{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:46:55Z","timestamp":1790635615982,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1038\/ng.3458","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T11:54:25Z","timestamp":1448884465000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":204,"title":["Regulators of genetic risk of breast cancer identified by integrative network analysis"],"prefix":"10.1038","volume":"48","author":[{"given":"Mauro A A","family":"Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"de Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Vaughn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-730X","authenticated-orcid":false,"given":"Theresa E","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne D","family":"Tilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Markowetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A J","family":"Ponder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin B","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"BFng3458_CR1","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/ng.2355","volume":"44","author":"A Califano","year":"2012","unstructured":"Califano, A., Butte, A.J., Friend, S., Ideker, T. & Schadt, E. Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat. Genet. 44, 841\u2013847 (2012).","journal-title":"Nat. Genet."},{"key":"BFng3458_CR2","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.gde.2013.09.003","volume":"23","author":"MD Leiserson","year":"2013","unstructured":"Leiserson, M.D., Eldridge, J.V., Ramachandran, S. & Raphael, B.J. Network analysis of GWAS data. Curr. Opin. Genet. Dev. 23, 602\u2013610 (2013).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFng3458_CR3","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/ng1532","volume":"37","author":"K Basso","year":"2005","unstructured":"Basso, K. et al. Reverse engineering of regulatory networks in human B cells. Nat. Genet. 37, 382\u2013390 (2005).","journal-title":"Nat. Genet."},{"key":"BFng3458_CR4","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/ncomms3464","volume":"4","author":"MN Fletcher","year":"2013","unstructured":"Fletcher, M.N. et al. Master regulators of FGFR2 signalling and breast cancer risk. Nat. Commun. 4, 2464 (2013).","journal-title":"Nat. Commun."},{"key":"BFng3458_CR5","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ng.2563","volume":"45","author":"K Michailidou","year":"2013","unstructured":"Michailidou, K. et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat. Genet. 45, 353\u2013361 (2013).","journal-title":"Nat. Genet."},{"key":"BFng3458_CR6","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature10983","volume":"486","author":"C Curtis","year":"2012","unstructured":"Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486, 346\u2013352 (2012).","journal-title":"Nature"},{"key":"BFng3458_CR7","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/ng.2416","volume":"44","author":"R Cowper-Sal lari","year":"2012","unstructured":"Cowper-Sal lari, R. et al. Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat. Genet. 44, 1191\u20131198 (2012).","journal-title":"Nat. Genet."},{"key":"BFng3458_CR8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrc2795","volume":"10","author":"GP Risbridger","year":"2010","unstructured":"Risbridger, G.P., Davis, I.D., Birrell, S.N. & Tilley, W.D. Breast and prostate cancer: more similar than different. Nat. Rev. Cancer 10, 205\u2013212 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"BFng3458_CR9","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1534\/genetics.107.076687","volume":"178","author":"P Schliekelman","year":"2008","unstructured":"Schliekelman, P. Statistical power of expression quantitative trait loci for mapping of complex trait loci in natural populations. Genetics 178, 2201\u20132216 (2008).","journal-title":"Genetics"},{"key":"BFng3458_CR10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cell.2012.12.034","volume":"152","author":"Q Li","year":"2013","unstructured":"Li, Q. et al. Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell 152, 633\u2013641 (2013).","journal-title":"Cell"},{"key":"BFng3458_CR11","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61\u201370 (2012).","DOI":"10.1038\/nature11412"},{"key":"BFng3458_CR12","doi-asserted-by":"publisher","first-page":"D805","DOI":"10.1093\/nar\/gku1075","volume":"43","author":"SA Forbes","year":"2015","unstructured":"Forbes, S.A. et al. COSMIC: exploring the world's knowledge of somatic mutations in human cancer. Nucleic Acids Res. 43, D805\u2013D811 (2015).","journal-title":"Nucleic Acids Res."