{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:25:01Z","timestamp":1779261901968,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1993,2]]},"DOI":"10.1038\/ng0293-157","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:54:55Z","timestamp":1092862495000},"page":"157-164","source":"Crossref","is-referenced-by-count":85,"title":["CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents"],"prefix":"10.1038","volume":"3","author":[{"given":"Ann E.O.","family":"Trezise","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol C.","family":"Linder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Grieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik W.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Griswold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manual","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFng0293157_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1126\/science.2772657","volume":"245","author":"JM Rommens","year":"1989","unstructured":"Rommens, J.M. et al. Identification of the cystic fibrosis gene: Chromosome walking and jumping. Science 245, 1059\u20131065 (1989).","journal-title":"Science"},{"key":"BFng0293157_CR2","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1126\/science.2570460","volume":"245","author":"B-S Kerem","year":"1989","unstructured":"Kerem, B.-S. et al. Identification of the cystic fibrosis gene: Genetic analysis. Science 245, 1073\u20131080 (1989).","journal-title":"Science"},{"key":"BFng0293157_CR3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0092-8674(90)90148-8","volume":"63","author":"SH Cheng","year":"1990","unstructured":"Cheng, S.H. et al. Defective intracellular transport and processing of CFTR is the molecular basis if most cystic fibrosis. Cell 63, 827\u2013834 (1990).","journal-title":"Cell"},{"key":"BFng0293157_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/ng0892-321","volume":"1","author":"N Kartner","year":"1992","unstructured":"Kartner, N., Augustinas, O., Jensen, T.J., Naismith, A.L. & Riordan, J.R. Mislocatisation of \u0394F508 CFTR in cystic figrosis sweat gland. Nature Genet. 1, 321\u2013327 (1992).","journal-title":"Nature Genet."},{"key":"BFng0293157_CR5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1126\/science.1704151","volume":"251","author":"MP Anderson","year":"1991","unstructured":"Anderson, M.P., Rich, D.P., Gregory, R.J., Smith, A.E. & Welsh, M.J. Generation of cAMP-activated chloride currents by expression of CFTR. Science 251, 679\u2013682 (1991).","journal-title":"Science"},{"key":"BFng0293157_CR6","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/0092-8674(91)90498-N","volume":"64","author":"N Kartner","year":"1991","unstructured":"Kartner, N. et al. Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance. Cell 64, 681\u2013691 (1991).","journal-title":"Cell"},{"key":"BFng0293157_CR7","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/0092-8674(92)90155-6","volume":"68","author":"CE Bear","year":"1992","unstructured":"Bear, C.E. et al. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator. Cell 68, 809\u2013818 (1992).","journal-title":"Cell"},{"key":"BFng0293157_CR8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/353434a0","volume":"353","author":"AEO Trezise","year":"1991","unstructured":"Trezise, A.E.O. & Buchwald, M. In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator. Nature 353, 434\u2013437 (1991).","journal-title":"Nature"},{"key":"BFng0293157_CR9","first-page":"323","volume-title":"Cystic Fibrosis","author":"SM Brugman","year":"1984","unstructured":"Brugman, S.M. & Taussig, L.M. The reproductive system. In Cystic Fibrosis. (ed. Taussig, L.M.) 323\u2013337 (Thieme-Stratton, New York, 1984)."},{"key":"BFng0293157_CR10","first-page":"198","volume":"52","author":"Y Clermont","year":"1972","unstructured":"Clermont, Y. Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Phys. Rev. 52, 198\u2013236 (1972).","journal-title":"Phys. Rev."},{"key":"BFng0293157_CR11","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1749-6632.1952.tb26576.x","volume":"55","author":"CP Leblond","year":"1952","unstructured":"Leblond, C.P. & Clermont, Y. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann. N.Y. Acad. Sci. 55, 548\u2013573 (1952).","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"BFng0293157_CR12","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1095\/biolreprod43.3.525","volume":"43","author":"RA Hess","year":"1990","unstructured":"Hess, R.A. Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biol. Reprod. 43, 525\u2013542 (1990).","journal-title":"Biol. Reprod."},{"key":"BFng0293157_CR13","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1210\/mend-3-4-725","volume":"3","author":"CR Morales","year":"1989","unstructured":"Morales, C.R., Alcivar, A.A., Hecht, N.B. & Griswold, M.D. Specific mRNAs in sertoli and germinal cells of testes from stage synchronised rats. Molec. Endocrin. 3, 725\u2013733 (1989).","journal-title":"Molec. Endocrin."},{"key":"BFng0293157_CR14","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1210\/endo-120-4-1615","volume":"120","author":"LD Russell","year":"1987","unstructured":"Russell, L.D., Alger, L.E. & Nequin, L.G. Hormonal control of pubertal spermatogenesis. Endocrinology 120, 1615\u20131632 (1987).","journal-title":"Endocrinology"},{"key":"BFng0293157_CR15","first-page":"999","volume-title":"Physiology of Reproduction","author":"B Robaire","year":"1988","unstructured":"Robaire, B. & Hermo, L. Efferent ducts, epididymis, and vas deferens: structure, function and their regulation. In Physiology of Reproduction (eds Knobil, E. & Neill, J.) 999\u20131080 (Raven Press, New York 1988)."},{"key":"BFng0293157_CR16","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/j.1464-410X.1990.tb15006.x","volume":"66","author":"ND Heaton","year":"1990","unstructured":"Heaton, N.D. & Pryor, J.P. Vasa aplasia and cystic fibrosis. Br. J. Urol. 66, 538\u2013540 (1990).","journal-title":"Br. J. Urol."},{"key":"BFng0293157_CR17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1365-2605.1991.tb01272.x","volume":"14","author":"C Gottlieb","year":"1991","unstructured":"Gottlieb, C., Ploen, L., Kvist, U. & Strandvik, B. The fertility potential of male cystic fibrosis patients. Int. J. Andro. 14, 437\u2013440 (1991).","journal-title":"Int. J. Andro."},{"key":"BFng0293157_CR18","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1128\/MCB.11.3.1448","volume":"11","author":"BJ Stallard","year":"1991","unstructured":"Stallard, B.J., Collard, M.W. & Griswold, M.D. A transferrinlike (hemiferrin) mRNA is expressed in the germ cells of rat testis. Molec. cell. Biol. 11, 1448\u20131453 (1991).","journal-title":"Molec. cell. Biol."},{"key":"BFng0293157_CR19","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1073\/pnas.88.20.9262","volume":"88","author":"I Crawford","year":"1991","unstructured":"Crawford, I. et al. Immunocytochemical localisation of the cystic fibrosis gene product CFTR. Proc. natn. Acad. Sci. U.S.A. 88, 9262\u20139266 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0293157_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S0006-291X(05)81378-6","volume":"181","author":"JA Cohn","year":"1991","unstructured":"Cohn, J.A., Melhus, O., Page, L.J., Dittrich, K.L. & Vigna, S.R. CFTR: development of high-affinity antibodies and localisation in sweat gland. Biochem. Biophys. Res. Comm. 181, 36\u201343 (1991).","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"BFng0293157_CR21","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1096\/fasebj.4.10.2197151","volume":"4","author":"PM Quinton","year":"1990","unstructured":"Quinton, P.M. Cystic fibrosis: a disease in electrolyte transport. FASEB J. 4, 2709\u20132717 (1990).","journal-title":"FASEB J."},{"key":"BFng0293157_CR22","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/aja.1001780109","volume":"178","author":"RL Sprando","year":"1987","unstructured":"Sprando, R.L. & Russell, L.D. Comparative study of cytoplasmic elimination in spermatids of selected mammalian species. Am. J. Anat. 178, 72\u201380 (1987).","journal-title":"Am. J. Anat."},{"key":"BFng0293157_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1083\/jcb.44.2.243","volume":"44","author":"DM Phillips","year":"1970","unstructured":"Phillips, D.M. Insect sperm: their structure and morphogenesis. J. cell Biol. 44, 243\u2013247 (1970).","journal-title":"J. cell Biol."},{"key":"BFng0293157_CR24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/337373a0","volume":"337","author":"RE Braun","year":"1989","unstructured":"Braun, R.E., Behringer, R.R., Peschon, J.J., Brinster, R.L. & Palmiter, R.D. Genetically haploid spermatids are phenotypically diploid. Nature 337, 373\u2013376 (1989).","journal-title":"Nature"},{"key":"BFng0293157_CR25","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1073\/pnas.88.6.2407","volume":"88","author":"KA Caldwell","year":"1991","unstructured":"Caldwell, K.A. & Handel, M.A. Protamine transcipt sharing among postmeiotic spermatids. Proc. natn. Acad. Sci. U.S.A. 88, 2407\u20132411 (1991).