{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:38Z","timestamp":1788307238617,"version":"build-2803163510"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,10,26]],"date-time":"2014-10-26T00:00:00Z","timestamp":1414281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1038\/ng.3129","type":"journal-article","created":{"date-parts":[[2014,10,26]],"date-time":"2014-10-26T14:39:50Z","timestamp":1414334390000},"page":"1274-1282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Common variants associated with general and MMR vaccine\u2013related febrile seizures"],"prefix":"10.1038","volume":"46","author":[{"given":"Bjarke","family":"Feenstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-8466","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Geller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth","family":"Carstensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Eitson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads V","family":"Hollegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Svanstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Hougaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Schoggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Yeh","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Melbye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Hviid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,26]]},"reference":[{"key":"BFng3129_CR1","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1056\/NEJMoa003077","volume":"345","author":"WE Barlow","year":"2001","unstructured":"Barlow, W.E. et al. The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine. N. Engl. J. Med. 345, 656\u2013661 (2001).","journal-title":"N. Engl. J. Med."},{"key":"BFng3129_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1001\/jama.292.3.351","volume":"292","author":"M Vestergaard","year":"2004","unstructured":"Vestergaard, M. et al. MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis. J. Am. Med. Assoc. 292, 351\u2013357 (2004).","journal-title":"J. Am. Med. Assoc."},{"key":"BFng3129_CR3","doi-asserted-by":"crossref","unstructured":"Stafstrom, C.E. in Febrile Seizures (eds. Baram, T.Z. & Shinnar, S.) 1\u201325 (Academic Press, San Diego, 2002).","DOI":"10.1016\/B978-012078141-6\/50003-2"},{"key":"BFng3129_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.pediatrneurol.2006.06.004","volume":"35","author":"JG Millichap","year":"2006","unstructured":"Millichap, J.G. & Millichap, J.J. Role of viral infections in the etiology of febrile seizures. Pediatr. Neurol. 35, 165\u2013172 (2006).","journal-title":"Pediatr. Neurol."},{"key":"BFng3129_CR5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S1474-4422(08)70039-5","volume":"7","author":"I Helbig","year":"2008","unstructured":"Helbig, I., Scheffer, I.E., Mulley, J.C. & Berkovic, S.F. Navigating the channels and beyond: unravelling the genetics of the epilepsies. Lancet Neurol. 7, 231\u2013245 (2008).","journal-title":"Lancet Neurol."},{"key":"BFng3129_CR6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.gde.2011.01.005","volume":"21","author":"A Poduri","year":"2011","unstructured":"Poduri, A. & Lowenstein, D. Epilepsy genetics\u2014past, present, and future. Curr. Opin. Genet. Dev. 21, 325\u2013332 (2011).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFng3129_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1136\/bmj.39087.691817.AE","volume":"334","author":"LG Sadleir","year":"2007","unstructured":"Sadleir, L.G. & Scheffer, I.E. Febrile seizures. Br. Med. J. 334, 307\u2013311 (2007).","journal-title":"Br. Med. J."},{"key":"BFng3129_CR8","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1212\/WNL.35.9.1268","volume":"35","author":"WA Hauser","year":"1985","unstructured":"Hauser, W.A., Annegers, J.F., Anderson, V.E. & Kurland, L.T. The risk of seizure disorders among relatives of children with febrile convulsions. Neurology 35, 1268\u20131273 (1985).","journal-title":"Neurology"},{"key":"BFng3129_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.eplepsyres.2013.02.011","volume":"105","author":"J Eckhaus","year":"2013","unstructured":"Eckhaus, J. et al. Genetics of febrile seizure subtypes and syndromes: a twin study. Epilepsy Res. 105, 103\u2013109 (2013).","journal-title":"Epilepsy Res."},{"key":"BFng3129_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0920-1211(02)00121-3","volume":"51","author":"MJ Kjeldsen","year":"2002","unstructured":"Kjeldsen, M.J., Kyvik, K.O., Friis, M.L. & Christensen, K. Genetic and environmental factors in febrile seizures: a Danish population-based twin study. Epilepsy Res. 51, 167\u2013177 (2002).","journal-title":"Epilepsy Res."