{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:17:57Z","timestamp":1790788677857,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1997,9]]},"DOI":"10.1038\/ng0997-84","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T16:27:51Z","timestamp":1092932871000},"page":"84-87","source":"Crossref","is-referenced-by-count":236,"title":["Mapping of a familial essential tremor gene, FET1, to chromosome 3q13"],"prefix":"10.1038","volume":"17","author":[{"given":"Jeffrey R.","family":"Gulcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00deorl\u00e1kur","family":"J\u00f3nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristleifur","family":"Kristj\u00e1nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Frigge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"K\u00e1rason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingibj\u00f6rg E.","family":"Einarsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hreinn","family":"Stef\u00e1nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Einarsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigr\u00fan","family":"Sigurdard\u00f0ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigur\u00f0ur","family":"Baldursson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3ley","family":"Bj\u00f6rnsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soff\u00eda M.","family":"Hrafnkelsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finnbogi","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Benedickz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1ri","family":"Stef\u00e1nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng099784_CR1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/brain\/117.4.805","volume":"117","author":"PG Bain","year":"1994","unstructured":"Bain, P.G. et al. A study of hereditary essential tremor. Brain 117, 805\u2013824 (1994).","journal-title":"Brain"},{"key":"BFng099784_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/00002826-199204000-00001","volume":"15","author":"WC Koller","year":"1992","unstructured":"Koller, W.C., Busenbark, K., Gray, C., Hassanein, R.S & Dubinsky, R. Classification of essential tremor. Clin. Neuropharmacol. 15, 81\u201387 (1992).","journal-title":"Clin. Neuropharmacol."},{"key":"BFng099784_CR3","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/ana.410350613","volume":"35","author":"WC Koller","year":"1994","unstructured":"Koller, W.C., Busenbark, K., Miner, K. & the Essential Tremor Study Group The relationship of essential tremor to other movement disorders: report on 678 patients. Ann. Neurol. 35, 717\u2013723 (1994).","journal-title":"Ann. Neurol."},{"key":"BFng099784_CR4","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1212\/WNL.45.4.645","volume":"45","author":"J Jankovic","year":"1995","unstructured":"Jankovic, J., Beach, J., Schwartz, K. & Constant, C. Tremor and longevity in relatives of patients with Parkinson's disease, essential tremor, and control subjects. Neurology 45, 645\u2013648 (1995).","journal-title":"Neurology"},{"key":"BFng099784_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1212\/WNL.44.1.61","volume":"44","author":"G Salemi","year":"1994","unstructured":"Salemi, G. et al. Prevalence of essential tremor: a door to door survey in Terrasini, Sicily. Neurology 44, 61\u201364 (1994).","journal-title":"Neurology"},{"key":"BFng099784_CR6","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1001\/archneur.1995.00540360079019","volume":"52","author":"ED Louis","year":"1995","unstructured":"Louis, E.D. et al. Differences in the prevalence of essential tremor among elderly African-Americans, whites, and Hispanics in northern Manhattan, NY. Arch. Neurol. 52, 1201\u20131205 (1995).","journal-title":"Arch. Neurol."},{"key":"BFng099784_CR7","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1212\/WNL.41.2_Part_1.234","volume":"41","author":"J-S Lou","year":"1991","unstructured":"Lou, J.-S. & Jankovic, J. Essential tremor: clinical correlates in 350 patients. Neurology 41, 234\u2013238 (1991).","journal-title":"Neurology"},{"key":"BFng099784_CR8","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1212\/WNL.41.12.1982","volume":"41","author":"KL Busenbark","year":"1991","unstructured":"Busenbark, K.L., Nash, J., Nash, S., Hubble, J.P. & Koller, W.C. Is essential tremor benign? Neurology 41, 1982\u20131983 (1991).","journal-title":"Neurology"},{"key":"BFng099784_CR9","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1212\/WNL.39.12.1587","volume":"39","author":"WC Koller","year":"1989","unstructured":"Koller, W.C. & Vetere-Overfield, B. Acute and chronic effects of propranolol and primidone in essential tremor. Neurology 39, 1587\u20131588 (1989).","journal-title":"Neurology"},{"key":"BFng099784_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/00002826-199002000-00007","volume":"13","author":"E Sasso","year":"1990","unstructured":"Sasso, E., Perucca, E., Fava, R. & Calzetti, S. Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. Clin. Neuropharmacol. 13, 67\u201376 (1990).","journal-title":"Clin. Neuropharmacol."},{"key":"BFng099784_CR11","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1136\/jnnp.32.6.509","volume":"32","author":"E Herskovitz","year":"1969","unstructured":"Herskovitz, E. & Blackwood, W. Essential tremor: a case report. J. Neurol. Neurosurg. Psychiatry 32, 509\u2013511 (1969).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"BFng099784_CR12","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1136\/jnnp.47.5.466","volume":"47","author":"AH Rajput","year":"1984","unstructured":"Rajput, A.H., Offord, K.P., Beard, C.M. & Kurland, L.T. Essential tremor in Rochester, Minnesota: a 45 year study. J. Neurol. Neurosurg. Psychiatry 47, 466\u2013470 (1984).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"BFng099784_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/ana.410340115","volume":"34","author":"IH Jenkins","year":"1993","unstructured":"Jenkins, I.H. et al. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann. Neurol. 34, 82\u201390 (1993).","journal-title":"Ann. Neurol."},{"key":"BFng099784_CR14","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/ana.410360413","volume":"36","author":"AJ Wills","year":"1994","unstructured":"Wills, A.J. et al. Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study. Ann. Neurol. 36, 636\u2013642 (1994).","journal-title":"Ann. Neurol."},{"key":"BFng099784_CR15","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/ana.410390515","volume":"39","author":"H Boecker","year":"1996","unstructured":"Boecker, H. et al. The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann. Neurol. 39, 650\u2013658 (1996).","journal-title":"Ann. Neurol."},{"key":"BFng099784_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0303-8467(95)00080-1","volume":"98","author":"JH Im","year":"1996","unstructured":"Im, J.H., Kim, J.S. & Lee, M.C. Disappearance of essential tremor after a small thalamic hemorrhage. Clin. Neurol. Neurosurg. 98, 40\u201342 (1996).","journal-title":"Clin. Neurol. Neurosurg."},{"key":"BFng099784_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/brain\/117.1.39","volume":"117","author":"TC Britton","year":"1994","unstructured":"Britton, T.C. et al. Rapid wrist movements in patients with essential tremor: the critical role of the second agonist burst. Brain 117, 39\u201347 (1994).","journal-title":"Brain"},{"key":"BFng099784_CR18","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1212\/WNL.46.5.1200","volume":"46","author":"ED Louis","year":"1996","unstructured":"Louis, E.D.&, Ottman, R. How familial is familial tremor?The genetic epidemiology of essential tremor. Neurology 46, 1200\u20131205 (1996).","journal-title":"Neurology"},{"key":"BFng099784_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/brain\/72.2.113","volume":"72","author":"M Critchley","year":"1949","unstructured":"Critchley, M. Observations on essential (heredofamilial) tremor. Brain  72, 113\u2013139 (1949).","journal-title":"Brain"},{"key":"BFng099784_CR20","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1212\/WNL.43.11.2212","volume":"43","author":"A D\u00fcrr","year":"1993","unstructured":"D\u00fcrr, A. et al. Familial essential tremor and idiopathic torsion dystonia are different genetic entities. Neurology 43, 2212\u20132214 (1993).","journal-title":"Neurology"},{"key":"BFng099784_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1001\/archneur.1997.00550150047015","volume":"54,","author":"J Jankovic","year":"1997","unstructured":"Jankovic, J., Beach, J., Pandolfo, M. & Patel, P.I. Familial essential tremor in four kindreds. Arch. Neurol. 54,, 289\u2013294 (1997).","journal-title":"Arch. Neurol."},{"key":"BFng099784_CR22","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/mds.870080324","volume":"8","author":"D Conway","year":"1993","unstructured":"Conway, D. et al. Linkage analysis with chromosome 9 markers in hereditary essential tremor. Mov. Disord. 8, 374\u2013376 (1993).","journal-title":"Mov. Disord."},{"key":"BFng099784_CR23","first-page":"1","volume-title":"Handbook of Tremor Disorders","author":"LJ Findley","year":"1994","unstructured":"Findley, L.J. & Koller, W.C. Definitions and behavioral classifications, in Handbook of Tremor Disorders. (eds Findley, L J. & Koller, W.C.) 1\u20135 (Dekker, New York, 1994)."},{"key":"BFng099784_CR24","first-page":"1347","volume":"58","author":"L Kruglyak","year":"1996","unstructured":"Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and nonparametric analysis: a unified multipoint approach. Am. J. Hum. Genet. 58, 1347\u20131363 (1996).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng099784_CR25","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng1195-241","volume":"11","author":"E Lander","year":"1995","unstructured":"Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241\u2013247 (1995).","journal-title":"Nature Genet."},{"key":"BFng099784_CR26","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1212\/WNL.46.2.458","volume":"46","author":"RW Baloh","year":"1996","unstructured":"Baloh, R.W., Foster, C.A., Yue, Q. & Nelson, S.F. Familial migraine with vertigo and essential tremor. Neurology 46, 458\u2013460 (1996).","journal-title":"Neurology"},{"key":"BFng099784_CR27","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1136\/jnnp.56.8.868","volume":"56","author":"PG Bain","year":"1993","unstructured":"Bain, P.G. etal. Assessing tremor severity. J. Neurol. Neurosurg. Psychiatry 56, 868\u2013873 (1993).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"BFng099784_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/BF00870673","volume":"24","author":"PG Bain","year":"1993","unstructured":"Bain, P.G., Mally, J., Gresty, M. & Findley, L.J. Assessing the impact of essential tremor on upper limb function. J. Neurol. 24, 54\u201361 (1993).","journal-title":"J. Neurol."},{"key":"BFng099784_CR29","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/380152a0","volume":"380","author":"C Dib","year":"1996","unstructured":"Dib, C. et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380, 152\u2013154 (1996).","journal-title":"Nature"},{"key":"BFng099784_CR30","doi-asserted-by":"publisher","first-page":"118","DOI":"10.2307\/2533202","volume":"50","author":"AS Whittemore","year":"1994","unstructured":"Whittemore, A.S. & Halpern, J. A class of tests for linkage using affected pedigree members. Biometrics 50, 118\u2013127 (1994).","journal-title":"Biometrics"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0997-84","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0997-84.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0997-84.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T20:59:34Z","timestamp":1684443574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0997-84"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["BFng099784"],"URL":"https:\/\/doi.org\/10.1038\/ng0997-84","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}