{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:41:40Z","timestamp":1792071700769,"version":"4.4.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/ni.3655","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T12:00:22Z","timestamp":1484568022000},"page":"293-302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":281,"title":["Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression"],"prefix":"10.1038","volume":"18","author":[{"given":"Monika","family":"Linke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Thi Thanh","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Katholnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schn\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Demel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Sch\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Kovacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyamdelger","family":"Sukhbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Niederreiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-4400","authenticated-orcid":false,"given":"Stephan","family":"Bl\u00fcml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kuess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Sexl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mikula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Weckwerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvand","family":"Haschemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Susani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hengstschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Gambello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-0797","authenticated-orcid":false,"given":"Thomas","family":"Weichhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"BFni3655_CR1","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/j.cell.2014.11.024","volume":"159","author":"CJ Cambier","year":"2014","unstructured":"Cambier, C.J., Falkow, S. & Ramakrishnan, L. Host evasion and exploitation schemes of Mycobacterium tuberculosis. Cell 159, 1497\u20131509 (2014).","journal-title":"Cell"},{"key":"BFni3655_CR2","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ni.1781","volume":"10","author":"DG Russell","year":"2009","unstructured":"Russell, D.G., Cardona, P.J., Kim, M.J., Allain, S. & Altare, F. Foamy macrophages and the progression of the human tuberculosis granuloma. Nat. Immunol. 10, 943\u2013948 (2009).","journal-title":"Nat. Immunol."},{"key":"BFni3655_CR3","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.smim.2014.09.009","volume":"26","author":"IM Orme","year":"2014","unstructured":"Orme, I.M. & Basaraba, R.J. The formation of the granuloma in tuberculosis infection. Semin. Immunol. 26, 601\u2013609 (2014).","journal-title":"Semin. Immunol."},{"key":"BFni3655_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3389\/fimmu.2013.00089","volume":"4","author":"E Hams","year":"2013","unstructured":"Hams, E., Aviello, G. & Fallon, P.G. The schistosoma granuloma: friend or foe? Front. Immunol. 4, 89 (2013).","journal-title":"Front. Immunol."},{"key":"BFni3655_CR5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1001\/jama.2011.10","volume":"305","author":"MC Iannuzzi","year":"2011","unstructured":"Iannuzzi, M.C. & Fontana, J.R. Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. J. Am. Med. Assoc. 305, 391\u2013399 (2011).","journal-title":"J. Am. Med. Assoc."},{"key":"BFni3655_CR6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fimmu.2013.00120","volume":"4","author":"HJ Petersen","year":"2013","unstructured":"Petersen, H.J. & Smith, A.M. The role of the innate immune system in granulomatous disorders. Front. Immunol. 4, 120 (2013).","journal-title":"Front. Immunol."},{"key":"BFni3655_CR7","first-page":"325","volume":"7","author":"SH Beegle","year":"2013","unstructured":"Beegle, S.H., Barba, K., Gobunsuy, R. & Judson, M.A. Current and emerging pharmacological treatments for sarcoidosis: a review. Drug Des. Devel. Ther. 7, 325\u2013338 (2013).","journal-title":"Drug Des. Devel. Ther."},{"key":"BFni3655_CR8","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ccm.2015.08.016","volume":"36","author":"G Zissel","year":"2015","unstructured":"Zissel, G. & M\u00fcller-Quernheim, J. Cellular players in the immunopathogenesis of sarcoidosis. Clin. Chest Med. 36, 549\u2013560 (2015).","journal-title":"Clin. Chest Med."},{"key":"BFni3655_CR9","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1164\/rccm.200912-1855OC","volume":"181","author":"HE Lockstone","year":"2010","unstructured":"Lockstone, H.E. et al. Gene set analysis of lung samples provides insight into pathogenesis of progressive, fibrotic pulmonary sarcoidosis. Am. J. Respir. Crit. Care Med. 181, 1367\u20131375 (2010).