{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:13:41Z","timestamp":1791983621873,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1997,9]]},"DOI":"10.1038\/ng0997-75","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T16:27:51Z","timestamp":1092932871000},"page":"75-78","source":"Crossref","is-referenced-by-count":435,"title":["Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons"],"prefix":"10.1038","volume":"17","author":[{"given":"Urs","family":"Albrecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Sutcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Cattanach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin V.","family":"Beechey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawna","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Eichele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Beaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng099775_CR1","first-page":"733","volume":"54","author":"RD Nicholls","year":"1994","unstructured":"Nicholls, R.D. New insights reveal complex mechanisms involved in genomic imprinting. Am. J. Hum. Genet. 54, 733\u2013740 (1994).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng099775_CR2","first-page":"811","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"DH Ledbetter","year":"1995","unstructured":"Ledbetter, D.H., Ballabio, A. Molecular cytogenetics of contiguous gene syndromes: mechanisms and consequences of gene dosage imbalance. in The Metabolic and Molecular Bases of Inherited Disease, 7th ed. (eds Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) 811\u2013839 (McGraw-Hill, New York, 1995)."},{"key":"BFng099775_CR3","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S0045-9380(06)80036-8","volume":"25","author":"CA Williams","year":"1995","unstructured":"Williams, C.A. et al. Angelman syndrome. Curr. Probl. Pediatr. 25, 216\u2013231 (1995).","journal-title":"Curr. Probl. Pediatr."},{"key":"BFng099775_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ng0495-395","volume":"9","author":"K Buiting","year":"1995","unstructured":"Buiting, K. et al. Inherited microdeletions in the Angelman and Prader-Willi syndromes define an imprinting centre on human chromosome 15. Nature Genet. 9, 395\u2013400 (1995).","journal-title":"Nature Genet."},{"key":"BFng099775_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/ng0197-74","volume":"15","author":"T Matsuura","year":"1997","unstructured":"Matsuura, T. et al. De novo truncating mutations in E6-AP ubiquitin\u2013protein ligase gene (UBE3A) in Angelman syndrome. Nature Genet. 15, 74\u201377 (1997).","journal-title":"Nature Genet."},{"key":"BFng099775_CR6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/ng0197-70","volume":"15","author":"T Kishino","year":"1997","unstructured":"Kishino, T., Lalande, M. & Wagstaff, J. UBE3A\/E6-AP mutations cause Angelman syndrome. Nature Genet. 15, 70\u201373 (1997).","journal-title":"Nature Genet."},{"key":"BFng099775_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/hmg\/3.2.309","volume":"3","author":"M Nakao","year":"1994","unstructured":"Nakao, M. et al. Imprinting analysis of three genes in the Prader\u2013Willi\/Angelman region: SNRPN, E6-associated protein, and PAR-2 (D15S225E). Hum. Mol. Genet. 3, 309\u2013315 (1994).","journal-title":"Hum. Mol. Genet."},{"key":"BFng099775_CR8","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1101\/gr.7.4.368","volume":"7","author":"JS Sutcliffe","year":"1997","unstructured":"Sutcliffe, J.S. et al. The E6\u2013AP ubiquitin\u2013protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. Genome Res. 7, 368\u2013377 (1997).","journal-title":"Genome Res."},{"key":"BFng099775_CR9","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/ajmg.1320280407","volume":"28","author":"RE Magenis","year":"1987","unstructured":"Magenis, R.E., Brown, M.G., Lacy, D.A., Budden, S. & LaFranchi, S. Is Angelman syndrome an alternate result of del(15)(q11q13)? Am. J. Med. Genet. 28, 829\u2013838 (1987).","journal-title":"Am. J. Med. Genet."},{"key":"BFng099775_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ajmg.1320460104","volume":"46","author":"JL Zackowski","year":"1993","unstructured":"Zackowski, J.L. et al. Cytogenetic and molecular analysis in Angelman syndrome. Am. J. Med. Genet. 46, 7\u201311 (1993).","journal-title":"Am. J. Med. Genet."},{"key":"BFng099775_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/ajmg.1320320235","volume":"32","author":"JHM Knoll","year":"1989","unstructured":"Knoll, J.H.M. et al. Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion. Am. J. Med. Genet. 