{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:29:19Z","timestamp":1792160959775,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,10,24]],"date-time":"2010-10-24T00:00:00Z","timestamp":1287878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,10,24]],"date-time":"2010-10-24T00:00:00Z","timestamp":1287878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1038\/ni.1953","type":"journal-article","created":{"date-parts":[[2010,10,24]],"date-time":"2010-10-24T14:09:21Z","timestamp":1287929361000},"page":"1127-1135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":652,"title":["Critical role for the chemokine receptor CXCR6 in NK cell\u2013mediated antigen-specific memory of haptens and viruses"],"prefix":"10.1038","volume":"11","author":[{"given":"Silke","family":"Paust","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvinder S","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E Ashley","family":"Moseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balimkiz","family":"Senman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Szczepanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalio","family":"Telenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W","family":"Askenase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W","family":"Compans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich H","family":"von Andrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,24]]},"reference":[{"issue":"Suppl","key":"BFni1953_CR1","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1016\/S0092-8674(02)00675-X","volume":"109","author":"CH Bassing","year":"2002","unstructured":"Bassing, C.H., Swat, W. & Alt, F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109 Suppl, S45\u2013S55 (2002).","journal-title":"Cell"},{"key":"BFni1953_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1126\/science.130.3368.159","volume":"130","author":"AJ Crowle","year":"1959","unstructured":"Crowle, A.J. Delayed hypersensitivity in mice; its detection by skin tests and its passive transfer. Science 130, 159\u2013160 (1959).","journal-title":"Science"},{"key":"BFni1953_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0167-5699(98)01438-8","volume":"20","author":"IM Orme","year":"1999","unstructured":"Orme, I.M. & Cooper, A.M. Cytokine\/chemokine cascades in immunity to tuberculosis. Immunol. Today 20, 307\u2013312 (1999).","journal-title":"Immunol. Today"},{"key":"BFni1953_CR4","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1073\/pnas.050569397","volume":"97","author":"FS Dhabhar","year":"2000","unstructured":"Dhabhar, F.S., Satoskar, A.R., Bluethmann, H., David, J.R. & McEwen, B.S. Stress-induced enhancement of skin immune function: A role for \u03b3 interferon. Proc. Natl. Acad. Sci. USA 97, 2846\u20132851 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1953_CR5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4049\/jimmunol.112.2.849","volume":"112","author":"P Phanuphak","year":"1974","unstructured":"Phanuphak, P., Moorhead, J.W. & Claman, H.N. Tolerance and contact sensitivity to DNFB in mice. II. Specific in vitro stimulation with a hapten, 2,4-dinitrobenzene sulfonic acid (DNB-SO3Na). J. Immunol. 112, 849\u2013851 (1974).","journal-title":"J. Immunol."},{"key":"BFni1953_CR6","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ni1581","volume":"9","author":"LL Lanier","year":"2008","unstructured":"Lanier, L.L. Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9, 495\u2013502 (2008).","journal-title":"Nat. Immunol."},{"key":"BFni1953_CR7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","volume":"23","author":"LL Lanier","year":"2005","unstructured":"Lanier, L.L. NK cell recognition. Annu. Rev. Immunol. 23, 225\u2013274 (2005).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni1953_CR8","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/35059110","volume":"409","author":"O Mandelboim","year":"2001","unstructured":"Mandelboim, O. et al. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 409, 1055\u20131060 (2001).","journal-title":"Nature"},{"key":"BFni1953_CR9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/ni1322","volume":"7","author":"R Gazit","year":"2006","unstructured":"Gazit, R. et al. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat. Immunol. 7, 517\u2013523 (2006).","journal-title":"Nat. Immunol."