{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:44:53Z","timestamp":1771476293210,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Clin Oncol"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/ncponc0839","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T11:58:44Z","timestamp":1180526324000},"page":"344-352","source":"Crossref","is-referenced-by-count":41,"title":["Malignant pleural mesothelioma: current concepts in treatment"],"prefix":"10.1038","volume":"4","author":[{"given":"Athanasios","family":"Tsiouris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin K","family":"Walesby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFncponc0839_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/01913120252959227","volume":"26","author":"VL Roggli","year":"2002","unstructured":"Roggli VL et al. (2002) Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases. Ultrastruct Pathol 26: 55\u201365","journal-title":"Ultrastruct Pathol"},{"key":"BFncponc0839_CR2","first-page":"237","volume":"30","author":"P Sebastien","year":"1980","unstructured":"Sebastien P et al. (1980) Asbestos retention in human respiratory tissues: comparative measurements in lung parenchyma and in parietal pleura. IARC Sci Publ 30: 237\u2013246","journal-title":"IARC Sci Publ"},{"key":"BFncponc0839_CR3","first-page":"792","volume":"55","author":"JG Ault","year":"1995","unstructured":"Ault JG et al. (1995) Behavior of crocidolite asbestos during mitosis in living vertebrate lung epithelial cells. Cancer Res 55: 792\u2013798","journal-title":"Cancer Res"},{"key":"BFncponc0839_CR4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0003-9861(84)90078-X","volume":"228","author":"SA Weitzman","year":"1984","unstructured":"Weitzman SA and Graceffa P (1984) Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide. Arch Biochem Biophys 228: 373\u2013376","journal-title":"Arch Biochem Biophys"},{"key":"BFncponc0839_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3816\/CLC.2003.n.031","volume":"5","author":"AF Gazdar","year":"2003","unstructured":"Gazdar AF and Carbone M (2003) Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40. Clin Lung Cancer 5: 177\u2013181","journal-title":"Clin Lung Cancer"},{"key":"BFncponc0839_CR6","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/nm0897-908","volume":"3","author":"M Carbone","year":"1997","unstructured":"Carbone M et al. (1997) Simian virus-40 large-T antigen binds p53 in human mesotheliomas. Nat Med 3: 908\u2013912","journal-title":"Nat Med"},{"key":"BFncponc0839_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2003.09.004","volume":"318","author":"G Barbanti-Brodano","year":"2004","unstructured":"Barbanti-Brodano G et al. (2004) Simian virus 40 infection in humans and association with human diseases: results and hypotheses. Virology 318: 1\u20139","journal-title":"Virology"},{"key":"BFncponc0839_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/(SICI)1097-4644(20000201)76:2<181::AID-JCB2>3.0.CO;2-9","volume":"76","author":"N Shivapurkar","year":"1999","unstructured":"Shivapurkar N et al. (1999) Presence of simian virus 40 sequences in malignant mesotheliomas and mesothelial cell proliferations. J Cell Biochem 76: 181\u2013188","journal-title":"J Cell Biochem"},{"key":"BFncponc0839_CR9","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/S0140-6736(04)17102-X","volume":"364","author":"F L\u00f3pez-R\u00edos","year":"2004","unstructured":"L\u00f3pez-R\u00edos F et al. (2004) Evidence against a role for SV40 infection in human mesotheliomas and high risk of false-positive PCR results owing to presence of SV40 sequences in common laboratory plasmids. Lancet. 364: 1157\u20131166","journal-title":"Lancet."