{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:43:43Z","timestamp":1790361823888,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1038\/nm.3580","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T17:13:20Z","timestamp":1401642800000},"page":"715-724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action"],"prefix":"10.1038","volume":"20","author":[{"given":"Mounia","family":"Tannour-Louet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Louet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Addai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sau Wai","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores J","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"BFnm3580_CR1","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/0140-6736(93)90953-E","volume":"341","author":"RM Sharpe","year":"1993","unstructured":"Sharpe, R.M. & Skakkebaek, N.E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392\u20131395 (1993).","journal-title":"Lancet"},{"key":"BFnm3580_CR2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrg1903","volume":"7","author":"D Wilhelm","year":"2006","unstructured":"Wilhelm, D. & Koopman, P. The makings of maleness: towards an integrated view of male sexual development. Nat. Rev. Genet. 7, 620\u2013631 (2006).","journal-title":"Nat. Rev. Genet."},{"key":"BFnm3580_CR3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.reprotox.2004.12.015","volume":"20","author":"AC Vidaeff","year":"2005","unstructured":"Vidaeff, A.C. & Sever, L.E. In utero exposure to environmental estrogens and male reproductive health: a systematic review of biological and epidemiologic evidence. Reprod. Toxicol. 20, 5\u201320 (2005).","journal-title":"Reprod. Toxicol."},{"key":"BFnm3580_CR4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.reprotox.2005.05.006","volume":"21","author":"L Storgaard","year":"2006","unstructured":"Storgaard, L., Bonde, J.P. & Olsen, J. Male reproductive disorders in humans and prenatal indicators of estrogen exposure. A review of published epidemiological studies. Reprod. Toxicol. 21, 4\u201315 (2006).","journal-title":"Reprod. Toxicol."},{"key":"BFnm3580_CR5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1126\/science.242076","volume":"190","author":"JA McLachlan","year":"1975","unstructured":"McLachlan, J.A., Newbold, R.R. & Bullock, B. Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science 190, 991\u2013992 (1975).","journal-title":"Science"},{"key":"BFnm3580_CR6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1530\/REP-06-0326","volume":"133","author":"HO Goyal","year":"2007","unstructured":"Goyal, H.O. et al. Estrogen receptor \u03b1 mediates estrogen-inducible abnormalities in the developing penis. Reproduction 133, 1057\u20131067 (2007).","journal-title":"Reproduction"},{"key":"BFnm3580_CR7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1095\/biolreprod.108.071951","volume":"81","author":"HO Goyal","year":"2009","unstructured":"Goyal, H.O., Braden, T.D., Williams, C.S. & Williams, J.W. Estrogen-induced developmental disorders of the rat penis involve both estrogen receptor (ESR)- and androgen receptor (AR)-mediated pathways. Biol. Reprod. 81, 507\u2013516 (2009).","journal-title":"Biol. Reprod."},{"key":"BFnm3580_CR8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2605.2011.01232.x","volume":"35","author":"L Simon","year":"2012","unstructured":"Simon, L. et al. Exposure of neonatal rats to anti-androgens induces penile mal-developments and infertility comparable to those induced by oestrogens. Int. J. Androl. 35, 364\u2013376 (2012).","journal-title":"Int. J. Androl."},{"key":"BFnm3580_CR9","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/endo.142.6.8211","volume":"142","author":"X Li","year":"2001","unstructured":"Li, X. et al. Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase. Endocrinology 142, 2435\u20132442 (2001).","journal-title":"Endocrinology"},{"key":"BFnm3580_CR10","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1091\/mbc.e07-03-0193","volume":"18","author":"TH Kloepper","year":"2007","unstructured":"Kloepper, T.H., Kienle, C.N. & Fasshauer, D. An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system. Mol. Biol. Cell 18, 3463\u20133471 (2007).","journal-title":"Mol. Biol. Cell"},{"key":"BFnm3580_CR11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cell.2008.07.023","volume":"134","author":"PR Pryor","year":"2008","unstructured":"Pryor, P.R. et al. Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb. Cell 134, 817\u2013827 (2008).","journal-title":"Cell"},{"key":"BFnm3580_CR12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/sj.embor.7400150","volume":"5","author":"PR Pryor","year":"2004","unstructured":"Pryor, P.R. et al. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO Rep. 5, 590\u2013595 (2004).","journal-title":"EMBO Rep."},{"key":"BFnm3580_CR13","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.146.4.765","volume":"146","author":"RJ Advani","year":"1999","unstructured":"Advani, R.J. et al. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J. Cell Biol. 146, 765\u2013776 (1999).","journal-title":"J. Cell Biol."