{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:22:39Z","timestamp":1791246159973,"version":"4.1.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,5,26]],"date-time":"2013-05-26T00:00:00Z","timestamp":1369526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1038\/nm.3189","type":"journal-article","created":{"date-parts":[[2013,5,26]],"date-time":"2013-05-26T15:15:35Z","timestamp":1369581335000},"page":"713-721","source":"Crossref","is-referenced-by-count":250,"title":["Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection"],"prefix":"10.1038","volume":"19","author":[{"given":"John R","family":"Grainger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Wohlfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan J","family":"Fuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bouladoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Askenase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Legrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Y","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M","family":"Brenchley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain D C","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Belkaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,26]]},"reference":[{"key":"BFnm3189_CR1","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1126\/science.1124234","volume":"312","author":"SR Gill","year":"2006","unstructured":"Gill, S.R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355\u20131359 (2006).","journal-title":"Science"},{"key":"BFnm3189_CR2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.chom.2011.10.004","volume":"10","author":"DR Littman","year":"2011","unstructured":"Littman, D.R. & Pamer, E.G. Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe 10, 311\u2013323 (2011).","journal-title":"Cell Host Microbe"},{"key":"BFnm3189_CR3","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2008.08.009","volume":"29","author":"JA Hall","year":"2008","unstructured":"Hall, J.A. et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29, 637\u2013649 (2008).","journal-title":"Immunity"},{"key":"BFnm3189_CR4","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.chom.2009.06.005","volume":"6","author":"A Benson","year":"2009","unstructured":"Benson, A., Pifer, R., Behrendt, C.L., Hooper, L.V. & Yarovinsky, F. Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe 6, 187\u2013196 (2009).","journal-title":"Cell Host Microbe"},{"key":"BFnm3189_CR5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1126\/science.1172747","volume":"325","author":"E Slack","year":"2009","unstructured":"Slack, E. et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325, 617\u2013620 (2009).","journal-title":"Science"},{"key":"BFnm3189_CR6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nri2322","volume":"8","author":"A Cerutti","year":"2008","unstructured":"Cerutti, A. The regulation of IgA class switching. Nat. Rev. Immunol. 8, 421\u2013434 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3189_CR7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1126\/science.1209791","volume":"334","author":"S Vaishnava","year":"2011","unstructured":"Vaishnava, S. et al. The antibacterial lectin RegIII\u03b3 promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255\u2013258 (2011).","journal-title":"Science"},{"key":"BFnm3189_CR8","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1126\/science.1220961","volume":"337","author":"TW Hand","year":"2012","unstructured":"Hand, T.W. et al. Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science 337, 1553\u20131556 (2012).","journal-title":"Science"},{"key":"BFnm3189_CR9","doi-asserted-by":"publisher","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","volume":"177","author":"MM Heimesaat","year":"2006","unstructured":"Heimesaat, M.M. et al. Gram-negative bacteria aggravate murine small intestinal TH1-type immunopathology following oral infection with Toxoplasma gondii. J. Immunol. 177, 8785\u20138795 (2006).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/nrgastro.2011.3","volume":"8","author":"SM Man","year":"2011","unstructured":"Man, S.M., Kaakoush, N.O. & Mitchell, H.M. The role of bacteria and pattern-recognition receptors in Crohn's disease. Nat. Rev. Gastroenterol. Hepatol. 8, 152\u2013168 (2011).