{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:19:23Z","timestamp":1791137963419,"version":"4.1.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Neurol"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1038\/ncpneuro0124","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T16:41:05Z","timestamp":1147797665000},"page":"159-166","source":"Crossref","is-referenced-by-count":240,"title":["Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease"],"prefix":"10.1038","volume":"2","author":[{"given":"Mary N","family":"Haan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFncpneuro0124_CR1","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.2337\/diacare.24.11.1936","volume":"24","author":"JP Boyle","year":"2001","unstructured":"Boyle JP et al. (2001) Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US. Diabetes Care 24: 1936\u20131940","journal-title":"Diabetes Care"},{"key":"BFncpneuro0124_CR2","unstructured":"ADNI: Alzheimer's Disease Neuroimaging Initiative [ http:\/\/www.clinicaltrials.gov\/show\/NCT00106899 ]"},{"key":"BFncpneuro0124_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.publhealth.25.101802.122951","volume":"25","author":"MN Haan","year":"2004","unstructured":"Haan MN and Wallace R (2004) Can dementia be prevented? Brain aging in a population-based context. Annu Rev Public Health 25: 1\u201324","journal-title":"Annu Rev Public Health"},{"key":"BFncpneuro0124_CR4","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","volume":"289","author":"SA Shumaker","year":"2003","unstructured":"Shumaker SA et al. (2003) Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 289: 2651\u20132662","journal-title":"JAMA"},{"key":"BFncpneuro0124_CR5","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1212\/WNL.53.9.1937","volume":"53","author":"A Ott","year":"1999","unstructured":"Ott A et al. (1999) Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 53: 1937\u20131942","journal-title":"Neurology"},{"key":"BFncpneuro0124_CR6","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.2337\/diabetes.51.4.1256","volume":"51","author":"R Peila","year":"2002","unstructured":"Peila R et al. (2002) Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu\u2013Asia Aging Study. Diabetes 51: 1256\u20131262","journal-title":"Diabetes"},{"key":"BFncpneuro0124_CR7","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1212\/01.WNL.0000140292.04932.87","volume":"63","author":"JA Luchsinger","year":"2004","unstructured":"Luchsinger JA et al. (2004) Hyperinsulinemia and risk of Alzheimer disease. Neurology 63: 1187\u20131192","journal-title":"Neurology"},{"key":"BFncpneuro0124_CR8","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1749-6632.1997.tb48496.x","volume":"826","author":"CL Leibson","year":"1997","unstructured":"Leibson CL et al. (1997) The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann NY Acad Sci 826: 422\u2013427","journal-title":"Ann NY Acad Sci"},{"key":"BFncpneuro0124_CR9","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1001\/archneur.61.5.661","volume":"61","author":"Z Arvanitakis","year":"2004","unstructured":"Arvanitakis Z et al. (2004) Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 61: 661\u2013666","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR10","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1212\/WNL.52.5.971","volume":"52","author":"JD Curb","year":"1999","unstructured":"Curb JD et al. (1999) Longitudinal association of vascular and Alzheimer's dementias, diabetes, and glucose tolerance. Neurology 52: 971\u2013975","journal-title":"Neurology"},{"key":"BFncpneuro0124_CR11","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/aje\/154.7.635","volume":"154","author":"JA Luchsinger","year":"2001","unstructured":"Luchsinger JA et al. (2001) Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol 154: 635\u2013641","journal-title":"Am J Epidemiol"},{"key":"BFncpneuro0124_CR12","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1212\/01.WNL.0000140291.86406.D1","volume":"63","author":"WL Xu","year":"2004","unstructured":"Xu WL et al. (2004) Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Neurology 63: 1181\u20131186","journal-title":"Neurology"},{"key":"BFncpneuro0124_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0047-6374(01)00364-5","volume":"1","author":"LJ Launer","year":"2002","unstructured":"Launer LJ (2002) Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Res Rev 1: 61\u201377","journal-title":"Ageing Res Rev"},{"key":"BFncpneuro0124_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0022-510X(02)00256-3","volume":"203","author":"R Kalaria","year":"2002","unstructured":"Kalaria R (2002) Similarities between Alzheimer's disease and vascular dementia. J Neurol Sci 203\u2013204: 29\u201334","journal-title":"J Neurol