{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:27Z","timestamp":1791330027161,"version":"4.3.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,3,15]],"date-time":"2009-03-15T00:00:00Z","timestamp":1237075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1038\/nm.1937","type":"journal-article","created":{"date-parts":[[2009,3,15]],"date-time":"2009-03-15T18:34:32Z","timestamp":1237142072000},"page":"442-446","source":"Crossref","is-referenced-by-count":163,"title":["Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding"],"prefix":"10.1038","volume":"15","author":[{"given":"Chi-Liang Eric","family":"Yen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Leng","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Grueter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Moriwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinny S","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Marmor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert V","family":"Farese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,3,15]]},"reference":[{"key":"BFnm1937_CR1","first-page":"353","volume":"14","author":"JV Neel","year":"1962","unstructured":"Neel, J.V. Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am. J. Hum. Genet. 14, 353\u2013362 (1962).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnm1937_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev.biochem.75.103004.142512","volume":"75","author":"DM Muoio","year":"2006","unstructured":"Muoio, D.M. & Newgard, C.B. Obesity-related derangements in metabolic regulation. Annu. Rev. Biochem. 75, 367\u2013401 (2006).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnm1937_CR3","unstructured":"The Food and Agricultural Organization of the United Nations. Food Consumption: Dietary Energy, Protein and Fat. http:\/\/www.fao.org\/\u00a0faostat\/foodsecurity\/index_en.htm (2008)."},{"key":"BFnm1937_CR4","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev.bi.49.070180.002331","volume":"49","author":"RM Bell","year":"1980","unstructured":"Bell, R.M. & Coleman, R.A. Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49, 459\u2013487 (1980).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnm1937_CR5","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/S0021-9258(19)83722-5","volume":"237","author":"JR Senior","year":"1962","unstructured":"Senior, J.R. & Isselbacher, K.J. Direct esterification of monoglycerides with palmityl coenzyme A by intestinal epithelial subcellular fractions. J. Biol. Chem. 237, 1454\u20131459 (1962).","journal-title":"J. Biol. Chem."},{"key":"BFnm1937_CR6","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1172\/JCI105660","volume":"46","author":"HJ Kayden","year":"1967","unstructured":"Kayden, H.J., Senior, J.R. & Mattson, F.H. The monoglyceride pathway of fat absorption in man. J. Clin. Invest. 46, 1695\u20131703 (1967).","journal-title":"J. Clin. Invest."},{"key":"BFnm1937_CR7","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/S0021-9258(18)93813-5","volume":"239","author":"FH Mattson","year":"1964","unstructured":"Mattson, F.H. & Volpenhein, R.A. The digestion and absorption of triglycerides. J. Biol. Chem. 239, 2772\u20132777 (1964).","journal-title":"J. Biol. Chem."},{"key":"BFnm1937_CR8","doi-asserted-by":"publisher","first-page":"8512","DOI":"10.1073\/pnas.132274899","volume":"99","author":"C-LE Yen","year":"2002","unstructured":"Yen, C.-L.E., Stone, S.J., Cases, S., Zhou, P. & Farese, R.V., Jr. Identification of a gene encoding MGAT1, a monoacylglylcerol acyltransferase. Proc. Natl. Acad. Sci. USA 99, 8512\u20138517 (2002).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm1937_CR9","doi-asserted-by":"publisher","first-page":"18532","DOI":"10.1074\/jbc.M301633200","volume":"278","author":"C-LE Yen","year":"2003","unstructured":"Yen, C.-L.E. & Farese, R.V., Jr. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J. Biol. Chem. 278, 18532\u201318537 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm1937_CR10","doi-asserted-by":"publisher","first-page":"13860","DOI":"10.1074\/jbc.M300139200","volume":"278","author":"J Cao","year":"2003","unstructured":"Cao, J., Lockwood, J., Burn, P. & Shi, Y. Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J. Biol. Chem. 278, 13860\u201313866 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm1937_CR11","doi-asserted-by":"publisher","first-page":"13611","DOI":"10.1074\/jbc.C300042200","volume":"278","author":"D Cheng","year":"2003","unstructured":"Cheng, D. et al. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. J. Biol. Chem. 278, 13611\u201313614 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm1937_CR12","doi-asserted-by":"publisher","first-page":"18878","DOI":"10.1074\/jbc.M313272200","volume":"279","author":"J Cao","year":"2004","unstructured":"Cao, J. et al. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. J. Biol. Chem. 279, 18878\u201318886 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnm1937_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1053\/j.gastro.2004.04.007","volume":"127","author":"RJ Jandacek","year":"2004","unstructured":"Jandacek, R.J., Heubi, J.E. & Tso, P. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology 127, 139\u2013144 (2004).","journal-title":"Gastroenterology"},{"key":"BFnm1937_CR14","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1194\/jlr.M500036-JLR200","volume":"46","author":"C-LE Yen","year":"2005","unstructured":"Yen, C.-L.E., Monetti, M., Burri, B.J. & Farese, R.V., Jr. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J. Lipid Res. 46, 1502\u20131511 (2005).","journal-title":"J. Lipid Res."},{"key":"BFnm1937_CR15","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","volume":"132","author":"LL Baggio","year":"2007","unstructured":"Baggio, L.L. & Drucker, D.J. Biology of incretins: GLP-1 and GIP. Gastroenterology 132, 2131\u20132157 (2007).","journal-title":"Gastroenterology"},{"key":"BFnm1937_CR16","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/35007527","volume":"404","author":"BB Lowell","year":"2000","unstructured":"Lowell, B.B. & Spiegelman, B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652\u2013660 (2000).","journal-title":"Nature"},{"key":"BFnm1937_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nrm1592","volume":"6","author":"S Krauss","year":"2005","unstructured":"Krauss, S., Zhang, C.Y. & Lowell, B.B. The mitochondrial uncoupling-protein homologues. Nat. Rev. Mol. Cell Biol. 6, 248\u2013261 (2005).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnm1937_CR18","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/nm1196-1254","volume":"2","author":"LA Scrocchi","year":"1996","unstructured":"Scrocchi, L.A. et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat. Med. 2, 1254\u20131258 (1996).","journal-title":"Nat. Med."},{"key":"BFnm1937_CR19","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1093\/hmg\/6.11.1887","volume":"6","author":"C Bouchard","year":"1997","unstructured":"Bouchard, C., P\u00e9russe, L., Chagnon, Y., Warden, C. & Ricquier, D. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum. Mol. Genet. 6, 1887\u20131889 (1997).","journal-title":"Hum. Mol. Genet."},{"key":"BFnm1937_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/0006-3002(59)90255-0","volume":"34","author":"F Snyder","year":"1959","unstructured":"Snyder, F. & Stephens, N. A simplified spectrophotometric determination of ester groups in lipids. Biochim. Biophys. Acta 34, 244\u2013245 (1959).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnm1937_CR21","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0022-2275(20)34758-1","volume":"21","author":"RL Hamilton Jr.","year":"1980","unstructured":"Hamilton, R.L., Jr., Goerke, J., Guo, L.S.S., Williams, M.C. & Havel, R.J. Unilamellar liposomes made with the French pressure cell: A simple preparative and semiquantitative technique. J. Lipid Res. 21, 981\u2013992 (1980).","journal-title":"J. Lipid Res."},{"key":"BFnm1937_CR22","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1194\/jlr.M500023-JLR200","volume":"46","author":"J Iqbal","year":"2005","unstructured":"Iqbal, J. & Hussain, M. Evidence for multiple complementary pathways for efficient cholesterol absorption in mice. J. Lipid Res. 46, 1491\u20131501 (2005).","journal-title":"J. Lipid Res."},{"key":"BFnm1937_CR23","doi-asserted-by":"publisher","first-page":"38870","DOI":"10.1074\/jbc.M106219200","volume":"276","author":"S Cases","year":"2001","unstructured":"Cases, S. et al. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J. Biol. Chem. 276, 38870\u201338876 (2001).","journal-title":"J. Biol. Chem."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.1937.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.1937","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.1937.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:23:21Z","timestamp":1684448601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.1937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,15]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["BFnm1937"],"URL":"https:\/\/doi.org\/10.1038\/nm.1937","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,15]]}}}