{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:56:56Z","timestamp":1791309416481,"version":"4.3.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T00:00:00Z","timestamp":1364688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1038\/nm.3146","type":"journal-article","created":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T19:29:17Z","timestamp":1364758157000},"page":"608-613","source":"Crossref","is-referenced-by-count":106,"title":["PPAR\u03b2\/\u03b4 governs Wnt signaling and bone turnover"],"prefix":"10.1038","volume":"19","author":[{"given":"Carina","family":"Scholtysek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Katzenbeisser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Uderhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Ipseiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario M","family":"Zaiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Donhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Kleyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Engelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Djouad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Peter","family":"Tuckermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Desvergne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kr\u00f6nke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,31]]},"reference":[{"key":"BFnm3146_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nm1025","volume":"10","author":"RM Evans","year":"2004","unstructured":"Evans, R.M., Barish, G.D. & Wang, Y.X. PPARs and the complex journey to obesity. Nat. Med. 10, 355\u2013361 (2004).","journal-title":"Nat. Med."},{"key":"BFnm3146_CR2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrendo.2010.155","volume":"6","author":"M Kawai","year":"2010","unstructured":"Kawai, M. & Rosen, C.J. PPAR\u03b3: a circadian transcription factor in adipogenesis and osteogenesis. Nat. Rev. Endocrinol. 6, 629\u2013636 (2010).","journal-title":"Nat. Rev. Endocrinol."},{"key":"BFnm3146_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1472-8206.2007.00486.x","volume":"21","author":"C Giaginis","year":"2007","unstructured":"Giaginis, C., Tsantili-Kakoulidou, A. & Theocharis, S. Peroxisome proliferator-activated receptors (PPARs) in the control of bone metabolism. Fundam. Clin. Pharmacol. 21, 231\u2013244 (2007).","journal-title":"Fundam. Clin. Pharmacol."},{"key":"BFnm3146_CR4","first-page":"9","volume":"33","author":"G Viccica","year":"2010","unstructured":"Viccica, G., Francucci, C.M. & Marcocci, C. The role of PPAR\u03b3 for the osteoblastic differentiation. J. Endocrinol. Invest. 33, 9\u201312 (2010).","journal-title":"J. Endocrinol. Invest."},{"key":"BFnm3146_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00198-007-0477-y","volume":"19","author":"A Grey","year":"2008","unstructured":"Grey, A. Skeletal consequences of thiazolidinedione therapy. Osteoporos. Int. 19, 129\u2013137 (2008).","journal-title":"Osteoporos. Int."},{"key":"BFnm3146_CR6","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1172\/JCI200419900","volume":"113","author":"T Akune","year":"2004","unstructured":"Akune, T. et al. PPAR\u03b3 insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J. Clin. Invest. 113, 846\u2013855 (2004).","journal-title":"J. Clin. Invest."},{"key":"BFnm3146_CR7","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/nm1672","volume":"13","author":"Y Wan","year":"2007","unstructured":"Wan, Y., Chong, L.W. & Evans, R.M. PPAR-\u03b3 regulates osteoclastogenesis in mice. Nat. Med. 13, 1496\u20131503 (2007).","journal-title":"Nat. Med."},{"key":"BFnm3146_CR8","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.cmet.2010.04.015","volume":"11","author":"W Wei","year":"2010","unstructured":"Wei, W. et al. PGC1\u03b2 mediates PPAR\u03b3 activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab. 11, 503\u2013516 (2010).","journal-title":"Cell Metab."},{"key":"BFnm3146_CR9","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrrheum.2009.137","volume":"5","author":"I Takada","year":"2009","unstructured":"Takada, I., Kouzmenko, A.P. & Kato, S. Wnt and PPAR\u03b3 signaling in osteoblastogenesis and adipogenesis. Nat. Rev. Rheumatol. 5, 442\u2013447 (2009).","journal-title":"Nat. Rev. Rheumatol."