},{"key":"BFncponc0839_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3816\/CLC.2003.n.031","volume":"5","author":"AF Gazdar","year":"2003","unstructured":"Gazdar AF and Carbone M (2003) Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40. Clin Lung Cancer 5: 177\u2013181","journal-title":"Clin Lung Cancer"},{"key":"BFncponc0839_CR11","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s11912-002-0012-4","volume":"4","author":"L Zellos","year":"2002","unstructured":"Zellos L and Sugarbaker DJ (2002) Current surgical management of malignant pleural mesothelioma. Curr Oncol Rep 4: 354\u2013360","journal-title":"Curr Oncol Rep"},{"key":"BFncponc0839_CR12","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1586\/14737140.6.6.831","volume":"6","author":"A Tsiouris","year":"2006","unstructured":"Tsiouris A et al. (2006) Current trends in the management of malignant pleural mesothelioma. Expert Rev Anticancer Ther 6: 831\u2013833","journal-title":"Expert Rev Anticancer Ther"},{"issue":"Suppl 1","key":"BFncponc0839_CR13","first-page":"S66","volume":"45","author":"GW Goerres","year":"2004","unstructured":"Goerres GW et al. (2004) Why most PET of lung and head-and-neck cancer will be PET\/CT. J Nucl Med 45 (Suppl 1): S66\u2013S71","journal-title":"J Nucl Med"},{"key":"BFncponc0839_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/thx.31.1.15","volume":"31","author":"EG Butchart","year":"1976","unstructured":"Butchart EG et al. (1976) Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura: experience with 29 patients. Thorax 31: 15\u201324","journal-title":"Thorax"},{"key":"BFncponc0839_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/BF02306613","volume":"4","author":"HI Pass","year":"1997","unstructured":"Pass HI et al. (1997) Surgically debulked malignant pleural mesothelioma: results and prognostic factors. Ann Surg Oncol 4: 215\u2013222","journal-title":"Ann Surg Oncol"},{"key":"BFncponc0839_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-5223(19)36577-8","volume":"102","author":"VW Rusch","year":"1991","unstructured":"Rusch VW et al. (1991) The role of extrapleural pneumonectomy in malignant pleural mesothelioma: a Lung Cancer Study Group trial. J Thorac Cardiovasc Surg 102: 1\u20139","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BFncponc0839_CR17","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/BF01728801","volume":"66","author":"A Calavrezos","year":"1988","unstructured":"Calavrezos A et al. (1988) Malignant mesothelioma of the pleura: a prospective therapeutic study of 132 patients from 1981\u20131985. Klin Wochenschr 66: 607\u2013613","journal-title":"Klin Wochenschr"},{"key":"BFncponc0839_CR18","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1016\/S0003-4975(99)01038-3","volume":"68","author":"VW Rusch","year":"1999","unstructured":"Rusch VW and Venkatraman ES (1999) Important prognostic factors in patients with malignant pleural mesothelioma, managed surgically. Ann Thorac Surg 68: 1799\u20131804","journal-title":"Ann Thorac Surg"},{"key":"BFncponc0839_CR19","first-page":"113","volume":"4","author":"KB Allen","year":"1994","unstructured":"Allen KB et al. (1994) Malignant pleural mesothelioma: extrapleural pneumonectomy and pleurectomy. Chest Surg Clin N Am 4: 113\u2013126","journal-title":"Chest Surg Clin N Am"},{"key":"BFncponc0839_CR20","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0022-5223(98)70274-0","volume":"115","author":"HI Pass","year":"1998","unstructured":"Pass HI et al. (1998) Preoperative tumor volume is associated with outcome in malignant pleural mesothelioma. J Thorac Cardiovasc Surg 115: 310\u2013317","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BFncponc0839_CR21","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S1010-7940(02)00273-7","volume":"22","author":"T Aziz","year":"2002","unstructured":"Aziz T et al. (2002) The management of malignant pleural mesothelioma; single centre experience in 10 years. Eur J Cardiothorac Surg 22: 298\u2013305","journal-title":"Eur J Cardiothorac Surg"},{"key":"BFncponc0839_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0022-5223(99)70469-1","volume":"117","author":"DJ Sugarbaker","year":"1999","unstructured":"Sugarbaker DJ et al. (1999) Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. J Thorac Cardiovasc Surg 117: 54\u201363","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BFncponc0839_CR23","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1200\/JCO.1994.12.6.1156","volume":"12","author":"V Rusch","year":"1994","unstructured":"Rusch V et al. (1994) A phase II trial of pleurectomy\/decortication followed by intrapleural and systemic chemotherapy for malignant pleural mesothelioma. J Clin Oncol 12: 