},{"key":"BFng3458_CR13","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.celrep.2013.01.004","volume":"3","author":"R Kittler","year":"2013","unstructured":"Kittler, R. et al. A comprehensive nuclear receptor network for breast cancer cells. Cell Rep. 3, 538\u2013551 (2013).","journal-title":"Cell Rep."},{"key":"BFng3458_CR14","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1210\/me.2012-1107","volume":"26","author":"TE Hickey","year":"2012","unstructured":"Hickey, T.E., Robinson, J.L., Carroll, J.S. & Tilley, W.D. Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene? Mol. Endocrinol. 26, 1252\u20131267 (2012).","journal-title":"Mol. Endocrinol."},{"key":"BFng3458_CR15","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/nature08712","volume":"463","author":"MS Carro","year":"2010","unstructured":"Carro, M.S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318\u2013325 (2010).","journal-title":"Nature"},{"key":"BFng3458_CR16","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.1158\/0008-5472.CAN-06-0031","volume":"66","author":"F Bertucci","year":"2006","unstructured":"Bertucci, F. et al. Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers. Cancer Res. 66, 4636\u20134644 (2006).","journal-title":"Cancer Res."},{"key":"BFng3458_CR17","doi-asserted-by":"publisher","first-page":"R134","DOI":"10.1186\/bcr3334","volume":"14","author":"M Shehata","year":"2012","unstructured":"Shehata, M. et al. Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res. 14, R134 (2012).","journal-title":"Breast Cancer Res."},{"key":"BFng3458_CR18","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.1073\/pnas.1106509108","volume":"109","author":"JM Haughian","year":"2012","unstructured":"Haughian, J.M. et al. Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch. Proc. Natl. Acad. Sci. USA 109, 2742\u20132747 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng3458_CR19","doi-asserted-by":"publisher","first-page":"e1002431","DOI":"10.1371\/journal.pgen.1002431","volume":"8","author":"J Fu","year":"2012","unstructured":"Fu, J. et al. Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet. 8, e1002431 (2012).","journal-title":"PLoS Genet."},{"key":"BFng3458_CR20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrg2969","volume":"12","author":"SB Montgomery","year":"2011","unstructured":"Montgomery, S.B. & Dermitzakis, E.T. From expression QTLs to personalized transcriptomics. Nat. Rev. Genet. 12, 277\u2013282 (2011).","journal-title":"Nat. Rev. Genet."},{"key":"BFng3458_CR21","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.gde.2015.01.004","volume":"30","author":"L Fachal","year":"2015","unstructured":"Fachal, L. & Dunning, A.M. From candidate gene studies to GWAS and post-GWAS analyses in breast cancer. Curr. Opin. Genet. Dev. 30, 32\u201341 (2015).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFng3458_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ng.730","volume":"43","author":"A Hurtado","year":"2011","unstructured":"Hurtado, A., Holmes, K.A., Ross-Innes, C.S., Schmidt, D. & Carroll, J.S. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nat. Genet. 43, 27\u201333 (2011).","journal-title":"Nat. Genet."},{"key":"BFng3458_CR23","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/msb.2011.59","volume":"7","author":"SL Kong","year":"2011","unstructured":"Kong, S.L., Li, G., Loh, S.L., Sung, W.K. & Liu, E.T. Cellular reprogramming by the conjoint action of ER\u03b1, FOXA1, and GATA3 to a ligand-inducible growth state. Mol. Syst. Biol. 7, 526 (2011).","journal-title":"Mol. Syst. Biol."},{"key":"BFng3458_CR24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1158\/2159-8290.CD-11-0224","volume":"2","author":"R Marcotte","year":"2012","unstructured":"Marcotte, R. et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discov. 2, 172\u2013189 (2012).","journal-title":"Cancer Discov."