{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:42:45Z","timestamp":1790847765866,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,8,31]],"date-time":"2014-08-31T00:00:00Z","timestamp":1409443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/ng.3079","type":"journal-article","created":{"date-parts":[[2014,8,31]],"date-time":"2014-08-31T19:07:53Z","timestamp":1409512073000},"page":"1120-1125","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":201,"title":["Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma"],"prefix":"10.1038","volume":"46","author":[{"name":"Wellcome Trust Case Control Consortium 2","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-5952","authenticated-orcid":false,"given":"Puya","family":"Gharahkhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NEIGHBORHOOD Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn P","family":"Burdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys","family":"Fogarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwani","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex W","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew H","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Cremin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N Cooke","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J","family":"Loomis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-3496","authenticated-orcid":false,"given":"Louis R","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananth C","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McGuffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Topouzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Casson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Chehade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiger","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Souzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Landers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude T","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Klebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B","family":"Ruddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Healey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Radford-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Whiteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janey L","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Mackey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"MacGregor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie E","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,31]]},"reference":[{"key":"BFng3079_CR1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"HA Quigley","year":"2006","unstructured":"Quigley, H.A. & Broman, A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 90, 262\u2013267 (2006).","journal-title":"Br. J. Ophthalmol."},{"key":"BFng3079_CR2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","volume":"40","author":"RJ Casson","year":"2012","unstructured":"Casson, R.J., Chidlow, G., Wood, J.P., Crowston, J.G. & Goldberg, I. Definition of glaucoma: clinical and experimental concepts. Clin. Experiment. Ophthalmol. 40, 341\u2013349 (2012).","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"BFng3079_CR3","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1126\/science.275.5300.668","volume":"275","author":"EM Stone","year":"1997","unstructured":"Stone, E.M. et al. Identification of a gene that causes primary open angle glaucoma. Science 275, 668\u2013670 (1997).","journal-title":"Science"},{"key":"BFng3079_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.ajhg.2009.08.016","volume":"85","author":"F Pasutto","year":"2009","unstructured":"Pasutto, F. et al. Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. Am. J. Hum. Genet. 85, 447\u2013456 (2009).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng3079_CR5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng.661","volume":"42","author":"G Thorleifsson","year":"2010","unstructured":"Thorleifsson, G. et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat. Genet. 42, 906\u2013909 (2010).","journal-title":"Nat. Genet."},{"key":"BFng3079_CR6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ng.824","volume":"43","author":"KP Burdon","year":"2011","unstructured":"Burdon, K.P. et al. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B\u2013AS1. Nat. Genet. 43, 574\u2013578 (2011).","journal-title":"Nat. Genet."},{"key":"BFng3079_CR7","doi-asserted-by":"crossref","first-page":"e1002654","DOI":"10.1371\/journal.pgen.1002654","volume":"8","author":"JL Wiggs","year":"2012","unstructured":"Wiggs, J.L. et al. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 8, e1002654 (2012).","journal-title":"PLoS Genet."},{"key":"BFng3079_CR8","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1056\/NEJM199304153281507","volume":"328","author":"HA Quigley","year":"1993","unstructured":"Quigley, H.A. Open-angle glaucoma. N. Engl. J. Med. 328, 1097\u20131106 (1993).","journal-title":"N. Engl. J. Med."},{"key":"BFng3079_CR9","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00439-013-1349-5","volume":"133","author":"AB Ozel","year":"2014","unstructured":"Ozel, A.B. et al. Genome-wide association study and meta-analysis of intraocular pressure. Hum. Genet. 133, 41\u201357 (2014).","journal-title":"Hum. Genet."},{"key":"BFng3079_CR10","doi-asserted-by":"publisher","first-page":"e1002611","DOI":"10.1371\/journal.pgen.1002611","volume":"8","author":"LM van Koolwijk","year":"2012","unstructured":"van Koolwijk, L.M. et al. Common genetic determinants of intraocular pressure and primary open-angle glaucoma. PLoS Genet. 