{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:57:13Z","timestamp":1791125833242,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2003,8,10]],"date-time":"2003-08-10T00:00:00Z","timestamp":1060473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Immunol"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1038\/ni963","type":"journal-article","created":{"date-parts":[[2003,8,8]],"date-time":"2003-08-08T12:24:51Z","timestamp":1060345491000},"page":"857-865","source":"Crossref","is-referenced-by-count":162,"title":["Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells"],"prefix":"10.1038","volume":"4","author":[{"given":"Liquan","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan W","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Orihuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Tuomanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renren","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,8,10]]},"reference":[{"key":"BFni963_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1146\/annurev.immunol.16.1.645","volume":"16","author":"JI Healy","year":"1998","unstructured":"Healy, J.I. & Goodnow, C.C. Positive versus negative signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 16, 645\u2013670 (1998).","journal-title":"Annu. Rev. Immunol."},{"key":"BFni963_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1084\/jem.190.1.75","volume":"190","author":"F Loder","year":"1999","unstructured":"Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190, 75\u201389 (1999).","journal-title":"J. Exp. Med."},{"key":"BFni963_CR3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nri799","volume":"2","author":"F Martin","year":"2002","unstructured":"Martin, F. & Kearney, J.F. Marginal-zone B cells. Nat. Rev. Immunol. 2, 323\u2013335 (2002).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni963_CR4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/eji.1830120707","volume":"12","author":"D Gray","year":"1982","unstructured":"Gray, D., MacLennan, I.C., Bazin, H. & Khan, M. Migrant \u03bc+\u03b4+ and static \u03bc+\u03b4\u2212 B lymphocyte subsets. Eur. J. Immunol. 12, 564\u2013569 (1982).","journal-title":"Eur. J. Immunol."},{"key":"BFni963_CR5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0167-5699(98)01308-5","volume":"19","author":"J Spencer","year":"1998","unstructured":"Spencer, J., Perry, M.E. & Dunn-Walters, D.K. Human marginal-zone B cells. Immunol. Today. 19, 421\u2013426 (1998).","journal-title":"Immunol. Today."},{"key":"BFni963_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1600-065X.2000.imr017520.x","volume":"175","author":"LA Herzenberg","year":"2000","unstructured":"Herzenberg, L.A. B-1 cells: the lineage question revisited. Immunol. Rev. 175, 9\u201322 (2000).","journal-title":"Immunol. Rev."},{"key":"BFni963_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1600-065X.2000.imr017515.x","volume":"175","author":"F Martin","year":"2000","unstructured":"Martin, F. & Kearney, J.F. B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a \u201cnatural immune memory\u201d. Immunol. Rev. 175, 70\u201379 (2000).","journal-title":"Immunol. Rev."},{"key":"BFni963_CR8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S1074-7613(01)00129-7","volume":"14","author":"F Martin","year":"2001","unstructured":"Martin, F., Oliver, A.M. & Kearney, J.F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity. 14, 617\u2013629 (2001).","journal-title":"Immunity."},{"key":"BFni963_CR9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0952-7915(02)00328-X","volume":"14","author":"A Cariappa","year":"2002","unstructured":"Cariappa, A. & Pillai, S. Antigen-dependent B-cell development. Curr. Opin. Immunol. 14, 241\u2013249 (2002).","journal-title":"Curr. Opin. Immunol."},{"key":"BFni963_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0092-8674(00)80957-5","volume":"96","author":"TG Willis","year":"1999","unstructured":"Willis, T.G. et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96, 35\u201345 (1999).","journal-title":"Cell"},{"key":"BFni963_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/8767","volume":"22","author":"Q Zhang","year":"1999","unstructured":"Zhang, Q. et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). Nat. Genet. 22, 63\u201368 (1999).","journal-title":"Nat. Genet."},{"key":"BFni963_CR12","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1038\/sj.onc.1204576","volume":"20","author":"D Yui","year":"2001","unstructured":"Yui, D. et al. Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. Oncogene. 20, 4317\u201323 (2001).","journal-title":"Oncogene."},{"key":"BFni963_CR13","doi-asserted-by":"publisher","first-page":"11114","DOI":"10.1074\/jbc.275.15.11114","volume":"275","author":"T Yoneda","year":"2000","unstructured":"Yoneda, T. et al. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J. Biol. Chem. 275, 11114\u201311120 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR14","doi-asserted-by":"publisher","first-page":"41082","DOI":"10.1074\/jbc.C000726200","volume":"275","author":"J Bertin","year":"2000","unstructured":"Bertin, J. et al. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10\/CLAP and activates NF-\u03baB. J. Biol. Chem. 275, 41082\u201341086 (2000).