},{"key":"BFni1953_CR10","doi-asserted-by":"publisher","first-page":"8826","DOI":"10.1073\/pnas.092258599","volume":"99","author":"HR Smith","year":"2002","unstructured":"Smith, H.R. et al. Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc. Natl. Acad. Sci. USA 99, 8826\u20138831 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1953_CR11","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nature03847","volume":"436","author":"S Kim","year":"2005","unstructured":"Kim, S. et al. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436, 709\u2013713 (2005).","journal-title":"Nature"},{"key":"BFni1953_CR12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0065-2776(08)01002-X","volume":"101","author":"AH Jonsson","year":"2009","unstructured":"Jonsson, A.H. & Yokoyama, W.M. Natural killer cell tolerance licensing and other mechanisms. Adv. Immunol. 101, 27\u201379 (2009).","journal-title":"Adv. Immunol."},{"key":"BFni1953_CR13","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature07665","volume":"457","author":"JC Sun","year":"2009","unstructured":"Sun, J.C., Beilke, J.N. & Lanier, L.L. Adaptive immune features of natural killer cells. Nature 457, 557\u2013561 (2009).","journal-title":"Nature"},{"key":"BFni1953_CR14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1440-1711.2005.01311.x","volume":"83","author":"AA Scalzo","year":"2005","unstructured":"Scalzo, A.A., Manzur, M., Forbes, C.A., Brown, M.G. & Shellam, G.R. NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populations. Immunol. Cell Biol. 83, 144\u2013149 (2005).","journal-title":"Immunol. Cell Biol."},{"key":"BFni1953_CR15","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/ng934","volume":"31","author":"MP Martin","year":"2002","unstructured":"Martin, M.P. et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 31, 429\u2013434 (2002).","journal-title":"Nat. Genet."},{"key":"BFni1953_CR16","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1084\/jem.20070695","volume":"204","author":"G Alter","year":"2007","unstructured":"Alter, G. et al. Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR\/HLA subtypes. J. Exp. Med. 204, 3027\u20133036 (2007).","journal-title":"J. Exp. Med."},{"key":"BFni1953_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/ni1332","volume":"7","author":"JG O'Leary","year":"2006","unstructured":"O'Leary, J.G., Goodarzi, M., Drayton, D.L. & von Andrian, U.H. T cell\u2013 and B cell\u2013independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 7, 507\u2013516 (2006).","journal-title":"Nat. Immunol."},{"key":"BFni1953_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.0906-6705.2005.290b.x","volume":"14","author":"WH Boehncke","year":"2005","unstructured":"Boehncke, W.H. et al. Leukocyte extravasation as a target for anti-inflammatory therapy\u2014Which molecule to choose? Exp. Dermatol. 14, 70\u201380 (2005).","journal-title":"Exp. Dermatol."},{"key":"BFni1953_CR19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1073\/pnas.92.2.377","volume":"92","author":"JP DiSanto","year":"1995","unstructured":"DiSanto, J.P., Muller, W., Guy-Grand, D., Fischer, A. & Rajewsky, K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor \u03b3 chain. Proc. Natl. Acad. Sci. USA 92, 377\u2013381 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni1953_CR20","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.0105-2896.2010.00906.x","volume":"235","author":"S Paust","year":"2010","unstructured":"Paust, S., Senman, B. & von Andrian, U.H. Adaptive immune responses mediated by natural killer cells. Immunol. Rev. 235, 286\u2013296 (2010).","journal-title":"Immunol. Rev."},{"key":"BFni1953_CR21","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1182\/blood-2007-06-096487","volume":"111","author":"P Matangkasombut","year":"2008","unstructured":"Matangkasombut, P. et al. Lack of iNKT cells in patients with combined immune deficiency due to hypomorphic RAG mutations. Blood 111, 271\u2013274 (2008).","journal-title":"Blood"},{"key":"BFni1953_CR22","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1371\/journal.pbio.0030113","volume":"3","author":"F Geissmann","year":"2005","unstructured":"Geissmann, F. et al. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 3, e113 (2005).","journal-title":"PLoS Biol."