},{"key":"BFng3129_CR11","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12531","volume":"501","author":"T Lappalainen","year":"2013","unstructured":"Lappalainen, T. et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature 501, 506\u2013511 (2013).","journal-title":"Nature"},{"key":"BFng3129_CR12","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/ng.2756","volume":"45","author":"HJ Westra","year":"2013","unstructured":"Westra, H.J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238\u20131243 (2013).","journal-title":"Nat. Genet."},{"key":"BFng3129_CR13","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.1073\/pnas.0511345103","volume":"103","author":"MJ Zilliox","year":"2006","unstructured":"Zilliox, M.J., Parmigiani, G. & Griffin, D.E. Gene expression patterns in dendritic cells infected with measles virus compared with other pathogens. Proc. Natl. Acad. Sci. USA 103, 3363\u20133368 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng3129_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature09907","volume":"472","author":"JW Schoggins","year":"2011","unstructured":"Schoggins, J.W. et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472, 481\u2013485 (2011).","journal-title":"Nature"},{"key":"BFng3129_CR15","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.jaci.2007.04.036","volume":"120","author":"N Dhiman","year":"2007","unstructured":"Dhiman, N. et al. Variations in measles vaccine\u2013specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors. J. Allergy Clin. Immunol. 120, 666\u2013672 (2007).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3129_CR16","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1016\/j.vaccine.2012.01.025","volume":"30","author":"RB Kennedy","year":"2012","unstructured":"Kennedy, R.B. et al. Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. Vaccine 30, 2159\u20132167 (2012).","journal-title":"Vaccine"},{"key":"BFng3129_CR17","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1128\/CVI.05652-11","volume":"19","author":"HD Clifford","year":"2012","unstructured":"Clifford, H.D. et al. CD46 measles virus receptor polymorphisms influence receptor protein expression and primary measles vaccine responses in naive Australian children. Clin. Vaccine Immunol. 19, 704\u2013710 (2012).","journal-title":"Clin. Vaccine Immunol."},{"key":"BFng3129_CR18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000331585","volume":"72","author":"IG Ovsyannikova","year":"2011","unstructured":"Ovsyannikova, I.G. et al. The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine\u2013induced immune responses: a replication study and examination of novel polymorphisms. Hum. Hered. 72, 206\u2013223 (2011).","journal-title":"Hum. Hered."},{"key":"BFng3129_CR19","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/nature01315","volume":"421","author":"C Kemper","year":"2003","unstructured":"Kemper, C. et al. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421, 388\u2013392 (2003).","journal-title":"Nature"},{"key":"BFng3129_CR20","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0092-8674(93)80071-L","volume":"75","author":"RE D\u00f6rig","year":"1993","unstructured":"D\u00f6rig, R.E., Marcil, A., Chopra, A. & Richardson, C.D. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295\u2013305 (1993).","journal-title":"Cell"},{"key":"BFng3129_CR21","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1128\/JVI.67.10.6025-6032.1993","volume":"67","author":"D Naniche","year":"1993","unstructured":"Naniche, D. et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67, 6025\u20136032 (1993).","journal-title":"J. Virol."},{"key":"BFng3129_CR22","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1128\/JVI.75.9.4399-4401.2001","volume":"75","author":"N Ono","year":"2001","unstructured":"Ono, N. et al. Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor. J. Virol. 75, 4399\u20134401 (2001).","journal-title":"J. Virol."},{"key":"BFng3129_CR23","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/ana.21712","volume":"66","author":"EA Thomas","year":"2009","unstructured":"Thomas, E.A. et al. Heat opens axon initial segment sodium channels: a febrile seizure mechanism? Ann. Neurol. 66, 219\u2013226 (2009).","journal-title":"Ann. Neurol."},{"key":"BFng3129_CR24","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S0140-6736(02)09968-3","volume":"360","author":"SE Heron","year":"2002","unstructured":"Heron, S.E. et al. Sodium-channel defects in benign familial neonatal-infantile seizures. Lancet 360, 851\u2013852 (2002).","journal-title":"Lancet"},{"key":"BFng3129_CR25","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1093\/brain\/awq057","volume":"133","author":"Y Liao","year":"2010","unstructured":"Liao, Y. et al. Molecular correlates of age-dependent seizures in an inherited neonatal-infantile epilepsy. Brain 133, 1403\u20131414 (2010).","journal-title":"Brain"},{"key":"BFng3129_CR26","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1371\/journal.pbio.0060107","volume":"6","author":"EE Schadt","year":"2008","unstructured":"Schadt, E.E. et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 6, e107 (2008).","journal-title":"PLoS Biol."