{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:18:08Z","timestamp":1791425888699,"version":"4.3.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1038\/ni.3233","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T16:55:00Z","timestamp":1438620900000},"page":"918-926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":209,"title":["Commensal bacteria direct selective cargo sorting to promote symbiosis"],"prefix":"10.1038","volume":"16","author":[{"given":"Qin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-0901","authenticated-orcid":false,"given":"Zhihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"BFni3233_CR1","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1126\/science.1127119","volume":"313","author":"HL Cash","year":"2006","unstructured":"Cash, H.L., Whitham, C.V., Behrendt, C.L. & Hooper, L.V. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126\u20131130 (2006).","journal-title":"Science"},{"key":"BFni3233_CR2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.it.2014.09.007","volume":"35","author":"T Alenghat","year":"2014","unstructured":"Alenghat, T. & Artis, D. Epigenomic regulation of host-microbiota interactions. Trends Immunol. 35, 518\u2013525 (2014).","journal-title":"Trends Immunol."},{"key":"BFni3233_CR3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00281-014-0455-3","volume":"37","author":"Y Furusawa","year":"2015","unstructured":"Furusawa, Y., Obata, Y. & Hase, K. Commensal microbiota regulates T cell fate decision in the gut. Semin. Immunopathol. 37, 17\u201325 (2015).","journal-title":"Semin. Immunopathol."},{"key":"BFni3233_CR4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot, J.P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599\u2013603 (2001).","journal-title":"Nature"},{"key":"BFni3233_CR5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603\u2013606 (2001).","journal-title":"Nature"},{"key":"BFni3233_CR6","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1126\/science.1104911","volume":"307","author":"KS Kobayashi","year":"2005","unstructured":"Kobayashi, K.S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731\u2013734 (2005).","journal-title":"Science"},{"key":"BFni3233_CR7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.immuni.2014.06.015","volume":"41","author":"D Ramanan","year":"2014","unstructured":"Ramanan, D., Tang, M.S., Bowcutt, R., Loke, P. & Cadwell, K. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity 41, 311\u2013324 (2014).","journal-title":"Immunity"},{"key":"BFni3233_CR8","doi-asserted-by":"publisher","first-page":"15813","DOI":"10.1073\/pnas.0907722106","volume":"106","author":"T Petnicki-Ocwieja","year":"2009","unstructured":"Petnicki-Ocwieja, T. et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl. Acad. Sci. USA 106, 15813\u201315818 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3233_CR9","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ng.175","volume":"40","author":"JC Barrett","year":"2008","unstructured":"Barrett, J.C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955\u2013962 (2008).","journal-title":"Nat. Genet."},{"key":"BFni3233_CR10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ng.717","volume":"42","author":"A Franke","year":"2010","unstructured":"Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42, 1118\u20131125 (2010).","journal-title":"Nat. Genet."},{"key":"BFni3233_CR11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/ng.764","volume":"43","author":"CA Anderson","year":"2011","unstructured":"Anderson, C.A. et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 43, 246\u2013252 (2011).","journal-title":"Nat. Genet."},{"key":"BFni3233_CR12","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","volume":"44","author":"A Zimprich","year":"2004","unstructured":"Zimprich, A. et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601\u2013607 (2004).","journal-title":"Neuron"},{"key":"BFni3233_CR13","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","volume":"44","author":"C Pais\u00e1n-Ru\u00edz","year":"2004","unstructured":"Pais\u00e1n-Ru\u00edz, C. et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595\u2013600 (2004).","journal-title":"Neuron"},{"key":"BFni3233_CR14","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/ni.2113","volume":"12","author":"Z Liu","year":"2011","unstructured":"Liu, Z. et al. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 12, 1063\u20131070 (2011).","journal-title":"Nat. Immunol."},{"key":"BFni3233_CR15","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.4049\/jimmunol.1000548","volume":"185","author":"A Gardet","year":"2010","unstructured":"Gardet, A. et al. LRRK2 is involved in the IFN-\u03b3 response and host response to pathogens. J. Immunol. 185, 5577\u20135585 (2010).","journal-title":"J. Immunol."},{"key":"BFni3233_CR16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-physiol-030212-183744","volume":"75","author":"HC Clevers","year":"2013","unstructured":"Clevers, H.C. & Bevins, C.L. Paneth cells: maestros of the small intestinal crypts. Annu. Rev. Physiol. 75, 289\u2013311 (2013).","journal-title":"Annu. Rev. Physiol."