{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:25:32Z","timestamp":1791804332820,"version":"4.3.4"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1994,4]]},"DOI":"10.1038\/ng0494-348","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:48:10Z","timestamp":1092862090000},"page":"348-356","source":"Crossref","is-referenced-by-count":1041,"title":["Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development"],"prefix":"10.1038","volume":"6","author":[{"given":"Ichiro","family":"Satokata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0494348_CR1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1101\/gad.3.1.26","volume":"3","author":"RE Hill","year":"1989","unstructured":"Hill, R.E. et al. A new family of mouse homeo box-containing genes: molecular structure chromosomal location & developmental expression of Hox-7.1. Genes Dev. 3, 26\u201337 (1989).","journal-title":"Genes Dev."},{"key":"BFng0494348_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/j.1460-2075.1989.tb03352.x","volume":"8","author":"B Robert","year":"1989","unstructured":"Robert, B., Sassoon, D., Jacq, B., Gehring, W. & Buckingham, M. >Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J. 8, 91\u2013100 (1989).","journal-title":"EMBO J."},{"key":"BFng0494348_CR3","first-page":"115","volume-title":"Molecular Approaches toDevelopmental Biology","author":"WJ Gehring","year":"1987","unstructured":"Gehring, W.J. The homeobox: Structural and evolutionary aspects, in Molecular Approaches toDevelopmental Biology (eds Firtel, R.A. & Davidson, E.H.) 115\u2013129 (Liss, New York, 1987)."},{"key":"BFng0494348_CR4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0378-1119(91)90182-B","volume":"98","author":"PWH Holland","year":"1991","unstructured":"Holland, P.W.H. Cloning and evolutionary analysis of msh like homeobox genes from mouse, zebrafish and ascidian. Gene 98, 253\u2013257 (1991).","journal-title":"Gene"},{"key":"BFng0494348_CR5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1242\/dev.112.4.1053","volume":"112","author":"AP Monaghan","year":"1991","unstructured":"Monaghan, A.P. et al. The Msh-like homeobox genes define domains in the developing vertebrate eye. Development 112,1053\u20131061 (1991).","journal-title":"Development"},{"key":"BFng0494348_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1006\/geno.1993.1149","volume":"16","author":"JR Bell","year":"1993","unstructured":"Bell, J.R. et al. Genomic structure, chromosomal location, and evolution of the mouse Hox-8 gene. Genomics 16, 123\u2013131 and 17, 800 (1993).","journal-title":"Genomics"},{"key":"BFng0494348_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/BF00195823","volume":"84","author":"A Ivens","year":"1990","unstructured":"Ivens, A. et al. The human homeobox gene Hox7 maps chromosome 4p16.1 and may be implicated in Wolf-Hirschhorn syndrome. Human Genet. 84, 473\u2013476 (1990).","journal-title":"Human Genet."},{"key":"BFng0494348_CR8","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/0888-7543(91)90074-O","volume":"11","author":"JE Hewitt","year":"1991","unstructured":"Hewitt, J.E., Clark, L.N., Ivens, A. & Williamson, R. Structure and sequence of the human homeobox gene Hox7. Genomics 11, 670\u2013678 (1991).","journal-title":"Genomics"},{"key":"BFng0494348_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/0092-8674(93)90379-5","volume":"75","author":"EW Jabs","year":"1993","unstructured":"Jabs, E.W. et al. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell 75, 443\u2013450 (1993).","journal-title":"Cell"},{"key":"BFng0494348_CR10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1242\/dev.111.2.269","volume":"111","author":"A MacKenzie","year":"1991","unstructured":"MacKenzie, A., Leeming, G.L., Jowett, A.K., Ferguson, M.W.J. & Sharpe, P.T. The homeobox gene Hox7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development 111, 269\u2013285 (1991).","journal-title":"Development"},{"key":"BFng0494348_CR11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1242\/dev.113.2.601","volume":"113","author":"A MacKenzie","year":"1991","unstructured":"MacKenzie, A., Ferguson, M.W.J. & Sharpe, P.T. Hox-7 expression during murine craniofacial development. Development 113, 601\u2013611 (1991).","journal-title":"Development"},{"key":"BFng0494348_CR12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1242\/dev.115.2.403","volume":"115","author":"A