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR15","doi-asserted-by":"publisher","first-page":"21405","DOI":"10.1074\/jbc.M102488200","volume":"276","author":"L Wang","year":"2001","unstructured":"Wang, L. et al. Card10 is a novel caspase recruitment domain\/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-\u03baB. J. Biol. Chem. 276, 21405\u201321409 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR16","doi-asserted-by":"publisher","first-page":"30589","DOI":"10.1074\/jbc.M103824200","volume":"276","author":"LM McAllister-Lucas","year":"2001","unstructured":"McAllister-Lucas, L.M. et al. Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-\u03baB induction. J. Biol. Chem. 276, 30589\u201330597 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR17","doi-asserted-by":"publisher","first-page":"5184","DOI":"10.1093\/emboj\/cdf505","volume":"21","author":"JL Pomerantz","year":"2002","unstructured":"Pomerantz, J.L., Denny, E.M. & Baltimore, D. CARD11 mediates factor-specific activation of NF-\u03baB by the T cell receptor complex. EMBO J. 21, 5184\u20135194 (2002).","journal-title":"EMBO J."},{"key":"BFni963_CR18","doi-asserted-by":"publisher","first-page":"11877","DOI":"10.1074\/jbc.M010512200","volume":"276","author":"J Bertin","year":"2001","unstructured":"Bertin, J. et al. CARD11 and CARD14 are novel caspase recruitment domain (CARD)\/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-\u03baB. J. Biol. Chem. 276, 11877\u201311882 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR19","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/ni830","volume":"3","author":"O Gaide","year":"2002","unstructured":"Gaide, O. et al. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-\u03baB activation. Nat. Immunol. 3, 836\u2013843 (2002).","journal-title":"Nat. Immunol."},{"key":"BFni963_CR20","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/ni824","volume":"3","author":"D Wang","year":"2002","unstructured":"Wang, D. et al. A requirement for CARMA1 in TCR-induced NF-\u03baB activation. Nat. Immunol. 3, 830\u2013835 (2002).","journal-title":"Nat. Immunol."},{"key":"BFni963_CR21","doi-asserted-by":"publisher","first-page":"20605","DOI":"10.1074\/jbc.M201204200","volume":"277","author":"H Cheng","year":"2002","unstructured":"Cheng, H., Cenciarelli, C., Tao, M., Parks, W.P. & Cheng-Mayer, C. HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of I\u03ba B kinase \u03b2 subunit. J. Biol. Chem. 277, 20605\u201320610 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR22","doi-asserted-by":"publisher","first-page":"44069","DOI":"10.1074\/jbc.M107373200","volume":"276","author":"L Bouchier-Hayes","year":"2001","unstructured":"Bouchier-Hayes, L. et al. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-\u03baB activation pathways. J. Biol. Chem. 276, 44069\u201344077 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFni963_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0092-8674(01)00189-1","volume":"104","author":"J Ruland","year":"2001","unstructured":"Ruland, J. et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-\u03baB and neural tube closure. Cell 104, 33\u201342 (2001).","journal-title":"Cell"},{"key":"BFni963_CR24","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0952-7915(00)00204-1","volume":"13","author":"F Martin","year":"2001","unstructured":"Martin, F. & Kearney, J.F. B1 cells: similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13, 195\u2013201 (2001).","journal-title":"Curr. Opin. Immunol."},{"key":"BFni963_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0952-7915(99)80025-9","volume":"11","author":"RJ Benschop","year":"1999","unstructured":"Benschop, R.J. & Cambier, J.C. B cell development: signal transduction by antigen receptors and their surrogates. Curr. Opin. Immunol. 11, 143\u2013151 (1999).","journal-title":"Curr. Opin. Immunol."},{"key":"BFni963_CR26","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","volume":"282","author":"A Poltorak","year":"1998","unstructured":"Poltorak, A. et al. Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene. Science. 282, 2085\u20132088 (1998).","journal-title":"Science."},{"key":"BFni963_CR27","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nri910","volume":"2","author":"Q Li","year":"2002","unstructured":"Li, Q. & Verma, I.M. NF-\u03baB regulation in the immune system. Nat. Rev. Immunol. 2, 725\u2013734 (2002).","journal-title":"Nat. Rev. Immunol."},{"key":"BFni963_CR28","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1084\/jem.192.8.1175","volume":"192","author":"A Cariappa","year":"2000","unstructured":"Cariappa, A., Liou, H.C., Horwitz, B.H. & Pillai, S. Nuclear factor \u03baB is required for the development of marginal zone B lymphocytes. J. Exp. Med. 192, 1175\u20131182 (2000).","journal-title":"J. Exp. Med."},{"key":"BFni963_CR29","doi-asserted-by":"publisher","first-page":"6351","DOI":"10.1093\/emboj\/19.23.6351","volume":"19","author":"M Grossmann","year":"2000","unstructured":"Grossmann, M. et al. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19, 6351\u20136360 (2000).","journal-title":"EMBO J."},{"key":"BFni963_CR30","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0952-7915(00)00201-6","volume":"13","author":"KM Ansel","year":"2001","unstructured":"Ansel, K.M. & Cyster, J.G. Chemokines in lymphopoiesis and lymphoid organ development. Curr. Opin. Immunol. 13, 172\u2013179 (2001).","journal-title":"Curr. Opin. Immunol."