{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:21:07Z","timestamp":1791174067081,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T00:00:00Z","timestamp":1306022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1038\/nm.2388","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T13:42:25Z","timestamp":1306071745000},"page":"684-691","source":"Crossref","is-referenced-by-count":418,"title":["Lrp5 functions in bone to regulate bone mass"],"prefix":"10.1038","volume":"17","author":[{"given":"Yajun","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Niziolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan T","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra R","family":"Zylstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Alenina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Matthes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A","family":"Conlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Brommage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faika","family":"Mseeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi M","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Zambrowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gerrits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A","family":"Gossen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Warman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G","family":"Robling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,22]]},"reference":[{"key":"BFnm2388_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","volume":"107","author":"Y Gong","year":"2001","unstructured":"Gong, Y. et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107, 513\u2013523 (2001).","journal-title":"Cell"},{"key":"BFnm2388_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1086\/338450","volume":"70","author":"RD Little","year":"2002","unstructured":"Little, R.D. et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70, 11\u201319 (2002).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnm2388_CR3","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1056\/NEJMoa013444","volume":"346","author":"LM Boyden","year":"2002","unstructured":"Boyden, L.M. et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346, 1513\u20131521 (2002).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2388_CR4","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","volume":"10","author":"W Balemans","year":"2001","unstructured":"Balemans, W. et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum. Mol. Genet. 10, 537\u2013543 (2001).","journal-title":"Hum. Mol. Genet."},{"key":"BFnm2388_CR5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1086\/318811","volume":"68","author":"ME Brunkow","year":"2001","unstructured":"Brunkow, M.E. et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am. J. Hum. Genet. 68, 577\u2013589 (2001).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnm2388_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cell.2006.08.039","volume":"127","author":"R Morello","year":"2006","unstructured":"Morello, R. et al. CRTAP is required for prolyl 3-hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell 127, 291\u2013304 (2006).","journal-title":"Cell"},{"key":"BFnm2388_CR7","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1086\/497706","volume":"77","author":"M Ai","year":"2005","unstructured":"Ai, M., Heeger, S., Bartels, C.F. & Schelling, D.K. Clinical and molecular findings in osteoporosis-pseudoglioma syndrome. Am. J. Hum. Genet. 77, 741\u2013753 (2005).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnm2388_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1086\/368277","volume":"72","author":"L Van Wesenbeeck","year":"2003","unstructured":"Van Wesenbeeck, L. et al. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am. J. Hum. Genet. 72, 763\u2013771 (2003).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnm2388_CR9","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.1128\/MCB.25.12.4946-4955.2005","volume":"25","author":"M Ai","year":"2005","unstructured":"Ai, M., Holmen, S.L., Van Hul, W., Williams, B.O. & Warman, M.L. Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol. Cell. Biol. 25, 4946\u20134955 (2005).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2388_CR10","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1359\/jbmr.040907","volume":"19","author":"SL Holmen","year":"2004","unstructured":"Holmen, S.L. et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J. Bone Miner. Res. 19, 2033\u20132040 (2004).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR11","doi-asserted-by":"publisher","first-page":"38276","DOI":"10.1074\/jbc.M609509200","volume":"281","author":"MV Semenov","year":"2006","unstructured":"Semenov, M.V. & He, X. LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. J. Biol. Chem. 281, 38276\u201338284 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFnm2388_CR12","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1083\/jcb.200201089","volume":"157","author":"M Kato","year":"2002","unstructured":"Kato, M. et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157, 303\u2013314 (2002).","journal-title":"J. Cell Biol."