},{"key":"BFng3129_CR27","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1093\/brain\/awt233","volume":"136","author":"D Kasperaviciute","year":"2013","unstructured":"Kasperaviciute, D. et al. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain 136, 3140\u20133150 (2013).","journal-title":"Brain"},{"key":"BFng3129_CR28","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1086\/516650","volume":"80","author":"EL Heinzen","year":"2007","unstructured":"Heinzen, E.L. et al. Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am. J. Hum. Genet. 80, 876\u2013883 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng3129_CR29","doi-asserted-by":"publisher","first-page":"5903","DOI":"10.1523\/JNEUROSCI.5270-06.2007","volume":"27","author":"I Ogiwara","year":"2007","unstructured":"Ogiwara, I. et al. Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27, 5903\u20135914 (2007).","journal-title":"J. Neurosci."},{"key":"BFng3129_CR30","doi-asserted-by":"publisher","first-page":"649325","DOI":"10.1155\/2011\/649325","volume":"2011","author":"E Rossignol","year":"2011","unstructured":"Rossignol, E. Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders. Neural Plast. 2011, 649325 (2011).","journal-title":"Neural Plast."},{"key":"BFng3129_CR31","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/aps.2011.48","volume":"32","author":"C Duran","year":"2011","unstructured":"Duran, C. & Hartzell, H.C. Physiological roles and diseases of Tmem16\/Anoctamin proteins: are they all chloride channels? Acta Pharmacol. Sin. 32, 685\u2013692 (2011).","journal-title":"Acta Pharmacol. Sin."},{"key":"BFng3129_CR32","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.ajhg.2012.10.024","volume":"91","author":"G Charlesworth","year":"2012","unstructured":"Charlesworth, G. et al. Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. Am. J. Hum. Genet. 91, 1041\u20131050 (2012).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng3129_CR33","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/nn.3468","volume":"16","author":"F Huang","year":"2013","unstructured":"Huang, F. et al. TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing. Nat. Neurosci. 16, 1284\u20131290 (2013).","journal-title":"Nat. Neurosci."},{"key":"BFng3129_CR34","doi-asserted-by":"publisher","first-page":"e1001045","DOI":"10.1371\/journal.pgen.1001045","volume":"6","author":"TE Meyer","year":"2010","unstructured":"Meyer, T.E. et al. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six loci influencing serum magnesium levels. PLoS Genet. 6, e1001045 (2010).","journal-title":"PLoS Genet."},{"key":"BFng3129_CR35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0021-9258(18)76290-X","volume":"96","author":"HD Kruse","year":"1932","unstructured":"Kruse, H.D., Orent, E.R. & McCollum, E.V. Studies on magnesium deficiency in animals. I. Symptomatology resulting from magnesium deprivation. J. Biol. Chem. 96, 519\u2013539 (1932).","journal-title":"J. Biol. Chem."},{"key":"BFng3129_CR36","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0140-6736(60)91323-4","volume":"2","author":"S Hanna","year":"1960","unstructured":"Hanna, S., Harrison, M., MacIntyre, I. & Fraser, R. The syndrome of magnesium deficiency in man. Lancet 2, 172\u2013176 (1960).","journal-title":"Lancet"},{"key":"BFng3129_CR37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0006-8993(86)91274-6","volume":"398","author":"WW Anderson","year":"1986","unstructured":"Anderson, W.W., Lewis, D.V., Swartzwelder, H.S. & Wilson, W.A. Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res. 398, 215\u2013219 (1986).","journal-title":"Brain Res."},{"key":"BFng3129_CR38","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.yebeh.2011.07.024","volume":"22","author":"M Ghasemi","year":"2011","unstructured":"Ghasemi, M. & Schachter, S.C. The NMDA receptor complex as a therapeutic target in epilepsy: a review. Epilepsy Behav. 22, 617\u2013640 (2011).","journal-title":"Epilepsy Behav."},{"issue":"suppl. 5","key":"BFng3129_CR39","doi-asserted-by":"publisher","first-page":"S157","DOI":"10.1086\/317521","volume":"31","author":"JA Boulant","year":"2000","unstructured":"Boulant, J.A. Role of the preoptic-anterior hypothalamus in thermoregulation and fever. Clin. Infect. Dis. 31 (suppl. 5), S157\u2013S161 (2000).","journal-title":"Clin. Infect. Dis."