{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:34:38Z","timestamp":1792622078541,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T00:00:00Z","timestamp":1305417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1038\/ni.2037","type":"journal-article","created":{"date-parts":[[2011,5,15]],"date-time":"2011-05-15T13:58:08Z","timestamp":1305467888000},"page":"536-543","source":"Crossref","is-referenced-by-count":369,"title":["The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells"],"prefix":"10.1038","volume":"12","author":[{"given":"Wataru","family":"Ise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Kohyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara U","family":"Schraml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Schwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttiya","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W","family":"Alt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene M","family":"Oltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,15]]},"reference":[{"key":"BFni2037_CR1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.1164206","volume":"322","author":"K Hildner","year":"2008","unstructured":"Hildner, K. et al. Batf3 deficiency reveals a critical role for CD8\u03b1+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097\u20131100 (2008).","journal-title":"Science"},{"key":"BFni2037_CR2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nature08114","volume":"460","author":"BU Schraml","year":"2009","unstructured":"Schraml, B.U. et al. The AP-1 transcription factor Batf controls TH17 differentiation. Nature 460, 405\u2013409 (2009).","journal-title":"Nature"},{"key":"BFni2037_CR3","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1084\/jem.20091627","volume":"207","author":"BT Edelson","year":"2010","unstructured":"Edelson, B.T. et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8\u03b1+ conventional dendritic cells. J. Exp. Med. 207, 823\u2013836 (2010).","journal-title":"J. Exp. Med."},{"key":"BFni2037_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.20041257","volume":"201","author":"CL Langrish","year":"2005","unstructured":"Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233\u2013240 (2005).","journal-title":"J. Exp. Med."},{"key":"BFni2037_CR5","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1084\/jem.20091548","volume":"207","author":"BC Betz","year":"2010","unstructured":"Betz, B.C. et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207, 933\u2013942 (2010).","journal-title":"J. Exp. Med."},{"key":"BFni2037_CR6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","volume":"325","author":"RI Nurieva","year":"2009","unstructured":"Nurieva, R.I. et al. Bcl6 Mediates the development of T follicular helper cells. Science 325, 1001\u20131005 (2009).","journal-title":"Science"},{"key":"BFni2037_CR7","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1126\/science.1175870","volume":"325","author":"RJ Johnston","year":"2009","unstructured":"Johnston, R.J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006\u20131010 (2009).","journal-title":"Science"},{"key":"BFni2037_CR8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","volume":"31","author":"D Yu","year":"2009","unstructured":"Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457\u2013468 (2009).","journal-title":"Immunity"},{"key":"BFni2037_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/ni.1690","volume":"10","author":"AT Bauquet","year":"2009","unstructured":"Bauquet, A.T. et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10, 167\u2013175 (2009).","journal-title":"Nat. Immunol."},{"key":"BFni2037_CR10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/j.1460-2075.1994.tb06305.x","volume":"13","author":"A Bottaro","year":"1994","unstructured":"Bottaro, A. et al. S-region transcription per-se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13, 665\u2013674 (1994).","journal-title":"EMBO J."},{"key":"BFni2037_CR11","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1002\/j.1460-2075.1993.tb06027.x","volume":"12","author":"J Zhang","year":"1993","unstructured":"Zhang, J. et al. A Selective defect in IgG2b switching as a result of targeted mutation of the I\u03b32b promoter and exon. EMBO J. 12, 3529\u20133537 (1993).","journal-title":"EMBO J."},{"key":"BFni2037_CR12","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nri2644","volume":"9","author":"C King","year":"2009","unstructured":"King, C. New insights into the differentiation and function of T follicular helper cells. Nat. Rev. Immunol. 9, 757\u2013766 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni2037_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00281-009-0194-z","volume":"32","author":"MA Linterman","year":"2010","unstructured":"Linterman, M.A. & Vinuesa, C.G. Signals that influence T follicular helper cell differentiation and function. Semin. Immunopathol. 32, 183\u2013196 (2010).","journal-title":"Semin. Immunopathol."