{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:01:48Z","timestamp":1790355708937,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1038\/ni.3563","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T14:51:54Z","timestamp":1477925514000},"page":"1447-1458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Protective neutralizing influenza antibody response in the absence of T follicular helper cells"],"prefix":"10.1038","volume":"17","author":[{"given":"Kosuke","family":"Miyauchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sugimoto-Ishige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Usami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hijikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Maemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Okada-Hatakeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitada","family":"Takemori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"BFni3563_CR1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature08157","volume":"459","author":"G Neumann","year":"2009","unstructured":"Neumann, G., Noda, T. & Kawaoka, Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 459, 931\u2013939 (2009).","journal-title":"Nature"},{"key":"BFni3563_CR2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1096\/fj.06-7880com","volume":"22","author":"L Yao","year":"2008","unstructured":"Yao, L., Korteweg, C., Hsueh, W. & Gu, J. Avian influenza receptor expression in H5N1-infected and noninfected human tissues. FASEB J. 22, 733\u2013740 (2008).","journal-title":"FASEB J."},{"key":"BFni3563_CR3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.virol.2010.12.015","volume":"411","author":"JK Whitmire","year":"2011","unstructured":"Whitmire, J.K. Induction and function of virus-specific CD4+ T cell responses. Virology 411, 216\u2013228 (2011).","journal-title":"Virology"},{"key":"BFni3563_CR4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri3152","volume":"12","author":"SL Swain","year":"2012","unstructured":"Swain, S.L., McKinstry, K.K. & Strutt, T.M. Expanding roles for CD4+ T cells in immunity to viruses. Nat. Rev. Immunol. 12, 136\u2013148 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni3563_CR5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","volume":"28","author":"J Zhu","year":"2010","unstructured":"Zhu, J., Yamane, H. & Paul, W.E. Differentiation of effector CD4 T cell populations (*). Annu. Rev. Immunol. 28, 445\u2013489 (2010).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni3563_CR6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","volume":"325","author":"RJ Johnston","year":"2009","unstructured":"Johnston, R.J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006\u20131010 (2009).","journal-title":"Science"},{"key":"BFni3563_CR7","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","volume":"325","author":"RI Nurieva","year":"2009","unstructured":"Nurieva, R.I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001\u20131005 (2009).","journal-title":"Science"},{"key":"BFni3563_CR8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1084\/jem.20141380","volume":"212","author":"K Hatzi","year":"2015","unstructured":"Hatzi, K. et al. BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms. J. Exp. Med. 212, 539\u2013553 (2015).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","volume":"31","author":"D Yu","year":"2009","unstructured":"Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457\u2013468 (2009).","journal-title":"Immunity"},{"key":"BFni3563_CR10","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","volume":"29","author":"S Crotty","year":"2011","unstructured":"Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621\u2013663 (2011).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni3563_CR11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nri3804","volume":"15","author":"NS De Silva","year":"2015","unstructured":"De Silva, N.S. & Klein, U. Dynamics of B cells in germinal centres. Nat. Rev. Immunol. 15, 137\u2013148 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni3563_CR12","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1084\/jem.20120127","volume":"209","author":"T Kaji","year":"2012","unstructured":"Kaji, T. et al. Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J. Exp. Med. 209, 2079\u20132097 (2012).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.276.5312.589","volume":"276","author":"AL Dent","year":"1997","unstructured":"Dent, A.L., Shaffer, A.L., Yu, X., Allman, D. & Staudt, L.M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276, 589\u2013592 (1997).","journal-title":"Science"},{"key":"BFni3563_CR14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.immuni.2013.02.020","volume":"38","author":"JS Hale","year":"2013","unstructured":"Hale, J.S. et al. Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity 38, 805\u2013817 (2013).","journal-title":"Immunity"},{"key":"BFni3563_CR15","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20112256","volume":"209","author":"JK Yoo","year":"2012","unstructured":"Yoo, J.K., Fish, E.N. & Braciale, T.J. LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection. J. Exp. Med. 209, 1853\u20131867 (2012).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR16","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/CVI.00156-06","volume":"13","author":"VC Huber","year":"2006","unstructured":"Huber, V.C. et al. Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza. Clin. Vaccine Immunol. 13, 981\u2013990 (2006).","journal-title":"Clin. Vaccine Immunol."},{"key":"BFni3563_CR17","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.3107127","volume":"236","author":"CM Snapper","year":"1987","unstructured":"Snapper, C.M. & Paul, W.E. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236, 944\u2013947 (1987).","journal-title":"Science"},{"key":"BFni3563_CR18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/intimm\/dxt030","volume":"25","author":"T Kaji","year":"2013","unstructured":"Kaji, T. et al. Both mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus. Int. Immunol. 25, 683\u2013695 (2013).","journal-title":"Int. Immunol."},{"key":"BFni3563_CR19","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.157.2.687","volume":"157","author":"LM Staudt","year":"1983","unstructured":"Staudt, L.M. & Gerhard, W. Generation of antibody diversity in the immune response of BALB\/c mice to influenza virus hemagglutinin. I. Significant variation in repertoire expression between individual mice. J. Exp. Med. 157, 687\u2013704 (1983).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR20","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.4049\/jimmunol.178.10.6200","volume":"178","author":"AF Cunningham","year":"2007","unstructured":"Cunningham, A.F. et al. Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection. J. Immunol. 178, 6200\u20136207 (2007).","journal-title":"J. Immunol."},{"key":"BFni3563_CR21","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1073\/pnas.082114899","volume":"99","author":"SL Peng","year":"2002","unstructured":"Peng, S.L., Szabo, S.J. & Glimcher, L.H. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl. Acad. Sci. USA 99, 5545\u20135550 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3563_CR22","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.celrep.2016.01.038","volume":"14","author":"X Liu","year":"2016","unstructured":"Liu, X. et al. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper cell differentiation. Cell Rep. 14, 1735\u20131747 (2016).","journal-title":"Cell Rep."},{"key":"BFni3563_CR23","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1084\/jem.20102065","volume":"208","author":"SK Lee","year":"2011","unstructured":"Lee, S.K. et al. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J. Exp. Med. 208, 1377\u20131388 (2011).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/icb.2013.49","volume":"92","author":"AS Weinmann","year":"2014","unstructured":"Weinmann, A.S. Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibility. Immunol. Cell Biol. 92, 34\u201339 (2014).","journal-title":"Immunol. Cell Biol."},{"key":"BFni3563_CR25","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1084\/jem.20101773","volume":"208","author":"LM Fahey","year":"2011","unstructured":"Fahey, L.M. et al. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J. Exp. Med. 208, 987\u2013999 (2011).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1084\/jem.20091738","volume":"207","author":"MA Linterman","year":"2010","unstructured":"Linterman, M.A. et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 207, 353\u2013363 (2010).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1749-6632.1996.tb52958.x","volume":"797","author":"MK Slifka","year":"1996","unstructured":"Slifka, M.K. & Ahmed, R. Long-term antibody production is sustained by antibody-secreting cells in the bone marrow following acute viral infection. Ann. NY Acad. Sci. 797, 166\u2013176 (1996).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFni3563_CR28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20021499","volume":"197","author":"A Purdy","year":"2003","unstructured":"Purdy, A. et al. Unique resistance of I\/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies. J. Exp. Med. 197, 233\u2013243 (2003).