},{"key":"BFnm3146_CR10","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1210\/er.2003-0034","volume":"26","author":"DJ Mulholland","year":"2005","unstructured":"Mulholland, D.J., Dedhar, S., Coetzee, G.A. & Nelson, C.C. Interaction of nuclear receptors with the Wnt\/\u03b2-catenin\/Tcf signaling axis: Wnt you like to know? Endocr. Rev. 26, 898\u2013915 (2005).","journal-title":"Endocr. Rev."},{"key":"BFnm3146_CR11","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1196\/annals.1402.034","volume":"1116","author":"I Takada","year":"2007","unstructured":"Takada, I., Suzawa, M., Matsumoto, K. & Kato, S. Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann. NY Acad. Sci. 1116, 182\u2013195 (2007).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnm3146_CR12","doi-asserted-by":"publisher","first-page":"5819","DOI":"10.1073\/pnas.0901676106","volume":"106","author":"M Okamura","year":"2009","unstructured":"Okamura, M. et al. COUP-TFII acts downstream of Wnt\/\u03b2-catenin signal to silence PPAR\u03b3 gene expression and repress adipogenesis. Proc. Natl. Acad. Sci. USA 106, 5819\u20135824 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3146_CR13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00774-009-0064-8","volume":"27","author":"T Kubota","year":"2009","unstructured":"Kubota, T., Michigami, T. & Ozono, K. Wnt signaling in bone metabolism. J. Bone Miner. Metab. 27, 265\u2013271 (2009).","journal-title":"J. Bone Miner. Metab."},{"key":"BFnm3146_CR14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","volume":"8","author":"DA Glass II","year":"2005","unstructured":"Glass, D.A. II et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8, 751\u2013764 (2005).","journal-title":"Dev. Cell"},{"key":"BFnm3146_CR15","doi-asserted-by":"publisher","first-page":"21162","DOI":"10.1074\/jbc.M501900200","volume":"280","author":"SL Holmen","year":"2005","unstructured":"Holmen, S.L. et al. Essential role of \u03b2-catenin in postnatal bone acquisition. J. Biol. Chem. 280, 21162\u201321168 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFnm3146_CR16","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1128\/MCB.01428-09","volume":"30","author":"I Kramer","year":"2010","unstructured":"Kramer, I. et al. Osteocyte Wnt\/\u03b2-catenin signaling is required for normal bone homeostasis. Mol. Cell Biol. 30, 3071\u20133085 (2010).","journal-title":"Mol. Cell Biol."},{"key":"BFnm3146_CR17","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.4161\/cc.3.12.1288","volume":"3","author":"D Wang","year":"2004","unstructured":"Wang, D., Mann, J.R. & DuBois, R.N. WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. Cell Cycle 3, 1512\u20131515 (2004).","journal-title":"Cell Cycle"},{"key":"BFnm3146_CR18","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ccr.2004.08.011","volume":"6","author":"D Wang","year":"2004","unstructured":"Wang, D. et al. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor \u03b4. Cancer Cell 6, 285\u2013295 (2004).","journal-title":"Cancer Cell"},{"key":"BFnm3146_CR19","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1128\/MCB.26.8.3266-3281.2006","volume":"26","author":"K Nadra","year":"2006","unstructured":"Nadra, K. et al. Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor \u03b2\/\u03b4. Mol. Cell Biol. 26, 3266\u20133281 (2006).","journal-title":"Mol. Cell Biol."},{"key":"BFnm3146_CR20","doi-asserted-by":"publisher","first-page":"S97","DOI":"10.1016\/S0925-4773(03)00099-6","volume":"119","author":"S Hayashi","year":"2002","unstructured":"Hayashi, S., Lewis, P., Pevny, L. & McMahon, A.P. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech. Dev. 119, S97\u2013S101 (2002).","journal-title":"Mech. Dev."},{"key":"BFnm3146_CR21","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nm.2388","volume":"17","author":"Y Cui","year":"2011","unstructured":"Cui, Y. et al. Lrp5 functions in bone to regulate bone mass. Nat. Med. 17, 684\u2013691 (2011).","journal-title":"Nat. Med."},{"key":"BFnm3146_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10059-012-2240-z","volume":"33","author":"ES Cho","year":"2012","unstructured":"Cho, E.S. et al. The effects of rosiglitazone on osteoblastic differentiation, osteoclast formation and bone resorption. Mol. Cells 33, 173\u2013181 (2012).","journal-title":"Mol. Cells"},{"key":"BFnm3146_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bone.2006.07.029","volume":"40","author":"BY Chan","year":"2007","unstructured":"Chan, B.Y. et al. PPAR agonists modulate human osteoclast formation and activity in vitro. Bone 40, 149\u2013159 (2007).","journal-title":"Bone"},{"key":"BFnm3146_CR24","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1172\/JCI27955","volume":"116","author":"GD Barish","year":"2006","unstructured":"Barish, G.D., Narkar, V.A. & Evans, R.M. PPAR\u03b4: a dagger in the heart of the metabolic syndrome. J. Clin. Invest. 