Sci"},{"key":"BFncpneuro0124_CR15","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/S0733-8619(05)70234-6","volume":"18","author":"H Chui","year":"2000","unstructured":"Chui H (2000) Vascular dementia, a new beginning: shifting focus from clinical phenotype to ischemic brain injury. Neurol Clin 18: 951\u2013978","journal-title":"Neurol Clin"},{"key":"BFncpneuro0124_CR16","doi-asserted-by":"publisher","first-page":"474","DOI":"10.2337\/diabetes.53.2.474","volume":"53","author":"J Janson","year":"2004","unstructured":"Janson J et al. (2004) Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 53: 474\u2013481","journal-title":"Diabetes"},{"key":"BFncpneuro0124_CR17","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1007\/s00125-003-1235-0","volume":"46","author":"T den Heijer","year":"2003","unstructured":"den Heijer T et al. (2003) Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 46: 1604\u20131610","journal-title":"Diabetologia"},{"issue":"Suppl 2","key":"BFncpneuro0124_CR18","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1159\/000049150","volume":"13","author":"RN Kalaria","year":"2002","unstructured":"Kalaria RN (2002) Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovasc Dis 13 (Suppl 2): S48\u2013S52","journal-title":"Cerebrovasc Dis"},{"key":"BFncpneuro0124_CR19","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1001\/archneur.62.7.1067","volume":"62","author":"C Geroldi","year":"2005","unstructured":"Geroldi C et al. (2005) Insulin resistance in cognitive impairment: the InCHIANTI study. Arch Neurol 62: 1067\u20131072","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR20","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.2337\/diacare.27.10.2335","volume":"27","author":"AJ Sommerfield","year":"2004","unstructured":"Sommerfield AJ et al. (2004) Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care 27: 2335\u20132340","journal-title":"Diabetes Care"},{"key":"BFncpneuro0124_CR21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s007020050068","volume":"105","author":"L Frolich","year":"1998","unstructured":"Frolich L et al. (1998) Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm 105: 423\u2013438","journal-title":"J Neural Transm"},{"key":"BFncpneuro0124_CR22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S1474-4422(04)00681-7","volume":"3","author":"S Craft","year":"2004","unstructured":"Craft S and Watson GS (2004) Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 3: 169\u2013178","journal-title":"Lancet Neurol"},{"key":"BFncpneuro0124_CR23","doi-asserted-by":"publisher","first-page":"19547","DOI":"10.1074\/jbc.272.31.19547","volume":"272","author":"M Hong","year":"1997","unstructured":"Hong M and Lee VM (1997) Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 272: 19547\u201319553","journal-title":"J Biol Chem"},{"key":"BFncpneuro0124_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1159\/000054469","volume":"70","author":"S Craft","year":"1999","unstructured":"Craft S et al. (1999) Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology 70: 146\u2013152","journal-title":"Neuroendocrinology"},{"key":"BFncpneuro0124_CR25","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1001\/archinte.165.7.777","volume":"165","author":"BH Goodpaster","year":"2005","unstructured":"Goodpaster BH et al. (2005) Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 165: 777\u2013783","journal-title":"Arch Intern Med"},{"key":"BFncpneuro0124_CR26","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.2165\/00003495-200060050-00004","volume":"60","author":"IW Campbell","year":"2000","unstructured":"Campbell IW (2000) Antidiabetic drugs present and future: will improving insulin resistance benefit cardiovascular risk in type 2 diabetes mellitus? Drugs 60: 1017\u20131028","journal-title":"Drugs"},{"key":"BFncpneuro0124_CR27","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","volume":"163","author":"D Gustafson","year":"2003","unstructured":"Gustafson D et al. (2003) An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med 163: 1524\u20131528","journal-title":"Arch Intern Med"},{"key":"BFncpneuro0124_CR28","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","volume":"62","author":"M Kivipelto","year":"2005","unstructured":"Kivipelto M et al. (2005) Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 62: 1556\u20131560","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR29","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1136\/bmj.38446.466238.E0","volume":"330","author":"RA Whitmer","year":"2005","unstructured":"Whitmer RA et al. (2005) Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ 330: 1360","journal-title":"BMJ"},{"key":"BFncpneuro0124_CR30","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3233\/JAD-2003-5505","volume":"5","author":"KA Lane","year":"2003","unstructured":"Lane