},{"key":"BFni1953_CR23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jim.2008.12.001","volume":"342","author":"CE Day","year":"2009","unstructured":"Day, C.E. et al. A novel method for isolation of human lung T cells from lung resection tissue reveals increased expression of GAPDH and CXCR6. J. Immunol. Methods 342, 91\u201397 (2009).","journal-title":"J. Immunol. Methods"},{"key":"BFni1953_CR24","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/79738","volume":"1","author":"M Matloubian","year":"2000","unstructured":"Matloubian, M., David, A., Engel, S., Ryan, J.E. & Cyster, J.G. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat. Immunol. 1, 298\u2013304 (2000).","journal-title":"Nat. Immunol."},{"key":"BFni1953_CR25","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1189\/jlb.0709482","volume":"87","author":"R van der Voort","year":"2010","unstructured":"van der Voort, R. et al. An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells. J. Leukoc. Biol. 87, 1029\u20131039 (2010).","journal-title":"J. Leukoc. Biol."},{"key":"BFni1953_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.4049\/jimmunol.174.1.277","volume":"174","author":"T Sato","year":"2005","unstructured":"Sato, T. et al. Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. J. Immunol. 174, 277\u2013283 (2005).","journal-title":"J. Immunol."},{"key":"BFni1953_CR27","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/0006-2952(87)90707-6","volume":"36","author":"BK Park","year":"1987","unstructured":"Park, B.K., Tingle, M.D., Grabowski, P.S., Coleman, J.W. & Kitteringham, N.R. Drug-protein conjugates\u2013XI. Disposition and immunogenicity of dinitrofluorobenzene, a model compound for the investigation of drugs as haptens. Biochem. Pharmacol. 36, 591\u2013599 (1987).","journal-title":"Biochem. Pharmacol."},{"key":"BFni1953_CR28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-065X.1998.tb01227.x","volume":"165","author":"JP Di Santo","year":"1998","unstructured":"Di Santo, J.P., Colucci, F. & Guy-Grand, D. Natural killer and T cells of innate and adaptive immunity: lymphoid compartments with different requirements for common gamma chain-dependent cytokines. Immunol. Rev. 165, 29\u201338 (1998).","journal-title":"Immunol. Rev."},{"key":"BFni1953_CR29","doi-asserted-by":"publisher","first-page":"864","DOI":"10.4049\/jimmunol.172.2.864","volume":"172","author":"AM Jamieson","year":"2004","unstructured":"Jamieson, A.M., Isnard, P., Dorfman, J.R., Coles, M.C. & Raulet, D.H. Turnover and proliferation of NK cells in steady state and lymphopenic conditions. J. Immunol. 172, 864\u2013870 (2004).","journal-title":"J. Immunol."},{"key":"BFni1953_CR30","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1128\/JVI.02052-06","volume":"81","author":"FS Quan","year":"2007","unstructured":"Quan, F.S., Huang, C., Compans, R.W. & Kang, S.M. Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus. J. Virol. 81, 3514\u20133524 (2007).","journal-title":"J. Virol."},{"key":"BFni1953_CR31","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.virusres.2009.04.005","volume":"143","author":"SM Kang","year":"2009","unstructured":"Kang, S.M., Song, J.M., Quan, F.S. & Compans, R.W. Influenza vaccines based on virus-like particles. Virus Res. 143, 140\u2013146 (2009).","journal-title":"Virus Res."},{"key":"BFni1953_CR32","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nri1783","volume":"6","author":"L Hangartner","year":"2006","unstructured":"Hangartner, L., Zinkernagel, R.M. & Hengartner, H. Antiviral antibody responses: the two extremes of a wide spectrum. Nat. Rev. Immunol. 6, 231\u2013243 (2006).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni1953_CR33","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.4049\/jimmunol.178.5.2688","volume":"178","author":"M Draghi","year":"2007","unstructured":"Draghi, M. et al. NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection. J. Immunol. 178, 2688\u20132698 (2007).","journal-title":"J. Immunol."},{"key":"BFni1953_CR34","doi-asserted-by":"publisher","first-page":"10869","DOI":"10.1128\/JVI.00542-07","volume":"81","author":"BZ Wang","year":"2007","unstructured":"Wang, B.Z. et al. Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles. J. Virol. 81, 10869\u201310878 (2007).","journal-title":"J. Virol."