{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:04:32Z","timestamp":1791353072596,"version":"4.3.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2009,5,24]],"date-time":"2009-05-24T00:00:00Z","timestamp":1243123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1038\/ni.1737","type":"journal-article","created":{"date-parts":[[2009,5,24]],"date-time":"2009-05-24T13:07:03Z","timestamp":1243170423000},"page":"706-712","source":"Crossref","is-referenced-by-count":477,"title":["Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide\u2013MHC class II complexes to CD4+ T cells"],"prefix":"10.1038","volume":"10","author":[{"given":"Tomohiro","family":"Yoshimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koubun","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehisa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakiyo","family":"Nakahira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutomo","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,24]]},"reference":[{"key":"BFni1737_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/00062752-200001000-00007","volume":"7","author":"SJ Galli","year":"2000","unstructured":"Galli, S.J. Mast cells and basophils. Curr. Opin. Hematol. 7, 32\u201339 (2000).","journal-title":"Curr. Opin. Hematol."},{"key":"BFni1737_CR2","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","volume":"23","author":"SJ Galli","year":"2005","unstructured":"Galli, S.J. et al. Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: recent advances. Annu. Rev. Immunol. 23, 749\u2013786 (2005).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1737_CR3","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nri914","volume":"2","author":"T Kawakami","year":"2002","unstructured":"Kawakami, T. & Galli, S.J. Regulation of mast-cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2, 773\u2013786 (2002).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni1737_CR4","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.4049\/jimmunol.158.6.2517","volume":"158","author":"CS Lantz","year":"1997","unstructured":"Lantz, C.S. et al. IgE regulates mouse basophil Fc\u03b5RI expression in vivo. J. Immunol. 158, 2517\u20132521 (1997).","journal-title":"J. Immunol."},{"key":"BFni1737_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1084\/jem.185.4.663","volume":"185","author":"M Yamaguchi","year":"1997","unstructured":"Yamaguchi, M. et al. IgE enhances mouse mast cell Fc\u03b5RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J. Exp. Med. 185, 663\u2013672 (1997).","journal-title":"J. Exp. Med."},{"key":"BFni1737_CR6","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1067\/mai.2000.108431","volume":"106","author":"SS Saini","year":"2000","unstructured":"Saini, S.S. et al. The relationship between serum IgE and surface levels of Fc\u03b5R on human leukocytes in various diseases: correlation of expression with Fc\u03b5RI on basophils but not on monocytes or eosinophils. J. Allergy Clin. Immunol. 106, 514\u2013520 (2000).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFni1737_CR7","doi-asserted-by":"publisher","first-page":"18105","DOI":"10.1073\/pnas.0509148102","volume":"102","author":"Y Arinobu","year":"2005","unstructured":"Arinobu, Y. et al. Developmental checkpoints of the basophil\/mast cell lineages in adult murine hematopoiesis. Proc. Natl. Acad. Sci. USA 102, 18105\u201318110 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1737_CR8","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1164\/ajrccm.161.5.9908090","volume":"161","author":"GM Gauvreau","year":"2000","unstructured":"Gauvreau, G.M. et al. Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am. J. Respir. Crit. Care Med. 161, 1473\u20131478 (2000).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFni1737_CR9","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S0091-6749(98)70248-9","volume":"101","author":"AM Irani","year":"1998","unstructured":"Irani, A.M. et al. Immunohistochemical detection of human basophils in late-phase skin reactions. J. Allergy Clin. Immunol. 101, 354\u2013362 (1998).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFni1737_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3109\/02770909609054536","volume":"33","author":"T Koshino","year":"1996","unstructured":"Koshino, T. et al. Airway basophil and mast cell density in patients with bronchial asthma: relationship to bronchial hyperresponsiveness. J. Asthma 33, 89\u201395 (1996).","journal-title":"J. Asthma"},{"key":"BFni1737_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0091-6749(00)90184-2","volume":"105","author":"AJ Macfarlane","year":"2000","unstructured":"Macfarlane, A.J. et al. Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin. J. Allergy Clin. Immunol. 105, 99\u2013107 (2000).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFni1737_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nri2458","volume":"9","author":"H Karasuyama","year":"2009","unstructured":"Karasuyama, H., Mukai, K., Tsujimura, Y. & Obata, K. Nat. Rev. Immunol. 9, 9\u201313 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni1737_CR13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.immuni.2005.06.011","volume":"23","author":"K Mukai","year":"2005","unstructured":"Mukai, K. et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23, 191\u2013202 (2005).","journal-title":"Immunity"},{"key":"BFni1737_CR14","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.immuni.2008.02.008","volume":"28","author":"Y Tsujimura","year":"2008","unstructured":"Tsujimura, Y. et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28, 581\u2013589 (2008).","journal-title":"Immunity"},{"key":"BFni1737_CR15","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/ni.f.217","volume":"9","author":"B Min","year":"2008","unstructured":"Min, B. Basophils: what they 'can do' versus what they 'actually do'. Nat. Immunol. 9, 1333\u20131339 (2008).","journal-title":"Nat. Immunol."},{"key":"BFni1737_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2332\/allergolint.55.99","volume":"55","author":"B Min","year":"2006","unstructured":"Min, B., Le Gros, G. & Paul, W.E. Basophils: a potential liaison between innate and adaptive immunity. Allergol. Int. 55, 99\u2013104 (2006).","journal-title":"Allergol. Int."},{"key":"BFni1737_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/MOH.0b013e3282f13ce8","volume":"15","author":"B Min","year":"2008","unstructured":"Min, B. & Paul, W.E. Basophils and type 2 immunity. Curr. Opin. Hematol. 15, 59\u201363 (2008).","journal-title":"Curr. Opin. Hematol."},{"key":"BFni1737_CR18","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1084\/jem.20040590","volume":"200","author":"B Min","year":"2004","unstructured":"Min, B. et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200, 507\u2013517 (2004).","journal-title":"J. Exp. Med."},{"key":"BFni1737_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.immuni.2008.12.006","volume":"30","author":"BM Sullivan","year":"2009","unstructured":"Sullivan, B.M. & Locksley, R.M. Basophils: a nonredundant contributor to host immunity. Immunity 30, 12\u201320 (2009).","journal-title":"Immunity"},{"key":"BFni1737_CR20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1074-7613(04)00026-3","volume":"20","author":"D Voehringer","year":"2004","unstructured":"Voehringer, D., Shinkai, K. & Locksley, R.M. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20, 267\u2013277 (2004).","journal-title":"Immunity"},{"key":"BFni1737_CR21","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1359-6101(00)00015-0","volume":"12","author":"K Nakanishi","year":"2001","unstructured":"Nakanishi, K., Yoshimoto, T., Tsutsui, H. & Okamura, H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 12, 53\u201372 (2001).","journal-title":"Cytokine Growth Factor Rev."},{"key":"BFni1737_CR22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1146\/annurev.immunol.19.1.423","volume":"19","author":"K Nakanishi","year":"2001","unstructured":"Nakanishi, K., Yoshimoto, T., Tsutsui, H. & Okamura, H. Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19, 423\u2013474 (2001).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1737_CR23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","volume":"21","author":"K Takeda","year":"2003","unstructured":"Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335\u2013376 (2003).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1737_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nri1001","volume":"3","author":"G Trinchieri","year":"2003","unstructured":"Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133\u2013146 (2003).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni1737_CR25","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1146\/annurev.iy.12.040194.003223","volume":"12","author":"RA Seder","year":"1994","unstructured":"Seder, R.A. & Paul, W.E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12, 635\u2013673 (1994).