KA et al. (2003) Apolipoprotein E and mortality in African-Americans and Yoruba. J Alzheimers Dis 5: 383\u2013390","journal-title":"J Alzheimers Dis"},{"key":"BFncpneuro0124_CR31","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/j.1532-5415.1996.tb01362.x","volume":"44","author":"E Barrett-Connor","year":"1996","unstructured":"Barrett-Connor E et al. (1996) Weight loss precedes dementia in community-dwelling older adults. J Am Geriatr Soc 44: 1147\u20131152","journal-title":"J Am Geriatr Soc"},{"key":"BFncpneuro0124_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1001\/archneur.62.1.55","volume":"62","author":"R Stewart","year":"2005","unstructured":"Stewart R et al. (2005) A 32-year prospective study of change in body weight and incident dementia: the Honolulu\u2013Asia Aging Study. Arch Neurol 62: 55\u201360","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR33","first-page":"1545","volume":"62","author":"W Jagust","year":"2005","unstructured":"Jagust W et al. (2005) Central obesity and the aging brain. Arch Neurol 62: 1545\u20131548","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR34","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1474-4422(05)70198-8","volume":"4","author":"S Rovio","year":"2005","unstructured":"Rovio S et al. (2005) Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol 4: 705\u2013711","journal-title":"Lancet Neurol"},{"key":"BFncpneuro0124_CR35","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/aje\/kwf074","volume":"156","author":"J Lindsay","year":"2002","unstructured":"Lindsay J et al. (2002) Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156: 445\u2013453","journal-title":"Am J Epidemiol"},{"key":"BFncpneuro0124_CR36","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1093\/aje\/kwi092","volume":"161","author":"LJ Podewils","year":"2005","unstructured":"Podewils LJ et al. (2005) Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol 161: 639\u2013651","journal-title":"Am J Epidemiol"},{"key":"BFncpneuro0124_CR37","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1080\/03014460310001620144","volume":"30","author":"G Veurink","year":"2003","unstructured":"Veurink G et al. (2003) Genetics, lifestyle and the roles of amyloid beta and oxidative stress in Alzheimer's disease. Ann Hum Biol 30: 639\u2013667","journal-title":"Ann Hum Biol"},{"key":"BFncpneuro0124_CR38","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/ana.10265","volume":"52","author":"R Schmidt","year":"2002","unstructured":"Schmidt R et al. (2002) Early inflammation and dementia: a 25-year follow-up of the Honolulu\u2013Asia Aging Study. Ann Neurol 52: 168\u2013174","journal-title":"Ann Neurol"},{"key":"BFncpneuro0124_CR39","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1001\/archneur.61.5.668","volume":"61","author":"MJ Engelhart","year":"2004","unstructured":"Engelhart MJ et al. (2004) Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch Neurol 61: 668\u2013672","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR40","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0021-9150(02)00316-7","volume":"166","author":"MA van de Ree","year":"2003","unstructured":"van de Ree MA et al. (2003) Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus. Atherosclerosis 166: 129\u2013135","journal-title":"Atherosclerosis"},{"issue":"Suppl 3","key":"BFncpneuro0124_CR41","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1038\/sj.ijo.0802502","volume":"27","author":"GS Hotamisligil","year":"2003","unstructured":"Hotamisligil GS (2003) Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 27 (Suppl 3): S53\u2013S55","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFncpneuro0124_CR42","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.neurobiolaging.2004.02.031","volume":"26","author":"C Napoli","year":"2005","unstructured":"Napoli C and Palinski W (2005) Neurodegenerative diseases: insights into pathogenic mechanisms from atherosclerosis. Neurobiol Aging 26: 293\u2013302","journal-title":"Neurobiol Aging"},{"key":"BFncpneuro0124_CR43","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.metabol.2005.02.001","volume":"54","author":"A Araki","year":"2005","unstructured":"Araki A et al. (2005) Association of plasma homocysteine with serum interleukin-6 and C-peptide levels in patients with type 2 diabetes. Metabolism 54: 809\u2013814","journal-title":"Metabolism"},{"key":"BFncpneuro0124_CR44","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1258\/0004563053492838","volume":"42","author":"G Ozdemir","year":"2005","unstructured":"Ozdemir G et al. (2005) Malondialdehyde, glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria. Ann Clin Biochem 42: 99\u2013104","journal-title":"Ann Clin Biochem"},{"key":"BFncpneuro0124_CR45","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cccn.2004.12.002","volume":"355","author":"T