{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:17:02Z","timestamp":1791515822685,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2012,11,11]],"date-time":"2012-11-11T00:00:00Z","timestamp":1352592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1038\/ng.2468","type":"journal-article","created":{"date-parts":[[2012,11,11]],"date-time":"2012-11-11T18:53:43Z","timestamp":1352660023000},"page":"1321-1325","source":"Crossref","is-referenced-by-count":535,"title":["The genetic landscape of mutations in Burkitt lymphoma"],"prefix":"10.1038","volume":"44","author":[{"given":"Cassandra","family":"Love","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dereje","family":"Jima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy L","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie H","family":"Dunphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W L","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopesh","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L","family":"Lugar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Rizzieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand S","family":"Lagoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Bernal-Mizrachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen P","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Flowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikkeri N","family":"Naresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Evens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Chadburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo I","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena B","family":"Czader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed I","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea B","family":"Moffitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McKinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjishnu","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Grubor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Dunson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep S","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,11]]},"reference":[{"key":"BFng2468_CR1","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1056\/NEJMoa055759","volume":"354","author":"SS Dave","year":"2006","unstructured":"Dave, S.S. et al. Molecular diagnosis of Burkitt's lymphoma. N. Engl. J. Med. 354, 2431\u20132442 (2006).","journal-title":"N. Engl. J. Med."},{"key":"BFng2468_CR2","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1365-2141.2011.08883.x","volume":"155","author":"JD Schiffman","year":"2011","unstructured":"Schiffman, J.D. et al. Genome wide copy number analysis of paediatric Burkitt lymphoma using formalin-fixed tissues reveals a subset with gain of chromosome 13q and corresponding miRNA over expression. Br. J. Haematol. 155, 477\u2013486 (2011).","journal-title":"Br. J. Haematol."},{"key":"BFng2468_CR3","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1056\/NEJMoa055351","volume":"354","author":"M Hummel","year":"2006","unstructured":"Hummel, M. et al. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N. Engl. J. Med. 354, 2419\u20132430 (2006).","journal-title":"N. Engl. J. Med."},{"key":"BFng2468_CR4","unstructured":"Swerdlow, S.H. et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 4th edn. (IARC Press, Lyon, France, 2008)."},{"key":"BFng2468_CR5","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1101\/gr.092759.109","volume":"19","author":"M Krzywinski","year":"2009","unstructured":"Krzywinski, M. et al. Circos: an information aesthetic for comparative genomics. Genome Res. 19, 1639\u20131645 (2009).","journal-title":"Genome Res."},{"key":"BFng2468_CR6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nmeth.1363","volume":"6","author":"K Chen","year":"2009","unstructured":"Chen, K. et al. BreakDancer: an algorithm for high-resolution mapping of genomic structural variation. Nat. Methods 6, 677\u2013681 (2009).","journal-title":"Nat. Methods"},{"key":"BFng2468_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nature08629","volume":"463","author":"ED Pleasance","year":"2010","unstructured":"Pleasance, E.D. et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463, 184\u2013190 (2010).","journal-title":"Nature"},{"key":"BFng2468_CR8","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/nar\/29.1.308","volume":"29","author":"ST Sherry","year":"2001","unstructured":"Sherry, S.T. et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 29, 308\u2013311 (2001).","journal-title":"Nucleic Acids Res."