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1737_CR26","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1084\/jem.179.4.1285","volume":"179","author":"T Yoshimoto","year":"1994","unstructured":"Yoshimoto, T. & Paul, W.E. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285\u20131295 (1994).","journal-title":"J. Exp. Med."},{"key":"BFni1737_CR27","doi-asserted-by":"publisher","first-page":"13962","DOI":"10.1073\/pnas.96.24.13962","volume":"96","author":"T Yoshimoto","year":"1999","unstructured":"Yoshimoto, T. et al. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc. Natl. Acad. Sci. USA 96, 13962\u201313966 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1737_CR28","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/intimm\/dxn037","volume":"20","author":"Y Kondo","year":"2008","unstructured":"Kondo, Y. et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int. Immunol. 20, 791\u2013800 (2008).","journal-title":"Int. Immunol."},{"key":"BFni1737_CR29","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ni1558","volume":"9","author":"CL Sokol","year":"2008","unstructured":"Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9, 310\u2013318 (2008).","journal-title":"Nat. Immunol."},{"key":"BFni1737_CR30","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1084\/jem.20042202","volume":"202","author":"Y Sasaki","year":"2005","unstructured":"Sasaki, Y. et al. IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity. J. Exp. Med. 202, 607\u2013616 (2005).","journal-title":"J. Exp. Med."},{"key":"BFni1737_CR31","doi-asserted-by":"publisher","first-page":"6930","DOI":"10.1073\/pnas.95.12.6930","volume":"95","author":"M Lohning","year":"1998","unstructured":"Lohning, M. et al. T1\/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc. Natl. Acad. Sci. USA 95, 6930\u20136935 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1737_CR32","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1084\/jem.180.6.2401","volume":"180","author":"LM Bradley","year":"1994","unstructured":"Bradley, L.M., Watson, S.R. & Swain, S.L. Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin. J. Exp. Med. 180, 2401\u20132406 (1994).","journal-title":"J. Exp. Med."},{"key":"BFni1737_CR33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1111\/j.1398-9995.2006.01149.x","volume":"61","author":"JM Reimer","year":"2006","unstructured":"Reimer, J.M. et al. Isolation of transcriptionally active umbilical cord blood-derived basophils expressing Fc epsilon RI, HLA-DR and CD203c. Allergy 61, 1063\u20131070 (2006).","journal-title":"Allergy"},{"key":"BFni1737_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1074-7613(01)00084-X","volume":"14","author":"J Hu-Li","year":"2001","unstructured":"Hu-Li, J. et al. Regulation of expression of IL-4 alleles: analysis using a chimeric GFP\/IL-4 gene. Immunity 14, 1\u201311 (2001).","journal-title":"Immunity"},{"key":"BFni1737_CR35","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1073\/pnas.87.4.1421","volume":"87","author":"SZ Ben-Sasson","year":"1990","unstructured":"Ben-Sasson, S.Z., Le Gros, G., Conrad, D.H., Finkelman, F.D. & Paul, W.E. Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc. Natl. Acad. Sci. USA 87, 1421\u20131425 (1990).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1737_CR36","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1182\/blood-2006-11-058800","volume":"110","author":"S Nakae","year":"2007","unstructured":"Nakae, S. et al. TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood 110, 2565\u20132568 (2007).","journal-title":"Blood"},{"key":"BFni1737_CR37","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/ni729","volume":"2","author":"T Ohteki","year":"2001","unstructured":"Ohteki, T., Suzue, K., Maki, C., Ota, T. & Koyasu, S. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat. Immunol. 2, 1138\u20131143 (2001).","journal-title":"Nat. Immunol."},{"key":"BFni1737_CR38","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ni.1621","volume":"9","author":"A Denzel","year":"2008","unstructured":"Denzel, A. et al. Basophils enhance immunological memory responses. Nat. Immunol. 9, 733\u2013742 (2008).","journal-title":"Nat. Immunol."