MacKenzie","year":"1992","unstructured":"MacKenzie, A., Ferguson, M.W.J. & Sharpe, P.T. Expression patterns of the homeobox gene Hox 8 in the mouse embryo suggest a role in specifying tooth initiation and shape. Development 115, 403\u2013420 (1992).","journal-title":"Development"},{"key":"BFng0494348_CR13","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/0012-1606(91)90345-4","volume":"148","author":"HR Suzuki","year":"1991","unstructured":"Suzuki, H.R., Padanilam, B.J., Vitale, E., Ramirez, F. & Solursh, M. Repeating developmental expression of G-Hox7, a novel homeobox-containing gene in the chicken. Dev. Biol. 148, 375\u2013388 (1991).","journal-title":"Dev. Biol."},{"key":"BFng0494348_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/mrd.1080320402","volume":"32","author":"GE Lyons","year":"1992","unstructured":"Lyons, G.E., Houzelstein, D., Sassoon, D., Robert, B. & Buckingham, M. Multiple sites of Hox-7 expression during mouse embryogenesis: comparison with retinoic acid receptor mRNA localization. Molec. repro. Dev. 32, 303\u2013314(1992).","journal-title":"Molec. repro. Dev."},{"key":"BFng0494348_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/aja.1001970305","volume":"197","author":"PS Chan-Thomas","year":"1993","unstructured":"Chan-Thomas, P.S., Thompson, R.P., Robert, B., Yacoub, M.H. & Barton, P.J.R. Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in chick. Develop. Dyn. 197, 203\u2013216 (1993).","journal-title":"Develop. Dyn."},{"key":"BFng0494348_CR16","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1101\/gad.5.12b.2363","volume":"5","author":"B Robert","year":"1991","unstructured":"Robert, B., Lyons, G., Simandl, B.K., Kuroiwa, A. & Buckingham, M. The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds. Genes Dev. 5, 2363\u20132374 (1991).","journal-title":"Genes Dev."},{"key":"BFng0494348_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/352429a0","volume":"352","author":"DR Davidson","year":"1991","unstructured":"Davidson, D.R., Crawley, A., Hill, R.E. & Tickle, C. Position dependent expression of two related homeobox genes in developing vertebrate limbs. Nature 352, 429\u2013431 (1991).","journal-title":"Nature"},{"key":"BFng0494348_CR18","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1242\/dev.113.4.1487","volume":"113","author":"CND Coelho","year":"1991","unstructured":"Coelho, C.N.D., Krabbenhoft, K.M., Upholt, W.B., Fallon, J.F. & Kosher, R.A. Altered expression of the chicken homeobox-containing gene GHox-7 and GHox-8 in the limb buds of limbless mutant chick embryos. Development 113, 1487\u20131493 (1991).","journal-title":"Development"},{"key":"BFng0494348_CR19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1242\/dev.115.2.629","volume":"115","author":"CND Coelho","year":"1992","unstructured":"Coelho, C.N.D., Upholt, W.B. & Kosher, R.A. Role of the chicken homeobox-containing genes GHox-4.6 and GHox-8 in the specification of positional identities during the development of normal and polydactylous chick limb buds. Development 115, 629\u2013637 (1992).","journal-title":"Development"},{"key":"BFng0494348_CR20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1242\/dev.116.3.811","volume":"116","author":"MA Ros","year":"1992","unstructured":"Ros, M.A. et al. Apical ridge dependent and independent mesodermal domains of GHox-7 and GHox-8 expression in chick limb buds. Development 116, 811\u2013818 (1992).","journal-title":"Development"},{"key":"BFng0494348_CR21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.119.1.41","volume":"119","author":"JM Brown","year":"1993","unstructured":"Brown, J.M. et al. Experimental analysis of the control of expression of the homeobox-gene Msx-1 in the developing limb and face. Development 119, 41\u201348 (1993).","journal-title":"Development"},{"key":"BFng0494348_CR22","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1002\/j.1460-2075.1991.tb07777.x","volume":"10","author":"Y Takahashi","year":"1991","unstructured":"Takahashi, Y., Bontoux, M. & Le Douarin, N.M. Epithelio-mesenchymal interactions are critical for Quox 7 expression and membrane bone differentiation in the neural crest derived mandibular mesenchyme. EMBOJ. 10, 2387\u20132393(1991).","journal-title":"EMBOJ."