{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:27:09Z","timestamp":1790980029128,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1997,12]]},"DOI":"10.1038\/ng1297-483","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T20:35:28Z","timestamp":1092861328000},"page":"483-486","source":"Crossref","is-referenced-by-count":119,"title":["DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus"],"prefix":"10.1038","volume":"17","author":[{"given":"Chamelli","family":"Jhappan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Herbert C.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Gottesman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng1297483_CR1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/301527a0","volume":"301","author":"GC Bosma","year":"1983","unstructured":"Bosma, G.C., Custer, R.P. & Bosma, M.J. A severe combined immunodeficiency mutation in the mouse. Nature. 301, 527\u2013530 (1983).","journal-title":"Nature."},{"key":"BFng1297483_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0065-2776(08)60886-X","volume":"64","author":"M Gellert","year":"1997","unstructured":"Gellert, M. Recent advances in understanding V(D)J recombination. Adv. Immunol. 64, 39\u201364 (1997).","journal-title":"Adv. Immunol."},{"key":"BFng1297483_CR3","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/347479a0","volume":"347","author":"GM Fulop","year":"1990","unstructured":"Fulop, G.M. & Phillips, R.A. The scid mutation in mice causes a general defect in DNA repair. Nature. 347, 479\u2013482 (1990).","journal-title":"Nature."},{"key":"BFng1297483_CR4","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1073\/pnas.88.4.1394","volume":"88","author":"KA Biedermann","year":"1991","unstructured":"Biedermann, K.A., Sun, J.R., Giaccia, A.J., Tosto, L.M. & Brown, J.M. Scid mutation in mice confers hypersensitivity to ionizing radiationand a deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sd. USA 88, 1394\u20131397 (1991).","journal-title":"Proc. Natl. Acad. Sd. USA"},{"key":"BFng1297483_CR5","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1073\/pnas.88.10.4061","volume":"88","author":"EA Hendrickson","year":"1991","unstructured":"Hendrickson, E.A. et al. A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc. Natl. Acad. Sci. USA. 88, 4061\u20134065 (1991).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"BFng1297483_CR6","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/0092-8674(95)90360-7","volume":"80","author":"T Blunt","year":"1995","unstructured":"Blunt, T. et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813\u2013823 (1995).","journal-title":"Cell"},{"key":"BFng1297483_CR7","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1126\/science.7855601","volume":"267","author":"CU Kirchgessner","year":"1995","unstructured":"Kirchgessner, C.U. et al. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267, 1178\u20131183 (1995).","journal-title":"Science"},{"key":"BFng1297483_CR8","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1073\/pnas.92.8.3171","volume":"92","author":"SR Peterson","year":"1995","unstructured":"Peterson, S.R. et al. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA 92, 3171\u20133174 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1297483_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0092-8674(93)90057-W","volume":"72","author":"TM Gottlieb","year":"1993","unstructured":"Gottlieb, T.M. & Jackson, S.P., The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131\u2013142 (1993).","journal-title":"Cell"},{"key":"BFng1297483_CR10","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0092-8674(00)80111-7","volume":"86","author":"C Zhu","year":"1996","unstructured":"Zhu, C., Bogue, M.A., Lim, D.S., Hasty, P., & Roth, D.B. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86, 379\u2013389 (1996).","journal-title":"Cell"},{"key":"BFng1297483_CR11","doi-asserted-by":"publisher","first-page":"10285","DOI":"10.1073\/pnas.93.19.10285","volume":"93","author":"T Blunt","year":"1996","unstructured":"Blunt, T. et al. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl. Acad. Sci. USA 93, 10285\u201310290 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1297483_CR12","doi-asserted-by":"publisher","first-page":"5507","DOI":"10.1128\/MCB.16.10.5507","volume":"16","author":"JS Danska","year":"1996","unstructured":"Danska, J.S., Holland, D.P., Mariathasan, S., Williams, K.M. & Guidos, C.J. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol. Cell. Biol. 16, 5507\u20135517 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1297483_CR13","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1073\/pnas.94.6.2438","volume":"94","author":"R Araki","year":"1997","unstructured":"Araki, R. et al. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc. Natl. Acad. Sci. USA 94, 2438\u20132443 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1297483_CR14","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.4049\/jimmunol.158.8.3565","volume":"158","author":"EK Shin","year":"1997","unstructured":"Shin, E.K., Perryman, L.E. & Meek, K. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation.J. Immunol. 158, 3565\u20133569 (1997).","journal-title":"J. Immunol."},{"key":"BFng1297483_CR15","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/386761a0","volume":"386","author":"KW Kinzler","year":"1997","unstructured":"Kinzler, K.W. & Vogelstein, B. Gatekeepers and caretakers. Nature. 386, 761\u2013763 (1997).","journal-title":"Nature."