},{"key":"BFng3458_CR25","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s12020-011-9522-x","volume":"40","author":"SA Andres","year":"2011","unstructured":"Andres, S.A. & Wittliff, J.L. Relationships of ESR1 and XBP1 expression in human breast carcinoma and stromal cells isolated by laser capture microdissection compared to intact breast cancer tissue. Endocrine 40, 212\u2013221 (2011).","journal-title":"Endocrine"},{"key":"BFng3458_CR26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1101\/gad.552910","volume":"24","author":"CS Ross-Innes","year":"2010","unstructured":"Ross-Innes, C.S. et al. Cooperative interaction between retinoic acid receptor-\u03b1 and estrogen receptor in breast cancer. Genes Dev. 24, 171\u2013182 (2010).","journal-title":"Genes Dev."},{"key":"BFng3458_CR27","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1038\/emboj.2011.216","volume":"30","author":"JL Robinson","year":"2011","unstructured":"Robinson, J.L. et al. Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. EMBO J. 30, 3019\u20133027 (2011).","journal-title":"EMBO J."},{"key":"BFng3458_CR28","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1002\/stem.1707","volume":"32","author":"AH Davies","year":"2014","unstructured":"Davies, A.H. et al. YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer. Stem Cells 32, 1437\u20131450 (2014).","journal-title":"Stem Cells"},{"key":"BFng3458_CR29","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.humpath.2012.09.005","volume":"44","author":"A Cimino-Mathews","year":"2013","unstructured":"Cimino-Mathews, A. et al. Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomas. Hum. Pathol. 44, 959\u2013965 (2013).","journal-title":"Hum. Pathol."},{"key":"BFng3458_CR30","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.molonc.2011.08.002","volume":"5","author":"HG Moon","year":"2011","unstructured":"Moon, H.G. et al. NFIB is a potential target for estrogen receptor\u2013negative breast cancers. Mol. Oncol. 5, 538\u2013544 (2011).","journal-title":"Mol. Oncol."},{"key":"BFng3458_CR31","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.1158\/0008-5472.CAN-13-3579","volume":"74","author":"L Ai","year":"2014","unstructured":"Ai, L. et al. TRIM29 suppresses TWIST1 and invasive breast cancer behavior. Cancer Res. 74, 4875\u20134887 (2014).","journal-title":"Cancer Res."},{"key":"BFng3458_CR32","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1101\/gad.12.12.1917","volume":"12","author":"TN Seagroves","year":"1998","unstructured":"Seagroves, T.N. et al. C\/EBP\u03b2, but not C\/EBP\u03b1, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes Dev. 12, 1917\u20131928 (1998).","journal-title":"Genes Dev."},{"key":"BFng3458_CR33","doi-asserted-by":"publisher","first-page":"5614","DOI":"10.1038\/onc.2013.322","volume":"32","author":"J Johansson","year":"2013","unstructured":"Johansson, J. et al. MiR-155\u2013mediated loss of C\/EBP\u03b2 shifts the TGF-\u03b2 response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer. Oncogene 32, 5614\u20135624 (2013).","journal-title":"Oncogene"},{"key":"BFng3458_CR34","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nature10573","volume":"479","author":"A Van Keymeulen","year":"2011","unstructured":"Van Keymeulen, A. et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479, 189\u2013193 (2011).","journal-title":"Nature"},{"key":"BFng3458_CR35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1083\/jcb.201307046","volume":"203","author":"D Lafkas","year":"2013","unstructured":"Lafkas, D. et al. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J. Cell Biol. 203, 47\u201356 (2013).","journal-title":"J. Cell Biol."},{"key":"BFng3458_CR36","doi-asserted-by":"publisher","first-page":"e1002069","DOI":"10.1371\/journal.pbio.1002069","volume":"13","author":"V Rodilla","year":"2015","unstructured":"Rodilla, V. et al. Luminal progenitors restrict their lineage potential during mammary gland development. PLoS Biol. 13, e1002069 (2015).","journal-title":"PLoS Biol."},{"key":"BFng3458_CR37","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nm.2000","volume":"15","author":"E Lim","year":"2009","unstructured":"Lim, E. et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 15, 907\u2013913 (2009).","journal-title":"Nat. Med."},{"key":"BFng3458_CR38","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.stem.2010.07.010","volume":"7","author":"G Molyneux","year":"2010","unstructured":"Molyneux, G. et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7, 403\u2013417 (2010).","journal-title":"Cell Stem Cell"},{"key":"BFng3458_CR39","doi-asserted-by":"publisher","first-page":"a003293","DOI":"10.1101\/cshperspect.a003293","volume":"3","author":"CM Perou","year":"2011","unstructured":"Perou, C.M. & Borresen-Dale, A.L. Systems biology and genomics of breast cancer. Cold Spring Harb. Perspect. Biol. 3, a003293 (2011).