{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:22:57Z","timestamp":1790979777962,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1993,11]]},"DOI":"10.1038\/ng1193-217","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:43:46Z","timestamp":1092861826000},"page":"217-224","source":"Crossref","is-referenced-by-count":256,"title":["Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning"],"prefix":"10.1038","volume":"5","author":[{"given":"Jim","family":"McWhir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Selfridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshana","family":"Squires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Melton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng1193217_CR1","volume-title":"DNA repair","author":"EC Friedberg","year":"1985","unstructured":"Friedberg, E.C. in DNA repair (W.H. Freeman, San Francisco, 1985)."},{"key":"BFng1193217_CR2","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/362709a0","volume":"362","author":"T Lindahl","year":"1993","unstructured":"Lindahl, T. Instability and decay of the primary structure of DNA. Nature 362, 709\u2013715 (1993).","journal-title":"Nature"},{"key":"BFng1193217_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/bies.950150405","volume":"15","author":"G Weeda","year":"1993","unstructured":"Weeda, G., Hoeijmakers, J.H.J. & Bootsma, D. Genes controlling nucleotide excision repair in eukaryotic cells. BioEssays 15, 249\u2013258 (1993).","journal-title":"BioEssays"},{"key":"BFng1193217_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0921-8777(93)90062-L","volume":"293","author":"ARS Collins","year":"1993","unstructured":"Collins, A.R.S. Mutant rodent cell lines sensitive to UV ionizing radiation and cross linking agents: a comprehensive survey of genetic and biochemical characteristics. Mut. Res. DNA repair 293, 99\u2013118 (1993).","journal-title":"Mut. Res. DNA repair"},{"key":"BFng1193217_CR5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/mutage\/4.5.349","volume":"4","author":"D Busch","year":"1989","unstructured":"Busch, D. et al. Summary of complementation groups of uv-sensitive CHO cell mutants isolated by large scale screening. Mutagenesis 4, 349\u2013354 (1989).","journal-title":"Mutagenesis"},{"key":"BFng1193217_CR6","first-page":"2949","volume-title":"The Metabolic Basis of Inherited Disease","author":"JE Cleaver","year":"1989","unstructured":"Cleaver, J.E. & Kraemer, K.H. in The Metabolic Basis of Inherited Disease Vol. 2 (eds Scriver, C.R. et al.) 2949\u20132971 (McGraw Hill, New York, 1989)."},{"key":"BFng1193217_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1073\/pnas.89.1.261","volume":"89","author":"WL Flejter","year":"1992","unstructured":"Flejter, W.L., McDaniel, L.D., Johns, D., Friedberg, E.C. & Schultz, R.A. Correction of xeroderma pigmentosum complementation group D mutant cell phenotypes by chromosome and gene transfer: Involvement of the human ERCC2 DNA repair gene. Proc. natn. Acad. Sci. U.S.A. 89, 261\u2013265 (1992).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BFng1193217_CR8","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/0092-8674(90)90122-U","volume":"62","author":"G Weeda","year":"1990","unstructured":"Weeda, G. et al. A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome. Cell 62, 777\u2013791 (1990).","journal-title":"Cell"},{"key":"BFng1193217_CR9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/363185a0","volume":"363","author":"A O'Donovan","year":"1993","unstructured":"O'Donovan, A. & Wood, R.D. Identical defects in DNA repair in xeroderma pigmentosum group G and rodent ERCC group 5. Nature 363, 185\u2013188 (1993).","journal-title":"Nature"},{"key":"BFng1193217_CR10","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/0092-8674(92)90390-X","volume":"71","author":"C Troelstra","year":"1992","unstructured":"Troelstra, C., Van Gool, A., de Wit, J., Vermeulen, W. & Hoeijmakers, J.H.J. ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes. Cell 71, 939\u2013953 (1992).","journal-title":"Cell"},{"key":"BFng1193217_CR11","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1002\/j.1460-2075.1993.tb06043.x","volume":"12","author":"M Biggerstaff","year":"1993","unstructured":"Biggerstaff, M., Szymowski, D.E. & Wood, R.D. Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro. EMBO J. 12, 3685\u20133692 (1993).","journal-title":"EMBO J."},{"key":"BFng1193217_CR12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/310425a0","volume":"310","author":"A Westerveld","year":"1984","unstructured":"Westerveld, A. et al. Molecular cloning of a human DNA repair gene. Nature 310, 425\u2013429 (1984).","journal-title":"Nature"},{"key":"BFng1193217_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0921-8777(89)90059-1","volume":"217","author":"M van Duin","year":"1989","unstructured":"van Duin, M. et al. The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I. Mutat. Res. 217, 83\u201392 (1989).","journal-title":"Mutat. Res."},{"key":"BFng1193217_CR14","doi-asserted-by":"publisher","first-page":"5305","DOI":"10.1093\/nar\/16.12.5305","volume":"16","author":"M van Duin","year":"1988","unstructured":"van Duin, M. et al. Evolution and mutagenesis of the mammalian excision repair gene ERCC-1. Nucl. Acids Res. 16, 5305\u20135322 (1988).","journal-title":"Nucl. Acids Res."},{"key":"BFng1193217_CR15","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1016\/S0021-9258(19)50510-5","volume":"267","author":"M Biggerstaff","year":"1992","unstructured":"Biggerstaff, M. & Wood, R.D. Requirement for ERCC-1 and ERCC-3 gene products in DNA excision repair in vitro: complementation using rodent and human cell extracts. J. biol. Chem. 267, 6879\u20136885 (1992).","journal-title":"J. biol. Chem."},{"key":"BFng1193217_CR16","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1128\/MCB.10.6.2485","volume":"10","author":"RH Schiestl","year":"1990","unstructured":"Schiestl, R.H. & Prakash, S.A. RAD10, an excision repair gene of Saccharomyces cerevisiae, is involved in the RAD1 pathway of mitotic recombination. Molec. Cell. Biol. 10, 2485\u20132491 (1990).","journal-title":"Molec. Cell. Biol."},{"key":"BFng1193217_CR17","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/362860a0","volume":"362","author":"AE Tomkinson","year":"1993","unstructured":"Tomkinson, A.E., Bardwell, A.J., Bardwell, L., Tappe, N.J. & Friedberg, E.C. Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease. Nature 362, 860\u2013862 (1993).","journal-title":"Nature"},{"key":"BFng1193217_CR18","doi-asserted-by":"publisher","first-page":"5633","DOI":"10.1093\/nar\/19.20.5633","volume":"19","author":"PBGM Belt","year":"1991","unstructured":"Belt, P.B.G.M., Van Oosterwijk, M.F., Odijk, H., Hoeijmakers, J.H.J. & Backendorf, C. Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene. Nucl. Acids Res. 19, 5633\u20135637 (1991).","journal-title":"Nucl. Acids Res."},{"key":"BFng1193217_CR19","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/0092-8674(92)90621-I","volume":"69","author":"KD Gulyas","year":"1992","unstructured":"Gulyas, K.D. & Donahue, T.F. SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3. Cell 69, 1031\u20131042 (1992).","journal-title":"Cell"},{"key":"BFng1193217_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.8465201","volume":"260","author":"LS Schaeffer","year":"1993","unstructured":"Schaeffer, L.S. et al. DNA repair helicase: a component of BTF2(TFIIH) basic transcription factor. Science 260, 58\u201363 (1993).","journal-title":"Science"},{"key":"BFng1193217_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/bies.950120205","volume":"12","author":"DL Mitchell","year":"1990","unstructured":"Mitchell, D.L. & Hartman, P.S. The regulation of DNA repair during development. BioEssays 12, 74\u201379 (1990).","journal-title":"BioEssays"},{"key":"BFng1193217_CR22","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/0092-8674(92)90421-8","volume":"70","author":"B Vogelstein","year":"1992","unstructured":"Vogelstein, B. & Kinzler, K.W. p53 function and dysfunction. Cell 70, 523\u2013526 (1992).","journal-title":"Cell"},{"key":"BFng1193217_CR23","first-page":"6304","volume":"51","author":"MB Kastan","year":"1991","unstructured":"Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B. & Craig, R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304\u20136311 (1991).","journal-title":"Cancer Res."