1156\u20131163","journal-title":"J Clin Oncol"},{"key":"BFncponc0839_CR24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5694\/j.1326-5377.1991.tb121175.x","volume":"154","author":"RP Brancatisano","year":"1991","unstructured":"Brancatisano RP et al. (1991) Pleurectomy for mesothelioma. Med J Aust 154: 455\u2013457, 460","journal-title":"Med J Aust"},{"key":"BFncponc0839_CR25","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/S1010-7940(96)01008-1","volume":"11","author":"O Soysal","year":"1997","unstructured":"Soysal O et al. (1997) Pleurectomy\/decortication for palliation in malignant pleural mesothelioma: results of surgery. Eur J Cardiothorac Surg 11: 210\u2013213","journal-title":"Eur J Cardiothorac Surg"},{"key":"BFncponc0839_CR26","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/1010-7940(89)90056-0","volume":"3","author":"R Achatzy","year":"1989","unstructured":"Achatzy R et al. (1989) The diagnosis, therapy and prognosis of diffuse malignant mesothelioma. Eur J Cardiothorac Surg 3: 445\u2013447","journal-title":"Eur J Cardiothorac Surg"},{"key":"BFncponc0839_CR27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/978-1-4615-1589-0_13","volume":"105","author":"L Ho","year":"2001","unstructured":"Ho L et al (2001) Malignant pleural mesothelioma. Cancer Treat Res 105: 327\u2013373","journal-title":"Cancer Treat Res"},{"key":"BFncponc0839_CR28","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1378\/chest.108.3.754","volume":"108","author":"C Boutin","year":"1995","unstructured":"Boutin C et al. (1995) Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma: a randomized trial of local radiotherapy. Chest 108: 754\u2013758","journal-title":"Chest"},{"key":"BFncponc0839_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.bjc.6601957","volume":"91","author":"S Bydder","year":"2004","unstructured":"Bydder S et al. (2004) A randomised trial of single-dose radiotherapy to prevent procedure tract metastasis by malignant mesothelioma. Br J Cancer 91: 9\u201310","journal-title":"Br J Cancer"},{"key":"BFncponc0839_CR30","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3109\/02841869709001287","volume":"36","author":"LR Holsti","year":"1997","unstructured":"Holsti LR et al. (1997) Altered fractionation of hemithorax irradiation for pleural mesothelioma and failure patterns after treatment. Acta Oncol 36: 397\u2013405","journal-title":"Acta Oncol"},{"key":"BFncponc0839_CR31","first-page":"245","volume":"5","author":"BR Mychalczak","year":"1989","unstructured":"Mychalczak BR et al. (1989) Results of treatment of malignant pleural mesothelioma with surgery, brachytherapy, and external beam irradiation [abstract] Endocurie Hypertherm Oncol 5: 245\u2013246","journal-title":"Endocurie Hypertherm Oncol"},{"key":"BFncponc0839_CR32","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1067\/mtc.2001.116560","volume":"122","author":"VW Rusch","year":"2001","unstructured":"Rusch VW et al. (2001) A phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma. J Thorac Cardiovasc Surg 122: 788\u2013795","journal-title":"J Thorac Cardiovasc Surg"},{"key":"BFncponc0839_CR33","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ijrobp.2006.03.012","volume":"65","author":"AM Allen","year":"2006","unstructured":"Allen AM et al. (2006) Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys 65: 640\u2013645","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFncponc0839_CR34","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.ijrobp.2006.06.048","volume":"66","author":"SY Jang","year":"2006","unstructured":"Jang SY et al. (2006) Dosimetric verification for intensity-modulated radiotherapy of thoracic cancers using experimental and Monte Carlo approaches. Int J Radiat Oncol Biol Phys 66: 939\u2013948","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFncponc0839_CR35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0169-5002(02)00180-0","volume":"38","author":"T Berghmans","year":"2002","unstructured":"Berghmans T et al. (2002) Activity of chemotherapy and immunotherapy on malignant mesothelioma: a systematic review of the literature with meta-analysis. Lung Cancer 38: 111\u2013121","journal-title":"Lung