{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:58:00Z","timestamp":1791356280007,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1038\/ng0796-350","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:19:18Z","timestamp":1092860358000},"page":"350-353","source":"Crossref","is-referenced-by-count":279,"title":["Accelerated telomere shortening in ataxia telangiectasia"],"prefix":"10.1038","volume":"13","author":[{"given":"Judith A.","family":"Metcalfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Parkhill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Biggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Byrd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Malcolm R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0796350_CR1","first-page":"347","volume-title":"Handbook of clinical Neurology. Hereditary and Spinocerebellar Atrophies","author":"RP Sedgwick","year":"1991","unstructured":"Sedgwick, R.P. & Boder, E. Ataxia telangiectasia. in Handbook of clinical Neurology. Hereditary and Spinocerebellar Atrophies. vol. 16. (ed. de Jong, J.M.J.V) 347\u2013423 (Elsevier Science, Amsterdam, 1991)."},{"key":"BFng0796350_CR2","first-page":"135","volume":"30","author":"K Hayashi","year":"1975","unstructured":"Hayashi, K. & Schmid, W. Tandem duplication q14 and dicentric formation by end-to-end chromosome fusions in ataxia telangiectasia. Humangenetik 30, 135\u2013141 (1975).","journal-title":"Humangenetik"},{"key":"BFng0796350_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/ijc.2910270309","volume":"27","author":"AMR Taylor","year":"1981","unstructured":"Taylor, A.M.R., Oxford, J. & Metcalfe, J.A. Spontaneous cytogenetic abnormalities in lymphocytes from 13 patients with ataxia telangiectasia. Int. J. Cancer. 27, 311\u2013319 (1981).","journal-title":"Int. J. Cancer."},{"key":"BFng0796350_CR4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/BF00291379","volume":"83","author":"TL Kojis","year":"1989","unstructured":"Kojis, T.L., Schreck, R.R., Gatti, R.A. & Sparkes, R.S. Tissue specificity of chromosomal rearrangements in ataxia telangiectasia. Hum.Genet. 83, 347\u2013352 (1989).","journal-title":"Hum.Genet."},{"key":"BFng0796350_CR5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/BF00291396","volume":"67","author":"RH Fitzjerald","year":"1984","unstructured":"Fitzjerald, R H. & Morris, C.M. Telomeric associations in B cell lymphoid leukaemia. Hum.Genet. 67, 385\u2013390 (1984).","journal-title":"Hum.Genet."},{"key":"BFng0796350_CR6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/BF00401240","volume":"73","author":"R Morgan","year":"1986","unstructured":"Morgan, R., Jarzabek, V., Jaffe, J.R., Hecht, B.K. & Sandberg, A.A. Telomeric fusion in pre-T-cell acute lymphoblastic leukaemia. Hum. Genet. 73, 260\u2013263 (1986).","journal-title":"Hum. Genet."},{"key":"BFng0796350_CR7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/BF00388457","volume":"71","author":"N Mandahl","year":"1985","unstructured":"Mandahl, N. et al. Telomeric associations in malignant fibrous histiocytoma. Hum. Genet. 71, 321\u2013324 (1985).","journal-title":"Hum. Genet."},{"key":"BFng0796350_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000132555","volume":"47","author":"S Pathak","year":"1988","unstructured":"Pathak, S., Wang, Z., Dhaliwal, M.K. & Sacks, P.C. Telomeric associations; another characteristic of cancer chromosomes Cytogenet. Cell. Genet. 47, 227\u2013229 (1988).","journal-title":"Cell. Genet."},{"key":"BFng0796350_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0165-4608(89)90150-7","volume":"40","author":"R Aledo","year":"1989","unstructured":"Aledo, R., Aurias, A., Avril, M.F. & Dutrillaux, B. Jumping end to end dicentrics in a case of squamous cell carcinoma from a patient with xeroderma pigmentosum. Cancer Genet. Cytogenet. 40, 95\u2013103 (1989).","journal-title":"Cancer Genet. Cytogenet."},{"key":"BFng0796350_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF00356029","volume":"102","author":"D Saltman","year":"1993","unstructured":"Saltman, D., Morgan, R., Cleary, M.L. & de Lange, T. Telomeric structure in cells with chromosome end association. Chromosoma 102, 121\u2013138 (1993).","journal-title":"Chromosoma"},{"key":"BFng0796350_CR11","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1159\/000132766","volume":"50","author":"D Saltman","year":"1989","unstructured":"Saltman, D. et al. Telomeric associations in lymphoblastoid cell lines from a patient with B-cell follicular lymphoma. Cytogenet. Cell Genet. 50, 230\u2013233 (1989).","journal-title":"Cell Genet."},{"key":"BFng0796350_CR12","first-page":"465","volume":"28","author":"PA Benn","year":"1976","unstructured":"Benn, P A. Specific chromosome aberrations in senescent fibroblast lines derived from human embryos. Am. J. Hum. Genet. 28, 465\u2013473 (1976).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0796350_CR13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1182\/blood.V87.2.423.bloodjournal872423","volume":"87","author":"AMR Taylor","year":"1996","unstructured":"Taylor, A.M.R., Metcalfe, J.A., Thick, J. & Mak, Y.