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0293157_CR26","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1128\/MCB.12.6.2545","volume":"12","author":"JR Murti","year":"1992","unstructured":"Murti, J.R., Bumbulis, M. & Schimenti, J.C. High-frequency germ line gene conversion in transgenic mice. Molec. cell Biol. 12, 2545\u20132552 (1992).","journal-title":"Molec. cell Biol."},{"key":"BFng0293157_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0092-8674(88)90010-4","volume":"55","author":"J Schimenti","year":"1988","unstructured":"Schimenti, J. et al. A candidate gene family for the mouse t complex responder (Tcr) locus responsible for haploid effects on sperm function. Cell 55, 71\u201378 (1988).","journal-title":"Cell"},{"key":"BFng0293157_CR28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/978-1-4684-5958-6_4","volume":"20","author":"L-C Tsui","year":"1991","unstructured":"Tsui, L.-C. & Buchwald, M. Biochemical and molecular genetics of cystic fibrosis. Adv. hum. Genet., 20, 153\u2013266 (1991).","journal-title":"Adv. hum. Genet."},{"key":"BFng0293157_CR29","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1126\/science.2475911","volume":"245","author":"JR Riordan","year":"1989","unstructured":"Riordan, J.R. et al. Identification of the cystic fibrosis gene: cloning and characterisation of complementary DNA. Science 245, 1066\u20131073 (1989).","journal-title":"Science"},{"key":"BFng0293157_CR30","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/0168-9525(90)90209-O","volume":"6","author":"RP Erikson","year":"1990","unstructured":"Erikson, R.P. Post-meiotic gene expression. Trends Genet. 6, 264\u2013269 (1990).","journal-title":"Trends Genet."},{"issue":"s2b","key":"BFng0293157_CR31","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1111\/j.1365-2605.1978.tb00512.x","volume":"1","author":"P. Y. D. Wong","year":"1978","unstructured":"Wong, P.Y.D., Au, C.L. & Ngai, H.K. Electrolyte and water transport in rat epididymis; its possible role in sperm maturation. Int. J. Androl. Suppl2, 608\u2013628 (1978).","journal-title":"International Journal of Andrology"},{"key":"BFng0293157_CR32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1113\/jphysiol.1978.sp012174","volume":"275","author":"PYD Wong","year":"1978","unstructured":"Wong, P.Y.D. & Yeung, C.H. Absorptive and secretory functions of the perfused rat cauda epididymis. J. Physiol. 275, 13\u201326 (1978).","journal-title":"J. Physiol."},{"key":"BFng0293157_CR33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1242\/dev.113.1.305","volume":"113","author":"A Harris","year":"1991","unstructured":"Harris, A., Chalkley, G., Goodman, S. & Coleman, L. Expression of the cystic fibrosis gene in human development. Development 113, 305\u2013310 (1991).","journal-title":"Development"},{"key":"BFng0293157_CR34","first-page":"753","volume-title":"Physiology of Reproduction","author":"BP Setchell","year":"1988","unstructured":"Setchell, B.P. & Brooks, D.E. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In Physiology of Reproduction (eds Knobil, E. & Neill, J.) 753\u2013836 (Raven Press, New York 1988)."},{"key":"BFng0293157_CR35","first-page":"103","volume-title":"Physiology of Reproduction","author":"MJK Harper","year":"1988","unstructured":"Harper, M.J.K. Gamete and zygote transport. In Physiology of Reproduction (eds Knobil, E. & Neill, J.) 103\u2013134 (Raven Press, New York, 1988)."},{"key":"BFng0293157_CR36","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.85.12.4350","volume":"85","author":"RJ Arceci","year":"1988","unstructured":"Arceci, R.J., Croop, J.M., Horwitz, S.B. & Housman, D. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc. natn. Acad. Sci. U.S.A. 85, 4350\u20134354 (1988).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0293157_CR37","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1002\/j.1460-2075.1992.tb05528.x","volume":"11","author":"AEO Trezise","year":"1992","unstructured":"Trezise, A.E.O. et al. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression. EMBO J. 11, 4291\u20134303 (1992).","journal-title":"EMBO J."