32, 285\u2013290 (1989).","journal-title":"Am. J. Med. Genet."},{"key":"BFng099775_CR12","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/ajmg.1320350308","volume":"35","author":"CA Williams","year":"1990","unstructured":"Williams, C.A. et al. Maternal origin of 15q11-13 deletions in Angelman syndrome suggests a role for genomic imprinting. Am. J. Med. Genet. 35, 350\u2013353 (1990).","journal-title":"Am. J. Med. Genet."},{"key":"BFng099775_CR13","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/0140-6736(91)90278-W","volume":"337","author":"S Malcolm","year":"1991","unstructured":"Malcolm, S. et al. Uniparental paternal disomy in Angelman's syndrome. Lancet 337, 694\u2013697 (1991).","journal-title":"Lancet"},{"key":"BFng099775_CR14","first-page":"741","volume":"54","author":"A Reis","year":"1994","unstructured":"Reis, A. et al. Imprinting mutations suggested by abnormal DNA methylation patterns in familial Angelman and Prader-Willi syndromes. Am. J. Hum. Genet. 54, 741\u2013747 (1994).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng099775_CR15","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s003359900479","volume":"8","author":"B Cattanach","year":"1997","unstructured":"Cattanach, B. et al. A mouse model of Angelman syndrome. Mamm. Genome 8, 472\u2013478 (1997).","journal-title":"Mamm. Genome"},{"key":"BFng099775_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1006\/bbrc.1993.2434","volume":"197","author":"B van Hille","year":"1993","unstructured":"van Hille, B., Vanek, M., Richener, H., Green, J.R. & Bilbe, G. Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H+-ATPase. Biochem. Biophys. Res. Commun. 197, 15\u201321 (1993).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFng099775_CR17","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1212\/WNL.41.3.416","volume":"41","author":"V Jay","year":"1991","unstructured":"Jay, V., Becker, I.E., Chan, F.-W. & Perry, T.L. Puppet-like syndrome of Angelman: a pathologic and neurochemical study. Neurology 41, 416\u2013422 (1991).","journal-title":"Neurology"},{"key":"BFng099775_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/BF00299421","volume":"83","author":"T Kyriakidas","year":"1992","unstructured":"Kyriakidas, T., Hallam, L.A., Hockey, A., Silberstein, P. & Kakulas, B.A. Angelman's syndrome: a neuropathological study. Acta Neuropathol. 83, 675\u2013678 (1992).","journal-title":"Acta Neuropathol."},{"key":"BFng099775_CR19","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1128\/MCB.13.2.775","volume":"13","author":"JM Huibregtse","year":"1993","unstructured":"Huibregtse, J.M., Scheffner, M. & Howley, P.M. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell Biol. 13, 775\u2013784 (1993).","journal-title":"Mol. Cell Biol."},{"key":"BFng099775_CR20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/373081a0","volume":"373","author":"M Scheffner","year":"1995","unstructured":"Scheffner, M., Nuber, U. & Huibregtse, J.M. Protein ubiquitinatipn involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373, 81\u201383 (1995).","journal-title":"Nature"},{"key":"BFng099775_CR21","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/371714a0","volume":"371","author":"TH Vu","year":"1994","unstructured":"Vu, T.H. & Hoffman, A.R. Promoter-specific imprinting of the human insulin-like growth factor-II gene. Nature 371, 714\u2013717 (1994).","journal-title":"Nature"},{"key":"BFng099775_CR22","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0092-8674(91)90513-X","volume":"64","author":"TM DeChiara","year":"1991","unstructured":"DeChiara, T.M., Robertson, E.J. & Efstratiadis, A. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64, 849\u2013859 (1991).","journal-title":"Cell"},{"key":"BFng099775_CR23","first-page":"23","volume-title":"Molecular and Cellular Methods in Developmental Toxicology","author":"U Albrecht","year":"1997","unstructured":"Albrecht, U., Eichele, G., Helms, J.A. & Lu, H.-C. Visualization of gene expression patterns by in situ hybridization. in Molecular and Cellular Methods in Developmental Toxicology (ed. Daston, G.P.) 23\u201348 (CRC Press, Boca Raton, FL 1997)."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0997-75","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0997-75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0997-75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:59:33Z","timestamp":1684443573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0997-75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["BFng099775"],"URL":"https:\/\/doi.org\/10.1038\/ng0997-75","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}