{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:15:33Z","timestamp":1792120533789,"version":"4.4.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1038\/ng.3696","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T12:04:17Z","timestamp":1476705857000},"page":"1564-1569","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":376,"title":["Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number"],"prefix":"10.1038","volume":"48","author":[{"given":"Jonathan J","family":"Lyons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang T","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil N","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"DiMaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Oler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-5375","authenticated-orcid":false,"given":"Peter D","family":"Arkwright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherene","family":"Agama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J","family":"McElwee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryland","family":"Pao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E","family":"Rothenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Hohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly D","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George H","family":"Caughey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean D","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-3811","authenticated-orcid":false,"given":"Leslie G","family":"Biesecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"BFng3696_CR1","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.aller.2014.05.002","volume":"42","author":"C Fellinger","year":"2014","unstructured":"Fellinger, C. et al. Clinical characteristics and risk profile of patients with elevated baseline serum tryptase. Allergol. Immunopathol. (Madr.) 42, 544\u2013552 (2014).","journal-title":"Allergol. Immunopathol. (Madr.)"},{"key":"BFng3696_CR2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1515\/CCLM.2010.124","volume":"48","author":"A Gonzalez-Quintela","year":"2010","unstructured":"Gonzalez-Quintela, A. et al. Factors influencing serum total tryptase concentrations in a general adult population. Clin. Chem. Lab. Med. 48, 701\u2013706 (2010).","journal-title":"Clin. Chem. Lab. Med."},{"key":"BFng3696_CR3","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/01.PSY.0000075977.90337.E7","volume":"65","author":"P Henningsen","year":"2003","unstructured":"Henningsen, P., Zimmermann, T. & Sattel, H. Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosom. Med. 65, 528\u2013533 (2003).","journal-title":"Psychosom. Med."},{"key":"BFng3696_CR4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11882-012-0326-8","volume":"13","author":"JC Cardet","year":"2013","unstructured":"Cardet, J.C., Castells, M.C. & Hamilton, M.J. Immunology and clinical manifestations of non-clonal mast cell activation syndrome. Curr. Allergy Asthma Rep. 13, 10\u201318 (2013).","journal-title":"Curr. Allergy Asthma Rep."},{"key":"BFng3696_CR5","doi-asserted-by":"crossref","first-page":"e000755","DOI":"10.1161\/JAHA.113.000755","volume":"3","author":"H Li","year":"2014","unstructured":"Li, H. et al. Autoimmune basis for postural tachycardia syndrome. J. Am. Heart Assoc. 3, e000755 (2014).","journal-title":"J. Am. Heart Assoc."},{"key":"BFng3696_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1365-2982.2009.01421.x","volume":"22","author":"N Zarate","year":"2010","unstructured":"Zarate, N. et al. Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link? Neurogastroenterol. Motil. 22, 252\u2013e78 (2010).","journal-title":"Neurogastroenterol. Motil."},{"key":"BFng3696_CR7","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.jaci.2013.11.039","volume":"133","author":"JJ Lyons","year":"2014","unstructured":"Lyons, J.J. et al. Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J. Allergy Clin. Immunol. 133, 1471\u20131474 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3696_CR8","doi-asserted-by":"publisher","first-page":"c7167","DOI":"10.1136\/bmj.c7167","volume":"342","author":"J Ross","year":"2011","unstructured":"Ross, J. & Grahame, R. Joint hypermobility syndrome. Br. Med. J. 342, c7167 (2011).","journal-title":"Br. Med. J."},{"key":"BFng3696_CR9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/ar2005","volume":"8","author":"D Buskila","year":"2006","unstructured":"Buskila, D. & Sarzi-Puttini, P. Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res. Ther. 8, 218 (2006).","journal-title":"Arthritis Res. Ther."},{"key":"BFng3696_CR10","doi-asserted-by":"crossref","first-page":"751768","DOI":"10.5402\/2012\/751768","volume":"2012","author":"M Castori","year":"2012","unstructured":"Castori, M. Ehlers\u2013Danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder with mucocutaneous, articular, and systemic manifestations. ISRN Dermatol. 2012, 751768 (2012).","journal-title":"ISRN Dermatol."},{"key":"BFng3696_CR11","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.jaci.2014.06.007","volume":"134","author":"V Sabato","year":"2014","unstructured":"Sabato, V. et al. Familial hypertryptasemia with associated mast cell activation syndrome. J. Allergy Clin. Immunol. 