{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:33:36Z","timestamp":1791855216597,"version":"4.3.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,3,18]],"date-time":"2012-03-18T00:00:00Z","timestamp":1332028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/nm.2713","type":"journal-article","created":{"date-parts":[[2012,3,18]],"date-time":"2012-03-18T18:05:22Z","timestamp":1332093922000},"page":"521-528","source":"Crossref","is-referenced-by-count":466,"title":["A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer"],"prefix":"10.1038","volume":"18","author":[{"given":"King Pan","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel M","family":"Hillmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T H","family":"Chuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Chun","family":"Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun Kiat","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey S M","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramila N","family":"Ariyaratne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Soh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wah Heng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W J","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John C","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing Yi","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbupalam","family":"Thalamuthu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Ting","family":"Poh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Leen","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Tha","family":"Mya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gee Fung","family":"How","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang Piu","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balram","family":"Chowbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Tien","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veera S","family":"Nadarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Joo","family":"Chng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lay Cheng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeow Tee","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Poh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Ee","family":"Seet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Kim","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noan-Minh","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Sing","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S W","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Soda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M","family":"N\u00f6then","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Y","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Shahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e8re","family":"Cacheux-Rataboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Kin","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng Huat","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A","family":"Soo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan Min","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Teck","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Tiong","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,18]]},"reference":[{"key":"BFnm2713_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nrd2871","volume":"8","author":"PA J\u00e4nne","year":"2009","unstructured":"J\u00e4nne, P.A., Gray, N. & Settleman, J. Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat. Rev. Drug Discov. 8, 709\u2013723 (2009).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFnm2713_CR2","first-page":"478","volume":"82","author":"AM Carella","year":"1997","unstructured":"Carella, A.M. et al. New insights in biology and current therapeutic options for patients with chronic myelogenous leukemia. Haematologica 82, 478\u2013495 (1997).","journal-title":"Haematologica"},{"key":"BFnm2713_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1056\/NEJMoa011954","volume":"346","author":"JH Schiller","year":"2002","unstructured":"Schiller, J.H. et al. Comparison of four chemotherapy regimens for advanced non\u2013small-cell lung cancer. N. Engl. J. Med. 346, 92\u201398 (2002).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2713_CR4","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1200\/JCO.2010.31.8923","volume":"29","author":"VL Keedy","year":"2011","unstructured":"Keedy, V.L. et al. American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) mutation testing for patients with advanced non\u2013small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. J. Clin. Oncol. 29, 2121\u20132127 (2011).","journal-title":"J. Clin. Oncol."},{"key":"BFnm2713_CR5","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1200\/JCO.2009.25.0779","volume":"27","author":"M Baccarani","year":"2009","unstructured":"Baccarani, M. et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J. Clin. Oncol. 27, 6041\u20136051 (2009).","journal-title":"J. Clin. Oncol."},{"key":"BFnm2713_CR6","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1056\/NEJMra1010600","volume":"364","author":"L Wang","year":"2011","unstructured":"Wang, L., McLeod, H.L. & Weinshilboum, R.M. Genomics and drug response. N. Engl. J. Med. 364, 1144\u20131153 (2011).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2713_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrm2308","volume":"9","author":"RJ Youle","year":"2008","unstructured":"Youle, R.J. & Strasser, A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9, 47\u201359 (2008).