8, e1002611 (2012).","journal-title":"PLoS Genet."},{"key":"BFng3079_CR11","doi-asserted-by":"publisher","first-page":"e1000978","DOI":"10.1371\/journal.pgen.1000978","volume":"6","author":"WD Ramdas","year":"2010","unstructured":"Ramdas, W.D. et al. A genome-wide association study of optic disc parameters. PLoS Genet. 6, e1000978 (2010).","journal-title":"PLoS Genet."},{"key":"BFng3079_CR12","doi-asserted-by":"crossref","unstructured":"ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol. 9, e1001046 (2011).","DOI":"10.1371\/journal.pbio.1001046"},{"key":"BFng3079_CR13","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1093\/bioinformatics\/btq452","volume":"26","author":"TP Yang","year":"2010","unstructured":"Yang, T.P. et al. Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics 26, 2474\u20132476 (2010).","journal-title":"Bioinformatics"},{"key":"BFng3079_CR14","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","volume":"40","author":"LD Ward","year":"2012","unstructured":"Ward, L.D. & Kellis, M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930\u2013D934 (2012).","journal-title":"Nucleic Acids Res."},{"key":"BFng3079_CR15","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1093\/hmg\/2.7.915","volume":"2","author":"IM Hanson","year":"1993","unstructured":"Hanson, I.M. et al. PAX6 mutations in aniridia. Hum. Mol. Genet. 2, 915\u2013920 (1993).","journal-title":"Hum. Mol. Genet."},{"key":"BFng3079_CR16","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1101\/gr.137323.112","volume":"22","author":"AP Boyle","year":"2012","unstructured":"Boyle, A.P. et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22, 1790\u20131797 (2012).","journal-title":"Genome Res."},{"key":"BFng3079_CR17","first-page":"1319","volume":"12","author":"N Tserentsoodol","year":"2006","unstructured":"Tserentsoodol, N. et al. Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors. Mol. Vis. 12, 1319\u20131333 (2006).","journal-title":"Mol. Vis."},{"key":"BFng3079_CR18","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1006\/bbrc.2001.4823","volume":"283","author":"L Bellincampi","year":"2001","unstructured":"Bellincampi, L. et al. Identification of an alternative transcript of ABCA1 gene in different human cell types. Biochem. Biophys. Res. Commun. 283, 590\u2013597 (2001).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFng3079_CR19","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1194\/jlr.M500133-JLR200","volume":"46","author":"RR Singaraja","year":"2005","unstructured":"Singaraja, R.R. et al. Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1. J. Lipid Res. 46, 2061\u20132071 (2005).","journal-title":"J. Lipid Res."},{"key":"BFng3079_CR20","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.nbd.2013.01.018","volume":"54","author":"JM Karasinska","year":"2013","unstructured":"Karasinska, J.M. et al. ABCA1 influences neuroinflammation and neuronal death. Neurobiol. Dis. 54, 445\u2013455 (2013).","journal-title":"Neurobiol. Dis."},{"key":"BFng3079_CR21","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1091\/mbc.e01-12-0148","volume":"13","author":"Y Qian","year":"2002","unstructured":"Qian, Y. et al. PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. Mol. Biol. Cell 13, 2311\u20132322 (2002).","journal-title":"Mol. Biol. Cell"},{"key":"BFng3079_CR22","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1006\/excr.1999.4795","volume":"255","author":"Y Qian","year":"2000","unstructured":"Qian, Y., Baisden, J.M., Zot, H.G., Van Winkle, W.B. & Flynn, D.C. The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. Exp. Cell Res. 255, 102\u2013113 (2000).","journal-title":"Exp. Cell Res."},{"key":"BFng3079_CR23","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1016\/j.ajpath.2012.02.030","volume":"180","author":"B Junglas","year":"2012","unstructured":"Junglas, B. et al. Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. Am. J. Pathol. 180, 2386\u20132403 (2012).","journal-title":"Am. J. Pathol."},{"key":"BFng3079_CR24","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1128\/MCB.01274-08","volume":"29","author":"HS Kwon","year":"2009","unstructured":"Kwon, H.S., Lee, H.S., Ji, Y., Rubin, J.S. & Tomarev, S.I. Myocilin is a modulator of Wnt signaling. Mol. Cell. Biol. 29, 2139\u20132154 (2009).","journal-title":"Mol. Cell. Biol."},{"key":"BFng3079_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.05.002","volume":"37","author":"T Inoue","year":"2013","unstructured":"Inoue, T. & Tanihara, H. Rho-associated kinase inhibitors: a novel glaucoma therapy. Prog. Retin. Eye Res. 37, 1\u201312 (2013).","journal-title":"Prog. Retin. Eye Res."},{"key":"BFng3079_CR26","doi-asserted-by":"publisher","first-page":"41R","DOI":"10.1093\/glycob\/cwg054","volume":"13","author":"DJ Becker","year":"2003","unstructured":"Becker, D.J. & Lowe, J.B. Fucose: biosynthesis and biological function in mammals. Glycobiology 13, 41R\u201353R (2003).","journal-title":"Glycobiology"},{"key":"BFng3079_CR27","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/jb\/mvn011","volume":"143","author":"E Miyoshi","year":"2008","unstructured":"Miyoshi, E., Moriwaki, K. & Nakagawa, T. Biological function of fucosylation in cancer biology. J. Biochem. 143, 725\u2013729 (2008).","journal-title":"J. Biochem."},{"key":"BFng3079_CR28","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s004170000241","volume":"239","author":"M Inatani","year":"2001","unstructured":"Inatani, M. et al. Transforming growth factor-\u03b22 levels in aqueous humor of glaucomatous eyes. Graefes Arch. Clin. Exp. Ophthalmol. 