},{"key":"BFni3233_CR17","doi-asserted-by":"publisher","first-page":"20858","DOI":"10.1073\/pnas.0808723105","volume":"105","author":"S Vaishnava","year":"2008","unstructured":"Vaishnava, S., Behrendt, C.L., Ismail, A.S., Eckmann, L. & Hooper, L.V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 105, 20858\u201320863 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3233_CR18","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nature12599","volume":"503","author":"TE Adolph","year":"2013","unstructured":"Adolph, T.E. et al. Paneth cells as a site of origin for intestinal inflammation. Nature 503, 272\u2013276 (2013).","journal-title":"Nature"},{"key":"BFni3233_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1126\/science.286.5437.113","volume":"286","author":"CL Wilson","year":"1999","unstructured":"Wilson, C.L. et al. Regulation of intestinal \u03b1-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113\u2013117 (1999).","journal-title":"Science"},{"key":"BFni3233_CR20","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","volume":"134","author":"A Kaser","year":"2008","unstructured":"Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743\u2013756 (2008).","journal-title":"Cell"},{"key":"BFni3233_CR21","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nature01520","volume":"422","author":"NH Salzman","year":"2003","unstructured":"Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y. & Bevins, C.L. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422, 522\u2013526 (2003).","journal-title":"Nature"},{"key":"BFni3233_CR22","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1084\/jem.20070563","volume":"204","author":"K Brandl","year":"2007","unstructured":"Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R.P. & Pamer, E.G. MyD88-mediated signals induce the bactericidal lectin RegIII\u03b3 and protect mice against intestinal Listeria monocytogenes infection. J. Exp. Med. 204, 1891\u20131900 (2007).","journal-title":"J. Exp. Med."},{"key":"BFni3233_CR23","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1126\/science.1218831","volume":"337","author":"H Chu","year":"2012","unstructured":"Chu, H. et al. Human \u03b1-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 337, 477\u2013481 (2012).","journal-title":"Science"},{"key":"BFni3233_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nature07416","volume":"456","author":"K Cadwell","year":"2008","unstructured":"Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259\u2013263 (2008).","journal-title":"Nature"},{"key":"BFni3233_CR25","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1083\/jcb.200902096","volume":"186","author":"M Sumakovic","year":"2009","unstructured":"Sumakovic, M. et al. UNC-108\/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans. J. Cell Biol. 186, 897\u2013914 (2009).","journal-title":"J. Cell Biol."},{"key":"BFni3233_CR26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/77783","volume":"1","author":"T Ayabe","year":"2000","unstructured":"Ayabe, T. et al. Secretion of microbicidal \u03b1-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1, 113\u2013118 (2000).","journal-title":"Nat. Immunol."},{"key":"BFni3233_CR27","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"T Sato","year":"2009","unstructured":"Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262\u2013265 (2009).","journal-title":"Nature"},{"key":"BFni3233_CR28","doi-asserted-by":"crossref","unstructured":"Bowman, G.R., Cowan, A.T. & Turkewitz, A.P. Biogenesis of Dense-core Secretory Granules (Landes Bioscience and Springer Science + Business Media, 2009).","DOI":"10.1007\/978-0-387-93877-6_10"},{"key":"BFni3233_CR29","first-page":"124","volume":"21","author":"T Kim","year":"2006","unstructured":"Kim, T., Gondre-Lewis, M.C., Arnaoutova, I. & Loh, Y.P. Dense-core secretory granule biogenesis. Physiology (Bethesda) 21, 124\u2013133 (2006).","journal-title":"Physiology (Bethesda)"},{"key":"BFni3233_CR30","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1083\/jcb.200902095","volume":"186","author":"SL Edwards","year":"2009","unstructured":"Edwards, S.L. et al. Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. J. Cell Biol. 186, 881\u2013895 (2009).","journal-title":"J. Cell Biol."},{"key":"BFni3233_CR31","doi-asserted-by":"publisher","first-page":"18944","DOI":"10.1073\/pnas.1203306109","volume":"109","author":"N Sasidharan","year":"2012","unstructured":"Sasidharan, N. et al. RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 109, 18944\u201318949 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3233_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000199319","volume":"34","author":"Y Satoh","year":"1986","unstructured":"Satoh, Y., Ishikawa, K., Ono, K. & Vollrath, L. Quantitative light microscopic observations on Paneth cells of germ-free and ex-germ-free Wistar rats. Digestion 34, 115\u2013121 (1986).","journal-title":"Digestion"},{"key":"BFni3233_CR33","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1172\/JCI36509","volume":"119","author":"EE Nieuwenhuis","year":"2009","unstructured":"Nieuwenhuis, E.E. et al. Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J. Clin. Invest. 119, 1241\u20131250 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFni3233_CR34","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1136\/gutjnl-2012-304190","volume":"63","author":"MT Shanahan","year":"2014","unstructured":"Shanahan, M.T. et al. Mouse Paneth cell antimicrobial function is independent of Nod2. Gut 63, 903\u2013910 (2014).","journal-title":"Gut"},{"key":"BFni3233_CR35","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1136\/gut.52.11.1591","volume":"52","author":"Y Ogura","year":"2003","unstructured":"Ogura, Y. et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 52, 1591\u20131597 (2003).","journal-title":"Gut"},{"key":"BFni3233_CR36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1083\/jcb.201306010","volume":"202","author":"FA Barr","year":"2013","unstructured":"Barr, F.A. Review series: Rab GTPases and membrane identity: causal or inconsequential? J. Cell Biol. 202, 191\u2013199 (2013).","journal-title":"J. Cell Biol."