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"BFnm3189_CR11","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.immuni.2009.08.010","volume":"31","author":"M Bogunovic","year":"2009","unstructured":"Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513\u2013525 (2009).","journal-title":"Immunity"},{"key":"BFnm3189_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.immuni.2011.01.016","volume":"34","author":"U Hadis","year":"2011","unstructured":"Hadis, U. et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34, 237\u2013246 (2011).","journal-title":"Immunity"},{"key":"BFnm3189_CR13","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1084\/jem.20070590","volume":"204","author":"JL Coombes","year":"2007","unstructured":"Coombes, J.L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-\u03b2 and retinoic acid-dependent mechanism. J. Exp. Med. 204, 1757\u20131764 (2007).","journal-title":"J. Exp. Med."},{"key":"BFnm3189_CR14","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1084\/jem.20070602","volume":"204","author":"CM Sun","year":"2007","unstructured":"Sun, C.M. et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid. J. Exp. Med. 204, 1775\u20131785 (2007).","journal-title":"J. Exp. Med."},{"key":"BFnm3189_CR15","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.immuni.2009.10.001","volume":"31","author":"G Oldenhove","year":"2009","unstructured":"Oldenhove, G. et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31, 772\u2013786 (2009).","journal-title":"Immunity"},{"key":"BFnm3189_CR16","doi-asserted-by":"publisher","first-page":"800","DOI":"10.4049\/jimmunol.1100769","volume":"188","author":"A Benson","year":"2012","unstructured":"Benson, A. et al. Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J. Immunol. 188, 800\u2013810 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1084\/jem.20101387","volume":"209","author":"A Rivollier","year":"2012","unstructured":"Rivollier, A., He, J., Kole, A., Valatas, V. & Kelsall, B.L. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J. Exp. Med. 209, 139\u2013155 (2012).","journal-title":"J. Exp. Med."},{"key":"BFnm3189_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","volume":"26","author":"NV Serbina","year":"2008","unstructured":"Serbina, N.V., Jia, T., Hohl, T.M. & Pamer, E.G. Monocyte-mediated defense against microbial pathogens. Annu. Rev. Immunol. 26, 421\u2013452 (2008).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm3189_CR19","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.immuni.2012.08.026","volume":"37","author":"E Zigmond","year":"2012","unstructured":"Zigmond, E. et al. Ly6C(hi) Monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 37, 1076\u20131090 (2012).","journal-title":"Immunity"},{"key":"BFnm3189_CR20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.immuni.2011.04.013","volume":"34","author":"YG Kim","year":"2011","unstructured":"Kim, Y.G. et al. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 34, 769\u2013780 (2011).","journal-title":"Immunity"},{"key":"BFnm3189_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1073\/pnas.1005201108","volume":"108","author":"N Iijima","year":"2011","unstructured":"Iijima, N., Mattei, L.M. & Iwasaki, A. Recruited inflammatory monocytes stimulate antiviral TH1 immunity in infected tissue. Proc. Natl. Acad. Sci. USA 108, 284\u2013289 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3189_CR22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.chom.2009.10.007","volume":"6","author":"TM Hohl","year":"2009","unstructured":"Hohl, T.M. et al. Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe 6, 470\u2013481 (2009).","journal-title":"Cell Host Microbe"},{"key":"BFnm3189_CR23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.immuni.2008.05.019","volume":"29","author":"IR Dunay","year":"2008","unstructured":"Dunay, I.R. et al. Gr1+ inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity 29, 306\u2013317 (2008).","journal-title":"Immunity"},{"key":"BFnm3189_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","volume":"19","author":"NV Serbina","year":"2003","unstructured":"Serbina, N.V., Salazar-Mather, T.P., Biron, C.A., Kuziel, W.A. & Pamer, E.G. TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19, 59\u201370 (2003).","journal-title":"Immunity"},{"key":"BFnm3189_CR25","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/mi.2012.24","volume":"5","author":"BM Fournier","year":"2012","unstructured":"Fournier, B.M. & Parkos, C.A. The role of neutrophils during intestinal inflammation. Mucosal Immunol. 5, 354\u2013366 (2012).","journal-title":"Mucosal Immunol."},{"key":"BFnm3189_CR26","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","volume":"157","author":"RT Gazzinelli","year":"1996","unstructured":"Gazzinelli, R.T. et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-\u03b3 and TNF-\u03b1. J. Immunol. 