},{"key":"BFni1737_CR39","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1182\/blood-2006-07-037739","volume":"109","author":"K Oh","year":"2007","unstructured":"Oh, K., Shen, T., Le Gros, G. & Min, B. Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood 109, 2921\u20132927 (2007).","journal-title":"Blood"},{"key":"BFni1737_CR40","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1182\/blood-2008-05-154773","volume":"113","author":"C Ohnmacht","year":"2008","unstructured":"Ohnmacht, C. & Voehringer, D. Basophil effector function and homeostasis during helminth infection. Blood 113, 2816\u20132825 (2008).","journal-title":"Blood"},{"key":"BFni1737_CR41","doi-asserted-by":"publisher","first-page":"735","DOI":"10.4049\/jimmunol.174.2.735","volume":"174","author":"M Mack","year":"2005","unstructured":"Mack, M. et al. Identification of antigen-capturing cells as basophils. J. Immunol. 174, 735\u2013741 (2005).","journal-title":"J. Immunol."},{"key":"BFni1737_CR42","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/365340a0","volume":"365","author":"JF Gauchat","year":"1993","unstructured":"Gauchat, J.F. et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365, 340\u2013343 (1993).","journal-title":"Nature"},{"key":"BFni1737_CR43","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0140-6736(08)61449-X","volume":"372","author":"IM Adcock","year":"2008","unstructured":"Adcock, I.M., Caramori, G. & Chung, K.F. New targets for drug development in asthma. Lancet 372, 1073\u20131087 (2008).","journal-title":"Lancet"},{"key":"BFni1737_CR44","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2332\/allergolint.R-08-164","volume":"57","author":"K Okubo","year":"2008","unstructured":"Okubo, K. & Nagakura, T. Anti-IgE antibody therapy for Japanese cedar pollinosis: omalizumab update. Allergol. Int. 57, 205\u2013209 (2008).","journal-title":"Allergol. Int."},{"key":"BFni1737_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000155739","volume":"148","author":"K Verbruggen","year":"2008","unstructured":"Verbruggen, K., Van Cauwenberge, P. & Bachert, C. Anti-IgE for the treatment of allergic rhinitis\u2014and eventually nasal polyps? Int. Arch. Allergy Immunol. 148, 87\u201398 (2008).","journal-title":"Int. Arch. Allergy Immunol."},{"key":"BFni1737_CR46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4049\/jimmunol.73.5.296","volume":"73","author":"HN Eisen","year":"1954","unstructured":"Eisen, H.N., Carsten, M.E. & Belman, S. Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction. J. Immunol. 73, 296\u2013308 (1954).","journal-title":"J. Immunol."},{"key":"BFni1737_CR47","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.4049\/jimmunol.179.7.4415","volume":"179","author":"T Yoshimoto","year":"2007","unstructured":"Yoshimoto, T., Yoshimoto, T., Yasuda, K., Mizuguchi, J. & Nakanishi, K. IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol. 179, 4415\u20134423 (2007).","journal-title":"J. Immunol."},{"key":"BFni1737_CR48","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nm1733","volume":"14","author":"H Kosaka","year":"2008","unstructured":"Kosaka, H., Yoshimoto, T., Yoshimoto, T., Fujimoto, J. & Nakanishi, K. Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation. Nat. Med. 14, 437\u2013441 (2008).","journal-title":"Nat. Med."},{"key":"BFni1737_CR49","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1084\/jem.20021633","volume":"197","author":"I Caramalho","year":"2003","unstructured":"Caramalho, I. et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197, 403\u2013411 (2003).","journal-title":"J. Exp. Med."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni.1737.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.1737","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.1737.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T05:17:13Z","timestamp":1684991833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.1737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,24]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["BFni1737"],"URL":"https:\/\/doi.org\/10.1038\/ni.1737","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1160903.623401","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1160903.624112","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1160903.623584","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1160903.622878","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1160903.622332","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,24]]}}}