},{"key":"BFng2468_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1126\/science.1190371","volume":"329","author":"X Yi","year":"2010","unstructured":"Yi, X. et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329, 75\u201378 (2010).","journal-title":"Science"},{"key":"BFng2468_CR10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/ng.680","volume":"42","author":"Y Li","year":"2010","unstructured":"Li, Y. et al. Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat. Genet. 42, 969\u2013972 (2010).","journal-title":"Nat. Genet."},{"key":"BFng2468_CR11","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nature08250","volume":"461","author":"SB Ng","year":"2009","unstructured":"Ng, S.B. et al. Targeted capture and massively parallel sequencing of 12 human exomes. Nature 461, 272\u2013276 (2009).","journal-title":"Nature"},{"key":"BFng2468_CR12","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nbt0308-256b","volume":"26","author":"N Siva","year":"2008","unstructured":"Siva, N. 1000 Genomes project. Nat. Biotechnol. 26, 256 (2008).","journal-title":"Nat. Biotechnol."},{"key":"BFng2468_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nrc1299","volume":"4","author":"PA Futreal","year":"2004","unstructured":"Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177\u2013183 (2004).","journal-title":"Nat. Rev. Cancer"},{"key":"BFng2468_CR14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","volume":"476","author":"RD Morin","year":"2011","unstructured":"Morin, R.D. et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476, 298\u2013303 (2011).","journal-title":"Nature"},{"key":"BFng2468_CR15","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ng.892","volume":"43","author":"L Pasqualucci","year":"2011","unstructured":"Pasqualucci, L. et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat. Genet. 43, 830\u2013837 (2011).","journal-title":"Nat. Genet."},{"key":"BFng2468_CR16","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1073\/pnas.1121343109","volume":"109","author":"JG Lohr","year":"2012","unstructured":"Lohr, J.G. et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc. Natl. Acad. Sci. USA 109, 3879\u20133884 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng2468_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nature09671","volume":"470","author":"VN Ngo","year":"2011","unstructured":"Ngo, V.N. et al. Oncogenically active MYD88 mutations in human lymphoma. Nature 470, 115\u2013119 (2011).","journal-title":"Nature"},{"key":"BFng2468_CR18","doi-asserted-by":"publisher","first-page":"9991","DOI":"10.1073\/pnas.1732008100","volume":"100","author":"G Wright","year":"2003","unstructured":"Wright, G. et al. A gene expression\u2013based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA 100, 9991\u20139996 (2003).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng2468_CR19","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng2468_CR20","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.6401867","volume":"219","author":"R Dalla-Favera","year":"1983","unstructured":"Dalla-Favera, R., Martinotti, S., Gallo, R.C., Erikson, J. & Croce, C.M. Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science 219, 963\u2013967 (1983).","journal-title":"Science"},{"key":"BFng2468_CR21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/306194a0","volume":"306","author":"CD Little","year":"1983","unstructured":"Little, C.D., Nau, M.M., Carney, D.N., Gazdar, A.F. & Minna, J.D. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306, 194\u2013196 (1983).","journal-title":"Nature"},{"key":"BFng2468_CR22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/BF01613296","volume":"117","author":"P M\u00fcnzel","year":"1991","unstructured":"M\u00fcnzel, P., Marx, D., Kochel, H., Schauer, A. & Bock, K.W. Genomic alterations of the c-myc protooncogene in relation to the overexpression of c-erbB2 and Ki-67 in human breast and cervix carcinomas. J. Cancer Res. Clin. Oncol. 117, 603\u2013607 (1991).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"BFng2468_CR23","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/exmp.1999.2259","volume":"66","author":"ZR Wang","year":"1999","unstructured":"Wang, Z.R., Liu, W., Smith, S.T., Parrish, R.S. & Young, S.R. c-myc and chromosome 8 centromere studies of ovarian cancer by interphase FISH. Exp. Mol. Pathol. 66, 140\u2013148 (1999).","journal-title":"Exp. Mol. Pathol."},{"key":"BFng2468_CR24","first-page":"1769","volume":"57","author":"LH Augenlicht","year":"1997","unstructured":"Augenlicht, L.H. et al. Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial. Cancer Res. 57, 1769\u20131775 (1997).","journal-title":"Cancer Res."},{"key":"BFng2468_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nri2507","volume":"9","author":"BL Kee","year":"2009","unstructured":"Kee, B.L. E and ID proteins branch out. Nat. Rev. Immunol. 