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"BFng3458_CR40","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1186\/bcr2560","volume":"12","author":"E Lim","year":"2010","unstructured":"Lim, E. et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 12, R21 (2010).","journal-title":"Breast Cancer Res."},{"key":"BFng3458_CR41","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1101\/gad.1614608","volume":"22","author":"SR Oakes","year":"2008","unstructured":"Oakes, S.R. et al. The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev. 22, 581\u2013586 (2008).","journal-title":"Genes Dev."},{"key":"BFng3458_CR42","doi-asserted-by":"publisher","first-page":"e1001461","DOI":"10.1371\/journal.pbio.1001461","volume":"10","author":"M Kalyuga","year":"2012","unstructured":"Kalyuga, M. et al. ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biol. 10, e1001461 (2012).","journal-title":"PLoS Biol."},{"key":"BFng3458_CR43","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/onc.2012.62","volume":"32","author":"GM Bernardo","year":"2013","unstructured":"Bernardo, G.M. et al. FOXA1 represses the molecular phenotype of basal breast cancer cells. Oncogene 32, 554\u2013563 (2013).","journal-title":"Oncogene"},{"key":"BFng3458_CR44","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","volume":"28","author":"AA Shabalin","year":"2012","unstructured":"Shabalin, A.A. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics 28, 1353\u20131358 (2012).","journal-title":"Bioinformatics"},{"key":"BFng3458_CR45","doi-asserted-by":"publisher","first-page":"e1002240","DOI":"10.1371\/journal.pcbi.1002240","volume":"7","author":"D Venet","year":"2011","unstructured":"Venet, D., Dumont, J.E. & Detours, V. Most random gene expression signatures are significantly associated with breast cancer outcome. PLoS Comput. Biol. 7, e1002240 (2011).","journal-title":"PLoS Comput. Biol."},{"key":"BFng3458_CR46","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M.E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."},{"key":"BFng3458_CR47","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng3458_CR48","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1126\/science.1132939","volume":"313","author":"J Lamb","year":"2006","unstructured":"Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929\u20131935 (2006).","journal-title":"Science"},{"key":"BFng3458_CR49","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ymeth.2009.03.001","volume":"48","author":"D Schmidt","year":"2009","unstructured":"Schmidt, D. et al. ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods 48, 240\u2013248 (2009).","journal-title":"Methods"},{"key":"BFng3458_CR50","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1214\/aos\/1013699998","volume":"29","author":"Y Benjamini","year":"2001","unstructured":"Benjamini, Y. & Yekutieli, D. The control of the false discovery rate in multiple testing under dependency. Ann. Satist. 29, 1165\u20131188 (2001).","journal-title":"Ann. Satist."},{"key":"BFng3458_CR51","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman, R.C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004).","journal-title":"Genome Biol."},{"key":"BFng3458_CR52","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2012-13-4-r29","volume":"13","author":"MA Castro","year":"2012","unstructured":"Castro, M.A. et al. R\/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations. Genome Biol. 13, R29 (2012).","journal-title":"Genome Biol."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.3458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3458","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:10:33Z","timestamp":1684429833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.3458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,30]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["BFng3458"],"URL":"https:\/\/doi.org\/10.1038\/ng.3458","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725972059.793513360","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,30]]},"assertion":[{"value":"23 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}