},{"key":"BFni3233_CR37","first-page":"839","volume":"28","author":"AL Aloisi","year":"2013","unstructured":"Aloisi, A.L. & Bucci, C. Rab GTPases-cargo direct interactions: fine modulators of intracellular trafficking. Histol. Histopathol. 28, 839\u2013849 (2013).","journal-title":"Histol. Histopathol."},{"key":"BFni3233_CR38","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1053\/j.gastro.2013.09.048","volume":"146","author":"KL VanDussen","year":"2014","unstructured":"VanDussen, K.L. et al. Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology 146, 200\u2013209 (2014).","journal-title":"Gastroenterology"},{"key":"BFni3233_CR39","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4161\/auto.5.2.7560","volume":"5","author":"K Cadwell","year":"2009","unstructured":"Cadwell, K., Patel, K.K., Komatsu, M. & Virgin, H.W. 4th & Stappenbeck, T.S. A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease. Autophagy 5, 250\u2013252 (2009).","journal-title":"Autophagy"},{"key":"BFni3233_CR40","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.cell.2010.05.009","volume":"141","author":"K Cadwell","year":"2010","unstructured":"Cadwell, K. et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141, 1135\u20131145 (2010).","journal-title":"Cell"},{"key":"BFni3233_CR41","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1093\/hmg\/ddp346","volume":"18","author":"J Alegre-Abarrategui","year":"2009","unstructured":"Alegre-Abarrategui, J. et al. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022\u20134034 (2009).","journal-title":"Hum. Mol. Genet."},{"key":"BFni3233_CR42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ni.1823","volume":"11","author":"LH Travassos","year":"2010","unstructured":"Travassos, L.H. et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 11, 55\u201362 (2010).","journal-title":"Nat. Immunol."},{"key":"BFni3233_CR43","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.molcel.2015.03.020","volume":"58","author":"S Chauhan","year":"2015","unstructured":"Chauhan, S., Mandell, M.A. & Deretic, V. IRGM governs the core autophagy machinery to conduct antimicrobial defense. Mol. Cell 58, 507\u2013521 (2015).","journal-title":"Mol. Cell"},{"key":"BFni3233_CR44","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nm.2069","volume":"16","author":"R Cooney","year":"2010","unstructured":"Cooney, R. et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16, 90\u201397 (2010).","journal-title":"Nat. Med."},{"key":"BFni3233_CR45","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.neuron.2012.11.033","volume":"77","author":"DA MacLeod","year":"2013","unstructured":"MacLeod, D.A. et al. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 77, 425\u2013439 (2013).","journal-title":"Neuron"},{"key":"BFni3233_CR46","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/jb\/mvv005","volume":"157","author":"HJ Yun","year":"2015","unstructured":"Yun, H.J. et al. An early endosome regulator, Rab5b, is an LRRK2 kinase substrate. J. Biochem. 157, 485\u2013495 (2015).","journal-title":"J. Biochem."},{"key":"BFni3233_CR47","doi-asserted-by":"publisher","first-page":"e111632","DOI":"10.1371\/journal.pone.0111632","volume":"9","author":"D Waschb\u00fcsch","year":"2014","unstructured":"Waschb\u00fcsch, D. et al. LRRK2 transport is regulated by its novel interacting partner Rab32. PLoS ONE 9, e111632 (2014).","journal-title":"PLoS ONE"},{"key":"BFni3233_CR48","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/labinvest.2013.99","volume":"93","author":"J Zong","year":"2013","unstructured":"Zong, J. et al. NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload. Lab. Invest. 93, 1128\u20131136 (2013).","journal-title":"Lab. Invest."},{"key":"BFni3233_CR49","doi-asserted-by":"publisher","first-page":"5219","DOI":"10.1074\/jbc.M109410200","volume":"277","author":"T Ayabe","year":"2002","unstructured":"Ayabe, T. et al. Activation of Paneth cell \u03b1-defensins in mouse small intestine. J. Biol. Chem. 277, 5219\u20135228 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFni3233_CR50","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1038\/nprot.2013.153","volume":"8","author":"H Miyoshi","year":"2013","unstructured":"Miyoshi, H. & Stappenbeck, T.S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nat. Protoc. 8, 2471\u20132482 (2013).","journal-title":"Nat. Protoc."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ni.3233.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni.3233","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni.3233.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T19:03:33Z","timestamp":1730142213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.3233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,3]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["BFni3233"],"URL":"https:\/\/doi.org\/10.1038\/ni.3233","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,3]]},"assertion":[{"value":"19 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}