{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:46:39Z","timestamp":1791978399430,"version":"4.4.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1038\/ng0897-383","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:32:53Z","timestamp":1092861173000},"page":"383-386","source":"Crossref","is-referenced-by-count":974,"title":["Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene"],"prefix":"10.1038","volume":"16","author":[{"given":"Mark D.","family":"Fleming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Cameron C.","family":"Trenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Foernzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy C.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng0897383_CR1","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1182\/blood.V35.6.838.838","volume":"35","author":"ES Russell","year":"1970","unstructured":"Russell, E.S. et al. Characterization and genetic studies of microcytic anemia in house mouse. Blood 35, 838\u2013850 (1970).","journal-title":"Blood"},{"key":"BFng0897383_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3181\/00379727-141-36720","volume":"141","author":"JA Edwards","year":"1972","unstructured":"Edwards, J.A. & Hoke, J.E. Defect of intestinal mucosal iron uptake in mice with hereditary microcytic anemia. Proc. Soc. Exp. Biol. Med. 141, 81\u201384 (1972).","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BFng0897383_CR3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood.V40.6.893.893","volume":"40","author":"DE Harrison","year":"1972","unstructured":"Harrison, D.E. Marrow transplantation and iron therapy in mouse hereditary microcytic anemia. Blood 40, 893\u2013901 (1972).","journal-title":"Blood"},{"key":"BFng0897383_CR4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1182\/blood.V46.3.381.381","volume":"46","author":"JA Edwards","year":"1975","unstructured":"Edwards, J.A. & Hoke, J.E. Red cell iron uptake in hereditary microcytic anemia. Blood 46, 381\u2013388 (1975).","journal-title":"Blood"},{"key":"BFng0897383_CR5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/0888-7543(95)80053-O","volume":"25","author":"S Grunheid","year":"1995","unstructured":"Grunheid, S., Cellier, M., Vidal, S. & Gros, P. Identification and characterization of a second mouse Nramp gene. Genomics 25, 514\u2013525 (1995).","journal-title":"Genomics"},{"key":"BFng0897383_CR6","first-page":"42","volume":"51","author":"S Handa","year":"1987","unstructured":"Handa, S., Ferguson, J.M., Wallace, M.E. & Bulfield, G. Characterization and mapping of a viable anaemic mutant in the mouse: a new allele, mkvan, at the microcytic anaemia locus. Genet. Res. 51, 42\u201347 (1987).","journal-title":"Genet."},{"key":"BFng0897383_CR7","first-page":"35","volume":"53","author":"EC McFarland","year":"1975","unstructured":"McFarland, E.C. & Russell, E.S. Microcytic anemia (mk) has been located close to Ca on chromosome 15. Mouse News Letter 53, 35 (1975).","journal-title":"Mouse News Letter"},{"key":"BFng0897383_CR8","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1126\/science.2884728","volume":"236","author":"ES Lander","year":"1987","unstructured":"Lander, E.S. & Botstein, D. Homozygosity mapping: a new way to map human recessive traits with the DNA of inbred children. Science 236, 1567\u20131570 (1987).","journal-title":"Science"},{"key":"BFng0897383_CR9","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1093\/nar\/8.7.1499","volume":"8","author":"AP Bird","year":"1980","unstructured":"Bird, A.P. DNA methylation and the frequency of CpG in animal DNA. Nucleic Acids Res. 8, 1499\u20131504 (1980).","journal-title":"Nucleic Acids Res."},{"key":"BFng0897383_CR10","unstructured":"Hogan, B., Costantini, F. & Lacy, E. Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1986)."},{"key":"BFng0897383_CR11","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1073\/pnas.93.10.5105","volume":"93","author":"F Supek","year":"1996","unstructured":"Supek, F., Supekova, L., Nelson, H. & Nelson, N. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc. Natl. Acad. Sci. USA 93, 5105\u20135110 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng0897383_CR12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0168-9525(96)30042-5","volume":"12","author":"M Cellier","year":"1996","unstructured":"Cellier, M., Belouchi, A. & Gros, P. Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet. 12, 201\u2013204 (1996).","journal-title":"Trends Genet."