},{"key":"BFni963_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/76882","volume":"1","author":"R Guinamard","year":"2000","unstructured":"Guinamard, R., Okigaki, M., Schlessinger, J. & Ravetch, J.V. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat. Immunol. 1, 31\u201336 (2000).","journal-title":"Nat. Immunol."},{"key":"BFni963_CR32","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/ni0901-855","volume":"2","author":"I Girkontaite","year":"2001","unstructured":"Girkontaite, I. et al. Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat. Immunol. 2, 855\u2013862 (2001).","journal-title":"Nat. Immunol."},{"key":"BFni963_CR33","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.4049\/jimmunol.167.4.1909","volume":"167","author":"DS Weih","year":"2001","unstructured":"Weih, D.S., Yilmaz, Z.B. & Weih, F. Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J. Immunol. 167, 1909\u20131919 (2001).","journal-title":"J. Immunol."},{"key":"BFni963_CR34","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/35090591","volume":"412","author":"Y Fukui","year":"2001","unstructured":"Fukui, Y. et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 412, 826\u2013831 (2001).","journal-title":"Nature."},{"key":"BFni963_CR35","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1126\/science.286.5447.2156","volume":"286","author":"AF Ochsenbein","year":"1999","unstructured":"Ochsenbein, A.F. et al. Control of early viral and bacterial distribution and disease by natural antibodies. Science. 286, 2156\u20132159 (1999).","journal-title":"Science."},{"key":"BFni963_CR36","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1073\/pnas.96.5.2250","volume":"96","author":"N Baumgarth","year":"1999","unstructured":"Baumgarth, N., Herman, O.C., Jager, G.C., Brown, L. & Herzenberg, L.A. Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. Proc. Natl. Acad. Sci. USA 96, 2250\u20132255 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFni963_CR37","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/1074-7613(95)90114-0","volume":"3","author":"WN Khan","year":"1995","unstructured":"Khan, W.N. et al. Defective B cell development and function in Btk-deficient mice. Immunity 3, 283\u2013299 (1995).","journal-title":"Immunity"},{"key":"BFni963_CR38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/1074-7613(95)90115-9","volume":"3","author":"JD Kerner","year":"1995","unstructured":"Kerner, J.D. et al. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3, 301\u2013312 (1995).","journal-title":"Immunity"},{"key":"BFni963_CR39","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1016\/S0960-9822(01)00668-6","volume":"12","author":"M Thome","year":"2002","unstructured":"Thome, M. & Tschopp, J. Bcl10. Curr. Biol. 12, R45 (2002).","journal-title":"Curr. Biol."},{"key":"BFni963_CR40","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/00062752-200201000-00009","volume":"9","author":"AC Wotherspoon","year":"2002","unstructured":"Wotherspoon, A.C., Dogan, A. & Du, M.Q. Mucosa-associated lymphoid tissue lymphoma. Curr. Opin. Hematol. 9, 50\u201355 (2002).","journal-title":"Curr. Opin. Hematol."},{"key":"BFni963_CR41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1074-7613(00)00005-4","volume":"13","author":"D Wang","year":"2000","unstructured":"Wang, D. et al. Phospholipase C\u03b32 is essential in the functions of B cell and several Fc receptors. Immunity 13, 25\u201335 (2000).","journal-title":"Immunity"},{"key":"BFni963_CR42","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4049\/jimmunol.157.2.598","volume":"157","author":"VM Lentz","year":"1996","unstructured":"Lentz, V.M., Cancro, M.P., Nashold, F.E. & Hayes, C.E. Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A\/WySnJ mouse. J. Immunol. 157, 598\u2013606 (1996).","journal-title":"J. Immunol."},{"key":"BFni963_CR43","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/35006090","volume":"404","author":"Z Sun","year":"2000","unstructured":"Sun, Z. et al. PKC-\u03b8 is required for TCR-induced NF-\u03baB activation in mature but not immature T lymphocytes. Nature 404, 402\u2013407 (2000).","journal-title":"Nature"},{"key":"BFni963_CR44","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1126\/science.1061217","volume":"293","author":"H Tettelin","year":"2001","unstructured":"Tettelin, H. et al. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 293, 498\u2013506 (2001).","journal-title":"Science."},{"key":"BFni963_CR45","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/0006-3002(60)90205-5","volume":"39","author":"S Lacks","year":"1960","unstructured":"Lacks, S. & Hotchkiss, R.D. A study of the genetic material determining an enzyme activity in pneumococcus. Biochim. Biophys. Acta 39, 508\u2013517 (1960).","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Nature Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ni963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni963","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ni963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:54:50Z","timestamp":1684436090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ni963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,10]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["BFni963"],"URL":"https:\/\/doi.org\/10.1038\/ni963","relation":{},"ISSN":["1529-2908","1529-2916"],"issn-type":[{"value":"1529-2908","type":"print"},{"value":"1529-2916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,10]]}}}