{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:27:08Z","timestamp":1790321228414,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,5,25]],"date-time":"2014-05-25T00:00:00Z","timestamp":1400976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/ng.2971","type":"journal-article","created":{"date-parts":[[2014,5,25]],"date-time":"2014-05-25T17:17:53Z","timestamp":1401038273000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Long-range enhancers regulating Myc expression are required for normal facial morphogenesis"],"prefix":"10.1038","volume":"46","author":[{"given":"Veli Vural","family":"Uslu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Petretich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ruf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Langenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno A","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Marioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Spitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,25]]},"reference":[{"key":"BFng2971_CR1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","volume":"12","author":"MJ Dixon","year":"2011","unstructured":"Dixon, M.J., Marazita, M.L., Beaty, T.H. & Murray, J.C. Cleft lip and palate: understanding genetic and environmental influences. Nat. Rev. Genet. 12, 167\u2013178 (2011).","journal-title":"Nat. Rev. Genet."},{"key":"BFng2971_CR2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.molmed.2011.07.007","volume":"17","author":"E Mangold","year":"2011","unstructured":"Mangold, E., Ludwig, K.U. & N\u00f6then, M.M. Breakthroughs in the genetics of orofacial clefting. Trends Mol. Med. 17, 725\u2013733 (2011).","journal-title":"Trends Mol. Med."},{"key":"BFng2971_CR3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ng.333","volume":"41","author":"S Birnbaum","year":"2009","unstructured":"Birnbaum, S. et al. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat. Genet. 41, 473\u2013477 (2009).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng.580","volume":"42","author":"TH Beaty","year":"2010","unstructured":"Beaty, T.H. et al. A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. Nat. Genet. 42, 525\u2013529 (2010).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR5","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ng.2360","volume":"44","author":"KU Ludwig","year":"2012","unstructured":"Ludwig, K.U. et al. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat. Genet. 44, 968\u2013971 (2012).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1399-0004.2002.610402.x","volume":"61","author":"JC Murray","year":"2002","unstructured":"Murray, J.C. Gene\/environment causes of cleft lip and\/or palate. Clin. Genet. 61, 248\u2013256 (2002).","journal-title":"Clin. Genet."},{"key":"BFng2971_CR7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ng.840","volume":"43","author":"ML Freedman","year":"2011","unstructured":"Freedman, M.L. et al. Principles for the post-GWAS functional characterization of cancer risk loci. Nat. Genet. 43, 513\u2013518 (2011).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0070-2153(08)00602-9","volume":"84","author":"A Gritli-Linde","year":"2008","unstructured":"Gritli-Linde, A. The etiopathogenesis of cleft lip and cleft palate: usefulness and caveats of mouse models. Curr. Top. Dev. Biol. 84, 37\u2013138 (2008).","journal-title":"Curr. Top. Dev. Biol."},{"key":"BFng2971_CR9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/ng.790","volume":"43","author":"S Ruf","year":"2011","unstructured":"Ruf, S. et al. Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Nat. Genet. 43, 379\u2013386 (2011).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR10","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/dvdy.20646","volume":"235","author":"R Jiang","year":"2006","unstructured":"Jiang, R., Bush, J.O. & Lidral, A.C. Development of the upper lip: morphogenetic and molecular mechanisms. Dev. Dyn. 235, 1152\u20131166 (2006).","journal-title":"Dev. Dyn."},{"key":"BFng2971_CR11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature09692","volume":"470","author":"A Rada-Iglesias","year":"2011","unstructured":"Rada-Iglesias, A. et al. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 470, 279\u2013283 (2011).","journal-title":"Nature"},{"key":"BFng2971_CR12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature07829","volume":"459","author":"ND Heintzman","year":"2009","unstructured":"Heintzman, N.D. et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459, 108\u2013112 (2009).","journal-title":"Nature"},{"key":"BFng2971_CR13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature11243","volume":"488","author":"Y Shen","year":"2012","unstructured":"Shen, Y. et al. A map of the cis-regulatory sequences in the mouse genome. Nature 488, 116\u2013120 (2012).","journal-title":"Nature"},{"key":"BFng2971_CR14","doi-asserted-by":"crossref","first-page":"1241006","DOI":"10.1126\/science.1241006","volume":"342","author":"C Attanasio","year":"2013","unstructured":"Attanasio, C. et al. Fine tuning of craniofacial morphology by distant-acting enhancers. Science 342, 1241006 (2013).","journal-title":"Science"},{"key":"BFng2971_CR15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/eji.200737972","volume":"38","author":"C-Y Huang","year":"2008","unstructured":"Huang, C.