{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:28:54Z","timestamp":1792250934778,"version":"4.4.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2003,5,1]]},"DOI":"10.1038\/ni0503-404","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T13:42:21Z","timestamp":1051537341000},"page":"404-409","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["The death effector domain protein family: regulators of cellular homeostasis"],"prefix":"10.1038","volume":"4","author":[{"given":"Michael D.","family":"Tibbetts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lenardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFni0503404_CR1","doi-asserted-by":"crossref","first-page":"10932","DOI":"10.1016\/S0021-9258(18)82075-0","volume":"268","author":"N Itoh","year":"1993","unstructured":"Itoh, N. & Nagata, S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J. Biol. Chem. 268, 10932\u201310937 (1993).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR2","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/0092-8674(93)90464-2","volume":"74","author":"LA Tartaglia","year":"1993","unstructured":"Tartaglia, L.A., Ayres, T.M., Wong, G.H. & Goeddel, D.V. A novel domain within the 55 kD TNF receptor signals cell death. Cell 74, 845\u2013853 (1993).","journal-title":"Cell"},{"key":"BFni0503404_CR3","doi-asserted-by":"publisher","first-page":"7795","DOI":"10.1074\/jbc.270.14.7795","volume":"270","author":"MP Boldin","year":"1995","unstructured":"Boldin, M.P. et al. A novel protein that interacts with the death domain of Fas\/APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270, 7795\u20137798 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0092-8674(95)90071-3","volume":"81","author":"AM Chinnaiyan","year":"1995","unstructured":"Chinnaiyan, A.M., O'Rourke, K., Tewari, M. & Dixit, V.M. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505\u2013512 (1995).","journal-title":"Cell"},{"key":"BFni0503404_CR5","doi-asserted-by":"publisher","first-page":"7464","DOI":"10.1073\/pnas.93.15.7464","volume":"93","author":"T Fernandes-Alnemri","year":"1996","unstructured":"Fernandes-Alnemri, T. et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. USA 93, 7464\u20137469 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni0503404_CR6","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1074\/jbc.273.5.2926","volume":"273","author":"M Muzio","year":"1998","unstructured":"Muzio, M., Stockwell, B.R., Stennicke, H.R., Salvasen, G.S. & Dixit, V.M. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273, 2926\u20132930 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR7","doi-asserted-by":"publisher","first-page":"46639","DOI":"10.1074\/jbc.M105102200","volume":"276","author":"FC Kischkel","year":"2001","unstructured":"Kischkel, F.C. et al. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J. Biol. Chem. 276, 46639\u201346646 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR8","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1074\/jbc.273.8.4345","volume":"273","author":"DA Martin","year":"1998","unstructured":"Martin, D.A., Siegel, R.M., Zheng, L. & Lenardo, M.J. Membrane oligomerization and cleavage activates the caspase-8 (FLICE\/MACH\u03b11) death signal. J. Biol. Chem. 273, 4345\u20134349 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR9","doi-asserted-by":"publisher","first-page":"13884","DOI":"10.1073\/pnas.241358198","volume":"98","author":"J Wang","year":"2001","unstructured":"Wang, J., Chun, H.J., Wong, W., Spencer, D.M. & Lenardo, M.J. Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. USA 98, 13884\u201313888 (2001).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni0503404_CR10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0092-8674(00)81265-9","volume":"85","author":"MP Boldin","year":"1996","unstructured":"Boldin, M.P., Goncharov, T.M., Goltsev, Y.V. & Wallach, D.I. Involvement of MACH, a novel MORT1\/FADD-interacting protease, in Fas\/Apo-1 and TNF receptor-induced cell death. Cell 85, 803\u2013815 (1996).","journal-title":"Cell"},{"key":"BFni0503404_CR11","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0092-8674(00)81266-0","volume":"85","author":"M Muzio","year":"1996","unstructured":"Muzio, M. et al. FLICE, a novel FADD-homologous ICE\/CED-3-like protease, is recruited to the CD95 (Fas\/APO-1) death-inducing signaling complex. Cell 85, 817\u2013827 (1996).","journal-title":"Cell"},{"key":"BFni0503404_CR12","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S0968-0004(01)01905-3","volume":"26","author":"CH Weber","year":"2001","unstructured":"Weber, C.H. & Vincenz, C. The death domain superfamily: a tale of two interfaces? Trends Biochem. Sci. 26, 475\u2013481 (2001).","journal-title":"Trends Biochem. Sci."