{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:44:52Z","timestamp":1791121492313,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1994,3]]},"DOI":"10.1038\/ng0394-282","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T21:06:51Z","timestamp":1092863211000},"page":"282-286","source":"Crossref","is-referenced-by-count":68,"title":["A complex bilateral polysyndactyly disease locus maps to chromosome 7q36"],"prefix":"10.1038","volume":"6","author":[{"given":"Olga","family":"Tsukurov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie","family":"Boehmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Nicolai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben C. J.","family":"Hamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Traill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zaleske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Mankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Yeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystal","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cliff","family":"Tabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0394282_CR1","volume-title":"Mendelian Inheritance in Man.","author":"VA McKusick","year":"1992","unstructured":"McKusick, V.A. Mendelian Inheritance in Man. 10th edn (John Hopkins University Press, Baltimore, 1992)."},{"key":"BFng0394282_CR2","unstructured":"The Holy Bible, according to the authorized version; with notes explanatory and practical; prepared and arranged by d'Olyly, G. & Mant, R. (Oxford, Clarendon Press, 1817)."},{"key":"BFng0394282_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0363-5023(86)80075-2","volume":"11A","author":"J-PA Nicolai","year":"1986","unstructured":"Nicolai, J.-P.A. & Schoch, L.S. Polydactyly in the Bible. J. hand Surg. 11A, 293 (1986).","journal-title":"J. hand Surg."},{"key":"BFng0394282_CR4","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1159\/000152803","volume":"26","author":"AB Scott-Emuakpor","year":"1976","unstructured":"Scott-Emuakpor, A.B. & Madueke, E.D.N. The study of genetic variation in Nigeria. II. The genetics of polydactyly. Hum. Hered. 26, 198\u2013202 (1976).","journal-title":"Hum. Hered."},{"key":"BFng0394282_CR5","first-page":"375","volume-title":"New Chromosomal Syndromes","author":"RC Lewandowski","year":"1977","unstructured":"Lewandowski, R.C., & Yrnis, J.J. Phenotypic mapping in man. In New Chromosomal Syndromes (ed. Yunis, J. J.) 375\u2013376 (Academic Press, New York, 1977)."},{"key":"BFng0394282_CR6","volume-title":"The Genetics of Hand Malformations","author":"SA Temtamy","year":"1978","unstructured":"Temtamy, S.A. & McKusick, V.A. The Genetics of Hand Malformations (Alan R. Liss, New York, 1978)."},{"key":"BFng0394282_CR7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/352539a0","volume":"352","author":"AM Vortkamp","year":"1991","unstructured":"Vortkamp, A.M. & Grzeschik, K.-H. GUl3 zinc-finger gene interrupted by translocations in Greig syndrome families. Nature 352, 539\u2013540 (1991).","journal-title":"Nature"},{"key":"BFng0394282_CR8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0363-5023(88)80019-4","volume":"13A","author":"J-PA Nicolai","year":"1988","unstructured":"Nicolai, J.-P.A. & Hamel, B.C.J. A family with complex bilateral polysyndactyly. J. hand Surg. 13A, 405\u2013407 (1988).","journal-title":"J. hand Surg."},{"key":"BFng0394282_CR9","doi-asserted-by":"crossref","unstructured":"NIH\/CEPH Collaborative Mapping Group. A comprehensive genetic linkage map of the human genome. Science 258, 67\u201386 (1992).","DOI":"10.1126\/science.1439770"},{"key":"BFng0394282_CR10","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/359794a0","volume":"359","author":"J Weissenbach","year":"1992","unstructured":"Weissenbach, J. et al. A second-generation linkage map of the human genome. Nature 359, 794\u2013801 (1992).","journal-title":"Nature"},{"key":"BFng0394282_CR11","first-page":"509","volume":"53","author":"AV Hing","year":"1993","unstructured":"Hing, A.V., Helms, C. & Donis-Keller, H. VNTR and microsatellite polymorphisms within the subtelomeric region of 7q. Am. J. hum. Genet. 53, 509\u2013517 (1993).","journal-title":"Am. J. hum. Genet."},{"key":"BFng0394282_CR12","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0888-7543(89)90324-8","volume":"4","author":"SJ Poole","year":"1989","unstructured":"Poole, S.J., Law, M.L., Kao, F.-T. & Lau, Y.