-F. Leukemia and lymphoma in ataxia telangiectasia. Blood 87, 423\u2013438 (1996).","journal-title":"Blood"},{"key":"BFng0796350_CR14","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/346866a0","volume":"346","author":"ND Hastie","year":"1990","unstructured":"Hastie, N.D. et al. Telomere reduction in human colorectal carcinoma and with aging. Nature 346, 866\u2013868 (1990).","journal-title":"Nature"},{"key":"BFng0796350_CR15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/345458a0","volume":"345","author":"CB Hartey","year":"1990","unstructured":"Hartey, C.B., Futcher, A.B. & Greider, C.W. Telomeres shorten during maging of human fibroblasts. Nature 345, 458\u2013460 (1990).","journal-title":"Nature"},{"key":"BFng0796350_CR16","doi-asserted-by":"publisher","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","volume":"89","author":"RC Allsop","year":"1992","unstructured":"Allsop, R.C. et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA 89, 10114\u201310118 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng0796350_CR17","first-page":"661","volume":"52","author":"H Vaziri","year":"1993","unstructured":"Vaziri, H. et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52, 661\u2013667 (1993).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng0796350_CR18","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/978-1-4899-4501-3_9","volume-title":"Genetic Predisposition to Cancer","author":"AMR Taylor","year":"1996","unstructured":"Taylor, A.M.R. et al. Malignant disease and variations in radiosensitivity in ataxia telangiectasia. in Genetic Predisposition to Cancer (eds Eeles, RA, Ponder, B.A.J., Easton D.F. & Norwich, A.) 138\u2013151 (Chapman and Hall, London, 1996)."},{"key":"BFng0796350_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev.bi.53.070184.001115","volume":"53","author":"EH Blackburn","year":"1984","unstructured":"Blackburn, E.H. & Szostak, J.W. The molecular structure of centromeres and telomeres. Annu. Rev. Biochem. 53, 163\u2013194 (1984).","journal-title":"Annu. Rev. Biochem."},{"key":"BFng0796350_CR20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1146\/annurev.ge.23.120189.003051","volume":"23","author":"VA Zakian","year":"1989","unstructured":"Zakian, V.A. Structure and function of telomeres. Annu. Rev. Genet. 23, 579\u2013604 (1989).","journal-title":"Annu. Rev. Genet."},{"key":"BFng0796350_CR21","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","volume":"11","author":"CM Counter","year":"1992","unstructured":"Counter, C.M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO. J. 11, 1921\u20131929 (1992).","journal-title":"EMBO. J."},{"key":"BFng0796350_CR22","first-page":"423","volume":"7","author":"S Bacchetti","year":"1995","unstructured":"Bacchetti, S. & Counter, C.M. Telomeres and telomerase in human cancer (a review). Int. J. Oncol. 7, 423\u2013432 (1995).","journal-title":"Int. J. Oncol."},{"key":"BFng0796350_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000134069","volume":"71","author":"TK Pandita","year":"1995","unstructured":"Pandita, T.K., Pathak, S. & Geard, C. Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells. Cytogenet.Cell. Genet. 71, 86\u201393 (1995).","journal-title":"Cytogenet.Cell. Genet."},{"key":"BFng0796350_CR24","first-page":"823","volume-title":"cerevisiae, is homologous to the human ataxia telangiectasia gene.","author":"PW Greenwell","year":"1995","unstructured":"Greenwell, P.W. et al. TEL1,a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82, 823\u2013829 (1995)."},{"key":"BFng0796350_CR25","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1126\/science.7792600","volume":"268","author":"K Savitsky","year":"1995","unstructured":"Savitsky, K. et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749\u20131753 (1995).","journal-title":"Science"},{"key":"BFng0796350_CR26","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0168-9525(89)90137-6","volume":"5","author":"ND Hastie","year":"1989","unstructured":"Hastie, N.D. & Allshire, R.C. Human telomeres: fusion and interstial sites. Trends Genet. 5, 326\u2013531 (1989).","journal-title":"Trends Genet."},{"key":"BFng0796350_CR27","first-page":"564","volume":"8","author":"J Thick","year":"1994","unstructured":"Thick, J., Mak, Y.-F., Metcalfe, J.A., Beatty, D. & Taylor, A.M.R. A gene on chromosome Xq28 associated with T cell prolymphocytic leukaemia in two patients with ataxia telangiectasia. Leukemia. 8, 564\u2013573 (1994).","journal-title":"Leukemia."},{"key":"BFng0796350_CR28","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/jmg.24.11.669","volume":"24","author":"AMR Taylor","year":"1987","unstructured":"Taylor, A.M.R. et al. Variant forms of ataxia telangiectasia. J. Med. Genet. 24, 669\u2013667 (1987).","journal-title":"J. Med. Genet."},{"key":"BFng0796350_CR29","volume-title":"Molecular cloning: A Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook, J., Fritsch, E.F. & Maniatis, T. Molecular cloning: A Laboratory Manual, 2nd ed.(Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1989)."},{"key":"BFng0796350_CR30","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1126\/science.7605428","volume":"266","author":"NW Kim","year":"1994","unstructured":"Kim, N.W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011\u20132015 (1994).","journal-title":"Science"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0796-350","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0796-350.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0796-350.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:48:40Z","timestamp":1684442920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0796-350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["BFng0796350"],"URL":"https:\/\/doi.org\/10.1038\/ng0796-350","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}