},{"key":"BFncpneph0848_CR146","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/j.1440-1681.1993.tb01747.x","volume":"20","author":"A Di Grande","year":"1993","unstructured":"Di Grande A et al. (1993) Release of a substance from the human placenta having digoxin-like immunoreactivity. Clin Exp Pharmacol Physiol 20: 603\u2013607","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFncpneph0848_CR147","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1006\/cbir.1994.1101","volume":"18","author":"E Amler","year":"1994","unstructured":"Amler E et al. (1994) Human hypertensive placenta contains an increased amount of Na,K-ATPase with higher affinity for cardiac glycosides. Cell Biol Int 18: 723\u2013727","journal-title":"Cell Biol Int"},{"key":"BFncpneph0848_CR148","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1161\/01.HYP.36.3.442","volume":"36","author":"RI Dmitrieva","year":"2000","unstructured":"Dmitrieva RI et al. (2000) Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage. Hypertension 36: 442\u2013448","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR149","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1097\/01.hjh.0000163153.27954.33","volume":"23","author":"OV Fedorova","year":"2005","unstructured":"Fedorova OV et al. (2005) Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake. J Hypertens 23: 835\u2013842","journal-title":"J Hypertens"},{"key":"BFncpneph0848_CR150","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1159\/000088461","volume":"25","author":"HV Vu","year":"2005","unstructured":"Vu HV et al. (2005) Involvement of marinobufagenin in a rat model of human preeclampsia. Am J Nephrol 25: 520\u2013528","journal-title":"Am J Nephrol"},{"key":"BFncpneph0848_CR151","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.placenta.2005.12.004","volume":"27","author":"HL LaMarca","year":"2006","unstructured":"LaMarca HL et al. (2006) Marinobufagenin impairs first trimester cytotrophoblast differentiation. Placenta 27: 984\u2013988","journal-title":"Placenta"},{"key":"BFncpneph0848_CR152","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1365-2826.2004.01181.x","volume":"16","author":"H Weidemann","year":"2004","unstructured":"Weidemann H et al. (2004) Diverse effects of stress and additional adrenocorticotropic hormone on digitalis-like compounds in normal and nude mice. J Neuroendocrinol 16: 458\u2013463","journal-title":"J Neuroendocrinol"},{"key":"BFncpneph0848_CR153","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1161\/01.HYP.0000165024.47728.f7","volume":"45","author":"N Bauer","year":"2005","unstructured":"Bauer N et al. (2005) Ouabain-like compound changes rapidly on physical exercise in humans and dogs: effects of beta-blockade and angiotensin-converting enzyme inhibition. Hypertension 45: 1024\u20131028","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR154","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/cvr\/27.6.1045","volume":"27","author":"AY Bagrov","year":"1993","unstructured":"Bagrov AY et al. (1993) Effect of antidigoxin antibody on myocardial Na,K-pump activity and of endogenous digoxin-like factor in acute myocardial ischemia in rats. Cardiovasc Res 27: 1045\u20131050","journal-title":"Cardiovasc Res"},{"key":"BFncpneph0848_CR155","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0165-0327(98)00208-0","volume":"54","author":"G Grider","year":"1999","unstructured":"Grider G et al. (1999) Endogenous digoxin-like immunoreactive factor (DLIF) serum concentrations are decreased in manic bipolar patients compared to normal controls. J Affect Disord 54: 261\u2013267","journal-title":"J Affect Disord"},{"key":"BFncpneph0848_CR156","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.biopsych.2005.12.021","volume":"60","author":"I Goldstein","year":"2006","unstructured":"Goldstein I et al. (2006) Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders. Biol Psychiatry 60: 491\u2013499","journal-title":"Biol Psychiatry"},{"key":"BFncpneph0848_CR157","doi-asserted-by":"publisher","first-page":"PL219","DOI":"10.1016\/S0024-3205(99)00131-9","volume":"64","author":"YY Bagrov","year":"1999","unstructured":"Bagrov YY et al. (1999) Involvement of endogenous digitalis-like factors in voluntary selection of alcohol by rats. Life Sci 64: PL219\u2013PL225","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR158","first-page":"153","volume":"8","author":"A Clerico","year":"1990","unstructured":"Clerico A and Giampietro O (1990) Is the endogenous digitalis-like factor the link between hypertension and metabolic disorders as diabetes mellitus, obesity and acromegaly? Clin Physiol Biochem 8: 153\u2013168","journal-title":"Clin Physiol Biochem"},{"key":"BFncpneph0848_CR159","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/ajh\/6.5.397","volume":"6","author":"S Chen","year":"1993","unstructured":"Chen S et al. (1993) Role of digitalis-like substance in the hypertension of streptozotocin-induced diabetes in reduced renal mass rats. Am