},{"key":"BFng1297483_CR16","first-page":"13","volume":"16","author":"SJ Strada","year":"1984","unstructured":"Strada, S.J., Martin, M.W. & Thompson, W.J. General properties of multiple molecular forms of cyclic nucleotide phosphodiesterase in the nervous system. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 16, 13\u201329 (1984).","journal-title":"Adv. Cyclic Nucleotide Protein Phosphorylation Res."},{"key":"BFng1297483_CR17","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1016\/S0021-9258(17)39823-X","volume":"259","author":"K Suoranta","year":"1984","unstructured":"Suoranta, K. & Londesborough, J. Purification of intact and nicked forms of a zinc-containing, Mg2+-dependent, low Km cyclic AMP phosphodiesterase from bakers' yeast. J. Biol. Chem. 259, 6964\u20136971 (1984).","journal-title":"J. Biol. Chem."},{"key":"BFng1297483_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/0092-8674(88)90414-X","volume":"52","author":"N Sarvetnick","year":"1988","unstructured":"Sarvetnick, N., Liggitt, D., Pitts, S.L., Hansen, S.E. & Stewart, T.A. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52, 773\u2013782 (1988).","journal-title":"Cell"},{"key":"BFng1297483_CR19","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/0092-8674(90)90076-Q","volume":"61","author":"C Jhappan","year":"1990","unstructured":"Jhappan, C. et al. TGF\u03b1 overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61, 1137\u20131146 (1990).","journal-title":"Cell"},{"key":"BFng1297483_CR20","doi-asserted-by":"publisher","first-page":"10792","DOI":"10.1073\/pnas.92.23.10792","volume":"92","author":"RD Miller","year":"1995","unstructured":"Miller, R.D. et al. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc. Natl. Acad. Sci. USA 92, 10792\u201310795 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1297483_CR21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1073\/pnas.92.1.320","volume":"92","author":"NJ Finnie","year":"1995","unstructured":"Finnie, N.J., Gottlieb, T.M., Blunt, T., Jeggo, P.A. & Jackson, S.P. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 92, 320\u2013324 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFng1297483_CR22","first-page":"283","volume":"2","author":"CW Anderson","year":"1992","unstructured":"Anderson, C.W. & Lees-Miller, S.P. The nuclear serine\/threonine protein kinase DNA-PK. Crit. Rev. Eukaryotic Gene Express. 2, 283\u2013314 (1992).","journal-title":"Crit. Rev. Eukaryotic Gene Express."},{"key":"BFng1297483_CR23","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1128\/MCB.12.11.5041","volume":"12","author":"SP Lees-Miller","year":"1992","unstructured":"Lees-Miller, S.P., Sakaguchi, K., Ullrich, S.J., Appella, E. & Anderson, C.W., Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol. 12, 5041\u20135049 (1992).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1297483_CR24","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0092-8674(95)90482-4","volume":"82","author":"KO Hartley","year":"1995","unstructured":"Hartley, K.O. et al. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849\u2013856 (1995).","journal-title":"Cell"},{"key":"BFng1297483_CR25","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/382551a0","volume":"382","author":"A Nussenzweig","year":"1996","unstructured":"Nussenzweig, A. et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 382, 551\u2013555 (1996).","journal-title":"Nature."},{"key":"BFng1297483_CR26","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.4049\/jimmunol.143.4.1087","volume":"143","author":"AM Carroll","year":"1989","unstructured":"Carroll, A.M., Hardy, R.R. & Bosma, M.J. Occurrence of mature B (IGM+, B220+) and T (CD3+) lymphocytes in scid mice. J. Immunol. 143, 1087\u20131093 (1989).","journal-title":"J. Immunol."},{"key":"BFng1297483_CR27","first-page":"464","volume":"120","author":"RP Custer","year":"1985","unstructured":"Custer, R.P., Bosma, G.C. & Bosma, M.J. Severe combined immunodeficiency (SCID) in the mouse: pathology, reconstitution, neoplasms. Am. J. Pathol. 120, 464\u2013477 (1985).","journal-title":"Am. J. Pathol."},{"key":"BFng1297483_CR28","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1126\/science.7792600","volume":"268","author":"K Savitsky","year":"1995","unstructured":"Savitsky, K. et al. A single ataxia telangiectasia gene with a product similar to Pl-3 kinase. Science. 268, 1749\u20131753 (1995).","journal-title":"Science."},{"key":"BFng1297483_CR29","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S0092-8674(00)81302-1","volume":"85","author":"R Hakem","year":"1996","unstructured":"Hakem, R. et al. The tumor suppressor gene Brcal is required for embryonic cellular proliferation in the mouse. Cell 85, 1009\u20131023 (1996).","journal-title":"Cell"},{"key":"BFng1297483_CR30","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/386804a0","volume":"386","author":"SK Sharan","year":"1997","unstructured":"Sharan, S.K. et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804\u2013810 (1997).","journal-title":"Nature"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1297-483","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1297-483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1297-483.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T06:02:32Z","timestamp":1705212152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1297-483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["BFng1297483"],"URL":"https:\/\/doi.org\/10.1038\/ng1297-483","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]}}}