134, 1448\u20131450.e3 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3696_CR12","first-page":"1910","volume":"97","author":"YA Saito","year":"2002","unstructured":"Saito, Y.A., Schoenfeld, P. & Locke, G.R., III. The epidemiology of irritable bowel syndrome in North America: a systematic review. Am. J. Gastroenterol. 97, 1910\u20131915 (2002).","journal-title":"Am. J. Gastroenterol."},{"key":"BFng3696_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","volume":"63","author":"HB El-Serag","year":"2014","unstructured":"El-Serag, H.B., Sweet, S., Winchester, C.C. & Dent, J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 63, 871\u2013880 (2014).","journal-title":"Gut"},{"key":"BFng3696_CR14","first-page":"804","volume":"34","author":"L Remvig","year":"2007","unstructured":"Remvig, L., Jensen, D.V. & Ward, R.C. Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J. Rheumatol. 34, 804\u2013809 (2007).","journal-title":"J. Rheumatol."},{"key":"BFng3696_CR15","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jaci.2009.08.027","volume":"124","author":"F Ru\u00ebff","year":"2009","unstructured":"Ru\u00ebff, F. et al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase\u2014a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J. Allergy Clin. Immunol. 124, 1047\u20131054 (2009).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3696_CR16","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.jaci.2013.10.046","volume":"133","author":"GJ Sturm","year":"2014","unstructured":"Sturm, G.J. et al. Sensitization to Hymenoptera venoms is common, but systemic sting reactions are rare. J. Allergy Clin. Immunol. 133, 1635\u201343 e1 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3696_CR17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ng.3493","volume":"48","author":"V Savova","year":"2016","unstructured":"Savova, V. et al. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nat. Genet. 48, 231\u2013237 (2016).","journal-title":"Nat. Genet."},{"key":"BFng3696_CR18","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1126\/science.1072047","volume":"297","author":"JA Bailey","year":"2002","unstructured":"Bailey, J.A. et al. Recent segmental duplications in the human genome. Science 297, 1003\u20131007 (2002).","journal-title":"Science"},{"key":"BFng3696_CR19","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/ajmg.a.32948","volume":"149A","author":"PW Chiang","year":"2009","unstructured":"Chiang, P.W. et al. Somatic and germ-line mosaicism in Rubinstein\u2013Taybi syndrome. Am. J. Med. Genet. A. 149A, 1463\u20131467 (2009).","journal-title":"Am. J. Med. Genet. A."},{"key":"BFng3696_CR20","doi-asserted-by":"publisher","first-page":"6072","DOI":"10.4049\/jimmunol.179.9.6072","volume":"179","author":"NN Trivedi","year":"2007","unstructured":"Trivedi, N.N., Tong, Q., Raman, K., Bhagwandin, V.J. & Caughey, G.H. Mast cell \u03b1 and \u03b2 tryptases changed rapidly during primate speciation and evolved from \u03b3-like transmembrane peptidases in ancestral vertebrates. J. Immunol. 179, 6072\u20136079 (2007).","journal-title":"J. Immunol."},{"key":"BFng3696_CR21","first-page":"237","volume":"15","author":"DA Drossman","year":"2006","unstructured":"Drossman, D.A. & Dumitrascu, D.L. Rome III: new standard for functional gastrointestinal disorders. J. Gastrointestin. Liver Dis. 15, 237\u2013241 (2006).","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"BFng3696_CR22","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.mayocp.2012.10.013","volume":"87","author":"DM Sletten","year":"2012","unstructured":"Sletten, D.M., Suarez, G.A., Low, P.A., Mandrekar, J. & Singer, W. COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin. Proc. 87, 1196\u20131201 (2012).","journal-title":"Mayo Clin. Proc."},{"key":"BFng3696_CR23","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1101\/gr.092841.109","volume":"19","author":"LG Biesecker","year":"2009","unstructured":"Biesecker, L.G. et al. The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res. 19, 1665\u20131674 (2009).","journal-title":"Genome Res."},{"key":"BFng3696_CR24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1478-3231.2008.01839.x","volume":"29","author":"K Alfter","year":"2009","unstructured":"Alfter, K. et al. New aspects of liver abnormalities as part of the systemic mast cell activation syndrome. Liver Int. 29, 181\u2013186 (2009).","journal-title":"Liver Int."},{"key":"BFng3696_CR25","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.jaci.2014.02.013","volume":"133","author":"Y Zhang","year":"2014","unstructured":"Zhang, Y. et al. Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. J. Allergy Clin. Immunol. 133, 1400\u20131409, 1409.e1\u20131409.e5 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3696_CR26","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","volume":"155","author":"CW Brennan","year":"2013","unstructured":"Brennan, C.W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462\u2013477 (2013).","journal-title":"Cell"},{"key":"BFng3696_CR27","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.ajhg.2015.04.013","volume":"96","author":"JJ Johnston","year":"2015","unstructured":"Johnston, J.J. et al. Individualized iterative phenotyping for genome-wide analysis of loss-of-function mutations. Am. J. Hum. Genet. 