},{"key":"BFng3129_CR40","doi-asserted-by":"publisher","first-page":"e111","DOI":"10.1111\/j.1528-1167.2012.03467.x","volume":"53","author":"Y Sugiura","year":"2012","unstructured":"Sugiura, Y., Ogiwara, I., Hoshi, A., Yamakawa, K. & Ugawa, Y. Different degrees of loss of function between GEFS+ and SMEI Nav1.1 missense mutants at the same residue induced by rescuable folding defects. Epilepsia 53, e111\u2013e114 (2012).","journal-title":"Epilepsia"},{"key":"BFng3129_CR41","doi-asserted-by":"publisher","first-page":"9823","DOI":"10.1074\/jbc.M109.078568","volume":"285","author":"MS Martin","year":"2010","unstructured":"Martin, M.S. et al. Altered function of the SCN1A voltage-gated sodium channel leads to \u03b3-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J. Biol. Chem. 285, 9823\u20139834 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFng3129_CR42","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0140-6736(77)91826-8","volume":"1","author":"TL Turner","year":"1977","unstructured":"Turner, T.L., Cockburn, F. & Forfar, J.O. Magnesium therapy in neonatal tetany. Lancet 1, 283\u2013284 (1977).","journal-title":"Lancet"},{"key":"BFng3129_CR43","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1161\/STROKEAHA.108.527788","volume":"40","author":"AG Euser","year":"2009","unstructured":"Euser, A.G. & Cipolla, M.J. Magnesium sulfate for the treatment of eclampsia: a brief review. Stroke 40, 1169\u20131175 (2009).","journal-title":"Stroke"},{"key":"BFng3129_CR44","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.eplepsyres.2012.02.004","volume":"100","author":"AW Yuen","year":"2012","unstructured":"Yuen, A.W. & Sander, J.W. Can magnesium supplementation reduce seizures in people with epilepsy? A hypothesis. Epilepsy Res. 100, 152\u2013156 (2012).","journal-title":"Epilepsy Res."},{"key":"BFng3129_CR45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1017\/S0317167100013457","volume":"39","author":"PA Abdelmalik","year":"2012","unstructured":"Abdelmalik, P.A., Politzer, N. & Carlen, P.L. Magnesium as an effective adjunct therapy for drug resistant seizures. Can. J. Neurol. Sci. 39, 323\u2013327 (2012).","journal-title":"Can. J. Neurol. Sci."},{"key":"BFng3129_CR46","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ng.2441","volume":"44","author":"G Barcia","year":"2012","unstructured":"Barcia, G. et al. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nat. Genet. 44, 1255\u20131259 (2012).","journal-title":"Nat. Genet."},{"key":"BFng3129_CR47","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1038\/ng.2440","volume":"44","author":"SE Heron","year":"2012","unstructured":"Heron, S.E. et al. Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy. Nat. Genet. 44, 1188\u20131190 (2012).","journal-title":"Nat. Genet."},{"key":"BFng3129_CR48","doi-asserted-by":"publisher","first-page":"e1000579","DOI":"10.1371\/journal.pbio.1000579","volume":"9","author":"NR Wray","year":"2011","unstructured":"Wray, N.R., Purcell, S.M. & Visscher, P.M. Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol. 9, e1000579 (2011).","journal-title":"PLoS Biol."},{"key":"BFng3129_CR49","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1212\/WNL.34.2.175","volume":"34","author":"T Tsuboi","year":"1984","unstructured":"Tsuboi, T. Epidemiology of febrile and afebrile convulsions in children in Japan. Neurology 34, 175\u2013181 (1984).","journal-title":"Neurology"},{"key":"BFng3129_CR50","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/1403494811401482","volume":"39","author":"E Lynge","year":"2011","unstructured":"Lynge, E., Sandegaard, J.L. & Rebolj, M. The Danish National Patient Register. Scand. J. Public Health 39, 30\u201333 (2011).","journal-title":"Scand. J. Public Health"},{"key":"BFng3129_CR51","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jclinepi.2005.05.008","volume":"59","author":"M Vestergaard","year":"2006","unstructured":"Vestergaard, M. et al. The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. J. Clin. Epidemiol. 59, 61\u201366 (2006).","journal-title":"J. Clin. Epidemiol."},{"key":"BFng3129_CR52","first-page":"320","volume":"45","author":"LB Knudsen","year":"1998","unstructured":"Knudsen, L.B. & Olsen, J. The Danish Medical Birth Registry. Dan. Med. Bull. 45, 320\u2013323 (1998).","journal-title":"Dan. Med. Bull."},{"key":"BFng3129_CR53","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1586\/14760584.5.5.641","volume":"5","author":"A Hviid","year":"2006","unstructured":"Hviid, A. Postlicensure epidemiology of childhood vaccination: the Danish experience. Expert Rev. Vaccines 5, 641\u2013649 (2006).","journal-title":"Expert Rev. Vaccines"},{"key":"BFng3129_CR54","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1177\/14034948010290040201","volume":"29","author":"J Olsen","year":"2001","unstructured":"Olsen, J. et al. The Danish National Birth Cohort\u2014its background, structure and aim. Scand. J. Public Health 29, 300\u2013307 (2001).","journal-title":"Scand. J. Public Health"},{"key":"BFng3129_CR55","first-page":"441","volume":"53","author":"CB Pedersen","year":"2006","unstructured":"Pedersen, C.B., Gotzsche, H., Moller, J.O. & Mortensen, P.B. The Danish Civil Registration System. A cohort of eight million persons. Dan. Med. Bull. 53, 441\u2013449 (2006).","journal-title":"Dan. Med. Bull."