239, 109\u2013113 (2001).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"BFng3079_CR29","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s004170000252","volume":"239","author":"G Picht","year":"2001","unstructured":"Picht, G., Welge-Luessen, U., Grehn, F. & Lutjen-Drecoll, E. Transforming growth factor \u03b22 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch. Clin. Exp. Ophthalmol. 239, 199\u2013207 (2001).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"BFng3079_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1023\/B:INTE.0000018524.48581.79","volume":"25","author":"AA Ozcan","year":"2004","unstructured":"Ozcan, A.A., Ozdemir, N. & Canataroglu, A. The aqueous levels of TGF-\u03b22 in patients with glaucoma. Int. Ophthalmol. 25, 19\u201322 (2004).","journal-title":"Int. Ophthalmol."},{"key":"BFng3079_CR31","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1136\/bjo.83.2.209","volume":"83","author":"JD Pena","year":"1999","unstructured":"Pena, J.D., Taylor, A.W., Ricard, C.S., Vidal, I. & Hernandez, M.R. Transforming growth factor \u03b2 isoforms in human optic nerve heads. Br. J. Ophthalmol. 83, 209\u2013218 (1999).","journal-title":"Br. J. Ophthalmol."},{"key":"BFng3079_CR32","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1167\/iovs.05-1060","volume":"47","author":"DL Fleenor","year":"2006","unstructured":"Fleenor, D.L. et al. TGF\u03b22-induced changes in human trabecular meshwork: implications for intraocular pressure. Invest. Ophthalmol. Vis. Sci. 47, 226\u2013234 (2006).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFng3079_CR33","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","volume":"120","author":"A Heijl","year":"2002","unstructured":"Heijl, A., Leske, M.C., Bengtsson, B., Hyman, L. & Hussein, M. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch. Ophthalmol. 120, 1268\u20131279 (2002).","journal-title":"Arch. Ophthalmol."},{"key":"BFng3079_CR34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559\u2013575 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng3079_CR35","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson, N., Price, A.L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).","journal-title":"PLoS Genet."},{"key":"BFng3079_CR36","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price, A.L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904\u2013909 (2006).","journal-title":"Nat. Genet."},{"key":"BFng3079_CR37","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).","journal-title":"PLoS Genet."},{"key":"BFng3079_CR38","doi-asserted-by":"crossref","unstructured":"1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061\u20131073 (2010).","DOI":"10.1038\/nature09534"},{"key":"BFng3079_CR39","doi-asserted-by":"crossref","unstructured":"Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661\u2013678 (2007).","DOI":"10.1038\/nature05911"},{"key":"BFng3079_CR40","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrg2796","volume":"11","author":"J Marchini","year":"2010","unstructured":"Marchini, J. & Howie, B. Genotype imputation for genome-wide association studies. Nat. Rev. Genet. 11, 499\u2013511 (2010).","journal-title":"Nat. Rev. Genet."},{"key":"BFng3079_CR41","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing (Vienna, 2013)."},{"key":"BFng3079_CR42","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","volume":"26","author":"RJ Pruim","year":"2010","unstructured":"Pruim, R.J. et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336\u20132337 (2010).","journal-title":"Bioinformatics"},{"key":"BFng3079_CR43","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C.J., Li, Y. & Abecasis, G.R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"BFng3079_CR44","doi-asserted-by":"publisher","first-page":"D749","DOI":"10.1093\/nar\/gkt1196","volume":"42","author":"P Flicek","year":"2014","unstructured":"Flicek, P. et al. Ensembl 2014. Nucleic Acids Res. 42, D749\u2013D755 (2014).","journal-title":"Nucleic Acids Res."},{"key":"BFng3079_CR45","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent, W.J. et al. The human genome browser at UCSC. Genome Res. 12, 996\u20131006 (2002).","journal-title":"Genome Res."},{"key":"BFng3079_CR46","doi-asserted-by":"publisher","first-page":"baq020","DOI":"10.1093\/database\/baq020","volume":"2010","author":"M Safran","year":"2010","unstructured":"Safran, M. et al. GeneCards Version 3: the human gene integrator. Database (Oxford) 2010, baq020 (2010).","journal-title":"Database (Oxford)"},{"key":"BFng3079_CR47","doi-asserted-by":"crossref","unstructured":"UniProt Consortium. Activities at the Universal Protein Resource (UniProt). Nucleic Acids Res. 42, D191\u2013D198 (2014).","DOI":"10.1093\/nar\/gkt1140"},{"key":"BFng3079_CR48","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1093\/bioinformatics\/btq452","volume":"26","author":"TP Yang","year":"2010","unstructured":"Yang, T.P. et al. Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics 26, 2474\u20132476 (2010).","journal-title":"Bioinformatics"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.3079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3079","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T21:01:34Z","timestamp":1684443694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.3079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,31]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["BFng3079"],"URL":"https:\/\/doi.org\/10.1038\/ng.3079","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,31]]},"assertion":[{"value":"9 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}