},{"key":"BFni0503404_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/31972","volume":"392","author":"M Eberstadt","year":"1998","unstructured":"Eberstadt, M. et al. NMR structure and mutagenesis of the FADD (MORT1) death-effector domain. Nature 392, 941\u2013945 (1998).","journal-title":"Nature"},{"key":"BFni0503404_CR14","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s000180050361","volume":"55","author":"K Hofmann","year":"1999","unstructured":"Hofmann, K. The modular nature of apoptotic signaling proteins. Cell. Mol. Life Sci. 55, 1113\u20131128 (1999).","journal-title":"Cell. Mol. Life Sci."},{"key":"BFni0503404_CR15","doi-asserted-by":"publisher","first-page":"R118","DOI":"10.1016\/S0960-9822(01)00056-2","volume":"11","author":"F Martinon","year":"2001","unstructured":"Martinon, F., Hofman, K. & Tschopp, J. The pyrin domain: a possible member of the death domain family implicated in apoptosis and inflammation. Curr. Biol. 11, R118\u2013R120 (2001).","journal-title":"Curr. Biol."},{"key":"BFni0503404_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0968-0004(97)01043-8","volume":"22","author":"K Hofmann","year":"1997","unstructured":"Hofmann, K., Bucher, P. & Tschopp, J. The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22, 155\u2013156 (1997).","journal-title":"Trends Biochem. Sci."},{"key":"BFni0503404_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1128\/JVI.76.2.697-706.2002","volume":"76","author":"TL Garvey","year":"2002","unstructured":"Garvey, T.L. et al. Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. J. Virol. 76, 697\u2013706 (2002).","journal-title":"J. Virol."},{"key":"BFni0503404_CR18","doi-asserted-by":"publisher","first-page":"30761","DOI":"10.1074\/jbc.C000341200","volume":"275","author":"S Hu","year":"2000","unstructured":"Hu, S. & Yang, X. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J. Biol. Chem. 275, 30761\u201330764 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR19","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1046\/j.1365-2958.2000.01824.x","volume":"35","author":"SW Lee","year":"2000","unstructured":"Lee, S.W., Ko, Y.G., Bang, S., Kim, K.S. & Kim, S. Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death. Mol. Microbiol. 35, 1540\u20131549 (2000).","journal-title":"Mol. Microbiol."},{"key":"BFni0503404_CR20","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1126\/science.288.5475.2354","volume":"288","author":"RM Siegel","year":"2000","unstructured":"Siegel, R.M. et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288, 2354\u20132357 (2000).","journal-title":"Science"},{"key":"BFni0503404_CR21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/S0014-5793(02)03146-0","volume":"527","author":"M Kaufmann","year":"2002","unstructured":"Kaufmann, M. et al. Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett. 527, 250\u2013254 (2002).","journal-title":"FEBS Lett."},{"key":"BFni0503404_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0014-5793(01)02162-7","volume":"492","author":"CH Weber","year":"2001","unstructured":"Weber, C.H. & Vincenz, C. A docking model of key components of the DISC complex: death domain superfamily interactions redefined. FEBS Lett. 492, 171\u2013176 (2001).","journal-title":"FEBS Lett."},{"key":"BFni0503404_CR23","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1126\/science.7539157","volume":"268","author":"F Rieux-Laucat","year":"1995","unstructured":"Rieux-Laucat, F. et al. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268, 1347\u20131349 (1995).","journal-title":"Science"},{"key":"BFni0503404_CR24","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","volume":"81","author":"GH Fisher","year":"1995","unstructured":"Fisher, G.H. et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81, 935\u2013946 (1995).","journal-title":"Cell"},{"key":"BFni0503404_CR25","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1182\/blood.V89.4.1341","volume":"89","author":"MC Sneller","year":"1997","unstructured":"Sneller, M.C. et al. Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. Blood 89, 1341\u20131348 (1997).","journal-title":"Blood"},{"key":"BFni0503404_CR26","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S1097-2765(00)80032-5","volume":"1","author":"X Yang","year":"1998","unstructured":"Yang, X., Chang, H.Y. & Baltimore, D. Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell 1, 319\u2013325 (1998).","journal-title":"Mol. Cell"},{"key":"BFni0503404_CR27","doi-asserted-by":"crossref","unstructured":"Jaattela, M. & Tschopp, J. Caspase-independent cell death in T lymphocytes. Nat. Immunol. 4, 416\u2013423.","DOI":"10.1038\/ni0503-416"},{"key":"BFni0503404_CR28","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/82732","volume":"1","author":"N Holler","year":"2000","unstructured":"Holler, N. et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1, 489\u2013495 (2000).","journal-title":"Nat. Immunol."},{"key":"BFni0503404_CR29","doi-asserted-by":"publisher","first-page":"7470","DOI":"10.1128\/JVI.74.16.7470-7477.2000","volume":"74","author":"M Li","year":"2000","unstructured":"Li, M. & Beg, A.A. Induction of necrotic-like cell death by tumor necrosis factor-\u03b1 and caspase inhibitors: novel mechanism for killing virus-infected cells. J. Virol. 74, 7470\u20137477 (2000).","journal-title":"J. Virol."},{"key":"BFni0503404_CR30","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1073\/pnas.94.4.1172","volume":"94","author":"J Bertin","year":"1997","unstructured":"Bertin, J. et al. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc. Natl. Acad. Sci. USA 94, 1172\u20131176 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni0503404_CR31","doi-asserted-by":"publisher","first-page":"9621","DOI":"10.1074\/jbc.272.15.9621","volume":"272","author":"S Hu","year":"1997","unstructured":"Hu, S., Vincenz, C., Buller, M. & Dixit, V.M. A novel family of viral death effector domain-containing molecules that inhibit both CD95- and tumor necrosis factor receptor-1\u2013induced apoptosis. J. Biol. Chem. 272, 9621\u20139624 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/386517a0","volume":"386","author":"M Thome","year":"1997","unstructured":"Thome, M. et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386, 517\u2013521 (1997).","journal-title":"Nature"},{"key":"BFni0503404_CR33","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1006\/viro.2002.1518","volume":"300","author":"TL Garvey","year":"2002","unstructured":"Garvey, T.L., Bertin, J., Siegel, R.M., Lenardo, M.J. & Cohen, J. The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable with each other or with the DEDs of caspase-8. Virology 300, 217\u2013225 (2002).","journal-title":"Virology"},{"key":"BFni0503404_CR34","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/40657","volume":"388","author":"M Irmler","year":"1997","unstructured":"Irmler, M. et al. Inhibition of death receptor signals by cellular FLIP. Nature 388, 190\u2013195 (1997).","journal-title":"Nature"},{"key":"BFni0503404_CR35","doi-asserted-by":"publisher","first-page":"17255","DOI":"10.1074\/jbc.272.28.17255","volume":"272","author":"S Hu","year":"1997","unstructured":"Hu, S., Vincenz, C., Ni, J., Gentz, R. & Dixit, V.M. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1\u2013 and CD-95\u2013induced apoptosis. J. Biol. Chem. 272, 17255\u201317257 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR36","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1128\/MCB.21.12.3964-3973.2001","volume":"21","author":"S Kreuz","year":"2001","unstructured":"Kreuz, S., Siegmund, D., Scheurich, P. & Wajant, H. NF-\u03baB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 21, 3964\u20133973 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFni0503404_CR37","doi-asserted-by":"publisher","first-page":"5299","DOI":"10.1128\/MCB.21.16.5299-5305.2001","volume":"21","author":"O Michaeu","year":"2001","unstructured":"Michaeu, O., Lens, S., Gaide, O., Alevizopoulos, K. & Tschopp, J. NF-\u03baB signals induce the expression of c-FLIP. Mol. Cell. Biol. 21, 5299\u20135305 (2001).","journal-title":"Mol. Cell. Biol."},{"key":"BFni0503404_CR38","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/S0002-9440(10)62578-3","volume":"160","author":"RK Thomas","year":"2002","unstructured":"Thomas, R.K. et al. Constituitive expression of c-FLIP in Hodgkin and Reed-Sternberg cells. Amer. J. of Path. 160, 1521\u20131528 (2002).","journal-title":"Amer. J. of Path."