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFni3655_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3389\/fimmu.2012.00411","volume":"3","author":"S Ehlers","year":"2013","unstructured":"Ehlers, S. & Schaible, U.E. The granuloma in tuberculosis: dynamics of a host-pathogen collusion. Front. Immunol. 3, 411 (2013).","journal-title":"Front. Immunol."},{"key":"BFni3655_CR11","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/nri3211","volume":"12","author":"L Ramakrishnan","year":"2012","unstructured":"Ramakrishnan, L. Revisiting the role of the granuloma in tuberculosis. Nat. Rev. Immunol. 12, 352\u2013366 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni3655_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/ni.3048","volume":"16","author":"IM Orme","year":"2015","unstructured":"Orme, I.M., Robinson, R.T. & Cooper, A.M. The balance between protective and pathogenic immune responses in the TB-infected lung. Nat. Immunol. 16, 57\u201363 (2015).","journal-title":"Nat. Immunol."},{"key":"BFni3655_CR13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4049\/jimmunol.165.1.483","volume":"165","author":"S Ehlers","year":"2000","unstructured":"Ehlers, S., Kutsch, S., Ehlers, E.M., Benini, J. & Pfeffer, K. Lethal granuloma disintegration in mycobacteria-infected TNFRp55-\/- mice is dependent on T cells and IL-12. J. Immunol. 165, 483\u2013492 (2000).","journal-title":"J. Immunol."},{"key":"BFni3655_CR14","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1146\/annurev.immunol.22.012703.104635","volume":"22","author":"RJ North","year":"2004","unstructured":"North, R.J. & Jung, Y.J. Immunity to tuberculosis. Annu. Rev. Immunol. 22, 599\u2013623 (2004).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni3655_CR15","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1038\/labinvest.2012.125","volume":"92","author":"D Regev","year":"2012","unstructured":"Regev, D. et al. Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Lab. Invest. 92, 1541\u20131552 (2012).","journal-title":"Lab. Invest."},{"key":"BFni3655_CR16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00281-015-0531-3","volume":"38","author":"A Dorhoi","year":"2016","unstructured":"Dorhoi, A. & Kaufmann, S.H. Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis. Semin. Immunopathol. 38, 153\u2013166 (2016).","journal-title":"Semin. Immunopathol."},{"key":"BFni3655_CR17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante, M. & Sabatini, D.M. mTOR signaling in growth control and disease. Cell 149, 274\u2013293 (2012).","journal-title":"Cell"},{"key":"BFni3655_CR18","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"K Inoki","year":"2002","unstructured":"Inoki, K., Li, Y., Zhu, T., Wu, J. & Guan, K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648\u2013657 (2002).","journal-title":"Nat. Cell Biol."},{"key":"BFni3655_CR19","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nri3198","volume":"12","author":"H Chi","year":"2012","unstructured":"Chi, H. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325\u2013338 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni3655_CR20","doi-asserted-by":"publisher","first-page":"E4894","DOI":"10.1073\/pnas.1308905110","volume":"110","author":"Y Wang","year":"2013","unstructured":"Wang, Y. et al. Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. Proc. Natl. Acad. Sci. USA 110, E4894\u2013E4903 (2013).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni3655_CR21","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nri3901","volume":"15","author":"T Weichhart","year":"2015","unstructured":"Weichhart, T., Hengstschl\u00e4ger, M. & Linke, M. Regulation of innate immune cell function by mTOR. Nat. Rev. Immunol. 15, 599\u2013614 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni3655_CR22","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1038\/ncomms3834","volume":"4","author":"V Byles","year":"2013","unstructured":"Byles, V. et al. The TSC-mTOR pathway regulates macrophage polarization. Nat. Commun. 4, 2834 (2013).","journal-title":"Nat. Commun."},{"key":"BFni3655_CR23","doi-asserted-by":"publisher","first-page":"3658","DOI":"10.4049\/jimmunol.1102187","volume":"188","author":"H Pan","year":"2012","unstructured":"Pan, H., O'Brien, T.F., Zhang, P. & Zhong, X.P. The role of tuberous sclerosis complex 1 in regulating innate immunity. J. Immunol. 188, 3658\u20133666 (2012).","journal-title":"J. Immunol."},{"key":"BFni3655_CR24","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1159\/000430306","volume":"36","author":"C Fang","year":"2015","unstructured":"Fang, C. et al. Tsc1 is a Critical Regulator of Macrophage Survival and Function. Cell. Physiol. Biochem. 36, 1406\u20131418 (2015).","journal-title":"Cell. Physiol. Biochem."