},{"key":"BFng1193217_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/358015a0","volume":"358","author":"DP Lane","year":"1992","unstructured":"Lane, D.P. p53, guardian of the genome. Nature 358, 15\u201316 (1992).","journal-title":"Nature"},{"key":"BFng1193217_CR25","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/BF01235756","volume":"18","author":"J Selfridge","year":"1992","unstructured":"Selfridge, J., Pow, A.M., McWhir, J., Magin, T.M. & Melton, D.W. Gene targeting using a mouse HPRT minigene\/HPRT-deficient embryonic stem cell system: Inactivation of the mouse ERCC-1 gene. Som. Cell molec. Genet. 18, 325\u2013336 (1992).","journal-title":"Som. Cell molec. Genet."},{"key":"BFng1193217_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0921-8777(90)90069-H","volume":"235","author":"JD Regan","year":"1990","unstructured":"Regan, J.D. et al. Cyclobutane\u2014pyrimidine dimer excision in UV-sensitive CHO mutants and the effect of the ERCC2 repair gene. Mut. Res. 235, 157\u2013160 (1990).","journal-title":"Mut. Res."},{"key":"BFng1193217_CR27","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0027-5107(82)90273-1","volume":"95","author":"S Squires","year":"1982","unstructured":"Squires, S., Johnson, R.T. & Collins, A.R.S. Initial rates of DNA incision in UV-irradiated human cells. Differences between normal, XP and tumour cells. Mut Res. 95, 389\u2013404 (1982).","journal-title":"Mut Res."},{"key":"BFng1193217_CR28","doi-asserted-by":"publisher","first-page":"9195","DOI":"10.1093\/nar\/15.22.9195","volume":"15","author":"M van Duin","year":"1987","unstructured":"van Duin, M. et al. Genomic characterisation of the human DNA excision repair gene ERCC-1. Nucl. Acids Res. 15, 9195\u20139213 (1987).","journal-title":"Nucl. Acids Res."},{"key":"BFng1193217_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1242\/jcs.101.1.183","volume":"101","author":"CA Midgley","year":"1992","unstructured":"Midgley, C.A. et al. Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli. J. cell Sci. 101, 183\u2013189 (1992).","journal-title":"J. cell Sci."},{"key":"BFng1193217_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev.bi.57.070188.000333","volume":"57","author":"A Sancar","year":"1988","unstructured":"Sancar, A. & Sancar, G.B. DNA repair enzymes. A. Rev. Biochem. 57, 29\u201367 (1988).","journal-title":"A. Rev. Biochem."},{"key":"BFng1193217_CR31","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1016\/S0021-9258(18)83715-2","volume":"264","author":"JM Voigt","year":"1989","unstructured":"Voigt, J.M., van Houten, B., Sancar, A. & Topal, M.D. Repair of O6-methylguanine by abc excinuclease of E. coli in vitro. J. biol. Chem. 264, 5172\u20135176 (1989).","journal-title":"J. biol. Chem."},{"key":"BFng1193217_CR32","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/0921-8777(90)90068-G","volume":"235","author":"WK Yoke","year":"1990","unstructured":"Yoke, W.K., Wallace, S.S. & van Houten, B. uvr ABC nuclease complex repairs thymine glycol, an oxidative DNA base damage. Mut. Res. 235, 147\u2013156 (1990).","journal-title":"Mut. Res."},{"key":"BFng1193217_CR33","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1002\/ana.410320703","volume":"32","author":"CW Olanow","year":"1992","unstructured":"Olanow, C.W. An introduction to the free radical hypothesis in Parkinson's disease. Ann. Neurol. 32, S2\u2013S9 (1992).","journal-title":"Ann. Neurol."