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/cimm.2000.1703","volume":"204","author":"CY Koh","year":"2000","unstructured":"Koh, C.Y. & Yuan, D. The functional relevance of NK-cell-mediated upregulation of antigen-specific IgG2a responses. Cell. Immunol. 204, 135\u2013142 (2000).","journal-title":"Cell. Immunol."},{"key":"BFni3563_CR30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","volume":"247","author":"MJ Shlomchik","year":"2012","unstructured":"Shlomchik, M.J. & Weisel, F. Germinal center selection and the development of memory B and plasma cells. Immunol. Rev. 247, 52\u201363 (2012).","journal-title":"Immunol. Rev."},{"key":"BFni3563_CR31","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.4049\/jimmunol.0902710","volume":"184","author":"R Racine","year":"2010","unstructured":"Racine, R. et al. Impaired germinal center responses and suppression of local IgG production during intracellular bacterial infection. J. Immunol. 184, 5085\u20135093 (2010).","journal-title":"J. Immunol."},{"key":"BFni3563_CR32","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.4049\/jimmunol.1103735","volume":"188","author":"CJ Hastey","year":"2012","unstructured":"Hastey, C.J., Elsner, R.A., Barthold, S.W. & Baumgarth, N. Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. J. Immunol. 188, 5612\u20135622 (2012).","journal-title":"J. Immunol."},{"key":"BFni3563_CR33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.immuni.2015.06.013","volume":"43","author":"R Di Niro","year":"2015","unstructured":"Di Niro, R. et al. Salmonella infection drives promiscuous B cell activation followed by extrafollicular affinity maturation. Immunity 43, 120\u2013131 (2015).","journal-title":"Immunity"},{"key":"BFni3563_CR34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.immuni.2012.02.002","volume":"36","author":"Y Harada","year":"2012","unstructured":"Harada, Y. et al. The 3\u2032 enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity 36, 188\u2013200 (2012).","journal-title":"Immunity"},{"key":"BFni3563_CR35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.immuni.2011.12.014","volume":"36","author":"P Vijayanand","year":"2012","unstructured":"Vijayanand, P. et al. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity 36, 175\u2013187 (2012).","journal-title":"Immunity"},{"key":"BFni3563_CR36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni.2261","volume":"13","author":"K L\u00fcthje","year":"2012","unstructured":"L\u00fcthje, K. et al. The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat. Immunol. 13, 491\u2013498 (2012).","journal-title":"Nat. Immunol."},{"key":"BFni3563_CR37","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.4049\/jimmunol.164.10.5236","volume":"164","author":"PI Karachunski","year":"2000","unstructured":"Karachunski, P.I., Ostlie, N.S., Monfardini, C. & Conti-Fine, B.M. Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL\/6 mice. J. Immunol. 164, 5236\u20135244 (2000).","journal-title":"J. Immunol."},{"key":"BFni3563_CR38","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1077002","volume":"298","author":"K Ozaki","year":"2002","unstructured":"Ozaki, K. et al. A critical role for IL-21 in regulating immunoglobulin production. Science 298, 1630\u20131634 (2002).","journal-title":"Science"},{"key":"BFni3563_CR39","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.4049\/jimmunol.0903949","volume":"184","author":"J Bessa","year":"2010","unstructured":"Bessa, J., Kopf, M. & Bachmann, M.F. Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner. J. Immunol. 184, 4615\u20134619 (2010).","journal-title":"J. Immunol."},{"key":"BFni3563_CR40","doi-asserted-by":"crossref","first-page":"e17739","DOI":"10.1371\/journal.pone.0017739","volume":"6","author":"D Eto","year":"2011","unstructured":"Eto, D. et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One 6, e17739 (2011).","journal-title":"PLoS One"},{"key":"BFni3563_CR41","doi-asserted-by":"crossref","first-page":"e0144654","DOI":"10.1371\/journal.pone.0144654","volume":"10","author":"VH Carpio","year":"2015","unstructured":"Carpio, V.H. et al. IFN-\u03b3 and IL-21 double producing T cells are Bcl6-independent and survive into the memory phase in Plasmodium chabaudi infection. PLoS One 10, e0144654 (2015).","journal-title":"PLoS One"},{"key":"BFni3563_CR42","doi-asserted-by":"crossref","first-page":"12781","DOI":"10.1038\/srep12781","volume":"5","author":"L Xiao","year":"2015","unstructured":"Xiao, L. et al. Human IL-21+IFN-\u03b3+CD4+ T cells in nasal polyps are regulated by IL-12. Sci. Rep. 5, 12781 (2015).","journal-title":"Sci. Rep."