},{"key":"BFng0494348_CR23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/dev.117.2.461","volume":"117","author":"AK Jowett","year":"1993","unstructured":"Jowett, A.K., Vainio, S., Ferguson, M.W.J., Sharpe, P.T. & Thesleff, I. Epithelial-mesenchymal interactions are required for msx1 and msx2 gene expression in the developing murine molar tooth. Development 117, 461\u2013470(1993).","journal-title":"Development"},{"key":"BFng0494348_CR24","doi-asserted-by":"publisher","first-page":"10237","DOI":"10.1073\/pnas.89.21.10237","volume":"89","author":"Y Takahashi","year":"1992","unstructured":"Takahashi, Y., Monsoro-Burg, A.-H., Bontoux, M. & Le Douarin, N.M. A role for Quox-8 in the establishment of the dorsoventral pattern during vertebrate development. Proc. natn. Acad. Sci. U.S.A. 89, 10237\u201310241 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng0494348_CR25","first-page":"405","volume":"2","author":"DR Davidson","year":"1991","unstructured":"Davidson, D.R. & Hill, R.E. Msh-like genes: a family of homeobox genes with wide ranging expression during vertebrate development. Sem. Dev. Biol. 2, 405\u2013412 (1991).","journal-title":"Sem. Dev. Biol."},{"key":"BFng0494348_CR26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0012-1606(92)90154-9","volume":"152","author":"K Muneoka","year":"1992","unstructured":"Muneoka, K. & Sasoon, D. Molecular aspects of regeneration in developing vertebrate limbs. Dev. Biol. 152, 37\u201349 (1992).","journal-title":"Dev. Biol."},{"key":"BFng0494348_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/0012-1606(92)90153-8","volume":"152","author":"J-C Izpis\u00faa-Belmonte","year":"1992","unstructured":"Izpis\u00faa-Belmonte, J.-C. & Duboule, D. Homeobox genes and pattern formation in the vertebrate limb. Dev. Biol. 152, 26\u201336 (1992).","journal-title":"Dev. Biol."},{"key":"BFng0494348_CR28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1242\/dev.118.3.665","volume":"118","author":"EH Davidson","year":"1993","unstructured":"Davidson, E.H. Later embryogenesis: regulatory circuitry in morphogenetic fields. Development 118, 665\u2013690 (1993).","journal-title":"Development"},{"key":"BFng0494348_CR29","first-page":"39","volume":"36","author":"B Robert","year":"1993","unstructured":"Robert, B. et al. Induction phenomena in vertebrate limb formation and expression of homeobox genes. Ann. G\u00e9n\u00e9tique 36, 39\u201345 (1993).","journal-title":"Ann. G\u00e9n\u00e9tique"},{"key":"BFng0494348_CR30","first-page":"693","volume-title":"Syndromes of the Head and Neck.","author":"RJ Gorlin","year":"1990","unstructured":"Gorlin, R.J., Cohen, M.M.Jr., & Levin, L.S. Syndromes of the Head and Neck. Oxford Monograph on Medical genetics No. 19, Third edition. 693\u2013714 (Oxford University Press, Oxford, England, 1990)."},{"key":"BFng0494348_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0889-5406(86)90022-3","volume":"90","author":"R Ranta","year":"1986","unstructured":"Ranta, R. A review of tooth formation in children with cleft lip\/palate. A. J. Orthod. Dentofac. Orthop. 90, 11\u201318 (1986).","journal-title":"A. J. Orthod. Dentofac. Orthop."},{"key":"BFng0494348_CR32","first-page":"237","volume":"2","author":"P Randall","year":"1965","unstructured":"Randall, P., Krogman, W.M. & Jahina, S., Robin and the syndrome that bears his name. Cleft Palate J. 2, 237\u2013246 (1965).","journal-title":"Cleft Palate J."},{"key":"BFng0494348_CR33","first-page":"1138","volume-title":"Mendelian Inheritance in Man.","author":"VA McKusick","year":"1988","unstructured":"McKusick, V.A. Mendelian Inheritance in Man. 8th edn 1138\u20131139 (Johns Hopkins University Press, Baltimore 1988)."},{"key":"BFng0494348_CR34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1242\/dev.103.Supplement.101","volume":"103","author":"G Couly","year":"1988","unstructured":"Couly, G. and Le Douarin, N.M. The fate map of the cephalic neural primordium at the presomitic to the 3-somite stage in the avian embryo. Development Supp. 103, 101\u2013113 (1988).","journal-title":"Development Supp."},{"key":"BFng0494348_CR35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.117.2.409","volume":"117","author":"GF Couly","year":"1993","unstructured":"Couly, G.F., Coltey, P.M. & Le Douarin, N.M. The triple origin of skull in higher vertebrates: a study in quail-chick chimeras. Development 117, 409\u2013429 (1993).","journal-title":"Development"},{"key":"BFng0494348_CR36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1242\/dev.103.Supplement.121","volume":"103","author":"DM Noden","year":"1988","unstructured":"Noden, D.M. Interactions and fates of avian craniofacial mesenchyme. Development Supp. 103, 121\u2013140 (1988).","journal-title":"Development Supp."