},{"key":"BFni2037_CR14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","volume":"29","author":"RI Nurieva","year":"2008","unstructured":"Nurieva, R.I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138\u2013149 (2008).","journal-title":"Immunity"},{"key":"BFni2037_CR15","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nature07345","volume":"455","author":"H Qi","year":"2008","unstructured":"Qi, H. et al. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455, 764\u2013769 (2008).","journal-title":"Nature"},{"key":"BFni2037_CR16","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.immuni.2009.10.008","volume":"31","author":"H Kwon","year":"2009","unstructured":"Kwon, H. et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 31, 941\u2013952 (2009).","journal-title":"Immunity"},{"key":"BFni2037_CR17","doi-asserted-by":"publisher","first-page":"5099","DOI":"10.4049\/jimmunol.179.8.5099","volume":"179","author":"NM Haynes","year":"2007","unstructured":"Haynes, N.M. et al. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 179, 5099\u20135108 (2007).","journal-title":"J. Immunol."},{"key":"BFni2037_CR18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","volume":"29","author":"RI Nurieva","year":"2008","unstructured":"Nurieva, R.I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138\u2013149 (2008).","journal-title":"Immunity"},{"key":"BFni2037_CR19","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1146\/annurev.immunol.26.021607.090344","volume":"26","author":"C King","year":"2008","unstructured":"King, C., Tangye, S.G. & Mackay, C.R. T follicular helper (T-FH) cells in normal and dysregulated immune responses. Annu. Rev. Immunol. 26, 741\u2013766 (2008).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni2037_CR20","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<1040::AID-IMMU1040>3.0.CO;2-9","volume":"28","author":"J Hasbold","year":"1998","unstructured":"Hasbold, J. et al. Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4. Eur. J. Immunol. 28, 1040\u20131051 (1998).","journal-title":"Eur. J. Immunol."},{"key":"BFni2037_CR21","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.4049\/jimmunol.163.9.4707","volume":"163","author":"EK Deenick","year":"1999","unstructured":"Deenick, E.K., Hasbold, J. & Hodgkin, P.D. Switching to IgG3, IgG2b, and IgA is division linked and independent, revealing a stochastic framework for describing differentiation. J. Immunol. 163, 4707\u20134714 (1999).","journal-title":"J. Immunol."},{"key":"BFni2037_CR22","doi-asserted-by":"publisher","first-page":"13242","DOI":"10.1073\/pnas.0502779102","volume":"102","author":"JS Rush","year":"2005","unstructured":"Rush, J.S. et al. Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc. Natl. Acad. Sci. USA 102, 13242\u201313247 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni2037_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1091\/mbc.1.1.27","volume":"1","author":"RD Sanderson","year":"1989","unstructured":"Sanderson, R.D., Lalor, P. & Bernfield, M. B lymphocytes express and lose syndecan at specific stages of differentiation. Cell Regul. 1, 27\u201335 (1989).","journal-title":"Cell Regul."},{"key":"BFni2037_CR24","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1084\/jem.20042060","volume":"201","author":"EJ Blink","year":"2005","unstructured":"Blink, E.J. et al. Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J. Exp. Med. 201, 545\u2013554 (2005).","journal-title":"J. Exp. Med."},{"key":"BFni2037_CR25","doi-asserted-by":"publisher","first-page":"6978","DOI":"10.1073\/pnas.89.15.6978","volume":"89","author":"CC Chu","year":"1992","unstructured":"Chu, C.C., Paul, W.E. & Max, E.E. Quantitation of immunoglobulin \u03bc-\u03b3-1 heavy-chain switch region recombination by a digestion circularization polymerase chain-reaction method. Proc. Natl. Acad. Sci. USA 89, 6978\u20136982 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni2037_CR26","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature02596","volume":"429","author":"A Muto","year":"2004","unstructured":"Muto, A. et al. The transcriptional programme of antibody class switching involves the repressor Bach2. Nature 429, 566\u2013571 (2004).","journal-title":"Nature"},{"key":"BFni2037_CR27","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/ni1357","volume":"7","author":"U Klein","year":"2006","unstructured":"Klein, U. et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat. Immunol. 7, 773\u2013782 (2006).","journal-title":"Nat. Immunol."},{"key":"BFni2037_CR28","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1084\/jem.20061952","volume":"204","author":"EE Crouch","year":"2007","unstructured":"Crouch, E.E. et al. Regulation of AID expression in the immune response. J. Exp. Med. 204, 1145\u20131156 (2007).","journal-title":"J. Exp. Med."},{"key":"BFni2037_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0065-2776(04)86002-4","volume":"86","author":"DD Dudley","year":"2005","unstructured":"Dudley, D.D. et al. Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences. Adv. Immunol. 86, 43\u2013112 (2005).","journal-title":"Adv. Immunol."},{"key":"BFni2037_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev.immunol.26.021607.090248","volume":"26","author":"J Stavnezer","year":"2008","unstructured":"Stavnezer, J., Guikema, J.E.J. & Schrader, C.E. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26, 261\u2013292 (2008).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni2037_CR31","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nature01574","volume":"422","author":"J Chaudhuri","year":"2003","unstructured":"Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726\u2013730 (2003).","journal-title":"Nature"},{"key":"BFni2037_CR32","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/ni920","volume":"4","author":"AR Ramiro","year":"2003","unstructured":"Ramiro, A.R. et al. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4, 452\u2013456 (2003).","journal-title":"Nat. Immunol."},{"key":"BFni2037_CR33","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1189\/jlb.0909639","volume":"87","author":"Y Hiramatsu","year":"2010","unstructured":"Hiramatsu, Y. et al. c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-\u03b2 inhibits c-Maf-induced IL-21 production in CD4+ T cells. J. Leukoc. Biol. 87, 703\u2013712 (2010).","journal-title":"J. Leukoc. Biol."},{"key":"BFni2037_CR34","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1182\/blood-2010-01-264689","volume":"116","author":"C Vincent-Fabert","year":"2010","unstructured":"Vincent-Fabert, C. et al. Genomic deletion of the whole IgH 3\u2032 regulatory region (HS3a, HS1,2, HS3b, HS4) dramatically affects class switch recombination and Ig secretion to all isotypes. Blood 116, 1895\u20131898 (2010).","journal-title":"Blood"},{"key":"BFni2037_CR35","doi-asserted-by":"publisher","first-page":"860","DOI":"10.4049\/jimmunol.165.2.860","volume":"165","author":"M Iacobelli","year":"2000","unstructured":"Iacobelli, M., Wachsman, W. & McGuire, K.L. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J. Immunol. 165, 860\u2013868 (2000).","journal-title":"J. Immunol."},{"key":"BFni2037_CR36","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1038\/sj.onc.1203491","volume":"19","author":"DR Echlin","year":"2000","unstructured":"Echlin, D.R. et al. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. Oncogene 19, 1752\u20131763 (2000).","journal-title":"Oncogene"},{"key":"BFni2037_CR37","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/1521-4141(200105)31:5<1620::AID-IMMU1620>3.0.CO;2-3","volume":"31","author":"KL Williams","year":"2001","unstructured":"Williams, K.L. et al. Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Eur. J. Immunol. 31, 1620\u20131627 (2001).","journal-title":"Eur. J. Immunol."},{"key":"BFni2037_CR38","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nature05970","volume":"448","author":"T Korn","year":"2007","unstructured":"Korn, T. et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448, 484\u2013487 (2007).","journal-title":"Nature"},{"key":"BFni2037_CR39","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.4049\/jimmunol.161.8.3822","volume":"161","author":"S Ranganath","year":"1998","unstructured":"Ranganath, S. et al. GATA-3-dependent enhancer activity in IL-4 gene regulation. J. Immunol. 161, 3822\u20133826 (1998).","journal-title":"J. Immunol."},{"key":"BFni2037_CR40","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1128\/MCB.21.8.2716-2725.2001","volume":"21","author":"S Ranganath","year":"2001","unstructured":"Ranganath, S. & Murphy, K.M. Structure and specificity of GATA proteins in Th2 development. Mol. Cell. Biol. 21, 2716\u20132725 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFni2037_CR41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/ni1144","volume":"6","author":"JR Sedy","year":"2005","unstructured":"Sedy, J.R. et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6, 90\u201398 (2005).","journal-title":"Nat. Immunol."},{"key":"BFni2037_CR42","doi-asserted-by":"publisher","first-page":"855","DOI":"10.4049\/jimmunol.167.2.855","volume":"167","author":"H Zhu","year":"2001","unstructured":"Zhu, H. et al. Unexpected characteristics of the IFN-\u03b3 reporters in nontransformed T cells. J. Immunol. 167, 855\u2013865 (2001).","journal-title":"J. Immunol."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni.2037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.2037","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.2037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T15:30:58Z","timestamp":1686065458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.2037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,15]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["BFni2037"],"URL":"https:\/\/doi.org\/10.1038\/ni.2037","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10929957.11862055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10929957.12998054","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,15]]}}}