},{"key":"BFng0897383_CR13","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1073\/pnas.92.22.10089","volume":"92","author":"M Cellier","year":"1995","unstructured":"Cellier, M. et al. Nramp defines a family of membrane proteins. Proc. Natl. Acad. Sci. USA 92, 10089\u201310093 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng0897383_CR14","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0092-8674(93)90135-D","volume":"73","author":"SM Vidal","year":"1993","unstructured":"Vidal, S.M., Malo, D., Vogan, K., Skamene, E. & Gros, P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Beg. Cell 73, 469\u2013485 (1993).","journal-title":"Cell"},{"key":"BFng0897383_CR15","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1084\/jem.182.3.655","volume":"182","author":"S Vidal","year":"1995","unstructured":"Vidal, S. et al. The Ity\/Lsh\/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp 7 gene. J. Exp. Med. 182, 655\u2013666 (1995).","journal-title":"J. Exp. Med."},{"key":"BFng0897383_CR16","first-page":"717","volume":"185","author":"S Grunheid","year":"1997","unstructured":"Grunheid, S., Pinner, E., Desjardins, M. & Gros, P. Natural resistance to infection with intracellular pathogens: the Nrampl protein is recruited to the membrane of the phagosome. J. Exp. Med. 185, 717\u2013730 (1997).","journal-title":"J."},{"key":"BFng0897383_CR17","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1002\/j.1460-2075.1995.tb07303.x","volume":"14","author":"V Rodrigues","year":"1995","unstructured":"Rodrigues, V., Cheah, P.Y, Ray, K. & Chia, W. malvolio, the Drosophila homologue of mouse NRAMP-1 (Beg), is expressed in macrophages and in the nervous system and is required for normal taste behavior. EMBO J. 14, 3007\u20133020 (1995).","journal-title":"EMBO J."},{"key":"BFng0897383_CR18","doi-asserted-by":"crossref","first-page":"24625","DOI":"10.1016\/S0021-9258(18)35810-1","volume":"267","author":"AH West","year":"1992","unstructured":"West, A.H. et al. Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J. Biol. Chem. 267, 24625\u201324633 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFng0897383_CR19","first-page":"642","volume":"78","author":"ABR Thomson","year":"1971","unstructured":"Thomson, A.B.R., Olatunbosun, D. & Valberg, L.S. Interrelation of intestinal transport system for manganese and iron. J. Lab. Clin. Med. 78, 642\u2013655 (1971).","journal-title":"J. Lab. Clin. Med."},{"key":"BFng0897383_CR20","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0092-8674(94)90345-X","volume":"76","author":"A Dancis","year":"1994","unstructured":"Dancis, A. et al. Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 76, 393\u2013402 (1994).","journal-title":"Cell"},{"key":"BFng0897383_CR21","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0092-8674(94)90346-8","volume":"76","author":"C Askwith","year":"1994","unstructured":"Askwith, C. et al. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 76, 403\u2013410 (1994).","journal-title":"Cell"},{"key":"BFng0897383_CR22","first-page":"144","volume":"2","author":"ES Russell","year":"1970","unstructured":"Russell, E.S., McFarland, E.C. & Kent, E.L. Low viability, skin lesions, and reduced fertility associated with microcytic anemia in the mouse. Transplant. Proc. 2, 144\u2013151 (1970).","journal-title":"Transplant. Proc."},{"key":"BFng0897383_CR23","first-page":"559","volume":"59","author":"ED Weinberg","year":"1993","unstructured":"Weinberg, E.D. The iron-withholding defense system. ASM News 59, 559\u2013562 (1993).","journal-title":"ASM News"},{"key":"BFng0897383_CR24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF00357089","volume":"4","author":"KF Manly","year":"1993","unstructured":"Manly, K.F. A Macintosh program for storage and analysis of experimental genetic mapping data. Mamm. Genome 4, 303\u2013313 (1993).","journal-title":"Mamm. Genome"},{"key":"BFng0897383_CR25","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1006\/geno.1996.0177","volume":"33","author":"GG Lennon","year":"1996","unstructured":"Lennon, G.G., Auffray, C., Polymeropoulos, M. & Scares, M.B., The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 33, 151\u2013152 (1996).","journal-title":"Genomics"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0897-383","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0897-383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0897-383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:54:37Z","timestamp":1684443277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0897-383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["BFng0897383"],"URL":"https:\/\/doi.org\/10.1038\/ng0897-383","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}