{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:57:09Z","timestamp":1791125829549,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T00:00:00Z","timestamp":1412467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T00:00:00Z","timestamp":1412467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/ni.3008","type":"journal-article","created":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T15:06:27Z","timestamp":1412521587000},"page":"1079-1089","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":280,"title":["Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation"],"prefix":"10.1038","volume":"15","author":[{"given":"Katharina M","family":"Jeltsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-3907","authenticated-orcid":false,"given":"Sven","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Z\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitta A","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina U","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Rehage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian C","family":"Warth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L","family":"Edelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Gloury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lohs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Lech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E","family":"Stehklein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Geerlof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kremmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-0419","authenticated-orcid":false,"given":"Ingo","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schmidt-Supprian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Krappmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Ruland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Kallies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Heikenwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vigo","family":"Heissmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,5]]},"reference":[{"key":"BFni3008_CR1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nature07924","volume":"458","author":"K Matsushita","year":"2009","unstructured":"Matsushita, K. et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458, 1185\u20131190 (2009).","journal-title":"Nature"},{"key":"BFni3008_CR2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/icb.2013.11","volume":"91","author":"R Miao","year":"2013","unstructured":"Miao, R. et al. Targeted disruption of MCPIP1\/Zc3h12a results in fatal inflammatory disease. Immunol. Cell Biol. 91, 368\u2013376 (2013).","journal-title":"Immunol. Cell Biol."},{"key":"BFni3008_CR3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature03555","volume":"435","author":"CG Vinuesa","year":"2005","unstructured":"Vinuesa, C.G. et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435, 452\u2013458 (2005).","journal-title":"Nature"},{"key":"BFni3008_CR4","doi-asserted-by":"crossref","first-page":"e82542","DOI":"10.1371\/journal.pone.0082542","volume":"8","author":"Z Zhou","year":"2013","unstructured":"Zhou, Z. et al. MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms. PLoS ONE 8, e82542 (2013).","journal-title":"PLoS ONE"},{"key":"BFni3008_CR5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/imr.12051","volume":"253","author":"P Ivanov","year":"2013","unstructured":"Ivanov, P. & Anderson, P. Post-transcriptional regulatory networks in immunity. Immunol. Rev. 253, 253\u2013272 (2013).","journal-title":"Immunol. Rev."},{"key":"BFni3008_CR6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ni.1902","volume":"11","author":"E Glasmacher","year":"2010","unstructured":"Glasmacher, E. et al. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat. Immunol. 11, 725\u2013733 (2010).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR7","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2013.04.016","volume":"153","author":"K Leppek","year":"2013","unstructured":"Leppek, K. et al. Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs. Cell 153, 869\u2013881 (2013).","journal-title":"Cell"},{"key":"BFni3008_CR8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.immuni.2012.12.004","volume":"38","author":"KU Vogel","year":"2013","unstructured":"Vogel, K.U. et al. Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. Immunity 38, 655\u2013668 (2013).","journal-title":"Immunity"},{"key":"BFni3008_CR9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature06253","volume":"450","author":"D Yu","year":"2007","unstructured":"Yu, D. et al. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 450, 299\u2013303 (2007).","journal-title":"Nature"},{"key":"BFni3008_CR10","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/ni.2137","volume":"12","author":"H Iwasaki","year":"2011","unstructured":"Iwasaki, H. et al. The I\u03baB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat. Immunol. 12, 1167\u20131175 (2011).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR11","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2013.04.034","volume":"153","author":"T Uehata","year":"2013","unstructured":"Uehata, T. et al. Malt1-induced cleavage of regnase-1 in CD4+ helper T cells regulates immune activation. Cell 153, 1036\u20131049 (2013).","journal-title":"Cell"},{"key":"BFni3008_CR12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.molcel.2011.09.012","volume":"44","author":"HI Suzuki","year":"2011","unstructured":"Suzuki, H.I. et al. MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation. Mol. Cell 44, 424\u2013436 (2011).","journal-title":"Mol. Cell"},{"key":"BFni3008_CR13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nsmb.2855","volume":"21","author":"A Schlundt","year":"2014","unstructured":"Schlundt, A. et al. Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Nat. Struct. Mol. Biol. 21, 671\u2013678 (2014).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFni3008_CR14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nsmb.2857","volume":"21","author":"D Tan","year":"2014","unstructured":"Tan, D., Zhou, M., Kiledjian, M. & Tong, L. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nat. Struct. Mol. Biol. 21, 679\u2013685 (2014).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFni3008_CR15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ni1561","volume":"9","author":"B Coornaert","year":"2008","unstructured":"Coornaert, B. et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-\u03baB inhibitor A20. Nat. Immunol. 9, 263\u2013271 (2008).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR16","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/ni1568","volume":"9","author":"F Rebeaud","year":"2008","unstructured":"Rebeaud, F. et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat. Immunol. 9, 272\u2013281 (2008).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nri2338","volume":"8","author":"M Thome","year":"2008","unstructured":"Thome, M. Multifunctional roles for MALT1 in T-cell activation. Nat. Rev. Immunol. 8, 495\u2013500 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni3008_CR18","doi-asserted-by":"crossref","first-page":"7718","DOI":"10.4049\/jimmunol.0803313","volume":"182","author":"M D\u00fcwel","year":"2009","unstructured":"D\u00fcwel, M. et al. A20 negatively regulates T cell receptor signaling to NF-\u03baB by cleaving Malt1 ubiquitin chains. J. Immunol. 182, 7718\u20137728 (2009).","journal-title":"J. Immunol."},{"key":"BFni3008_CR19","doi-asserted-by":"crossref","first-page":"14596","DOI":"10.1073\/pnas.1105020108","volume":"108","author":"S Hailfinger","year":"2011","unstructured":"Hailfinger, S. et al. Malt1-dependent RelB cleavage promotes canonical NF-\u03baB activation in lymphocytes and lymphoma cell lines. Proc. Natl. Acad. Sci. USA 108, 14596\u201314601 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3008_CR20","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/emboj.2011.85","volume":"30","author":"J Staal","year":"2011","unstructured":"Staal, J. et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J. 30, 1742\u20131752 (2011).","journal-title":"EMBO J."},{"key":"BFni3008_CR21","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1172\/JCI63528","volume":"122","author":"A Br\u00fcstle","year":"2012","unstructured":"Br\u00fcstle, A. et al. The NF-\u03baB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J. Clin. Invest. 122, 4698\u20134709 (2012).","journal-title":"J. Clin. Invest."},{"key":"BFni3008_CR22","doi-asserted-by":"crossref","first-page":"e1001259","DOI":"10.1371\/journal.ppat.1001259","volume":"7","author":"SI Gringhuis","year":"2011","unstructured":"Gringhuis, S.I. et al. Selective C-Rel activation via Malt1 controls anti-fungal TH-17 immunity by dectin-1 and dectin-2. PLoS Pathog. 7, e1001259 (2011).","journal-title":"PLoS Pathog."},{"key":"BFni3008_CR23","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.4049\/jimmunol.1201351","volume":"190","author":"C Mc Guire","year":"2013","unstructured":"Mc Guire, C. et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J. Immunol. 190, 2896\u20132903 (2013).","journal-title":"J. Immunol."},{"key":"BFni3008_CR24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1742-2094-11-124","volume":"11","author":"C Mc Guire","year":"2014","unstructured":"Mc Guire, C. et al. Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J. Neuroinflammation 11, 124 (2014).","journal-title":"J. Neuroinflammation"},{"key":"BFni3008_CR25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1084\/jem.20110578","volume":"208","author":"A Bertossi","year":"2011","unstructured":"Bertossi, A. et al. Loss of Roquin induces early death and immune deregulation but not autoimmunity. J. Exp. Med. 208, 1749\u20131756 (2011).","journal-title":"J. Exp. Med."},{"key":"BFni3008_CR26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.iy.09.040191.001331","volume":"9","author":"PL Cohen","year":"1991","unstructured":"Cohen, P.L. & Eisenberg, R.A. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243\u2013269 (1991).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni3008_CR27","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.immuni.2012.10.010","volume":"37","author":"SK Lee","year":"2012","unstructured":"Lee, S.K. et al. Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 37, 880\u2013892 (2012).","journal-title":"Immunity"},{"key":"BFni3008_CR28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ccr.2012.11.002","volume":"22","author":"D Nagel","year":"2012","unstructured":"Nagel, D. et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell 22, 825\u2013837 (2012).","journal-title":"Cancer Cell"},{"key":"BFni3008_CR29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmb.2012.02.018","volume":"419","author":"C Wiesmann","year":"2012","unstructured":"Wiesmann, C. et al. Structural determinants of MALT1 protease activity. J. Mol. Biol. 419, 4\u201321 (2012).","journal-title":"J. Mol. Biol."},{"key":"BFni3008_CR30","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1084\/jem.20092641","volume":"207","author":"J Liang","year":"2010","unstructured":"Liang, J. et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-\u03baB signaling. J. Exp. Med. 207, 2959\u20132973 (2010).","journal-title":"J. Exp. Med."},{"key":"BFni3008_CR31","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/nature08922","volume":"464","author":"K Okamoto","year":"2010","unstructured":"Okamoto, K. et al. I\u03baB\u03b6 regulates TH17 development by cooperating with ROR nuclear receptors. Nature 464, 1381\u20131385 (2010).","journal-title":"Nature"},{"key":"BFni3008_CR32","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.4049\/jimmunol.164.9.4706","volume":"164","author":"JM Robertson","year":"2000","unstructured":"Robertson, J.M., Jensen, P.E. & Evavold, B.D. DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323\u2013339 epitope. J. Immunol. 164, 4706\u20134712 (2000).","journal-title":"J. Immunol."},{"key":"BFni3008_CR33","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.4049\/jimmunol.1301360","volume":"191","author":"LK Fogli","year":"2013","unstructured":"Fogli, L.K. et al. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J. Immunol. 191, 3100\u20133111 (2013).","journal-title":"J. Immunol."},{"key":"BFni3008_CR34","doi-asserted-by":"crossref","first-page":"18460","DOI":"10.1073\/pnas.0809850105","volume":"105","author":"T Korn","year":"2008","unstructured":"Korn, T. et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 105, 18460\u201318465 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3008_CR35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ni.1690","volume":"10","author":"AT Bauquet","year":"2009","unstructured":"Bauquet, A.T. et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat. Immunol. 10, 167\u2013175 (2009).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR36","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2012.08.023","volume":"37","author":"M Schuster","year":"2012","unstructured":"Schuster, M. et al. I\u03baB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37, 998\u20131008 (2012).","journal-title":"Immunity"},{"key":"BFni3008_CR37","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.4049\/jimmunol.1101757","volume":"187","author":"G Chen","year":"2011","unstructured":"Chen, G. et al. The NF-\u03baB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J. Immunol. 187, 4483\u20134491 (2011).","journal-title":"J. Immunol."},{"key":"BFni3008_CR38","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/eji.201041056","volume":"41","author":"K Reinhard","year":"2011","unstructured":"Reinhard, K. et al. c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur. J. Immunol. 41, 1388\u20131398 (2011).","journal-title":"Eur. J. Immunol."},{"key":"BFni3008_CR39","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1084\/jem.20110462","volume":"208","author":"Q Ruan","year":"2011","unstructured":"Ruan, Q. et al. The Th17 immune response is controlled by the Rel-ROR\u03b3-ROR\u03b3T transcriptional axis. J. Exp. Med. 208, 2321\u20132333 (2011).","journal-title":"J. Exp. Med."},{"key":"BFni3008_CR40","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ni1500","volume":"8","author":"A Br\u00fcstle","year":"2007","unstructured":"Br\u00fcstle, A. et al. The development of inflammatory TH-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8, 958\u2013966 (2007).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR41","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/ni.2710","volume":"14","author":"K Man","year":"2013","unstructured":"Man, K. et al. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat. Immunol. 14, 1155\u20131165 (2013).","journal-title":"Nat. Immunol."},{"key":"BFni3008_CR42","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2013.10.007","volume":"39","author":"S Yao","year":"2013","unstructured":"Yao, S. et al. Interferon regulatory factor 4 sustains CD8+ T cell expansion and effector differentiation. Immunity 39, 833\u2013845 (2013).","journal-title":"Immunity"},{"key":"BFni3008_CR43","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","volume":"146","author":"EV Dang","year":"2011","unstructured":"Dang, E.V. et al. Control of TH17\/Treg balance by hypoxia-inducible factor 1. Cell 146, 772\u2013784 (2011).","journal-title":"Cell"},{"key":"BFni3008_CR44","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","volume":"208","author":"LZ Shi","year":"2011","unstructured":"Shi, L.Z. et al. HIF1\u03b1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367\u20131376 (2011).","journal-title":"J. Exp. Med."},{"key":"BFni3008_CR45","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O","volume":"28","author":"A Oxenius","year":"1998","unstructured":"Oxenius, A., Bachmann, M.F., Zinkernagel, R.M. & Hengartner, H. Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28, 390\u2013400 (1998).","journal-title":"Eur. J. Immunol."},{"key":"BFni3008_CR46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","volume":"76","author":"MJ Barnden","year":"1998","unstructured":"Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based \u03b1- and \u03b2-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76, 34\u201340 (1998).","journal-title":"Immunol. Cell Biol."},{"key":"BFni3008_CR47","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","volume":"15","author":"PP Lee","year":"2001","unstructured":"Lee, P.P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763\u2013774 (2001).","journal-title":"Immunity"},{"key":"BFni3008_CR48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nsmb.1417","volume":"15","author":"KM Ansel","year":"2008","unstructured":"Ansel, K.M. et al. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat. Struct. Mol. Biol. 15, 523\u2013530 (2008).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFni3008_CR49","doi-asserted-by":"publisher","unstructured":"Warth, S.C. & Heissmeyer, V. Adenoviral transduction of naive CD4 T cells to study treg differentiation. J. Vis. Exp. doi:10.3791\/50455 (13 August 2013).","DOI":"10.3791\/50455"},{"key":"BFni3008_CR50","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1084\/jem.20072646","volume":"205","author":"M Lech","year":"2008","unstructured":"Lech, M. et al. Tir8\/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J. Exp. Med. 205, 1879\u20131888 (2008).","journal-title":"J. Exp. Med."}],"updated-by":[{"DOI":"10.1038\/s41590-026-02482-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000}}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ni.3008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni.3008","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni.3008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:30:59Z","timestamp":1772800259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.3008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,5]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFni3008"],"URL":"https:\/\/doi.org\/10.1038\/ni.3008","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,5]]},"assertion":[{"value":"10 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41590-026-02482-x","URL":"https:\/\/doi.org\/10.1038\/s41590-026-02482-x","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}