Helfenstein","year":"2005","unstructured":"Helfenstein T et al. (2005) Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects. Clin Chim Acta 355: 165\u2013172","journal-title":"Clin Chim Acta"},{"key":"BFncpneuro0124_CR46","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1161\/01.ATV.0000122852.22604.78","volume":"24","author":"A Ceriello","year":"2004","unstructured":"Ceriello A and Motz E (2004) Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24: 816\u2013823","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFncpneuro0124_CR47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/80.1.114","volume":"80","author":"P Quadri","year":"2004","unstructured":"Quadri P et al. (2004) Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 80: 114\u2013122","journal-title":"Am J Clin Nutr"},{"key":"BFncpneuro0124_CR48","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMoa011613","volume":"346","author":"S Seshadri","year":"2002","unstructured":"Seshadri S et al. (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346: 476\u2013483","journal-title":"N Engl J Med"},{"key":"BFncpneuro0124_CR49","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1093\/brain\/awg006","volume":"126","author":"T den Heijer","year":"2003","unstructured":"den Heijer T et al. (2003) Homocysteine and brain atrophy on MRI of non-demented elderly. Brain 126: 170\u2013175","journal-title":"Brain"},{"key":"BFncpneuro0124_CR50","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1093\/ageing\/31.6.440","volume":"31","author":"JH Williams","year":"2002","unstructured":"Williams JH et al. (2002) Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people. Age Ageing 31: 440\u2013444","journal-title":"Age Ageing"},{"key":"BFncpneuro0124_CR51","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1136\/bmj.315.7115.1045","volume":"315","author":"J Kuusisto","year":"1997","unstructured":"Kuusisto J et al. (1997) Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study. BMJ 315: 1045\u20131049","journal-title":"BMJ"},{"key":"BFncpneuro0124_CR52","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1046\/j.1464-5491.2000.00269.x","volume":"17","author":"JJ Nolan","year":"2000","unstructured":"Nolan JJ et al. (2000) Rosiglitazone taken once daily provides effective glycaemic control in patients with type 2 diabetes mellitus. Diabet Med 17: 287\u2013294","journal-title":"Diabet Med"},{"key":"BFncpneuro0124_CR53","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s00702-003-0018-6","volume":"110","author":"S Brune","year":"2003","unstructured":"Brune S et al. (2003) Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease. J Neural Transm 110: 1041\u20131050","journal-title":"J Neural Transm"},{"key":"BFncpneuro0124_CR54","first-page":"950","volume":"13","author":"GS Watson","year":"2005","unstructured":"Watson GS et al. (2005) Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 13: 950\u2013958","journal-title":"Am J Geriatr Psychiatry"},{"key":"BFncpneuro0124_CR55","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S1047-2797(02)00464-7","volume":"13","author":"JH Wu","year":"2003","unstructured":"Wu JH et al. (2003) Impact of antidiabetic medications on physical and cognitive functioning of older Mexican Americans with diabetes mellitus: a population-based cohort study. Ann Epidemiol 13: 369\u2013376","journal-title":"Ann Epidemiol"},{"key":"BFncpneuro0124_CR56","doi-asserted-by":"crossref","unstructured":"UKPDS authors (1999) Quality of life in type 2 diabetic patients is affected by complications but not by intensive policies to improve blood glucose or blood pressure control (UKPDS 37). UK Prospective Diabetes Study Group. Diabetes Care 22: 1125\u20131136","DOI":"10.2337\/diacare.22.7.1125"},{"key":"BFncpneuro0124_CR57","doi-asserted-by":"crossref","unstructured":"DCCT authors (1996) Effects of intensive diabetes therapy on neuropsychological function in adults in the Diabetes Control and Complications Trial. Ann Intern Med 124: 379\u2013388","DOI":"10.7326\/0003-4819-124-4-199602150-00001"},{"key":"BFncpneuro0124_CR58","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0306-4530(02)00015-X","volume":"28","author":"PS Aisen","year":"2003","unstructured":"Aisen PS et al. (2003) Steroid-induced elevation of glucose in Alzheimer's disease: relationship to gender, apolipoprotein E genotype and cognition. Psychoneuroendocrinology 28: 113\u2013120","journal-title":"Psychoneuroendocrinology"},{"key":"BFncpneuro0124_CR59","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1212\/WNL.62.1.66","volume":"62","author":"SA Reines","year":"2004","unstructured":"Reines SA et al. (2004) Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. Neurology 62: 