},{"key":"BFni3655_CR25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/dvg.20271","volume":"45","author":"O Hernandez","year":"2007","unstructured":"Hernandez, O., Way, S., McKenna, J. III & Gambello, M.J. Generation of a conditional disruption of the Tsc2 gene. Genesis 45, 101\u2013106 (2007).","journal-title":"Genesis"},{"key":"BFni3655_CR26","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.ajpath.2010.11.065","volume":"178","author":"S Prokop","year":"2011","unstructured":"Prokop, S., Heppner, F.L., Goebel, H.H. & Stenzel, W. M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. Am. J. Pathol. 178, 1279\u20131286 (2011).","journal-title":"Am. J. Pathol."},{"key":"BFni3655_CR27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1165\/rcmb.2013-0086MA","volume":"49","author":"AV Misharin","year":"2013","unstructured":"Misharin, A.V., Morales-Nebreda, L., Mutlu, G.M., Budinger, G.R. & Perlman, H. Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am. J. Respir. Cell Mol. Biol. 49, 503\u2013510 (2013).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFni3655_CR28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.stem.2008.02.009","volume":"2","author":"DJ Wong","year":"2008","unstructured":"Wong, D.J. et al. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2, 333\u2013344 (2008).","journal-title":"Cell Stem Cell"},{"key":"BFni3655_CR29","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nrm3629","volume":"14","author":"C Bertoli","year":"2013","unstructured":"Bertoli, C., Skotheim, J.M. & de Bruin, R.A. Control of cell cycle transcription during G1 and S phases. Nat. Rev. Mol. Cell Biol. 14, 518\u2013528 (2013).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFni3655_CR30","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/nrm2510","volume":"9","author":"H Hochegger","year":"2008","unstructured":"Hochegger, H., Takeda, S. & Hunt, T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat. Rev. Mol. Cell Biol. 9, 910\u2013916 (2008).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFni3655_CR31","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1158\/2159-8290.CD-15-0894","volume":"6","author":"CJ Sherr","year":"2016","unstructured":"Sherr, C.J., Beach, D. & Shapiro, G.I. Targeting CDK4 and CDK6: from discovery to tTherapy. Cancer Discov. 6, 353\u2013367 (2016).","journal-title":"Cancer Discov."},{"key":"BFni3655_CR32","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1042\/BST20130041","volume":"41","author":"JJ Howell","year":"2013","unstructured":"Howell, J.J., Ricoult, S.J., Ben-Sahra, I. & Manning, B.D. A growing role for mTOR in promoting anabolic metabolism. Biochem. Soc. Trans. 41, 906\u2013912 (2013).","journal-title":"Biochem. Soc. Trans."},{"key":"BFni3655_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/nyas.12122","volume":"1291","author":"D Lebwohl","year":"2013","unstructured":"Lebwohl, D. et al. Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases. Ann. NY Acad. Sci. 1291, 14\u201332 (2013).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFni3655_CR34","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1183\/09031936.93.06070951","volume":"6","author":"A Pforte","year":"1993","unstructured":"Pforte, A. et al. Proliferating alveolar macrophages in BAL and lung function changes in interstitial lung disease. Eur. Respir. J. 6, 951\u2013955 (1993).","journal-title":"Eur. Respir. J."},{"key":"BFni3655_CR35","first-page":"190","volume":"23","author":"S Petzmann","year":"2006","unstructured":"Petzmann, S. et al. Enhanced proliferation and decreased apoptosis in lung lavage cells of sarcoidosis patients. Sarcoidosis Vasc. Diffuse Lung Dis. 23, 190\u2013200 (2006).","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"BFni3655_CR36","first-page":"1214","volume":"147","author":"HY Lan","year":"1995","unstructured":"Lan, H.Y., Nikolic-Paterson, D.J., Mu, W. & Atkins, R.C. Local macrophage proliferation in multinucleated giant cell and granuloma formation in experimental Goodpasture's syndrome. Am. J. Pathol. 147, 1214\u20131220 (1995).","journal-title":"Am. J. Pathol."},{"key":"BFni3655_CR37","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/path.4487","volume":"235","author":"F Huaux","year":"2015","unstructured":"Huaux, F. et al. IL-1\u03b1 induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation. J. Pathol. 235, 698\u2013709 (2015).","journal-title":"J. Pathol."},{"key":"BFni3655_CR38","doi-asserted-by":"crossref","first-page":"1242974","DOI":"10.1126\/science.1242974","volume":"342","author":"MH Sieweke","year":"2013","unstructured":"Sieweke, M.H. & Allen, J.E. Beyond stem cells: self-renewal of differentiated macrophages. Science 342, 1242974 (2013).","journal-title":"Science"},{"key":"BFni3655_CR39","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/nm.3258","volume":"19","author":"CS Robbins","year":"2013","unstructured":"Robbins, C.S. et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat. Med. 19, 1166\u20131172 (2013).","journal-title":"Nat. Med."