-Y., Bredemeyer, A.L., Walker, L.M., Bassing, C.H. & Sleckman, B.P. Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP\u2013c-Myc knock-in mouse. Eur. J. Immunol. 38, 342\u2013349 (2008).","journal-title":"Eur. J. Immunol."},{"key":"BFng2971_CR16","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/dvg.20304","volume":"45","author":"K Wei","year":"2007","unstructured":"Wei, K. et al. Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45, 382\u2013390 (2007).","journal-title":"Genesis"},{"key":"BFng2971_CR17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/tera.1420370314","volume":"37","author":"J Karolyi","year":"1988","unstructured":"Karolyi, J., Erickson, R.P. & Liu, S. Genetics of susceptibility to 6-aminonicotinamide\u2013induced cleft palate in the mouse: studies in congenic and recombinant inbred strains. Teratology 37, 283\u2013287 (1988).","journal-title":"Teratology"},{"key":"BFng2971_CR18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc2819","volume":"10","author":"J van Riggelen","year":"2010","unstructured":"van Riggelen, J., Yetil, A. & Felsher, D.W. MYC as a regulator of ribosome biogenesis and protein synthesis. Nat. Rev. Cancer 10, 301\u2013309 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"BFng2971_CR19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2003.10.033","volume":"267","author":"DK Nelson","year":"2004","unstructured":"Nelson, D.K. & Williams, T. Frontonasal process\u2013specific disruption of AP-2\u03b1 results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects. Dev. Biol. 267, 72\u201392 (2004).","journal-title":"Dev. Biol."},{"key":"BFng2971_CR20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.stem.2012.07.006","volume":"11","author":"A Rada-Iglesias","year":"2012","unstructured":"Rada-Iglesias, A. et al. Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell Stem Cell 11, 633\u2013648 (2012).","journal-title":"Cell Stem Cell"},{"key":"BFng2971_CR21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1073\/pnas.1010740107","volume":"108","author":"N de Croz\u00e9","year":"2011","unstructured":"de Croz\u00e9, N., Maczkowiak, F. & Monsoro-Burq, A.H. Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network. Proc. Natl. Acad. Sci. USA 108, 155\u2013160 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng2971_CR22","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/j.1460-2075.1995.tb07137.x","volume":"14","author":"S Gaubatz","year":"1995","unstructured":"Gaubatz, S. et al. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J. 14, 1508\u20131519 (1995).","journal-title":"EMBO J."},{"key":"BFng2971_CR23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/ejhg.2011.110","volume":"19","author":"S Boehringer","year":"2011","unstructured":"Boehringer, S. et al. Genetic determination of human facial morphology: links between cleft-lips and normal variation. Eur. J. Hum. Genet. 19, 1192\u20131197 (2011).","journal-title":"Eur. J. Hum. Genet."},{"key":"BFng2971_CR24","doi-asserted-by":"crossref","first-page":"e1002932","DOI":"10.1371\/journal.pgen.1002932","volume":"8","author":"F Liu","year":"2012","unstructured":"Liu, F. et al. A genome-wide association study identifies five loci influencing facial morphology in Europeans. PLoS Genet. 8, e1002932 (2012).","journal-title":"PLoS Genet."},{"key":"BFng2971_CR25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature08451","volume":"461","author":"A Visel","year":"2009","unstructured":"Visel, A., Rubin, E.M. & Pennacchio, L.A. Genomic views of distant-acting enhancers. Nature 461, 199\u2013205 (2009).","journal-title":"Nature"},{"key":"BFng2971_CR26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2005.10.042","volume":"124","author":"O Hallikas","year":"2006","unstructured":"Hallikas, O. et al. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124, 47\u201359 (2006).","journal-title":"Cell"},{"key":"BFng2971_CR27","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cell.2011.10.023","volume":"147","author":"T Montavon","year":"2011","unstructured":"Montavon, T. et al. A regulatory archipelago controls Hox genes transcription in digits. Cell 147, 1132\u20131145 (2011).","journal-title":"Cell"},{"key":"BFng2971_CR28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.devcel.2013.01.025","volume":"24","author":"M Marini\u0107","year":"2013","unstructured":"Marini\u0107, M., Aktas, T., Ruf, S. & Spitz, F. An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev. Cell 24, 530\u2013542 (2013).","journal-title":"Dev. Cell"},{"key":"BFng2971_CR29","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","volume":"155","author":"D Hnisz","year":"2013","unstructured":"Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934\u2013947 (2013).","journal-title":"Cell"},{"key":"BFng2971_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gr.164079.113","volume":"24","author":"O Corradin","year":"2014","unstructured":"Corradin, O. et al. Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits. Genome Res. 24, 1\u201313 (2014).","journal-title":"Genome Res."},{"key":"BFng2971_CR31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature08801","volume":"464","author":"A Visel","year":"2010","unstructured":"Visel, A. et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464, 409\u2013412 (2010).","journal-title":"Nature"},{"key":"BFng2971_CR32","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature09753","volume":"470","author":"O Harismendy","year":"2011","unstructured":"Harismendy, O. et al. 9p21 DNA variants associated with coronary artery disease impair interferon-\u03b3 signalling response. Nature 470, 264\u2013268 (2011).","journal-title":"Nature"},{"key":"BFng2971_CR33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1534-5807(03)00160-6","volume":"4","author":"A Bellmeyer","year":"2003","unstructured":"Bellmeyer, A., Krase, J., Lindgren, J. & LaBonne, C. The protooncogene c-Myc is an essential regulator of neural crest formation in Xenopus. Dev. Cell 4, 827\u2013839 (2003).","journal-title":"Dev. Cell"},{"key":"BFng2971_CR34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7580.2007.00845.x","volume":"212","author":"TE Parsons","year":"2008","unstructured":"Parsons, T.E. et al. Phenotypic variability and craniofacial dysmorphology: increased shape variance in a mouse model for cleft lip. J. Anat. 212, 135\u2013143 (2008).","journal-title":"J. Anat."},{"key":"BFng2971_CR35","doi-asserted-by":"crossref","first-page":"e1003300","DOI":"10.1371\/journal.pgen.1003300","volume":"9","author":"T Terzian","year":"2013","unstructured":"Terzian, T. & Box, N. Genetics of ribosomal proteins: \u201ccuriouser and curiouser.\u201d. PLoS Genet. 9, e1003300 (2013).","journal-title":"PLoS Genet."},{"key":"BFng2971_CR36","doi-asserted-by":"crossref","first-page":"e1003094","DOI":"10.1371\/journal.pgen.1003094","volume":"9","author":"DE Watkins-Chow","year":"2013","unstructured":"Watkins-Chow, D.E. et al. Mutation of the Diamond-Blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet. 9, e1003094 (2013).","journal-title":"PLoS Genet."},{"key":"BFng2971_CR37","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/ng.188","volume":"40","author":"KA McGowan","year":"2008","unstructured":"McGowan, K.A. et al. Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat. Genet. 40, 963\u2013970 (2008).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12185-010-0693-7","volume":"92","author":"E Ito","year":"2010","unstructured":"Ito, E., Konno, Y., Toki, T. & Terui, K. Molecular pathogenesis in Diamond-Blackfan anemia. Int. J. Hematol. 92, 413\u2013418 (2010).","journal-title":"Int. J. Hematol."},{"key":"BFng2971_CR39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ng1999","volume":"39","author":"J Gudmundsson","year":"2007","unstructured":"Gudmundsson, J. et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat. Genet. 39, 631\u2013637 (2007).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng.111","volume":"40","author":"IPM Tomlinson","year":"2008","unstructured":"Tomlinson, I.P.M. et al. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat. Genet. 40, 623\u2013630 (2008).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR41","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/ng.407","volume":"41","author":"S Shete","year":"2009","unstructured":"Shete, S. et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat. Genet. 41, 899\u2013904 (2009).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR42","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/ng.668","volume":"42","author":"EL Goode","year":"2010","unstructured":"Goode, E.L. et al. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat. Genet. 42, 874\u2013879 (2010).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR43","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/ng.406","volume":"41","author":"S Tuupanen","year":"2009","unstructured":"Tuupanen, S. et al. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat. Genet. 41, 885\u2013890 (2009).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR44","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/ng.403","volume":"41","author":"MM Pomerantz","year":"2009","unstructured":"Pomerantz, M.M. et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat. Genet. 41, 882\u2013884 (2009).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR45","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1073\/pnas.0910668107","volume":"107","author":"N Ahmadiyeh","year":"2010","unstructured":"Ahmadiyeh, N. et al. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc. Natl. Acad. Sci. USA 107, 9742\u20139746 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng2971_CR46","doi-asserted-by":"crossref","first-page":"e1000597","DOI":"10.1371\/journal.pgen.1000597","volume":"5","author":"L Jia","year":"2009","unstructured":"Jia, L. et al. Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet. 5, e1000597 (2009).","journal-title":"PLoS Genet."