157, 798\u2013805 (1996).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR27","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1126\/science.1178331","volume":"327","author":"F Geissmann","year":"2010","unstructured":"Geissmann, F. et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656\u2013661 (2010).","journal-title":"Science"},{"key":"BFnm3189_CR28","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1084\/jem.185.7.1261","volume":"185","author":"TM Scharton-Kersten","year":"1997","unstructured":"Scharton-Kersten, T.M., Yap, G., Magram, J. & Sher, A. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 185, 1261\u20131273 (1997).","journal-title":"J. Exp. Med."},{"key":"BFnm3189_CR29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1365-3024.1998.00152.x","volume":"20","author":"H Jebbari","year":"1998","unstructured":"Jebbari, H., Roberts, C.W., Ferguson, D.J., Bluethmann, H. & Alexander, J. A protective role for IL-6 during early infection with Toxoplasma gondii. Parasite Immunol. 20, 231\u2013239 (1998).","journal-title":"Parasite Immunol."},{"key":"BFnm3189_CR30","doi-asserted-by":"publisher","first-page":"5375","DOI":"10.4049\/jimmunol.164.10.5375","volume":"164","author":"Y Suzuki","year":"2000","unstructured":"Suzuki, Y. et al. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB\/c and susceptible C57BL\/6 mice following peroral infection with Toxoplasma gondii. J. Immunol. 164, 5375\u20135382 (2000).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR31","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ni.1671","volume":"9","author":"KC El Kasmi","year":"2008","unstructured":"El Kasmi, K.C. et al. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat. Immunol. 9, 1399\u20131406 (2008).","journal-title":"Nat. Immunol."},{"key":"BFnm3189_CR32","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1600-065X.2008.00610.x","volume":"222","author":"JB Katz","year":"2008","unstructured":"Katz, J.B., Muller, A.J. & Prendergast, G.C. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol. Rev. 222, 206\u2013221 (2008).","journal-title":"Immunol. Rev."},{"key":"BFnm3189_CR33","doi-asserted-by":"crossref","first-page":"23261","DOI":"10.1016\/S0021-9258(18)54491-4","volume":"266","author":"MK O'Banion","year":"1991","unstructured":"O'Banion, M.K., Sadowski, H.B., Winn, V. & Young, D.A. A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem. 266, 23261\u201323267 (1991).","journal-title":"J. Biol. Chem."},{"key":"BFnm3189_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4049\/jimmunol.1101029","volume":"188","author":"P Kalinski","year":"2012","unstructured":"Kalinski, P. Regulation of immune responses by prostaglandin E2. J. Immunol. 188, 21\u201328 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.smim.2011.11.008","volume":"24","author":"MJ Molloy","year":"2012","unstructured":"Molloy, M.J., Bouladoux, N. & Belkaid, Y. Intestinal microbiota: shaping local and systemic immune responses. Semin. Immunol. 24, 58\u201366 (2012).","journal-title":"Semin. Immunol."},{"key":"BFnm3189_CR36","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.immuni.2011.02.016","volume":"34","author":"C Shi","year":"2011","unstructured":"Shi, C. et al. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands. Immunity 34, 590\u2013601 (2011).","journal-title":"Immunity"},{"key":"BFnm3189_CR37","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1128\/IAI.00472-09","volume":"78","author":"IR Dunay","year":"2010","unstructured":"Dunay, I.R., Fuchs, A. & Sibley, L.D. Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice. Infect. Immun. 78, 1564\u20131570 (2010).","journal-title":"Infect. Immun."},{"key":"BFnm3189_CR38","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00535-007-2096-y","volume":"42","author":"Y Naito","year":"2007","unstructured":"Naito, Y., Takagi, T. & Yoshikawa, T. Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease. J. Gastroenterol. 42, 787\u2013798 (2007).","journal-title":"J. Gastroenterol."},{"key":"BFnm3189_CR39","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1046\/j.1365-3024.1999.00237.x","volume":"21","author":"O Liesenfeld","year":"1999","unstructured":"Liesenfeld, O. et al. TNF-\u03b1, nitric oxide and IFN-\u03b3 are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii. Parasite Immunol. 21, 365\u2013376 (1999).","journal-title":"Parasite Immunol."