},{"key":"BFng3129_CR56","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/1471-2164-10-297","volume":"10","author":"MV Hollegaard","year":"2009","unstructured":"Hollegaard, M.V. et al. Genome-wide scans using archived neonatal dried blood spot samples. BMC Genomics 10, 297 (2009).","journal-title":"BMC Genomics"},{"key":"BFng3129_CR57","doi-asserted-by":"crossref","unstructured":"1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061\u20131073 (2010).","DOI":"10.1038\/nature09534"},{"key":"BFng3129_CR58","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nmeth.1785","volume":"9","author":"O Delaneau","year":"2012","unstructured":"Delaneau, O., Marchini, J. & Zagury, J.F. A linear complexity phasing method for thousands of genomes. Nat. Methods 9, 179\u2013181 (2012).","journal-title":"Nat. Methods"},{"key":"BFng3129_CR59","doi-asserted-by":"publisher","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","volume":"5","author":"BN Howie","year":"2009","unstructured":"Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).","journal-title":"PLoS Genet."},{"key":"BFng3129_CR60","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nrg2796","volume":"11","author":"J Marchini","year":"2010","unstructured":"Marchini, J. & Howie, B. Genotype imputation for genome-wide association studies. Nat. Rev. Genet. 11, 499\u2013511 (2010).","journal-title":"Nat. Rev. Genet."},{"key":"BFng3129_CR61","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","volume":"55","author":"B Devlin","year":"1999","unstructured":"Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997\u20131004 (1999).","journal-title":"Biometrics"},{"key":"BFng3129_CR62","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539\u20131558 (2002).","journal-title":"Stat. Med."},{"key":"BFng3129_CR63","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C.J., Li, Y. & Abecasis, G.R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"BFng3129_CR64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","volume":"19","author":"S Purcell","year":"2003","unstructured":"Purcell, S., Cherny, S.S. & Sham, P.C. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19, 149\u2013150 (2003).","journal-title":"Bioinformatics"},{"key":"BFng3129_CR65","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nmeth0810-575","volume":"7","author":"JM Schwarz","year":"2010","unstructured":"Schwarz, J.M., Rodelsperger, C., Schuelke, M. & Seelow, D. MutationTaster evaluates disease-causing potential of sequence alterations. Nat. Methods 7, 575\u2013576 (2010).","journal-title":"Nat. Methods"},{"key":"BFng3129_CR66","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei, I.A. et al. A method and server for predicting damaging missense mutations. Nat. Methods 7, 248\u2013249 (2010).","journal-title":"Nat. Methods"},{"key":"BFng3129_CR67","doi-asserted-by":"publisher","first-page":"14610","DOI":"10.1073\/pnas.1212379109","volume":"109","author":"JW Schoggins","year":"2012","unstructured":"Schoggins, J.W. et al. Dengue reporter viruses reveal viral dynamics in interferon receptor\u2013deficient mice and sensitivity to interferon effectors in vitro. Proc. Natl. Acad. Sci. USA 109, 14610\u201314615 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng3129_CR68","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/ng1097","volume":"33","author":"S Dupuis","year":"2003","unstructured":"Dupuis, S. et al. Impaired response to interferon-\u03b1\/\u03b2 and lethal viral disease in human STAT1 deficiency. Nat. Genet. 33, 388\u2013391 (2003).","journal-title":"Nat. Genet."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.3129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3129","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:02:43Z","timestamp":1684429363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.3129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,26]]},"references-count":68,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["BFng3129"],"URL":"https:\/\/doi.org\/10.1038\/ng.3129","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725071208.793502422","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725071208.793501306","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,26]]},"assertion":[{"value":"20 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}