},{"key":"BFni1953_CR35","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.4049\/jimmunol.164.5.2496","volume":"164","author":"LD Shultz","year":"2000","unstructured":"Shultz, L.D. et al. NOD\/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells. J. Immunol. 164, 2496\u20132507 (2000).","journal-title":"J. Immunol."},{"key":"BFni1953_CR36","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.4049\/jimmunol.166.8.5145","volume":"166","author":"A Wilbanks","year":"2001","unstructured":"Wilbanks, A. et al. Expression cloning of the STRL33\/BONZO\/TYMSTR ligand reveals elements of CC, CXC, and CX3C chemokines. J. Immunol. 166, 5145\u20135154 (2001).","journal-title":"J. Immunol."},{"key":"BFni1953_CR37","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.4049\/jimmunol.171.11.6225","volume":"171","author":"M Szczepanik","year":"2003","unstructured":"Szczepanik, M. et al. B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity. J. Immunol. 171, 6225\u20136235 (2003).","journal-title":"J. Immunol."},{"key":"BFni1953_CR38","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cellimm.2008.08.007","volume":"254","author":"E Aktas","year":"2009","unstructured":"Aktas, E., Kucuksezer, U.C., Bilgic, S., Erten, G. & Deniz, G. Relationship between CD107a expression and cytotoxic activity. Cell. Immunol. 254, 149\u2013154 (2009).","journal-title":"Cell. Immunol."},{"key":"BFni1953_CR39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/358021a0","volume":"358","author":"DH Raulet","year":"1992","unstructured":"Raulet, D.H. A sense of something missing. Nature 358, 21\u201322 (1992).","journal-title":"Nature"},{"key":"BFni1953_CR40","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.4049\/jimmunol.0902518","volume":"184","author":"T Carbone","year":"2010","unstructured":"Carbone, T. et al. CD56highCD16\u2212CD62L\u2212 NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses. J. Immunol. 184, 1102\u20131110 (2010).","journal-title":"J. Immunol."},{"key":"BFni1953_CR41","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/sj.jid.5700751","volume":"127","author":"F Scholz","year":"2007","unstructured":"Scholz, F. et al. Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin. J. Invest. Dermatol. 127, 1444\u20131455 (2007).","journal-title":"J. Invest. Dermatol."},{"key":"BFni1953_CR42","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ng2035","volume":"39","author":"MP Martin","year":"2007","unstructured":"Martin, M.P. et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat. Genet. 39, 733\u2013740 (2007).","journal-title":"Nat. Genet."},{"key":"BFni1953_CR43","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1086\/655782","volume":"202","author":"S Limou","year":"2010","unstructured":"Limou, S. et al. Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. J. Infect. Dis. 202, 908\u2013915 (2010).","journal-title":"J. Infect. Dis."},{"key":"BFni1953_CR44","doi-asserted-by":"publisher","first-page":"7833","DOI":"10.4049\/jimmunol.177.11.7833","volume":"177","author":"RD Berahovich","year":"2006","unstructured":"Berahovich, R.D., Lai, N.L., Wei, Z., Lanier, L.L. & Schall, T.J. Evidence for NK cell subsets based on chemokine receptor expression. J. Immunol. 177, 7833\u20137840 (2006).","journal-title":"J. Immunol."},{"key":"BFni1953_CR45","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","volume":"2","author":"X Cao","year":"1995","unstructured":"Cao, X. et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor \u03b3 chain. Immunity 2, 223\u2013238 (1995).","journal-title":"Immunity"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ni.1953.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni.1953","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni.1953.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T09:54:54Z","timestamp":1744278894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.1953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,24]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["BFni1953"],"URL":"https:\/\/doi.org\/10.1038\/ni.1953","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5808956.5790054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.5808956.8742054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.5808956.6338055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.5808956.6525055","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,24]]},"assertion":[{"value":"26 May 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}