},{"key":"BFnm3189_CR40","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s005990050036","volume":"28","author":"MA Cassatella","year":"1998","unstructured":"Cassatella, M.A. The neutrophil: one of the cellular targets of interleukin-10. Int. J. Clin. Lab. Res. 28, 148\u2013161 (1998).","journal-title":"Int. J. Clin. Lab. Res."},{"key":"BFnm3189_CR41","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","volume":"16","author":"ZG Fridlender","year":"2009","unstructured":"Fridlender, Z.G. et al. Polarization of tumor-associated neutrophil phenotype by TGF-\u03b2: \u201cN1\u201d versus \u201cN2\u201d TAN. Cancer Cell 16, 183\u2013194 (2009).","journal-title":"Cancer Cell"},{"key":"BFnm3189_CR42","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.4049\/jimmunol.0802918","volume":"183","author":"AE Troy","year":"2009","unstructured":"Troy, A.E. et al. IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis. J. Immunol. 183, 2037\u20132044 (2009).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR43","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1172\/JCI114547","volume":"85","author":"BN Cronstein","year":"1990","unstructured":"Cronstein, B.N., Daguma, L., Nichols, D., Hutchison, A.J. & Williams, M. The adenosine\/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. J. Clin. Invest. 85, 1150\u20131157 (1990).","journal-title":"J. Clin. Invest."},{"key":"BFnm3189_CR44","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.4049\/jimmunol.151.4.2166","volume":"151","author":"WA Wertheim","year":"1993","unstructured":"Wertheim, W.A. et al. Regulation of neutrophil-derived IL-8: the role of prostaglandin E2, dexamethasone, and IL-4. J. Immunol. 151, 2166\u20132175 (1993).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR45","doi-asserted-by":"publisher","first-page":"11613","DOI":"10.1074\/jbc.R600038200","volume":"282","author":"Y Sugimoto","year":"2007","unstructured":"Sugimoto, Y. & Narumiya, S. Prostaglandin E receptors. J. Biol. Chem. 282, 11613\u201311617 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnm3189_CR46","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.immuni.2012.03.026","volume":"36","author":"RS Goldszmid","year":"2012","unstructured":"Goldszmid, R.S. et al. NK cell-derived interferon-\u03b3 orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection. Immunity 36, 1047\u20131059 (2012).","journal-title":"Immunity"},{"key":"BFnm3189_CR47","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1056\/NEJM200108093450607","volume":"345","author":"GA FitzGerald","year":"2001","unstructured":"FitzGerald, G.A. & Patrono, C. The coxibs, selective inhibitors of cyclooxygenase-2. N. Engl. J. Med. 345, 433\u2013442 (2001).","journal-title":"N. Engl. J. Med."},{"key":"BFnm3189_CR48","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1093\/oxfordjournals.jbchem.a132272","volume":"84","author":"H Ohno","year":"1978","unstructured":"Ohno, H., Morikawa, Y. & Hirata, F. Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues. J. Biochem. 84, 1485\u20131494 (1978).","journal-title":"J. Biochem."},{"key":"BFnm3189_CR49","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/MAJ.0b013e3181ad8cd3","volume":"338","author":"A Lanas","year":"2009","unstructured":"Lanas, A. Nonsteroidal anti-inflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer. Am. J. Med. Sci. 338, 96\u2013106 (2009).","journal-title":"Am. J. Med. Sci."},{"key":"BFnm3189_CR50","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1126\/science.1225152","volume":"337","author":"S Naik","year":"2012","unstructured":"Naik, S. et al. Compartmentalized control of skin immunity by resident commensals. Science. 337, 1115\u20131119 (2012).","journal-title":"Science."},{"key":"BFnm3189_CR51","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1053\/j.gastro.2007.08.073","volume":"133","author":"AA K\u00fchl","year":"2007","unstructured":"K\u00fchl, A.A. et al. Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils. Gastroenterology 133, 1882\u20131892 (2007).","journal-title":"Gastroenterology"},{"key":"BFnm3189_CR52","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1084\/jem.20061886","volume":"204","author":"CF Anderson","year":"2007","unstructured":"Anderson, C.F., Oukka, M., Kuchroo, V.J. & Sacks, D. CD4+CD25\u2212Foxp3\u2212 TH1 cells are the source of IL-10\u2013mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204, 285\u2013297 (2007).","journal-title":"J. Exp. Med."