},{"key":"BFni0503404_CR39","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.1093\/emboj\/cdf356","volume":"21","author":"DW Chang","year":"2002","unstructured":"Chang, D.W. et al. c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. 21, 3704\u20133714 (2002).","journal-title":"EMBO J."},{"key":"BFni0503404_CR40","doi-asserted-by":"publisher","first-page":"5419","DOI":"10.1128\/MCB.22.15.5419-5433.2002","volume":"22","author":"S Lens","year":"2002","unstructured":"Lens, S. et al. The caspase 8 inhibitor c-FLIPL modulates T-cell receptor\u2013induced proliferation but not activation-induced cell death of lymphoctyes. Mol. Cell. Biol. 22, 5419\u20135433 (2002).","journal-title":"Mol. Cell. Biol."},{"key":"BFni0503404_CR41","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1038\/sj.onc.1202831","volume":"18","author":"G Condorelli","year":"1999","unstructured":"Condorelli, G. et al. PED\/PEA-15: an anti-apoptotic molecule that regulates FAS\/TNFR1-induced apoptosis. Oncogene 18, 4409\u20134415 (1999).","journal-title":"Oncogene"},{"key":"BFni0503404_CR42","doi-asserted-by":"publisher","first-page":"8244","DOI":"10.1523\/JNEUROSCI.19-19-08244.1999","volume":"19","author":"D Kitsberg","year":"1999","unstructured":"Kitsberg, D. et al. Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNF\u03b1-induced apoptosis. J. Neuroscience 19, 8244\u20138251 (1999).","journal-title":"J. Neuroscience"},{"key":"BFni0503404_CR43","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1016\/S0021-9258(18)53407-4","volume":"268","author":"H Araujo","year":"1993","unstructured":"Araujo, H., Danziger, N., Cordier, J., Glowinski, J. & Chneiweiss, H. Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268, 5911\u20135920 (1993).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR44","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1046\/j.1471-4159.1998.71031307.x","volume":"71","author":"M Kubes","year":"1998","unstructured":"Kubes, M., Cordier, J., Glowinski, J., Girault, J.A. & Chneiweiss, H. Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium\/calmodulin kinase II in vitro. J. Neurochem. 71, 1307\u20131314 (1998).","journal-title":"J. Neurochem."},{"key":"BFni0503404_CR45","doi-asserted-by":"publisher","first-page":"44944","DOI":"10.1074\/jbc.M104919200","volume":"276","author":"M Gomez-Angelats","year":"2001","unstructured":"Gomez-Angelats, M. & Cidlowski, J.A. Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas\/CD95-induced apoptosis. J. Biol. Chem. 276, 44944\u201344952 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR46","doi-asserted-by":"publisher","first-page":"25020","DOI":"10.1074\/jbc.M202946200","volume":"277","author":"C Xiao","year":"2002","unstructured":"Xiao, C., Yang, B.F., Asadi, N., Beguinot, F. & Hao, C. Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED\/PEA-15 in glioma cells. J. Biol. Chem. 277, 25020\u201325025 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR47","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1006\/dbio.1999.9510","volume":"216","author":"A Estelles","year":"1999","unstructured":"Estelles, A., Charlton, C.A. & Blau, H.M. The phosphoprotein PEA-15 inhibits Fas- but increases TNF-R1 mediated caspase-8 activity and apoptosis. Dev. Biol. 216, 16\u201328 (1999).","journal-title":"Dev. Biol."},{"key":"BFni0503404_CR48","doi-asserted-by":"publisher","first-page":"5974","DOI":"10.1093\/emboj\/17.20.5974","volume":"17","author":"AH Stegh","year":"1998","unstructured":"Stegh, A.H. et al. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 17, 5974\u20135986 (1998).","journal-title":"EMBO J."},{"key":"BFni0503404_CR49","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/sj.cdd.4400928","volume":"8","author":"O Schickling","year":"2001","unstructured":"Schickling, O., Stegh, A.H., Byrd, J. & Peter, M.E. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 8, 1157\u20131161 (2001).","journal-title":"Cell Death Differ."},{"key":"BFni0503404_CR50","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1083\/jcb.200112124","volume":"158","author":"J Lee","year":"2002","unstructured":"Lee, J. et al. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell. Biol. 158, 1051\u20131066 (2002).","journal-title":"J. Cell. Biol."