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnm2713_CR8","doi-asserted-by":"publisher","first-page":"14907","DOI":"10.1073\/pnas.0606176103","volume":"103","author":"J Kuroda","year":"2006","unstructured":"Kuroda, J. et al. Bim and Bad mediate imatinib-induced killing of Bcr\/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc. Natl. Acad. Sci. USA 103, 14907\u201314912 (2006).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2713_CR9","doi-asserted-by":"publisher","first-page":"9436","DOI":"10.1158\/0008-5472.CAN-05-0972","volume":"65","author":"KJ Aichberger","year":"2005","unstructured":"Aichberger, K.J. et al. Low-level expression of proapoptotic Bcl-2-interacting mediator in leukemic cells in patients with chronic myeloid leukemia: role of BCR\/ABL, characterization of underlying signaling pathways, and reexpression by novel pharmacologic compounds. Cancer Res. 65, 9436\u20139444 (2005).","journal-title":"Cancer Res."},{"key":"BFnm2713_CR10","doi-asserted-by":"publisher","first-page":"6172","DOI":"10.1128\/MCB.24.14.6172-6183.2004","volume":"24","author":"R Kuribara","year":"2004","unstructured":"Kuribara, R. et al. Roles of Bim in apoptosis of normal and Bcr-Abl\u2013expressing hematopoietic progenitors. Mol. Cell. Biol. 24, 6172\u20136183 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2713_CR11","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1371\/journal.pmed.0040316","volume":"4","author":"MS Cragg","year":"2007","unstructured":"Cragg, M.S., Kuroda, J., Puthalakath, H., Huang, D.C. & Strasser, A. Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med. 4, 1681\u20131689 (2007).","journal-title":"PLoS Med."},{"key":"BFnm2713_CR12","doi-asserted-by":"publisher","first-page":"e294","DOI":"10.1371\/journal.pmed.0040294","volume":"4","author":"Y Gong","year":"2007","unstructured":"Gong, Y. et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med. 4, e294 (2007).","journal-title":"PLoS Med."},{"key":"BFnm2713_CR13","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1371\/journal.pmed.0040315","volume":"4","author":"DB Costa","year":"2007","unstructured":"Costa, D.B. et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med 4, 1669\u20131679 (2007).","journal-title":"PLoS Med"},{"key":"BFnm2713_CR14","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1101\/gr.074906.107","volume":"19","author":"MJ Fullwood","year":"2009","unstructured":"Fullwood, M.J., Wei, C.L., Liu, E.T. & Ruan, Y. Next-generation DNA sequencing of paired-end tags (PET) for transcriptome and genome analyses. Genome Res. 19, 521\u2013532 (2009).","journal-title":"Genome Res."},{"key":"BFnm2713_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1101\/gr.113555.110","volume":"21","author":"AM Hillmer","year":"2011","unstructured":"Hillmer, A.M. et al. Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes. Genome Res. 21, 665\u2013675 (2011).","journal-title":"Genome Res."},{"key":"BFnm2713_CR16","first-page":"2976","volume":"62","author":"JW Liu","year":"2002","unstructured":"Liu, J.W., Chandra, D., Tang, S.H., Chopra, D. & Tang, D.G. Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. Cancer Res. 62, 2976\u20132981 (2002).","journal-title":"Cancer Res."},{"key":"BFnm2713_CR17","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/sj.cdd.4401529","volume":"12","author":"M Adachi","year":"2005","unstructured":"Adachi, M., Zhao, X. & Imai, K. Nomenclature of dynein light chain-linked BH3-only protein Bim isoforms. Cell Death Differ. 12, 192\u2013193 (2005).","journal-title":"Cell Death Differ."},{"key":"BFnm2713_CR18","doi-asserted-by":"publisher","first-page":"reviews0008","DOI":"10.1186\/gb-2002-3-11-reviews0008","volume":"3","author":"AN Ladd","year":"2002","unstructured":"Ladd, A.N. & Cooper, T.A. Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol. 3, reviews0008 (2002).","journal-title":"Genome Biol."},{"key":"BFnm2713_CR19","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1128\/MCB.18.4.2205","volume":"18","author":"RP Carstens","year":"1998","unstructured":"Carstens, R.P., McKeehan, W.L. & Garcia-Blanco, M.A. An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol. Cell. Biol. 18, 2205\u20132217 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm2713_CR20","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1097-2765(01)00320-3","volume":"8","author":"EH Cheng","year":"2001","unstructured":"Cheng, E.H. et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8, 705\u2013711 (2001).","journal-title":"Mol. Cell"},{"key":"BFnm2713_CR21","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0092-8674(00)00187-2","volume":"103","author":"DC Huang","year":"2000","unstructured":"Huang, D.C. & Strasser, A. BH3-only proteins-essential initiators of apoptotic cell death. Cell 103, 839\u2013842 (2000).","journal-title":"Cell"},{"key":"BFnm2713_CR22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/stem.5530010205","volume":"1","author":"I Kubonishi","year":"1983","unstructured":"Kubonishi, I. & Miyoshi, I. Establishment of a Ph1 chromosome-positive cell line from chronic myelogenous leukemia in blast crisis. Int. J. Cell Cloning 1, 105\u2013117 (1983).","journal-title":"Int. J. Cell Cloning"},{"key":"BFnm2713_CR23","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood.V96.3.1070","volume":"96","author":"FX Mahon","year":"2000","unstructured":"Mahon, F.X. et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 96, 1070\u20131079 (2000).","journal-title":"Blood"},{"key":"BFnm2713_CR24","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1182\/blood.V90.9.3691","volume":"90","author":"MW Deininger","year":"1997","unstructured":"Deininger, M.W., Goldman, J.M., Lydon, N. & Melo, J.V. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL\u2013positive cells. Blood 90, 3691\u20133698 (1997).","journal-title":"Blood"},{"key":"BFnm2713_CR25","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.ccr.2008.11.001","volume":"14","author":"NP Shah","year":"2008","unstructured":"Shah, N.P. et al. Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell 14, 485\u2013493 (2008).","journal-title":"Cancer Cell"},{"key":"BFnm2713_CR26","first-page":"5716","volume":"63","author":"C Ly","year":"2003","unstructured":"Ly, C., Arechiga, A.F., Melo, J.V., Walsh, C.M. & Ong, S.T. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E\u2013BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res. 63, 5716\u20135722 (2003).","journal-title":"Cancer Res."},{"key":"BFnm2713_CR27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nrc2615","volume":"9","author":"MS Cragg","year":"2009","unstructured":"Cragg, M.S., Harris, C., Strasser, A. & Scott, C.L. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat. Rev. Cancer 9, 321\u2013326 (2009).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnm2713_CR28","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11899-008-0012-z","volume":"3","author":"P La Ros\u00e9e","year":"2008","unstructured":"La Ros\u00e9e, P. & Hochhaus, A. Resistance to imatinib in chronic myelogenous leukemia: mechanisms and clinical implications. Curr. Hematol. Malig. Rep. 3, 72\u201379 (2008).","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"BFnm2713_CR29","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1126\/science.1099314","volume":"304","author":"JG Paez","year":"2004","unstructured":"Paez, J.G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497\u20131500 (2004).","journal-title":"Science"},{"key":"BFnm2713_CR30","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1056\/NEJMoa040938","volume":"350","author":"TJ Lynch","year":"2004","unstructured":"Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non\u2013small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129\u20132139 (2004).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2713_CR31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1056\/NEJMoa050753","volume":"353","author":"FA Shepherd","year":"2005","unstructured":"Shepherd, F.A. et al. Erlotinib in previously treated non\u2013small-cell lung cancer. N. Engl. J. Med. 353, 123\u2013132 (2005).","journal-title":"N. Engl. J. Med."},{"key":"BFnm2713_CR32","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(08)61758-4","volume":"372","author":"ES Kim","year":"2008","unstructured":"Kim, E.S. et al. Gefitinib versus docetaxel in previously treated non\u2013small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 372, 1809\u20131818 (2008).","journal-title":"Lancet"},{"key":"BFnm2713_CR33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1185\/030079906X89847","volume":"22","author":"K Park","year":"2006","unstructured":"Park, K. & Goto, K. A review of the benefit-risk profile of gefitinib in Asian patients with advanced non-small-cell lung cancer. Curr. Med. Res. Opin. 22, 561\u2013573 (2006).","journal-title":"Curr. Med. Res. Opin."},{"key":"BFnm2713_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1476-4598-6-63","volume":"6","author":"Y Lu","year":"2007","unstructured":"Lu, Y., Liang, K., Li, X. & Fan, Z. Responses of cancer cells with wild-type or tyrosine kinase domain\u2013mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1\u03b1. Mol. Cancer 6, 63 (2007).","journal-title":"Mol. Cancer"},{"key":"BFnm2713_CR35","doi-asserted-by":"publisher","first-page":"e13470","DOI":"10.1371\/journal.pone.0013470","volume":"5","author":"K Machida","year":"2010","unstructured":"Machida, K. et al. Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling. PLoS ONE 5, e13470 (2010).","journal-title":"PLoS ONE"},{"key":"BFnm2713_CR36","doi-asserted-by":"publisher","first-page":"4877","DOI":"10.1158\/1078-0432.CCR-07-5123","volume":"14","author":"JY Wu","year":"2008","unstructured":"Wu, J.Y. et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin. Cancer Res. 14, 4877\u20134882 (2008).","journal-title":"Clin. Cancer Res."},{"key":"BFnm2713_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.lungcan.2007.06.024","volume":"58","author":"H Sasaki","year":"2007","unstructured":"Sasaki, H. et al. EGFR exon 20 insertion mutation in Japanese lung cancer. Lung Cancer 58, 324\u2013328 (2007).","journal-title":"Lung Cancer"},{"key":"BFnm2713_CR38","doi-asserted-by":"publisher","first-page":"14109","DOI":"10.1074\/jbc.M109.078592","volume":"285","author":"PM Gordon","year":"2010","unstructured":"Gordon, P.M. & Fisher, D.E. Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line. J. Biol. Chem. 285, 14109\u201314114 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnm2713_CR39","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1182\/blood-2009-03-209544","volume":"115","author":"B Will","year":"2010","unstructured":"Will, B. et al. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood 115, 2901\u20132909 (2010).","journal-title":"Blood"},{"key":"BFnm2713_CR40","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nature05945","volume":"448","author":"M Soda","year":"2007","unstructured":"Soda, M. et al. Identification of the transforming EML4-ALK fusion gene in non\u2013small-cell lung cancer. Nature 448, 561\u2013566 (2007).","journal-title":"Nature"},{"key":"BFnm2713_CR41","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12185-008-0230-0","volume":"89","author":"WY Au","year":"2009","unstructured":"Au, W.Y. et al. Chronic myeloid leukemia in Asia. Int. J. Hematol. 89, 14\u201323 (2009).","journal-title":"Int. J. Hematol."},{"key":"BFnm2713_CR42","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1158\/2159-8290.CD-11-0106","volume":"1","author":"A Faber","year":"2011","unstructured":"Faber, A. et al. BIM expression in treatment naive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 1, 352\u2013365 (2011).","journal-title":"Cancer Discov."},{"key":"BFnm2713_CR43","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrg775","volume":"3","author":"L Cartegni","year":"2002","unstructured":"Cartegni, L., Chew, S.L. & Krainer, A.R. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat. Rev. Genet. 3, 285\u2013298 (2002).","journal-title":"Nat. Rev. Genet."},{"key":"BFnm2713_CR44","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1016\/j.febslet.2005.02.047","volume":"579","author":"N L\u00f3pez-Bigas","year":"2005","unstructured":"L\u00f3pez-Bigas, N., Audit, B., Ouzounis, C., Parra, G. & Guigo, R. Are splicing mutations the most frequent cause of hereditary disease? FEBS Lett. 579, 1900\u20131903 (2005).","journal-title":"FEBS Lett."},{"key":"BFnm2713_CR45","doi-asserted-by":"publisher","first-page":"9479","DOI":"10.1158\/0008-5472.CAN-08-1643","volume":"68","author":"S Yano","year":"2008","unstructured":"Yano, S. et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor\u2013activating mutations. Cancer Res. 68, 9479\u20139487 (2008).","journal-title":"Cancer Res."},{"key":"BFnm2713_CR46","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature09870","volume":"471","author":"TG Bivona","year":"2011","unstructured":"Bivona, T.G. et al. FAS and NF-\u03baB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471, 523\u2013526 (2011).","journal-title":"Nature"},{"key":"BFnm2713_CR47","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/JTO.0b013e3181cee47e","volume":"5","author":"M Takeda","year":"2010","unstructured":"Takeda, M. et al. De novo resistance to epidermal growth factor receptor\u2013tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer. J. Thorac. Oncol. 5, 399\u2013400 (2010).","journal-title":"J. Thorac. Oncol."},{"key":"BFnm2713_CR48","doi-asserted-by":"publisher","first-page":"6164","DOI":"10.1073\/pnas.0401471101","volume":"101","author":"A Egle","year":"2004","unstructured":"Egle, A., Harris, A.W., Bouillet, P. & Cory, S. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc. Natl. Acad. Sci. USA 101, 6164\u20136169 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm2713_CR49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/09286580600878844","volume":"14","author":"AW Foong","year":"2007","unstructured":"Foong, A.W. et al. Rationale and methodology for a population-based study of eye diseases in Malay people: the Singapore Malay eye study (SiMES). Ophthalmic Epidemiol. 14, 25\u201335 (2007).","journal-title":"Ophthalmic Epidemiol."},{"key":"BFnm2713_CR50","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3109\/09286580903144738","volume":"16","author":"R Lavanya","year":"2009","unstructured":"Lavanya, R. et al. Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. Ophthalmic Epidemiol. 16, 325\u2013336 (2009).","journal-title":"Ophthalmic Epidemiol."},{"key":"BFnm2713_CR51","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1101\/gr.113555.110","volume":"21","author":"AM Hillmer","year":"2011","unstructured":"Hillmer, A.M. et al. Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes. Genome Res. 21, 665\u2013675 (2011).","journal-title":"Genome Res."},{"key":"BFnm2713_CR52","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/nature06258","volume":"449","author":"KA Frazer","year":"2007","unstructured":"Frazer, K.A. et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851\u2013861 (2007).","journal-title":"Nature"},{"key":"BFnm2713_CR53","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/ng.237","volume":"40","author":"JM Korn","year":"2008","unstructured":"Korn, J.M. et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat. Genet. 40, 1253\u20131260 (2008).","journal-title":"Nat. Genet."},{"key":"BFnm2713_CR54","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nature03556","volume":"435","author":"FD Urnov","year":"2005","unstructured":"Urnov, F.D. et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435, 646\u2013651 (2005).","journal-title":"Nature"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.2713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.2713","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.2713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:31:53Z","timestamp":1684434713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.2713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,18]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["BFnm2713"],"URL":"https:\/\/doi.org\/10.1038\/nm.2713","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14267291.15779480","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.14267291.793468242","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,18]]}}}