},{"key":"BFng1193217_CR34","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1136\/jcp.42.6.624","volume":"42","author":"DJ Harrison","year":"1989","unstructured":"Harrison, D.J., Kharbanda, R., Cunningham, D.S., McLellan, L.I. & Hayes, J.D. Distribution of glutathione S-transferase isoenzymes in human kidney. J. clin. Pathol. 42, 624\u2013 628 (1989).","journal-title":"J. clin. Pathol."},{"key":"BFng1193217_CR35","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/2141050a0","volume":"214","author":"CJ Epstein","year":"1967","unstructured":"Epstein, C.J. & Gatens, E.A. Nuclear ploidy in mammalian parenchymal liver cells. Nature 214, 1050\u20131051 (1967).","journal-title":"Nature"},{"key":"BFng1193217_CR36","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1042\/bj2900637","volume":"290","author":"R Pinkus","year":"1993","unstructured":"Pinkus, R., Bergelson, S. & Daniel, V. Phenobarbitol induction of AP1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression. Biochem. J. 290, 637\u2013640 (1993).","journal-title":"Biochem. J."},{"key":"BFng1193217_CR37","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/362849a0","volume":"362","author":"AR Clarke","year":"1993","unstructured":"Clarke, A.R. et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849\u2013852 (1993).","journal-title":"Nature"},{"key":"BFng1193217_CR38","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/336688a0","volume":"336","author":"AG Smith","year":"1988","unstructured":"Smith, A.G. et al. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336, 688\u2013690 (1988).","journal-title":"Nature"},{"key":"BFng1193217_CR39","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/309255a0","volume":"309","author":"A Bradley","year":"1984","unstructured":"Bradley, A., Evans, M., Kaufman, M.H. & Robertson, E. Formation of germline chimaeras from embryo-derived teratocarcinoma cells. Nature 309, 255\u2013258 (1984).","journal-title":"Nature"},{"key":"BFng1193217_CR40","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0092-8674(89)90905-7","volume":"56","author":"S Thompson","year":"1989","unstructured":"Thompson, S., Clarke, A.R., Pow, A.M., Hooper, M.L. & Melton, D.W. Germline transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell 56, 313\u2013321 (1989).","journal-title":"Cell"},{"key":"BFng1193217_CR41","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.1093\/nar\/12.14.5609","volume":"12","author":"JR Jenkins","year":"1984","unstructured":"Jenkins, J.R., Rudge, K., Redmond, S. & Wadeevans, A. Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53. Nucl. Acids Res. 12, 5609\u20135626 (1984).","journal-title":"Nucl. Acids Res."},{"key":"BFng1193217_CR42","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0021-9258(19)70080-5","volume":"256","author":"AJ Minty","year":"1981","unstructured":"Minty, A.J. et al. Construction and characterisation of a recombinant plasmid molecule containing a complementary DNA transcript of mouse \u03b1 actin mRNA. J. biol. Chem. 256, 1008\u20131014 (1981).","journal-title":"J. biol. Chem."},{"key":"BFng1193217_CR43","first-page":"69","volume-title":"Flow Cytometry","author":"MG Ormerod","year":"1990","unstructured":"Ormerod, M.G. . in Flow Cytometry (ed. Ormerod, M.G.) 69\u201386 (IRL Press, Oxford, 1990)."},{"key":"BFng1193217_CR44","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cyto.990130202","volume":"13","author":"G Brugal","year":"1992","unstructured":"Brugal, G. et al. HOME: Highly optimized microscope environment. Cytometry 13, 109\u2013116 (1992).","journal-title":"Cytometry"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1193-217","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1193-217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1193-217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T21:18:54Z","timestamp":1684444734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1193-217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["BFng1193217"],"URL":"https:\/\/doi.org\/10.1038\/ng1193-217","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}