9, 175\u2013184 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFng2468_CR26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/ng.518","volume":"42","author":"RD Morin","year":"2010","unstructured":"Morin, R.D. et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat. Genet. 42, 181\u2013185 (2010).","journal-title":"Nat. Genet."},{"key":"BFng2468_CR27","doi-asserted-by":"publisher","first-page":"e118","DOI":"10.1182\/blood-2010-05-285403","volume":"116","author":"DD Jima","year":"2010","unstructured":"Jima, D.D. et al. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood 116, e118\u2013e127 (2010).","journal-title":"Blood"},{"key":"BFng2468_CR28","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/nar\/gkp1137","volume":"38","author":"PJ Cock","year":"2010","unstructured":"Cock, P.J., Fields, C.J., Goto, N., Heuer, M.L. & Rice, P.M. The Sanger FASTQ file format for sequences with quality scores, and the Solexa\/Illumina FASTQ variants. Nucleic Acids Res. 38, 1767\u20131771 (2010).","journal-title":"Nucleic Acids Res."},{"key":"BFng2468_CR29","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297\u20131303 (2010).","journal-title":"Genome Res."},{"key":"BFng2468_CR30","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","volume":"26","author":"H Li","year":"2010","unstructured":"Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589\u2013595 (2010).","journal-title":"Bioinformatics"},{"key":"BFng2468_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ygeno.2008.07.005","volume":"93","author":"G Parmigiani","year":"2009","unstructured":"Parmigiani, G. et al. Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics 93, 17\u201321 (2009).","journal-title":"Genomics"},{"key":"BFng2468_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson, J.T. et al. Integrative genomics viewer. Nat. Biotechnol. 29, 24\u201326 (2011).","journal-title":"Nat. Biotechnol."},{"key":"BFng2468_CR33","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1093\/bioinformatics\/btr317","volume":"27","author":"D Ge","year":"2011","unstructured":"Ge, D. et al. SVA: software for annotating and visualizing sequenced human genomes. Bioinformatics 27, 1998\u20132000 (2011).","journal-title":"Bioinformatics"},{"key":"BFng2468_CR34","doi-asserted-by":"publisher","first-page":"R232","DOI":"10.1186\/gb-2007-8-11-r232","volume":"8","author":"B Reva","year":"2007","unstructured":"Reva, B., Antipin, Y. & Sander, C. Determinants of protein function revealed by combinatorial entropy optimization. Genome Biol. 8, R232 (2007).","journal-title":"Genome Biol."},{"key":"BFng2468_CR35","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei, I.A. et al. A method and server for predicting damaging missense mutations. Nat. Methods 7, 248\u2013249 (2010).","journal-title":"Nat. Methods"},{"key":"BFng2468_CR36","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","volume":"4","author":"P Kumar","year":"2009","unstructured":"Kumar, P., Henikoff, S. & Ng, P.C. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat. Protoc. 4, 1073\u20131081 (2009).","journal-title":"Nat. Protoc."},{"key":"BFng2468_CR37","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/0022-2836(70)90057-4","volume":"48","author":"SB Needleman","year":"1970","unstructured":"Needleman, S.B. & Wunsch, C.D. A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48, 443\u2013453 (1970).","journal-title":"J. Mol. Biol."},{"key":"BFng2468_CR38","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1101\/gr.080531.108","volume":"19","author":"KD Pruitt","year":"2009","unstructured":"Pruitt, K.D. et al. The consensus coding sequence (CCDS) project: identifying a common protein-coding gene set for the human and mouse genomes. Genome Res. 19, 1316\u20131323 (2009).","journal-title":"Genome Res."},{"key":"BFng2468_CR39","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan, A.R. & Hall, I.M. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841\u2013842 (2010).","journal-title":"Bioinformatics"},{"key":"BFng2468_CR40","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1126\/science.1145720","volume":"318","author":"LD Wood","year":"2007","unstructured":"Wood, L.D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108\u20131113 (2007).","journal-title":"Science"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.2468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.2468","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.2468.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:50:44Z","timestamp":1684443044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.2468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,11]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["BFng2468"],"URL":"https:\/\/doi.org\/10.1038\/ng.2468","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,11]]}}}