},{"key":"BFng0494348_CR37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/dev.103.Supplement.155","volume":"103","author":"AGS Lumsden","year":"1988","unstructured":"Lumsden, A.G.S. Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development Supp. 103, 155\u2013169 (1988).","journal-title":"Development Supp."},{"key":"BFng0494348_CR38","first-page":"1","volume":"Xl","author":"MC Johnston","year":"1975","unstructured":"Johnston, M.C. The neural crest in abnormalities of the face and brain. Birth Defects: Original Article Series, Vol. Xl(7), 1 18 (The National March of Dimes Foundation, 1975).","journal-title":"Birth Defects: Original Article Series"},{"key":"BFng0494348_CR39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dev.103.Supplement.213","volume":"103","author":"KK Sulik","year":"1988","unstructured":"Sulik, K.K., Cook, C.S. & Webster, W.S. Teratogenesis and craniofacial malformations: relationships to cell death. Development Supp. 103, 213\u2013232 (1988).","journal-title":"Development Supp."},{"key":"BFng0494348_CR40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0003-9969(87)90022-7","volume":"32","author":"RM Palmer","year":"1987","unstructured":"Palmer, R.M. & Lumsden, A.G.S. Development of periodontal ligament and alveolar bone in homografted recombinations of enamel organs and papillary, pulpal and follicular mesenchyme in the mouse. Arch. Oral Biol. 32, 281\u2013289 (1987).","journal-title":"Arch. Oral Biol."},{"key":"BFng0494348_CR41","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0092-8674(05)80083-2","volume":"75","author":"S Vainio","year":"1993","unstructured":"Vainio, S., Karavanova, I., Jowett, A. & Thesleff, I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75, 45\u201358 (1993).","journal-title":"Cell"},{"key":"BFng0494348_CR42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0925-4773(91)90051-7","volume":"34","author":"CND Coelho","year":"1991","unstructured":"Coelho, C.N.D. et al. Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development. Mech. Dev. 34, 143\u2013154 (1991).","journal-title":"Mech. Dev."},{"key":"BFng0494348_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1432-0436.1992.tb00772.x","volume":"49","author":"CND Coelho","year":"1992","unstructured":"Coelho, C.N.D., Sumoy, L., Kosher, R.A. & Upholt, W.B., GHox-7: A chicken homeobox-containing gene expressed in a fashion consistent with a role in patterning events during embryonic chick limb development. Differentiation 49, 85\u201392 (1992).","journal-title":"Differentiation"},{"key":"BFng0494348_CR44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.103.Supplement.41","volume":"103","author":"M Ferguson","year":"1988","unstructured":"Ferguson, M. Palate development. Development Supp. 103, 41\u201360 (1988).","journal-title":"Development Supp."},{"key":"BFng0494348_CR45","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/jmor.1051090204","volume":"109","author":"N Fitch","year":"1961","unstructured":"Fitch, N. Development of cleft palate in mice homozygous for the shorthead mutation. J. Morphot. 109, 151\u2013157 (1961).","journal-title":"J. Morphot."},{"key":"BFng0494348_CR46","first-page":"227","volume":"38","author":"RE Seegmiller","year":"1977","unstructured":"Seegmiller, R.E. & Fraser, F.C. Mandibular growth retardation as a cause of cleft palate in mice homozygous for the chondrodysplasia gene. J. Embryol. exp. Morph. 38, 227\u2013238 (1977).","journal-title":"J. Embryol. exp. Morph."},{"key":"BFng0494348_CR47","first-page":"317","volume":"3","author":"DM Juriloff","year":"1983","unstructured":"Juriloff, D.M. & Harris, M.J. Abnormal facial development in the mouse mutant first arch. J. Cranio. Gen. devl. Biol. 3, 317\u2013337 (1983).","journal-title":"J. Cranio. Gen. devl. Biol."},{"key":"BFng0494348_CR48","unstructured":"Culiat, C.T. et al. Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the \u03b23 subunit of the type A\u03b3-aminobutyric acid receptor. Proc. natn. Acad. Sci. U.S.A. 90, 5105\u20135109(1993)."