66\u201371","journal-title":"Neurology"},{"key":"BFncpneuro0124_CR60","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1016\/j.jacc.2003.04.001","volume":"42","author":"JS Sidhu","year":"2003","unstructured":"Sidhu JS et al. (2003) The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients. J Am Coll Cardiol 42: 1757\u20131763","journal-title":"J Am Coll Cardiol"},{"key":"BFncpneuro0124_CR61","doi-asserted-by":"publisher","first-page":"468","DOI":"10.2337\/diacare.27.2.468","volume":"27","author":"DW Sommeijer","year":"2004","unstructured":"Sommeijer DW et al. (2004) Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes. Diabetes Care 27: 468\u2013473","journal-title":"Diabetes Care"},{"key":"BFncpneuro0124_CR62","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.2337\/diacare.27.7.1647","volume":"27","author":"B Charbonnel","year":"2004","unstructured":"Charbonnel B et al. (2004) The prospective pioglitazone clinical trial in macrovascular events (PROactive): can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients. Diabetes Care 27: 1647\u20131653","journal-title":"Diabetes Care"},{"key":"BFncpneuro0124_CR63","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.jacc.2005.03.041","volume":"45","author":"A Pfutzner","year":"2005","unstructured":"Pfutzner A et al. (2005) Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer study. J Am Coll Cardiol 45: 1925\u20131931","journal-title":"J Am Coll Cardiol"},{"key":"BFncpneuro0124_CR64","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/ana.10292","volume":"52","author":"M Simons","year":"2002","unstructured":"Simons M et al. (2002) Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol 52: 346\u2013350","journal-title":"Ann Neurol"},{"key":"BFncpneuro0124_CR65","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1001\/archneur.62.5.753","volume":"62","author":"DL Sparks","year":"2005","unstructured":"Sparks DL et al. (2005) Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 62: 753\u2013757","journal-title":"Arch Neurol"},{"key":"BFncpneuro0124_CR66","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0140-6736(04)15690-0","volume":"363","author":"R Collins","year":"2004","unstructured":"Collins R et al. (2004) Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet 363: 757\u2013767","journal-title":"Lancet"},{"key":"BFncpneuro0124_CR67","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1111\/j.1464-5491.2004.01332.x","volume":"21","author":"K Hallsten","year":"2004","unstructured":"Hallsten K et al. (2004) Enhancement of insulin-stimulated myocardial glucose uptake in patients with Type 2 diabetes treated with rosiglitazone. Diabet Med 21: 1280\u20131287","journal-title":"Diabet Med"},{"key":"BFncpneuro0124_CR68","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.yexcr.2004.09.032","volume":"304","author":"NC Inestrosa","year":"2005","unstructured":"Inestrosa NC et al. (2005) Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp Cell Res 304: 91\u2013104","journal-title":"Exp Cell Res"},{"key":"BFncpneuro0124_CR69","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1212\/01.WNL.0000144281.38555.E3","volume":"63","author":"V Solfrizzi","year":"2004","unstructured":"Solfrizzi V et al. (2004) Vascular risk factors, incidence of MCI, and rates of progression to dementia. Neurology 63: 1882\u20131891","journal-title":"Neurology"},{"key":"BFncpneuro0124_CR70","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000082662","volume":"19","author":"SM Rasquin","year":"2005","unstructured":"Rasquin SM et al. (2005) Predictive accuracy of MCI subtypes for Alzheimer's disease and vascular dementia in subjects with mild cognitive impairment: a 2-year follow-up study. Dement Geriatr Cogn Disord 19: 113\u2013119","journal-title":"Dement Geriatr Cogn Disord"},{"key":"BFncpneuro0124_CR71","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000064928","volume":"14","author":"C MacKnight","year":"2002","unstructured":"MacKnight C et al. (2002) Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging. Dement Geriatr Cogn Disord 14: 77\u201383","journal-title":"Dement Geriatr Cogn Disord"}],"container-title":["Nature Clinical Practice Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncpneuro0124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneuro0124","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ncpneuro0124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ncpneuro0124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:09:23Z","timestamp":1736381363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncpneuro0124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["BFncpneuro0124"],"URL":"https:\/\/doi.org\/10.1038\/ncpneuro0124","relation":{},"ISSN":["1745-834X","1745-8358"],"issn-type":[{"value":"1745-834X","type":"print"},{"value":"1745-8358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}