-F. Isolation and chromosomal localization of the human En-2 gene. Genomics 4, 225\u2013231 (1989).","journal-title":"Genomics"},{"key":"BFng0394282_CR13","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/0888-7543(90)90570-K","volume":"6","author":"GR Martin","year":"1990","unstructured":"Martin, G.R. et al. Mapping of the two mouse engrailed-like genes: close linkage of En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to hemlmelic extra-toes (Hx) on chromosome 5. Genomics 6, 302\u2013308 (1990).","journal-title":"Genomics"},{"key":"BFng0394282_CR14","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/S0888-7543(05)80128-4","volume":"14","author":"C Helms","year":"1992","unstructured":"Helms, C. et al. Closure of a genetic linkage map of human chromosome 7q with centromere and telomere polymorphisms. Genomics 14, 1041\u20131054 (1992).","journal-title":"Genomics"},{"key":"BFng0394282_CR15","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/ajmg.1320280320","volume":"28","author":"MG Bailer","year":"1987","unstructured":"Bailer, M.G. et al. Female external genitalia and mullerian duct derivatives in a 46, XY infant with the Smith-Lemli-Opitz syndrome. Am. J. hum. Genet 28, 723\u2013731 (1987).","journal-title":"Am. J. hum. Genet"},{"key":"BFng0394282_CR16","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/ajmg.1320340312","volume":"34","author":"R Berry","year":"1989","unstructured":"Berry, R. et al. Apparent Smith-Lemli-Opitz syndrome and Miller-Dicker syndrome in a family with segregating translocation t (7;17) (q34;p13. 1). Am. J. med. Genet. 34, 358\u2013365 (1989).","journal-title":"Am. J. med. Genet."},{"key":"BFng0394282_CR17","first-page":"24","volume-title":"Mouse News Lett.","author":"MM Dickie","year":"1968","unstructured":"Dickie, M.M., Mouse News Lett. 38, 24 (1968)."},{"key":"BFng0394282_CR18","first-page":"289","volume":"65","author":"TB Knudsen","year":"1981","unstructured":"Knudsen, T.B. & Kochhar, D.M. The role of morphogenetic cell death during abnormal limb bud outgrowth in mice heterozygous for the dominant mutation Hemimelic-extra toe (Hm). J. Embryol. exp. Morphol. 65 (suppl.), 289\u2013307 (1981).","journal-title":"J. Embryol. exp. Morphol."},{"key":"BFng0394282_CR19","first-page":"27","volume":"31","author":"MC Green","year":"1964","unstructured":"Green, M.C. Mouse News Lett. 31, 27 (1964).","journal-title":"Mouse News Lett."},{"key":"BFng0394282_CR20","first-page":"66","volume":"66","author":"HO Sweet","year":"1982","unstructured":"Sweet, H.O., Mouse News Lett. 66, 66 (1982).","journal-title":"Mouse News Lett."},{"key":"BFng0394282_CR21","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1073\/pnas.78.2.1095","volume":"78","author":"T Kornberg","year":"1981","unstructured":"Kornberg, T. engrailed: A gene controlling compartment and segment formation in Drosophila. Proc. natn. Acad. Sci. U.S.A. 78, 1095\u20131099 (1981).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0394282_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0092-8674(92)90471-N","volume":"68","author":"W McGinnis","year":"1992","unstructured":"McGinnis, W. & Krumlauf, R. Homeobox genes and axial patterning. Cell 68, 283\u2013302 (1992).","journal-title":"Cell"},{"key":"BFng0394282_CR23","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/358236a0","volume":"358","author":"BA Morgan","year":"1992","unstructured":"Morgan, B.A., Izpisua-Belmonte, J.-C., Duboule, D. & Tabin, C.J. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236\u2013239 (1992).","journal-title":"Nature"},{"key":"BFng0394282_CR24","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ng0792-295","volume":"1","author":"Y-HW Chou","year":"1992","unstructured":"Chou, Y-H.W. et al. The gene responsible for familial hypocalciuric hypocalcemia maps to chromosome 3q in for unrelate families. Nature Genet. 1, 295\u2013300 (1992).","journal-title":"Nature Genet."},{"key":"BFng0394282_CR25","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1007\/BF02619631","volume":"20","author":"MA Anderson","year":"1984","unstructured":"Anderson, M.A. & Gusella, J.F. Use of cyclosporin A in establishing Epstein-Barr virus transformed human lymphobiastic ceil lines. In vitro 20, 856\u2013858 (1984).","journal-title":"In vitro"},{"key":"BFng0394282_CR26","volume-title":"Current Protocols in Molecular Biology","author":"EJ Richards","year":"1992","unstructured":"Richards, E.J. Preparation and analysis of DNA. In Current Protocols in Molecular Biology (eds Ausubel, R. M. et al.) (Green Publishing, New York, 1992)."},{"key":"BFng0394282_CR27","first-page":"460","volume":"36","author":"GM Lathrop","year":"1984","unstructured":"Lathrop, G.M. & Lalouel, J.M. Easy calculations of lod scores and genetic risks on small computers. Am. J. hum. Genet. 36, 460\u2013465 (1984).","journal-title":"Am. J. hum. Genet."},{"key":"BFng0394282_CR28","volume-title":"Analysis of Human Genetic Linkage","author":"J Ott","year":"1992","unstructured":"Ott, J. Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1992)."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0394-282","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0394-282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0394-282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:25:13Z","timestamp":1684441513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0394-282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["BFng0394282"],"URL":"https:\/\/doi.org\/10.1038\/ng0394-282","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}