},{"key":"BFng0494348_CR49","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/364448a0","volume":"364","author":"Y Nakatsu","year":"1993","unstructured":"Nakatsu, Y. et al. A cluster of three GABA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature 364, 448\u2013450 (1993).","journal-title":"Nature"},{"key":"BFng0494348_CR50","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/0092-8674(93)90619-2","volume":"75","author":"M Gendron-Maguire","year":"1993","unstructured":"Gendron-Maguire, M. et al. Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75, 1317\u20131331 (1993).","journal-title":"Cell"},{"key":"BFng0494348_CR51","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/0092-8674(93)90620-6","volume":"75","author":"FM Rijli","year":"1993","unstructured":"Rijli, F.M. et al. A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a homeotic selector gene. Cell 75, 1333\u20131349 (1993).","journal-title":"Cell"},{"key":"BFng0494348_CR52","first-page":"270","volume":"50","author":"M Farrall","year":"1992","unstructured":"Farrall, M. & Holder, S. Familal recurrence-pattern analysis of cleft lip with or without cleft palate. Am. J. hum. Gen. 50, 270\u2013277 (1992).","journal-title":"Am. J. hum. Gen."},{"key":"BFng0494348_CR53","first-page":"648","volume":"51","author":"ML Marazita","year":"1992","unstructured":"Marazita, M.L., Hu, D-N, Spence, M.A., Liu, Y-E., Melnick, M. Cleft lip with or without cleft palate in Shanghai, China: evidence for an autosomal major locus. Am. J. hum. Gen. 51, 648\u2013653 (1992).","journal-title":"Am. J. hum. Gen."},{"key":"BFng0494348_CR54","first-page":"979","volume":"41","author":"DM Kurnit","year":"1987","unstructured":"Kurnit, D.M., Layton, W.M. & Matthysse, S., Genetics, chance, and morphogenesis. Am. J. hum. Gen. 41, 979\u2013995 (1987).","journal-title":"Am. J. hum. Gen."},{"key":"BFng0494348_CR55","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","volume":"69","author":"E Li","year":"1992","unstructured":"Li, E., Bestor, T. & Jaenisch, R. argeted mutation of the DNA methyl transferase gene results in embryonic lethality. Cell 69, 915\u2013926 (1992).","journal-title":"Cell"},{"key":"BFng0494348_CR56","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/342435a0","volume":"342","author":"M Zijlstra","year":"1989","unstructured":"Zijlstra, M., Li, E., Sajjadi, F., Subramani, S. & Jaensich, R. Germ line transmission of adisrupted \u03b22-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342, 435\u2013438 (1989).","journal-title":"Nature"},{"key":"BFng0494348_CR57","first-page":"71","volume-title":"Teratocarcinomas and embryonic stem cells a practical approach","author":"EJ Robertson","year":"1987","unstructured":"Robertson, E.J. Embryo-derived stem cell lines in Teratocarcinomas and embryonic stem cells a practical approach (ed. Roberston. E.J.)71\u2013112(IRL press, Oxford, 1987)."},{"key":"BFng0494348_CR58","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0092-8674(87)90646-5","volume":"51","author":"K Thomas","year":"1987","unstructured":"Thomas, K. & Capecchi, M. Site directed mutagenesis by gene targeting in mouse embryo derived stem cells. Cell 51, 503\u2013512 (1987).","journal-title":"Cell"},{"key":"BFng0494348_CR59","first-page":"113","volume-title":"Teratocarcinomas and embryonic stem cells, a practical approach","author":"A Bradley","year":"1987","unstructured":"Bradley, A. Production and analysis of chimaeric mice. in Teratocarcinomas and embryonic stem cells, a practical approach (ed. Robertson, E.J.) 113\u2013151 (IRL Press, Oxford, 1987)."},{"key":"BFng0494348_CR60","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1093\/nar\/19.15.4293","volume":"19","author":"PW Laird","year":"1991","unstructured":"Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nuc. Acid Res. 19, 4293 (1991).","journal-title":"Nuc. Acid Res."},{"key":"BFng0494348_CR61","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/tera.1420220306","volume":"22","author":"MJ McLeod","year":"1980","unstructured":"McLeod, M.J. Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22, 299\u2013301 (1980).","journal-title":"Teratology"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0494-348","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0494-348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0494-348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:31:28Z","timestamp":1684441888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0494-348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["BFng0494348"],"URL":"https:\/\/doi.org\/10.1038\/ng0494-348","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}