},{"key":"BFni0503404_CR51","doi-asserted-by":"publisher","first-page":"7501","DOI":"10.1074\/jbc.M110749200","volume":"277","author":"W Roth","year":"2002","unstructured":"Roth, W., Stenner-Liewen, F., Pawlowski, K., Godzik, A. & Reed, J.C. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 277, 7501\u20137508 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR52","doi-asserted-by":"publisher","first-page":"31945","DOI":"10.1074\/jbc.M102799200","volume":"276","author":"L Zheng","year":"2001","unstructured":"Zheng, L., Schickling, O., Peter, M.E. & Lenardo, M.J. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. 276, 31945\u201331952 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR53","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1083\/jcb.139.2.327","volume":"139","author":"FW Ng","year":"1997","unstructured":"Ng, F.W. et al. p28 Bap31, a Bcl-2\/Bcl-XL\u2013 and procaspase-8\u2013associated protein in the endoplasmic reticulum. J. Cell Biol. 139, 327\u2013338 (1997).","journal-title":"J. Cell Biol."},{"key":"BFni0503404_CR54","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1073\/pnas.97.6.2597","volume":"97","author":"H Zhang","year":"2000","unstructured":"Zhang, H. et al. BAR: an apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Proc. Natl. Acad. Sci. USA 97, 2597\u20132602 (2000).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni0503404_CR55","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1074\/jbc.M108947200","volume":"277","author":"AH Stegh","year":"2002","unstructured":"Stegh, A.H. et al. Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for bifunctional apoptosis regulator protein. J. Biol. Chem. 277, 4351\u20134360 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR56","doi-asserted-by":"publisher","first-page":"6731","DOI":"10.1128\/MCB.20.18.6731-6740.2000","volume":"20","author":"M Nguyen","year":"2000","unstructured":"Nguyen, M., Breckenridge, D.G., Ducret, A. & Shore, G.C. Caspase-resistant BAP31 inhibits Fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. Mol. Cell. Biol. 20, 6731\u20136740 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFni0503404_CR57","doi-asserted-by":"crossref","unstructured":"Wang, B. et al. Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. J. Biol. Chem. advance online publication, 15 January 2003 (doi:10.1074\/jbc.M209684200).","DOI":"10.1074\/jbc.M209684200"},{"key":"BFni0503404_CR58","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1083\/jcb.141.5.1243","volume":"141","author":"RM Siegel","year":"1998","unstructured":"Siegel, R.M. et al. Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis. J. Cell. Biol. 141, 1243\u20131253 (1998).","journal-title":"J. Cell. Biol."},{"key":"BFni0503404_CR59","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/32681","volume":"392","author":"J Zhang","year":"1998","unstructured":"Zhang, J., Cado, D., Chen, A., Kabra, N.H. & Winoto, A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD\/Mort1. Nature 392, 296\u2013300 (1998).","journal-title":"Nature"},{"key":"BFni0503404_CR60","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1074-7613(00)80549-X","volume":"8","author":"CM Walsh","year":"1998","unstructured":"Walsh, C.M. et al. A Role for FADD in T cell activation and development. Immunity 8, 439\u2013449 (1998).","journal-title":"Immunity"},{"key":"BFni0503404_CR61","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/emboj\/17.3.706","volume":"17","author":"K Newton","year":"1998","unstructured":"Newton, K., Harris, A.W., Bath, M.L., Smith, K.G. & Strasser, A. A dominant interfering mutant of FADD\/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymhocytes. EMBO J. 17, 706\u2013718 (1998).","journal-title":"EMBO J."},{"key":"BFni0503404_CR62","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1002\/1521-4141(200207)32:7<1986::AID-IMMU1986>3.0.CO;2-#","volume":"32","author":"A Mack","year":"2002","unstructured":"Mack, A. & Hacker, G. Inhibition of caspase or FADD function blocks proliferation but not MAP kinase activation and interleukin-2 production during primary stimulation of T cells. Eur. J. Immunol. 32, 1986\u20131992 (2002).","journal-title":"Eur. J. Immunol."},{"key":"BFni0503404_CR63","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1084\/jem.190.12.1879","volume":"190","author":"A Alam","year":"1999","unstructured":"Alam, A., Cohen, L.Y., Aouad, S. & Sekaly, R.P. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J. Exp. Med. 190, 1879\u20131890 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni0503404_CR64","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1084\/jem.190.12.1891","volume":"190","author":"NJ Kennedy","year":"1999","unstructured":"Kennedy, N.J., Kataoka, T., Tschopp, J. & Budd, R.C. Caspase activation is required for T cell proliferation. J. Exp. Med. 190, 1891\u20131896 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni0503404_CR65","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nature01063","volume":"419","author":"H Chun","year":"2002","unstructured":"Chun, H. et al. Pleiotropic lymphocyte activation defects due to caspase-8 mutation causes human immunodeficiency. Nature 419, 395\u2013399 (2002).","journal-title":"Nature"},{"key":"BFni0503404_CR66","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1038\/sj.onc.1203812","volume":"19","author":"PM Chaudhary","year":"2000","unstructured":"Chaudhary, P.M. et al. Activation of the NF-\u03baB pathway by caspase 8 and its homologs. Oncogene 19, 4451\u20134460 (2000).","journal-title":"Oncogene"},{"key":"BFni0503404_CR67","doi-asserted-by":"publisher","first-page":"10838","DOI":"10.1074\/jbc.275.15.10838","volume":"275","author":"WH Hu","year":"2000","unstructured":"Hu, W.H., Johnson, H. & Shu, H.B. Activation of NF-\u03baB by FADD, Casper, and Caspase 8. J. Biol. Chem. 275, 10838\u201310844 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFni0503404_CR68","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0092-8674(00)80605-4","volume":"98","author":"J Wang","year":"1999","unstructured":"Wang, J. et al. Inherited caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell 98, 47\u201358 (1999).","journal-title":"Cell"},{"key":"BFni0503404_CR69","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/S0960-9822(00)00512-1","volume":"10","author":"T Kataoka","year":"2000","unstructured":"Kataoka, T. et al. The caspase-8 inhibitor FLIP promotes activation of NF-\u03baB and Erk signaling pathways. Curr. Biol. 10, 640\u2013648 (2000).","journal-title":"Curr. Biol."},{"key":"BFni0503404_CR70","first-page":"1891","volume":"178","author":"MR Alderson","year":"1993","unstructured":"Alderson, M.R. et al. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178, 1891\u20131896 (1993).","journal-title":"J. Exp. Med."},{"key":"BFni0503404_CR71","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1091\/mbc.11.9.2863","volume":"11","author":"JW Ramos","year":"2000","unstructured":"Ramos, J.W. et al. Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. Mol. Biol. Cell 11, 2863\u20132872 (2000).","journal-title":"Mol. Biol. Cell"},{"key":"BFni0503404_CR72","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S1534-5807(01)00035-1","volume":"1","author":"E Formstecher","year":"2001","unstructured":"Formstecher, E. et al. PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev. Cell 1, 239\u2013250 (2001).","journal-title":"Dev. Cell"},{"key":"BFni0503404_CR73","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1126\/science.1073823","volume":"298","author":"NB Ivanova","year":"2002","unstructured":"Ivanova, N.B. et al. A stem cell molecular signature. Science 298, 601\u2013604 (2002).","journal-title":"Science"},{"key":"BFni0503404_CR74","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/ncb735","volume":"4","author":"FG Gervais","year":"2002","unstructured":"Gervais, F.G. et al. Recruitment and activation of caspase-8 by the Huntington-interacting protein Hip-1 and a novel partner Hippi. Nat. Cell Biol. 4, 95\u2013105 (2002).","journal-title":"Nat. Cell Biol."}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ni0503-404.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni0503-404","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ni0503-404.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T19:43:53Z","timestamp":1659123833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni0503-404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5,1]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5,1]]}},"alternative-id":["BFni0503404"],"URL":"https:\/\/doi.org\/10.1038\/ni0503-404","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5,1]]},"assertion":[{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}