J Hypertens 6: 397\u2013406","journal-title":"Am J Hypertens"},{"key":"BFncpneph0848_CR160","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.2741\/1695","volume":"10","author":"YY Bagrov","year":"2005","unstructured":"Bagrov YY et al. (2005) Endogenous digitalis-like ligands and Na\/K-ATPase inhibition in experimental diabetes mellitus. Front Biosci 10: 2257\u20132262","journal-title":"Front Biosci"},{"key":"BFncpneph0848_CR161","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0024-3205(01)01176-6","volume":"69","author":"JS Carroll","year":"2001","unstructured":"Carroll JS et al. (2001) Digitalis-like factor response to hyperinsulinemia accompanying a euglycemic hyperinsulinemic clamp or oral glucose tolerance test. Life Sci 69: 829\u2013837","journal-title":"Life Sci"},{"key":"BFncpneph0848_CR162","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.2741\/1688","volume":"10","author":"H Weidemann","year":"2005","unstructured":"Weidemann H (2005) Na\/K-ATPase, endogenous digitalis like compounds and cancer development\u2014a hypothesis. Front Biosci 10: 2165\u20132176","journal-title":"Front Biosci"},{"key":"BFncpneph0848_CR163","first-page":"32","volume":"1776","author":"T Mijatovic","year":"2007","unstructured":"Mijatovic T et al. (2007) Cardiotonic steroids on the road to anti-cancer therapy. Biochim Biophys Acta 1776: 32\u201357","journal-title":"Biochim Biophys Acta"},{"key":"BFncpneph0848_CR164","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.2174\/138161205774424735","volume":"11","author":"M Ferrandi","year":"2005","unstructured":"Ferrandi M et al. (2005) Ouabain antagonists as antihypertensive agents. Curr Pharm Des 11: 3301\u20133305","journal-title":"Curr Pharm Des"},{"key":"BFncpneph0848_CR165","unstructured":"ClinicalTrials.gov (online 2006) Efficacy of Rostafuroxin in the treatment of essential hypertension. [ http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00415038 ] (accessed 12 March 2008)"},{"key":"BFncpneph0848_CR166","first-page":"784","volume":"217","author":"P Finotti","year":"1981","unstructured":"Finotti P and Palatini P (1981) Canrenone as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase. J Pharmacol Exp Ther 217: 784\u2013790","journal-title":"J Pharmacol Exp Ther"},{"key":"BFncpneph0848_CR167","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/00005344-198801000-00012","volume":"11","author":"M de Mendon\u00e7a","year":"1988","unstructured":"de Mendon\u00e7a M et al. (1988) Antihypertensive effect of canrenone in a model where endogenous ouabain-like factors are present. J Cardiovasc Pharmacol 11: 75\u201383","journal-title":"J Cardiovasc Pharmacol"},{"key":"BFncpneph0848_CR168","first-page":"143","volume":"10","author":"S Waldorff","year":"1979","unstructured":"Waldorff S and Buch J (1979) Canrenoate\u2014a spironolactone metabolite: acute cardiac effects in digitalized patients. Eur J Cardiol 10: 143\u2013149","journal-title":"Eur J Cardiol"},{"key":"BFncpneph0848_CR169","unstructured":"ClinicalTrials.gov (online 2005) Efficacy study of Digibind for treatment of severe preeclampsia. [ http:\/\/clinicaltrials.gov\/show\/NCT00158743 ] (accessed 12 March 2008)"},{"key":"BFncpneph0848_CR170","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1007\/s00134-003-1955-0","volume":"29","author":"JC Menezes","year":"2003","unstructured":"Menezes JC et al. (2003) Digoxin antibody decreases natriuresis and diuresis in cerebral hemorrhage. Intensive Care Med 29: 2291\u20132296","journal-title":"Intensive Care Med"},{"key":"BFncpneph0848_CR171","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1161\/01.HYP.0000053446.43894.9F","volume":"41","author":"OV Fedorova","year":"2003","unstructured":"Fedorova OV et al. (2003) Reduction in myocardial PKC \u03b22, Na\/K-ATPase sensitivity to marinobufagenin and blood pressure in response to cicletanine. Hypertension 41: 505\u2013511","journal-title":"Hypertension"},{"key":"BFncpneph0848_CR172","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/01.HYP.0000248129.20524.d0","volume":"48","author":"OV Fedorova","year":"2006","unstructured":"Fedorova OV et al. (2006) ANP differentially modulates marinobufagenin-induced sodium pump inhibition in kidney and aorta. Hypertension 48: 1160\u20131168","journal-title":"Hypertension"}],"container-title":["Nature Clinical Practice Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0848","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneph0848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T17:21:07Z","timestamp":1738257667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpneph0848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,10]]},"references-count":172,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["BFncpneph0848"],"URL":"https:\/\/doi.org\/10.1038\/ncpneph0848","relation":{},"ISSN":["1745-8323","1745-8331"],"issn-type":[{"value":"1745-8323","type":"print"},{"value":"1745-8331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,10]]}}}