},{"key":"BFng0293157_CR38","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/355830a0","volume":"355","author":"MA Valverde","year":"1992","unstructured":"Valverde, M.A. et al. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature 355, 830\u2013833 (1992).","journal-title":"Nature"},{"key":"BFng0293157_CR39","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1126\/science.257.5073.1083","volume":"257","author":"JN Snouwaert","year":"1992","unstructured":"Snouwaert, J.N. et al. An animal model for cystic fibrosis made by gene targeting. Science 257, 1083\u20131088 (1992).","journal-title":"Science"},{"key":"BFng0293157_CR40","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1126\/science.257.5073.1125","volume":"257","author":"LL Clarke","year":"1992","unstructured":"Clarke, L.L. et al. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science 257, 1125\u20131128 (1992).","journal-title":"Science"},{"key":"BFng0293157_CR41","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/0140-6736(92)92223-3","volume":"340","author":"WH Colledge","year":"1992","unstructured":"Colledge, W.H., Ratcliff, R., Foster, D., Williamson, R. & Evans, M.J. Cystic fibrosis mouse with intestinal obstruction. Lancet 340, 680 (1992).","journal-title":"Lancet"},{"key":"BFng0293157_CR42","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/359211a0","volume":"359","author":"JR Dorin","year":"1992","unstructured":"Dorin, J.R. et al. Cystic fibrosis in the mouse by targeted insertional mutagenesis. Nature 359, 211\u2013215 (1992).","journal-title":"Nature"},{"key":"BFng0293157_CR43","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0895-4356(88)90063-7","volume":"41","author":"M Corey","year":"1988","unstructured":"Corey, M., McLaughlin, F.J., Williams, M. & Levison, H. A comparison of survival, growth and pulmonary function in patients with cystic fibrosis in Boston and Toronto. J. clin. Epidem. 41, 583\u2013591 (1988).","journal-title":"J. clin. Epidem."},{"key":"BFng0293157_CR44","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1001\/jama.1971.03190260044012","volume":"218","author":"J Chalon","year":"1971","unstructured":"Chalon, J., Loew, D.A.Y. & Orkin, L.R. Tracheobronchial cytologic changes during the menstrual cycle. JAMA 218, 1928\u20131931 (1971).","journal-title":"JAMA"},{"key":"BFng0293157_CR45","first-page":"114","volume":"6","author":"JE Badley","year":"1988","unstructured":"Badley, J.E., Bishop, G.A., St John, T. & Frelinger, J.A. A simple, rapid method for the purification of Poly A+ RNA. Biotechniques 6, 114\u2013116 (1988).","journal-title":"Biotechniques"},{"key":"BFng0293157_CR46","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","volume":"132","author":"AP Feinberg","year":"1983","unstructured":"Feinberg, A.P. & Vogelstein, B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6\u201313 (1983).","journal-title":"Anal. Biochem."},{"key":"BFng0293157_CR47","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0888-7543(05)80107-7","volume":"14","author":"AEO Trezise","year":"1992","unstructured":"Trezise, A.E.O., Szpirer, C. & Buchwald, M. Localisation of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) in the rat to chromosome 4 and implications for the evolution of mammalian chromosomes. Genomics 14, 869\u2013874 (1992).","journal-title":"Genomics"},{"key":"BFng0293157_CR48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1179\/014788889794651870","volume":"12","author":"DM Simmons","year":"1989","unstructured":"Simmons, D.M., Arriza, J.L. & Swanson, L.W. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabelled single-stranded RNA probes. J. Histotech. 12, 169\u2013181 (1989).","journal-title":"J. Histotech."},{"key":"BFng0293157_CR49","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/aja.1000990303","volume":"99","author":"EF Oakberg","year":"1956","unstructured":"Oakberg, E.F. A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. Am. J. Anat. 99, 391\u2013413 (1956).","journal-title":"Am. J. Anat."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0293-157","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0293-157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0293-157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:21:29Z","timestamp":1684441289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0293-157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["BFng0293157"],"URL":"https:\/\/doi.org\/10.1038\/ng0293-157","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]}}}