Cancer"},{"key":"BFncponc0839_CR36","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","volume":"366","author":"BW Robinson","year":"2005","unstructured":"Robinson BW et al. (2005) Malignant mesothelioma. Lancet 366: 397\u2013408","journal-title":"Lancet"},{"key":"BFncponc0839_CR37","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","volume":"21","author":"NJ Vogelzang","year":"2003","unstructured":"Vogelzang NJ et al. (2003) Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 21: 2636\u20132644","journal-title":"J Clin Oncol"},{"key":"BFncponc0839_CR38","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1053\/sonc.2002.30231","volume":"29","author":"P Baas","year":"2002","unstructured":"Baas P (2002) Chemotherapy for malignant mesothelioma: from doxorubicin to vinorelbine. Semin Oncol 29: 62\u201369","journal-title":"Semin Oncol"},{"key":"BFncponc0839_CR39","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1093\/annonc\/mdj073","volume":"17","author":"ME O'Brien","year":"2006","unstructured":"O'Brien ME et al. (2006) A randomised trial in malignant mesothelioma (M) of early (E) versus delayed (D) chemotherapy in symptomatically stable patients: the MED trial. Ann Oncol 17: 270\u2013275","journal-title":"Ann Oncol"},{"key":"BFncponc0839_CR40","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1200\/JCO.2005.03.3027","volume":"24","author":"A Bottomley","year":"2006","unstructured":"Bottomley A et al. (2006) Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer Institute, Canada, Intergroup Study. J Clin Oncol 24: 1435\u20131442","journal-title":"J Clin Oncol"},{"key":"BFncponc0839_CR41","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1200\/JCO.2004.10.071","volume":"22","author":"W Weder","year":"2004","unstructured":"Weder W et al. (2004) Neoadjuvant chemotherapy followed by extrapleural pneumonectomy in malignant pleural mesothelioma. J Clin Oncol 22: 3451\u20133457","journal-title":"J Clin Oncol"},{"issue":"Suppl 1","key":"BFncponc0839_CR42","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/j.lungcan.2005.03.022","volume":"49","author":"A Favaretto","year":"2005","unstructured":"Favaretto A (2005) Overview on ongoing or planned clinical trials in Europe. Lung Cancer 49 (Suppl 1): S117\u2013S121","journal-title":"Lung Cancer"},{"issue":"Suppl 1","key":"BFncponc0839_CR43","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.lungcan.2005.03.015","volume":"49","author":"RM Flores","year":"2005","unstructured":"Flores RM (2005) Induction chemotherapy, extrapleural pneumonectomy, and radiotherapy in the treatment of malignant pleural mesothelioma: the Memorial Sloan\u2013Kettering experience. Lung Cancer 49 (Suppl 1): S71\u2013S74","journal-title":"Lung Cancer"},{"issue":"Suppl","key":"BFncponc0839_CR44","doi-asserted-by":"publisher","first-page":"7179","DOI":"10.1200\/jco.2005.23.16_suppl.7179","volume":"23","author":"LM Krug","year":"2005","unstructured":"Krug LM et al. (2005) A multicenter phase 2 trial of neo-adjuvant pemetrexed plus cisplatin (PC) followed by extrapleural pneumonectomy (EPP) and radiation (RT) for malignant pleural mesothelioma (MPM) [abstract]. J Clin Oncol 23 (Suppl): 7179","journal-title":"J Clin Oncol"},{"issue":"Suppl 2","key":"BFncponc0839_CR45","doi-asserted-by":"publisher","first-page":"S225","DOI":"10.1016\/S0169-5002(05)80912-2","volume":"49","author":"N O'Rourke","year":"2005","unstructured":"O'Rourke N et al. (2005) A randomised controlled trial of radiotherapy to mesothelioma drain sites [abstract #P-419]. Lung Cancer 49 (Suppl 2): S225\u2013S226","journal-title":"Lung Cancer"}],"container-title":["Nature Clinical Practice Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncponc0839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncponc0839","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncponc0839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:47:18Z","timestamp":1684442838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncponc0839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["BFncponc0839"],"URL":"https:\/\/doi.org\/10.1038\/ncponc0839","relation":{},"ISSN":["1743-4254","1743-4262"],"issn-type":[{"value":"1743-4254","type":"print"},{"value":"1743-4262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}