{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:45:24Z","timestamp":1792676724992,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2011,8,28]],"date-time":"2011-08-28T00:00:00Z","timestamp":1314489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1038\/ng.910","type":"journal-article","created":{"date-parts":[[2011,8,28]],"date-time":"2011-08-28T13:49:38Z","timestamp":1314539378000},"page":"1018-1021","source":"Crossref","is-referenced-by-count":689,"title":["Germline mutations in BAP1 predispose to melanocytic tumors"],"prefix":"10.1038","volume":"43","author":[{"given":"Thomas","family":"Wiesner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C","family":"Obenauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajmohan","family":"Murali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Fried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus G","family":"Griewank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Windpassinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Wackernagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shea","family":"Loy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Viale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex E","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mono","family":"Pirun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D","family":"Socci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"R\u00fctten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Palmedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen C","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cerroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Kutzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris C","family":"Bastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Speicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,28]]},"reference":[{"key":"BFng910_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.0303-6987.2003.00179.x","volume":"31","author":"G Palmedo","year":"2004","unstructured":"Palmedo, G. et al. The T1796A mutation of the BRAF gene is absent in Spitz nevi. J. Cutan. Pathol. 31, 266\u2013270 (2004).","journal-title":"J. Cutan. Pathol."},{"key":"BFng910_CR2","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1073\/pnas.68.4.820","volume":"68","author":"AG Knudson Jr.","year":"1971","unstructured":"Knudson, A.G. Jr. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68, 820\u2013823 (1971).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng910_CR3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nbt.1523","volume":"27","author":"A Gnirke","year":"2009","unstructured":"Gnirke, A. et al. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat. Biotechnol. 27, 182\u2013189 (2009).","journal-title":"Nat. Biotechnol."},{"key":"BFng910_CR4","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1126\/science.1194472","volume":"330","author":"JW Harbour","year":"2010","unstructured":"Harbour, J.W. et al. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science 330, 1410\u20131413 (2010).","journal-title":"Science"},{"key":"BFng910_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nature07586","volume":"457","author":"CD Van Raamsdonk","year":"2009","unstructured":"Van Raamsdonk, C.D. et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457, 599\u2013602 (2009).","journal-title":"Nature"},{"key":"BFng910_CR6","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1056\/NEJMoa1000584","volume":"363","author":"CD Van Raamsdonk","year":"2010","unstructured":"Van Raamsdonk, C.D. et al. Mutations in GNA11 in uveal melanoma. N. Engl. J. Med. 363, 2191\u20132199 (2010).","journal-title":"N. Engl. J. Med."},{"key":"BFng910_CR7","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1126\/science.1140321","volume":"316","author":"S Matsuoka","year":"2007","unstructured":"Matsuoka, S. et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160\u20131166 (2007).","journal-title":"Science"},{"key":"BFng910_CR8","doi-asserted-by":"publisher","first-page":"19855","DOI":"10.1073\/pnas.0707579104","volume":"104","author":"MP Stokes","year":"2007","unstructured":"Stokes, M.P. et al. Profiling of UV-induced ATM\/ATR signaling pathways. Proc. Natl. Acad. Sci. USA 104, 19855\u201319860 (2007).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng910_CR9","doi-asserted-by":"publisher","first-page":"6953","DOI":"10.1158\/0008-5472.CAN-08-0365","volume":"68","author":"KH Ventii","year":"2008","unstructured":"Ventii, K.H. et al. BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res. 68, 6953\u20136962 (2008).","journal-title":"Cancer Res."},{"key":"BFng910_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nature08966","volume":"465","author":"JC Scheuermann","year":"2010","unstructured":"Scheuermann, J.C. et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465, 243\u2013247 (2010).","journal-title":"Nature"},{"key":"BFng910_CR11","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/sj.onc.1201861","volume":"16","author":"DE Jensen","year":"1998","unstructured":"Jensen, D.E. et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 16, 1097\u20131112 (1998).","journal-title":"Oncogene"},{"key":"BFng910_CR12","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1126\/science.1145720","volume":"318","author":"LD Wood","year":"2007","unstructured":"Wood, L.D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108\u20131113 (2007).","journal-title":"Science"},{"key":"BFng910_CR13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/ijc.2910570406","volume":"57","author":"DL Buchhagen","year":"1994","unstructured":"Buchhagen, D.L., Qiu, L. & Etkind, P. Homozygous deletion, rearrangement and hypermethylation implicate chromosome region 3p14.3\u20133p21.3 in sporadic breast-cancer development. Int. J. Cancer 57, 473\u2013479 (1994).","journal-title":"Int. J. Cancer"},{"key":"BFng910_CR14","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1056\/NEJMoa050092","volume":"353","author":"JA Curtin","year":"2005","unstructured":"Curtin, J.A. et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135\u20132147 (2005).","journal-title":"N. Engl. J. Med."},{"key":"BFng910_CR15","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1093\/nar\/gkg509","volume":"31","author":"PC Ng","year":"2003","unstructured":"Ng, P.C. & Henikoff, S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 31, 3812\u20133814 (2003).","journal-title":"Nucleic Acids Res."},{"key":"BFng910_CR16","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1093\/nar\/gkf493","volume":"30","author":"V Ramensky","year":"2002","unstructured":"Ramensky, V., Bork, P. & Sunyaev, S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res. 30, 3894\u20133900 (2002).","journal-title":"Nucleic Acids Res."},{"key":"BFng910_CR17","doi-asserted-by":"publisher","first-page":"R232","DOI":"10.1186\/gb-2007-8-11-r232","volume":"8","author":"B Reva","year":"2007","unstructured":"Reva, B., Antipin, Y. & Sander, C. Determinants of protein function revealed by combinatorial entropy optimization. Genome Biol. 8, R232 (2007).","journal-title":"Genome Biol."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng.910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.910","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng.910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T16:13:51Z","timestamp":1684426431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng.910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,28]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["BFng910"],"URL":"https:\/\/doi.org\/10.1038\/ng.910","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13372987.14743101","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13372987.14801055","asserted-by":"object"}]},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,28]]}}}