},{"key":"BFng2971_CR47","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1073\/pnas.0906067107","volume":"107","author":"J Sotelo","year":"2010","unstructured":"Sotelo, J. et al. Long-range enhancers on 8q24 regulate c-Myc. Proc. Natl. Acad. Sci. USA 107, 3001\u20133005 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng2971_CR48","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.1228606","volume":"338","author":"IK Sur","year":"2012","unstructured":"Sur, I.K. et al. Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science 338, 1360\u20131363 (2012).","journal-title":"Science"},{"key":"BFng2971_CR49","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.313104","volume":"18","author":"A Wilson","year":"2004","unstructured":"Wilson, A. et al. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 18, 2747\u20132763 (2004).","journal-title":"Genes Dev."},{"key":"BFng2971_CR50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2164-14-215","volume":"14","author":"C-K Chen","year":"2013","unstructured":"Chen, C.-K. et al. TRACER: a resource to study the regulatory architecture of the mouse genome. BMC Genomics 14, 215 (2013).","journal-title":"BMC Genomics"},{"key":"BFng2971_CR51","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1128\/MCB.17.1.100","volume":"17","author":"LM Facchini","year":"1997","unstructured":"Facchini, L.M., Chen, S., Marhin, W.W., Lear, J.N. & Penn, L.Z. The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol. Cell. Biol. 17, 100\u2013114 (1997).","journal-title":"Mol. Cell. Biol."},{"key":"BFng2971_CR52","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/3861","volume":"20","author":"Y H\u00e9rault","year":"1998","unstructured":"H\u00e9rault, Y., Rassoulzadegan, M., Cuzin, F. & Duboule, D. Engineering chromosomes in mice through targeted meiotic recombination (TAMERE). Nat. Genet. 20, 381\u2013384 (1998).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/gene.10030","volume":"32","author":"S-HE Tang","year":"2002","unstructured":"Tang, S.-H.E., Silva, F.J., Tsark, W.M.K. & Mann, J.R. A Cre\/loxP-deleter transgenic line in mouse strain 129S1\/SvImJ. Genesis 32, 199\u2013202 (2002).","journal-title":"Genesis"},{"key":"BFng2971_CR54","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/ng2060","volume":"9","author":"S Wu","year":"2007","unstructured":"Wu, S., Ying, G., Wu, Q. & Capecchi, M.R. Toward simpler and faster genome-wide mutagenesis in mice. Nat. Genet. 9, 922\u2013930 (2007).","journal-title":"Nat. Genet."},{"key":"BFng2971_CR55","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nmeth.2697","volume":"10","author":"SA Bustin","year":"2013","unstructured":"Bustin, S.A. et al. The need for transparency and good practices in the qPCR literature. Nat. Methods 10, 1063\u20131067 (2013).","journal-title":"Nat. Methods"},{"key":"BFng2971_CR56","unstructured":"Nagy, A., Gertsenstein, M., Vintersten, K. & Behringer, R.R. Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2003)."},{"key":"BFng2971_CR57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2148-8-73","volume":"8","author":"M Kawakami","year":"2008","unstructured":"Kawakami, M. & Yamamura, K.-I. Cranial bone morphometric study among mouse strains. BMC Evol. Biol. 8, 73 (2008).","journal-title":"BMC Evol. Biol."},{"key":"BFng2971_CR58","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676\u2013682 (2012).","journal-title":"Nat. Methods"},{"key":"BFng2971_CR59","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell, C., Pachter, L. & Salzberg, S.L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105\u20131111 (2009).","journal-title":"Bioinformatics"},{"key":"BFng2971_CR60","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).","journal-title":"Genome Biol."},{"key":"BFng2971_CR61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","volume":"151","author":"Z Nie","year":"2012","unstructured":"Nie, Z. et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 151, 68\u201379 (2012).","journal-title":"Cell"},{"key":"BFng2971_CR62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2012.08.026","volume":"151","author":"CY Lin","year":"2012","unstructured":"Lin, C.Y. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 151, 56\u201367 (2012).","journal-title":"Cell"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.2971.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.2971","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.2971.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:59:23Z","timestamp":1684429163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.2971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,25]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["BFng2971"],"URL":"https:\/\/doi.org\/10.1038\/ng.2971","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718415263.793497121","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718415263.793525248","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,25]]},"assertion":[{"value":"13 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}