116, 590\u2013597 (2006).","journal-title":"J. Clin. Invest."},{"key":"BFnm3146_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cell.2008.06.051","volume":"134","author":"VA Narkar","year":"2008","unstructured":"Narkar, V.A. et al. AMPK and PPAR\u03b4 agonists are exercise mimetics. Cell 134, 405\u2013415 (2008).","journal-title":"Cell"},{"key":"BFnm3146_CR26","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","volume":"130","author":"NK Lee","year":"2007","unstructured":"Lee, N.K. et al. Endocrine regulation of energy metabolism by the skeleton. Cell 130, 456\u2013469 (2007).","journal-title":"Cell"},{"key":"BFnm3146_CR27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00223-008-9175-9","volume":"83","author":"K Still","year":"2008","unstructured":"Still, K., Grabowski, P., Mackie, I., Perry, M. & Bishop, N. The peroxisome proliferator activator receptor \u03b1\/\u03b4 agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo. Calcif. Tissue Int. 83, 285\u2013292 (2008).","journal-title":"Calcif. Tissue Int."},{"key":"BFnm3146_CR28","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1161\/ATVBAHA.112.247890","volume":"32","author":"EJ Olson","year":"2012","unstructured":"Olson, E.J., Pearce, G.L., Jones, N.P. & Sprecher, D.L. Lipid effects of peroxisome proliferator-activated receptor-\u03b4 agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler. Thromb. Vasc. Biol. 32, 2289\u20132294 (2012).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnm3146_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0925-4773(02)00292-7","volume":"2","author":"S Hayashi","year":"2002","unstructured":"Hayashi, S., Lewis, P., Pevny, L. & McMahon, A.P. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene expression patterns. Gene Expr. Patterns 2, 93\u201397 (2002).","journal-title":"Gene expression patterns. Gene Expr. Patterns"},{"key":"BFnm3146_CR30","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1002\/jbmr.1702","volume":"27","author":"A Kleyer","year":"2012","unstructured":"Kleyer, A. et al. LXRs orchestrate osteoblast\/osteoclast crosstalk and counteract pathologic bone loss. J. Bone Miner. Res. 27, 2442\u20132451 (2012).","journal-title":"J. Bone Miner. Res."},{"key":"BFnm3146_CR31","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1002\/art.27496","volume":"62","author":"G Kr\u00f6nke","year":"2010","unstructured":"Kr\u00f6nke, G. et al. R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum. 62, 2303\u20132312 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnm3146_CR32","doi-asserted-by":"publisher","first-page":"e14247","DOI":"10.1371\/journal.pone.0014247","volume":"5","author":"C Bouffi","year":"2010","unstructured":"Bouffi, C., Bony, C., Courties, G., Jorgensen, C. & No\u00ebl, D. IL-6\u2013dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis. PLoS ONE 5, e14247 (2010).","journal-title":"PLoS ONE"},{"key":"BFnm3146_CR33","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315\u2013317 (2006).","journal-title":"Cytotherapy"},{"key":"BFnm3146_CR34","doi-asserted-by":"publisher","first-page":"51006","DOI":"10.1074\/jbc.M304103200","volume":"278","author":"G Kr\u00f6nke","year":"2003","unstructured":"Kr\u00f6nke, G. et al. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J. Biol. Chem. 278, 51006\u201351014 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm3146_CR35","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl, M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45 (2001).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.3146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3146","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:39:10Z","timestamp":1684449550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.3146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,31]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["BFnm3146"],"URL":"https:\/\/doi.org\/10.1038\/nm.3146","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,31]]}}}