},{"key":"BFni3655_CR40","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1007\/s00125-013-3139-y","volume":"57","author":"J Haase","year":"2014","unstructured":"Haase, J. et al. Local proliferation of macrophages in adipose tissue during obesity-induced inflammation. Diabetologia 57, 562\u2013571 (2014).","journal-title":"Diabetologia"},{"key":"BFni3655_CR41","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","volume":"23","author":"DC Fingar","year":"2004","unstructured":"Fingar, D.C. & Blenis, J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23, 3151\u20133171 (2004).","journal-title":"Oncogene"},{"key":"BFni3655_CR42","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ni1413","volume":"8","author":"J Song","year":"2007","unstructured":"Song, J., Salek-Ardakani, S., So, T. & Croft, M. The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat. Immunol. 8, 64\u201373 (2007).","journal-title":"Nat. Immunol."},{"key":"BFni3655_CR43","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0002-9440(10)61703-8","volume":"159","author":"PL Miliani de Marval","year":"2001","unstructured":"Miliani de Marval, P.L. et al. Transgenic expression of cyclin-dependent kinase 4 results in epidermal hyperplasia, hypertrophy, and severe dermal fibrosis. Am. J. Pathol. 159, 369\u2013379 (2001).","journal-title":"Am. J. Pathol."},{"key":"BFni3655_CR44","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","volume":"38","author":"EL Pearce","year":"2013","unstructured":"Pearce, E.L. & Pearce, E.J. Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633\u2013643 (2013).","journal-title":"Immunity"},{"key":"BFni3655_CR45","doi-asserted-by":"publisher","first-page":"605","DOI":"10.4049\/jimmunol.0901698","volume":"185","author":"JC Rodr\u00edguez-Prados","year":"2010","unstructured":"Rodr\u00edguez-Prados, J.C. et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J. Immunol. 185, 605\u2013614 (2010).","journal-title":"J. Immunol."},{"key":"BFni3655_CR46","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1183\/09031936.00033812","volume":"41","author":"S Hofmann","year":"2013","unstructured":"Hofmann, S. et al. Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. Eur. Respir. J. 41, 888\u2013900 (2013).","journal-title":"Eur. Respir. J."},{"key":"BFni3655_CR47","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1378\/chest.07-1178","volume":"132","author":"AS Teirstein","year":"2007","unstructured":"Teirstein, A.S. et al. Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest 132, 1949\u20131953 (2007).","journal-title":"Chest"},{"key":"BFni3655_CR48","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1097\/MCP.0000000000000082","volume":"20","author":"MA Judson","year":"2014","unstructured":"Judson, M.A. & Baughman, R.P. Worsening of pulmonary sarcoidosis. Curr. Opin. Pulm. Med. 20, 508\u2013516 (2014).","journal-title":"Curr. Opin. Pulm. Med."},{"key":"BFni3655_CR49","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1111\/j.1432-2277.2011.01256.x","volume":"24","author":"TM Manzia","year":"2011","unstructured":"Manzia, T.M. et al. Successful treatment of systemic de novo sarcoidosis with cyclosporine discontinuation and provision of rapamune after liver transplantation. Transpl. Int. 24, e69\u2013e70 (2011).","journal-title":"Transpl. Int."},{"key":"BFni3655_CR50","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/nprot.2010.74","volume":"5","author":"M Rosner","year":"2010","unstructured":"Rosner, M. et al. Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nat. Protoc. 5, 1081\u20131095 (2010).","journal-title":"Nat. Protoc."},{"key":"BFni3655_CR51","unstructured":"Van Noorden, C.J.F. & Frederiks, W.M. Enzyme Histochemistry: a Laboratory Manual of Current Methods (Oxford University Press, 1992)."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni.3655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.3655","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni.3655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:39:24Z","timestamp":1692632364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni.3655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,16]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFni3655"],"URL":"https:\/\/doi.org\/10.1038\/ni.3655","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727212287.793569758","asserted-by":"object"}]},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,16]]},"assertion":[{"value":"20 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}