},{"key":"BFni3563_CR43","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1126\/science.1175194","volume":"324","author":"JS Yi","year":"2009","unstructured":"Yi, J.S., Du, M. & Zajac, A.J. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324, 1572\u20131576 (2009).","journal-title":"Science"},{"key":"BFni3563_CR44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.4049\/jimmunol.0903915","volume":"185","author":"FY Yue","year":"2010","unstructured":"Yue, F.Y. et al. HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J. Immunol. 185, 498\u2013506 (2010).","journal-title":"J. Immunol."},{"key":"BFni3563_CR45","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1715","volume":"10","author":"RL Reinhardt","year":"2009","unstructured":"Reinhardt, R.L., Liang, H.E. & Locksley, R.M. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10, 385\u2013393 (2009).","journal-title":"Nat. Immunol."},{"key":"BFni3563_CR46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0167-5699(00)01636-4","volume":"21","author":"LS Walker","year":"2000","unstructured":"Walker, L.S., Gulbranson-Judge, A., Flynn, S., Brocker, T. & Lane, P.J. Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol. Today 21, 333\u2013337 (2000).","journal-title":"Immunol. Today"},{"key":"BFni3563_CR47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ni.1966","volume":"12","author":"S Tanaka","year":"2011","unstructured":"Tanaka, S. et al. The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat. Immunol. 12, 77\u201385 (2011).","journal-title":"Nat. Immunol."},{"key":"BFni3563_CR48","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/ni.1900","volume":"11","author":"CC Goodnow","year":"2010","unstructured":"Goodnow, C.C., Vinuesa, C.G., Randall, K.L., Mackay, F. & Brink, R. Control systems and decision making for antibody production. Nat. Immunol. 11, 681\u2013688 (2010).","journal-title":"Nat. Immunol."},{"key":"BFni3563_CR49","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20012065","volume":"197","author":"KA Pape","year":"2003","unstructured":"Pape, K.A. et al. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J. Exp. Med. 197, 1677\u20131687 (2003).","journal-title":"J. Exp. Med."},{"key":"BFni3563_CR50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1074-7613(02)00387-4","volume":"17","author":"H Toyama","year":"2002","unstructured":"Toyama, H. et al. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17, 329\u2013339 (2002).","journal-title":"Immunity"},{"key":"BFni3563_CR51","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1056\/NEJMoa040419","volume":"350","author":"TH Tran","year":"2004","unstructured":"Tran, T.H. et al. Avian influenza A (H5N1) in 10 patients in Vietnam. N. Engl. J. Med. 350, 1179\u20131188 (2004).","journal-title":"N. Engl. J. Med."},{"key":"BFni3563_CR52","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1128\/JVI.65.12.6856-6861.1991","volume":"65","author":"DM Roscoe","year":"1991","unstructured":"Roscoe, D.M., Ishikawa, K. & Lyles, D.S. Role of de novo protein synthesis in target cells recognized by cytotoxic T lymphocytes specific for vesicular stomatitis virus. J. Virol. 65, 6856\u20136861 (1991).","journal-title":"J. Virol."},{"key":"BFni3563_CR53","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1073\/pnas.1115369109","volume":"109","author":"T Onodera","year":"2012","unstructured":"Onodera, T. et al. Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection. Proc. Natl. Acad. Sci. USA 109, 2485\u20132490 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3563_CR54","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/978-1-61779-842-9_32","volume":"882","author":"E Alamyar","year":"2012","unstructured":"Alamyar, E., Duroux, P., Lefranc, M.P. & Giudicelli, V. IMGT tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT\/V-QUEST and IMGT\/HighV-QUEST for NGS. Methods Mol. Biol. 882, 569\u2013604 (2012).","journal-title":"Methods Mol. Biol."},{"key":"BFni3563_CR55","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer, A., Green, J., Pollard, J. Jr. & Tugendreich, S. Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30, 523\u2013530 (2014).","journal-title":"Bioinformatics"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni.3563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.3563","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.3563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:12:18Z","timestamp":1684433538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.3563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["BFni3563"],"URL":"https:\/\/doi.org\/10.1038\/ni.3563","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,31]]},"assertion":[{"value":"8 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}