96, 913\u2013925 (2015).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng3696_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ng786","volume":"30","author":"GR Abecasis","year":"2002","unstructured":"Abecasis, G.R., Cherny, S.S., Cookson, W.O. & Cardon, L.R. Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 30, 97\u2013101 (2002).","journal-title":"Nat. Genet."},{"key":"BFng3696_CR29","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/ajh.23672","volume":"89","author":"T Kristensen","year":"2014","unstructured":"Kristensen, T., Vestergaard, H., Bindslev-Jensen, C., M\u00f8ller, M.B. & Broesby-Olsen, S. Sensitive KIT D816V mutation analysis of blood as a diagnostic test in mastocytosis. Am. J. Hematol. 89, 493\u2013498 (2014).","journal-title":"Am. J. Hematol."},{"key":"BFng3696_CR30","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1111\/j.1365-2222.2010.03582.x","volume":"40","author":"M Ferrer","year":"2010","unstructured":"Ferrer, M. et al. Serum total tryptase levels are increased in patients with active chronic urticaria. Clin. Exp. Allergy 40, 1760\u20131766 (2010).","journal-title":"Clin. Exp. Allergy"},{"key":"BFng3696_CR31","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","volume":"26","author":"LB Schwartz","year":"2006","unstructured":"Schwartz, L.B. Diagnostic value of tryptase in anaphylaxis and mastocytosis. Immunol. Allergy Clin. North Am. 26, 451\u2013463 (2006).","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"BFng3696_CR32","doi-asserted-by":"publisher","first-page":"e114944","DOI":"10.1371\/journal.pone.0114944","volume":"9","author":"QT Le","year":"2014","unstructured":"Le, Q.T., Lotfi-Emran, S., Min, H.K. & Schwartz, L.B. A simple, sensitive and safe method to determine the human \u03b1\/\u03b2-tryptase genotype. PLoS One 9, e114944 (2014).","journal-title":"PLoS One"},{"key":"BFng3696_CR33","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1172\/JCI114786","volume":"86","author":"JS Miller","year":"1990","unstructured":"Miller, J.S., Moxley, G. & Schwartz, L.B. Cloning and characterization of a second complementary DNA for human tryptase. J. Clin. Invest. 86, 864\u2013870 (1990).","journal-title":"J. Clin. Invest."},{"key":"BFng3696_CR34","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.jaci.2009.07.026","volume":"124","author":"NN Trivedi","year":"2009","unstructured":"Trivedi, N.N., Tamraz, B., Chu, C., Kwok, P.Y. & Caughey, G.H. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J. Allergy Clin. Immunol. 124, 1099\u2013105.e1, 4 (2009).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFng3696_CR35","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1182\/blood.V94.7.2333.419k30_2333_2342","volume":"94","author":"AS Kirshenbaum","year":"1999","unstructured":"Kirshenbaum, A.S. et al. Demonstration that human mast cells arise from a progenitor cell population that is CD34+, c-kit+, and expresses aminopeptidase N (CD13). Blood 94, 2333\u20132342 (1999).","journal-title":"Blood"},{"key":"BFng3696_CR36","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.4049\/jimmunol.126.4.1290","volume":"126","author":"LB Schwartz","year":"1981","unstructured":"Schwartz, L.B., Lewis, R.A., Seldin, D. & Austen, K.F. Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells. J. Immunol. 126, 1290\u20131294 (1981).","journal-title":"J. Immunol."},{"key":"BFng3696_CR37","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0022-1759(02)00210-7","volume":"268","author":"C Tkaczyk","year":"2002","unstructured":"Tkaczyk, C., Metcalfe, D.D. & Gilfillan, A.M. Determination of protein phosphorylation in Fc\u025bRI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions. J. Immunol. Methods 268, 239\u2013243 (2002).","journal-title":"J. Immunol. Methods"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.3696.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3696","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.3696.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T09:41:37Z","timestamp":1692524497000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.3696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,17]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["BFng3696"],"URL":"https:\/\/doi.org\/10.1038\/ng.3696","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726854948.793526088","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,17]]},"assertion":[{"value":"26 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The NIH authors declare no conflicts of interest. L.B.S. receives royalties from VCU that are collected from Thermo Fisher for the tryptase UniCAP assay and receives consulting fees from Genentech, Inc. L.G.B. is an uncompensated advisor to Illumina and receives royalties from Genentech, Inc., and Amgen, and honoraria from Wiley-Blackwell.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}