},{"key":"BFnm2388_CR13","doi-asserted-by":"publisher","first-page":"5469","DOI":"10.1242\/dev.01405","volume":"131","author":"C Kokubu","year":"2004","unstructured":"Kokubu, C. et al. Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131, 5469\u20135480 (2004).","journal-title":"Development"},{"key":"BFnm2388_CR14","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1359\/jbmr.060719","volume":"21","author":"R Nakanishi","year":"2006","unstructured":"Nakanishi, R. et al. Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice. J. Bone Miner. Res. 21, 1713\u20131721 (2006).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1359\/jbmr.080216","volume":"23","author":"X Li","year":"2008","unstructured":"Li, X. et al. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J. Bone Miner. Res. 23, 860\u2013869 (2008).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR16","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1359\/jbmr.060311","volume":"21","author":"F Morvan","year":"2006","unstructured":"Morvan, F. et al. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J. Bone Miner. Res. 21, 934\u2013945 (2006).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR17","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1359\/jbmr.2003.18.6.960","volume":"18","author":"P Babij","year":"2003","unstructured":"Babij, P. et al. High bone mass in mice expressing a mutant LRP5 gene. J. Bone Miner. Res. 18, 960\u2013974 (2003).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR18","doi-asserted-by":"publisher","first-page":"4677","DOI":"10.1128\/MCB.24.11.4677-4684.2004","volume":"24","author":"Y Zhang","year":"2004","unstructured":"Zhang, Y. et al. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol. Cell. Biol. 24, 4677\u20134684 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2388_CR19","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1073\/pnas.0434590100","volume":"100","author":"S Maretto","year":"2003","unstructured":"Maretto, S. et al. Mapping Wnt\/\u03b2-catenin signaling during mouse development and in colorectal tumors. Proc. Natl. Acad. Sci. USA 100, 3299\u20133304 (2003).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2388_CR20","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","volume":"22","author":"EH Jho","year":"2002","unstructured":"Jho, E.H. et al. Wnt\/\u03b2-catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 22, 1172\u20131183 (2002).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2388_CR21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1177\/154405910708600404","volume":"86","author":"Y Lu","year":"2007","unstructured":"Lu, Y. et al. DMP1-targeted Cre expression in odontoblasts and osteocytes. J. Dent. Res. 86, 320\u2013325 (2007).","journal-title":"J. Dent. Res."},{"key":"BFnm2388_CR22","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.cell.2008.09.059","volume":"135","author":"VK Yadav","year":"2008","unstructured":"Yadav, V.K. et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135, 825\u2013837 (2008).","journal-title":"Cell"},{"key":"BFnm2388_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1124\/jpet.107.132670","volume":"325","author":"Q Liu","year":"2008","unstructured":"Liu, Q. et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J. Pharmacol. Exp. Ther. 325, 47\u201355 (2008).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnm2388_CR24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1126\/science.1078197","volume":"299","author":"DJ Walther","year":"2003","unstructured":"Walther, D.J. et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299, 76 (2003).","journal-title":"Science"},{"key":"BFnm2388_CR25","doi-asserted-by":"publisher","first-page":"10332","DOI":"10.1073\/pnas.0810793106","volume":"106","author":"N Alenina","year":"2009","unstructured":"Alenina, N. et al. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc. Natl. Acad. Sci. USA 106, 10332\u201310337 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2388_CR26","doi-asserted-by":"publisher","first-page":"e3301","DOI":"10.1371\/journal.pone.0003301","volume":"3","author":"KV Savelieva","year":"2008","unstructured":"Savelieva, K.V. et al. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS ONE 3, e3301 (2008).","journal-title":"PLoS ONE"},{"key":"BFnm2388_CR27","doi-asserted-by":"publisher","first-page":"33275","DOI":"10.1074\/jbc.M204935200","volume":"277","author":"BB Madison","year":"2002","unstructured":"Madison, B.B. et al. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J. Biol. Chem. 277, 33275\u201333283 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnm2388_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/gene.10092","volume":"33","author":"M Logan","year":"2002","unstructured":"Logan, M. et al. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33, 77\u201380 (2002).","journal-title":"Genesis"},{"key":"BFnm2388_CR29","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1359\/jbmr.061118","volume":"22","author":"UT Iwaniec","year":"2007","unstructured":"Iwaniec, U.T. et al. PTH stimulates bone formation in mice deficient in Lrp5. J. Bone Miner. Res. 22, 394\u2013402 (2007).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR30","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2008.11.007","volume":"135","author":"F Long","year":"2008","unstructured":"Long, F. When the gut talks to bone. Cell 135, 795\u2013796 (2008).","journal-title":"Cell"},{"key":"BFnm2388_CR31","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1056\/NEJMp0810058","volume":"360","author":"CJ Rosen","year":"2009","unstructured":"Rosen, C.J. Serotonin rising\u2014the bone, brain, bowel connection. N. Engl. J. Med. 360, 957\u2013959 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2388_CR32","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nm.2098","volume":"16","author":"VK Yadav","year":"2010","unstructured":"Yadav, V.K. et al. Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Nat. Med. 16, 308\u2013312 (2010).","journal-title":"Nat. Med."},{"key":"BFnm2388_CR33","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00223-008-9130-9","volume":"82","author":"W Balemans","year":"2008","unstructured":"Balemans, W. et al. The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif. Tissue Int. 82, 445\u2013453 (2008).","journal-title":"Calcif. Tissue Int."},{"key":"BFnm2388_CR34","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1359\/jbmr.060810","volume":"21","author":"DL Ellies","year":"2006","unstructured":"Ellies, D.L. et al. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J. Bone Miner. Res. 21, 1738\u20131749 (2006).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm2388_CR35","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bone.2007.05.009","volume":"41","author":"BT MacDonald","year":"2007","unstructured":"MacDonald, B.T. et al. Bone mass is inversely proportional to Dkk1 levels in mice. Bone 41, 331\u2013339 (2007).","journal-title":"Bone"},{"key":"BFnm2388_CR36","doi-asserted-by":"publisher","first-page":"5866","DOI":"10.1074\/jbc.M705092200","volume":"283","author":"AG Robling","year":"2008","unstructured":"Robling, A.G. et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin. J. Biol. Chem. 283, 5866\u20135875 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnm2388_CR37","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","volume":"42","author":"LF Bonewald","year":"2008","unstructured":"Bonewald, L.F. & Johnson, M.L. Osteocytes, mechanosensing and Wnt signaling. Bone 42, 606\u2013615 (2008).","journal-title":"Bone"},{"key":"BFnm2388_CR38","doi-asserted-by":"publisher","first-page":"31720","DOI":"10.1074\/jbc.M602308200","volume":"281","author":"JA Robinson","year":"2006","unstructured":"Robinson, J.A. et al. Wnt\/\u03b2-catenin signaling is a normal physiological response to mechanical loading in bone. J. Biol. Chem. 281, 31720\u201331728 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFnm2388_CR39","doi-asserted-by":"publisher","first-page":"23698","DOI":"10.1074\/jbc.M601000200","volume":"281","author":"K Sawakami","year":"2006","unstructured":"Sawakami, K. et al. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J. Biol. Chem. 281, 23698\u201323711 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFnm2388_CR40","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1006\/bbrc.1998.9545","volume":"251","author":"Y Dong","year":"1998","unstructured":"Dong, Y. et al. Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity. Biochem. Biophys. Res. Commun. 251, 784\u2013790 (1998).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnm2388_CR41","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nrn1990","volume":"7","author":"M Fuccillo","year":"2006","unstructured":"Fuccillo, M., Joyner, A.L. & Fishell, G. Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development. Nat. Rev. Neurosci. 7, 772\u2013783 (2006).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnm2388_CR42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.conb.2008.05.002","volume":"18","author":"W Zhong","year":"2008","unstructured":"Zhong, W. & Chia, W. Neurogenesis and asymmetric cell division. Curr. Opin. Neurobiol. 18, 4\u201311 (2008).","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnm2388_CR43","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","volume":"8","author":"TF Day","year":"2005","unstructured":"Day, T.F., Guo, X., Garrett-Beal, L. & Yang, Y. Wnt\/\u03b2-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev. Cell 8, 739\u2013750 (2005).","journal-title":"Dev. Cell"},{"key":"BFnm2388_CR44","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","volume":"8","author":"TP Hill","year":"2005","unstructured":"Hill, T.P., Spater, D., Taketo, M.M., Birchmeier, W. & Hartmann, C. Canonical Wnt\/\u03b2-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev. Cell 8, 727\u2013738 (2005).","journal-title":"Dev. Cell"},{"key":"BFnm2388_CR45","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1242\/dev.01564","volume":"132","author":"H Hu","year":"2005","unstructured":"Hu, H. et al. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132, 49\u201360 (2005).","journal-title":"Development"},{"key":"BFnm2388_CR46","doi-asserted-by":"publisher","first-page":"14515","DOI":"10.1074\/jbc.M700030200","volume":"282","author":"S Kang","year":"2007","unstructured":"Kang, S. et al. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT\/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 282, 14515\u201314524 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnm2388_CR47","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1242\/dev.01137","volume":"131","author":"OG Kelly","year":"2004","unstructured":"Kelly, O.G., Pinson, K.I. & Skarnes, W.C. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 131, 2803\u20132815 (2004).","journal-title":"Development"},{"key":"BFnm2388_CR48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/dvdy.10100","volume":"224","author":"R Dacquin","year":"2002","unstructured":"Dacquin, R., Starbuck, M., Schinke, T. & Karsenty, G. Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev. Dyn. 224, 245\u2013251 (2002).","journal-title":"Dev. Dyn."},{"key":"BFnm2388_CR49","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/clinchem\/31.5.695","volume":"31","author":"OC Ingebretsen","year":"1985","unstructured":"Ingebretsen, O.C., Bakken, A.M. & Farstad, M. Liquid chromatography of serotonin and adenine nucleotides in blood platelets, illustrated by evaluation of functional integrity of platelet preparations. Clin. Chem. 31, 695\u2013698 (1985).","journal-title":"Clin. Chem."},{"key":"BFnm2388_CR50","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/0024-3205(87)90696-5","volume":"41","author":"GM Anderson","year":"1987","unstructured":"Anderson, G.M., Stevenson, J.M. & Cohen, D.J. Steady-state model for plasma free and platelet serotonin in man. Life Sci. 41, 1777\u20131785 (1987).","journal-title":"Life Sci."},{"key":"BFnm2388_CR51","unstructured":"Wolff, J. The Law of Bone Remodeling (Springer-Verlag, 1892)."},{"key":"BFnm2388_CR52","doi-asserted-by":"publisher","first-page":"5860","DOI":"10.1073\/pnas.93.12.5860","volume":"93","author":"M Lakso","year":"1996","unstructured":"Lakso, M. et al. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl. Acad. Sci. USA 93, 5860\u20135865 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2388_CR53","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<106::AID-GENE30>3.0.CO;2-T","volume":"28","author":"FW Farley","year":"2000","unstructured":"Farley, F.W., Soriano, P., Steffen, L.S. & Dymecki, S.M. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28, 106\u2013110 (2000).","journal-title":"Genesis"},{"key":"BFnm2388_CR54","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","volume":"23","author":"F Schwenk","year":"1995","unstructured":"Schwenk, F., Baron, U. & Rajewsky, K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080\u20135081 (1995).","journal-title":"Nucleic Acids Res."},{"key":"BFnm2388_CR55","doi-asserted-by":"publisher","first-page":"17406","DOI":"10.1073\/pnas.0505259102","volume":"102","author":"P Cl\u00e9ment-Lacroix","year":"2005","unstructured":"Cl\u00e9ment-Lacroix, P. et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc. Natl. Acad. Sci. USA 102, 17406\u201317411 (2005).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2388_CR56","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","volume":"45","author":"MD Muzumdar","year":"2007","unstructured":"Muzumdar, M.D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global double-fluorescent Cre reporter mouse. Genesis 45, 593\u2013605 (2007).","journal-title":"Genesis"},{"key":"BFnm2388_CR57","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.neulet.2007.11.012","volume":"431","author":"K Tenner","year":"2008","unstructured":"Tenner, K., Qadri, F., Bert, B., Voigt, J.P. & Bader, M. The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neurosci. Lett. 431, 21\u201325 (2008).","journal-title":"Neurosci. Lett."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.2388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.2388","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.2388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:27:30Z","timestamp":1684434450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.2388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,22]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["BFnm2388"],"URL":"https:\/\/doi.org\/10.1038\/nm.2388","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10904956.12253055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10904956.12211055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10904956.11833055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10904956.14107055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.10904956.14740108","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,22]]}}}