},{"key":"BFnm3189_CR53","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1084\/jem.20062175","volume":"204","author":"D Jankovic","year":"2007","unstructured":"Jankovic, D. et al. Conventional T-bet+Foxp3\u2212 TH1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 204, 273\u2013283 (2007).","journal-title":"J. Exp. Med."},{"key":"BFnm3189_CR54","doi-asserted-by":"publisher","first-page":"4499","DOI":"10.4049\/jimmunol.0802740","volume":"182","author":"S Ostrand-Rosenberg","year":"2009","unstructured":"Ostrand-Rosenberg, S. & Sinha, P. Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499\u20134506 (2009).","journal-title":"J. Immunol."},{"key":"BFnm3189_CR55","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2119\/molmed.2010.00178","volume":"17","author":"AG Cuenca","year":"2011","unstructured":"Cuenca, A.G. et al. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol. Med. 17, 281\u2013292 (2011).","journal-title":"Mol. Med."},{"key":"BFnm3189_CR56","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri2294","volume":"8","author":"CN Serhan","year":"2008","unstructured":"Serhan, C.N., Chiang, N. & Van Dyke, T.E. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349\u2013361 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3189_CR57","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature10209","volume":"474","author":"B Khor","year":"2011","unstructured":"Khor, B., Gardet, A. & Xavier, R.J. Genetics and pathogenesis of inflammatory bowel disease. Nature 474, 307\u2013317 (2011).","journal-title":"Nature"},{"key":"BFnm3189_CR58","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1371\/journal.pgen.0030058","volume":"3","author":"C Libioulle","year":"2007","unstructured":"Libioulle, C. et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet. 3, e58 (2007).","journal-title":"PLoS Genet."},{"key":"BFnm3189_CR59","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1128\/IAI.64.6.2010-2018.1996","volume":"64","author":"E Grunvald","year":"1996","unstructured":"Grunvald, E. et al. Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii. Infect. Immun. 64, 2010\u20132018 (1996).","journal-title":"Infect. Immun."},{"key":"BFnm3189_CR60","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1126\/science.1636093","volume":"257","author":"RI Tepper","year":"1992","unstructured":"Tepper, R.I., Coffman, R.L. & Leder, P. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science 257, 548\u2013551 (1992).","journal-title":"Science"},{"key":"BFnm3189_CR61","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1128\/IAI.69.3.1847-1855.2001","volume":"69","author":"VP Mohan","year":"2001","unstructured":"Mohan, V.P. et al. Effects of tumor necrosis factor \u03b1 on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect. Immun. 69, 1847\u20131855 (2001).","journal-title":"Infect. Immun."},{"key":"BFnm3189_CR62","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","volume":"118","author":"S Rakoff-Nahoum","year":"2004","unstructured":"Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229\u2013241 (2004).","journal-title":"Cell"},{"key":"BFnm3189_CR63","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0091-679X(08)61845-2","volume":"45","author":"DS Roos","year":"1994","unstructured":"Roos, D.S., Donald, R.G., Morrissette, N.S. & Moulton, A.L. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii. Methods Cell Biol. 45, 27\u201363 (1994).","journal-title":"Methods Cell Biol."},{"key":"BFnm3189_CR64","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0014-4894(76)90040-0","volume":"39","author":"ER Pfefferkorn","year":"1976","unstructured":"Pfefferkorn, E.R. & Pfefferkorn, L.C. Toxoplasma gondii: isolation and preliminary characterization of temperature-sensitive mutants. Exp. Parasitol. 39, 365\u2013376 (1976).","journal-title":"Exp. Parasitol."},{"key":"BFnm3189_CR65","doi-asserted-by":"publisher","first-page":"8743","DOI":"10.1073\/pnas.1019574108","volume":"108","author":"AS Ismail","year":"2011","unstructured":"Ismail, A.S. et al. \u03b3\u03b4 intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc. Natl. Acad. Sci. USA 108, 8743\u20138748 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.3189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3189","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T19:06:09Z","timestamp":1688238369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.3189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,26]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["BFnm3189"],"URL":"https:\/\/doi.org\/10.1038\/nm.3189","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718017214.793477956","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,26]]}}}