},{"key":"BFnm3580_CR14","doi-asserted-by":"crossref","first-page":"20471","DOI":"10.1074\/jbc.M400798200","volume":"279","author":"SK Rao","year":"2004","unstructured":"Rao, S.K., Huynh, C., Proux-Gillardeaux, V., Galli, T. & Andrews, N.W. Identification of SNAREs involved in synaptotagmin VII\u2013regulated lysosomal exocytosis. J. Biol. Chem. 279, 20471\u201320479 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFnm3580_CR15","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.bbamcr.2009.09.011","volume":"1793","author":"CM Fader","year":"2009","unstructured":"Fader, C.M., Sanchez, D.G., Mestre, M.B. & Colombo, M.I. TI-VAMP\/VAMP7 and VAMP3\/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy\/multivesicular body pathways. Biochim. Biophys. Acta 1793, 1901\u20131916 (2009).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnm3580_CR16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2011.06.023","volume":"146","author":"K Moreau","year":"2011","unstructured":"Moreau, K., Ravikumar, B., Renna, M., Puri, C. & Rubinsztein, D.C. Autophagosome precursor maturation requires homotypic fusion. Cell 146, 303\u2013317 (2011).","journal-title":"Cell"},{"key":"BFnm3580_CR17","doi-asserted-by":"crossref","first-page":"e15392","DOI":"10.1371\/journal.pone.0015392","volume":"5","author":"M Tannour-Louet","year":"2010","unstructured":"Tannour-Louet, M. et al. Identification of de novo copy number variants associated with human disorders of sexual development. PLoS ONE 5, e15392 (2010).","journal-title":"PLoS ONE"},{"key":"BFnm3580_CR18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2605.1996.tb00474.x","volume":"19","author":"T Shono","year":"1996","unstructured":"Shono, T. et al. Scanning electron microscopy shows inhibited gubernacular development in relation to undescended testes in oestrogen-treated mice. Int. J. Androl. 19, 263\u2013270 (1996).","journal-title":"Int. J. Androl."},{"key":"BFnm3580_CR19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/dbio.2000.9785","volume":"224","author":"S Nef","year":"2000","unstructured":"Nef, S., Shipman, T. & Parada, L.F. A molecular basis for estrogen-induced cryptorchidism. Dev. Biol. 224, 354\u2013361 (2000).","journal-title":"Dev. Biol."},{"key":"BFnm3580_CR20","first-page":"325","volume":"6","author":"XW Jiang","year":"2004","unstructured":"Jiang, X.W., Li, J.H., Huang, T.H. & Deng, W.D. Effect of prenatal exposure to diethylstilbestrol on gubernacular development in fetal male mice. Asian J. Androl. 6, 325\u2013329 (2004).","journal-title":"Asian J. Androl."},{"key":"BFnm3580_CR21","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1210\/en.2007-0689","volume":"148","author":"CR Cederroth","year":"2007","unstructured":"Cederroth, C.R. et al. Estrogen receptor \u03b1 is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. Endocrinology 148, 5507\u20135519 (2007).","journal-title":"Endocrinology"},{"key":"BFnm3580_CR22","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.devcel.2012.01.018","volume":"22","author":"HM Kent","year":"2012","unstructured":"Kent, H.M. et al. Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. Dev. Cell 22, 979\u2013988 (2012).","journal-title":"Dev. Cell"},{"key":"BFnm3580_CR23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1210\/en.2005-1001","volume":"147","author":"JA Magee","year":"2006","unstructured":"Magee, J.A., Chang, L.W., Stormo, G.D. & Milbrandt, J. Direct, androgen receptor\u2013mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology 147, 590\u2013598 (2006).","journal-title":"Endocrinology"},{"key":"BFnm3580_CR24","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1093\/nar\/gkp352","volume":"37","author":"H Makkonen","year":"2009","unstructured":"Makkonen, H., Kauhanen, M., Paakinaho, V., Jaaskelainen, T. & Palvimo, J.J. Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers. Nucleic Acids Res. 37, 4135\u20134148 (2009).","journal-title":"Nucleic Acids Res."},{"key":"BFnm3580_CR25","doi-asserted-by":"crossref","first-page":"27776","DOI":"10.1074\/jbc.M110.156091","volume":"285","author":"H Chen","year":"2010","unstructured":"Chen, H. et al. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J. Biol. Chem. 285, 27776\u201327784 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnm3580_CR26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1741-4520.2008.00180.x","volume":"48","author":"H Nishida","year":"2008","unstructured":"Nishida, H. et al. Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes. Congenit. Anom. (Kyoto) 48, 63\u201367 (2008).","journal-title":"Congenit. Anom. (Kyoto)"},{"key":"BFnm3580_CR27","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1210\/en.2011-0263","volume":"152","author":"S Miyagawa","year":"2011","unstructured":"Miyagawa, S. et al. The role of sonic hedgehog\u2013Gli2 pathway in the masculinization of external genitalia. Endocrinology 152, 2894\u20132903 (2011).","journal-title":"Endocrinology"},{"key":"BFnm3580_CR28","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1210\/en.2002-220531","volume":"143","author":"A Rivas","year":"2002","unstructured":"Rivas, A., Fisher, J.S., McKinnell, C., Atanassova, N. & Sharpe, R.M. Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: evidence for importance of the androgen-estrogen balance. Endocrinology 143, 4797\u20134808 (2002).","journal-title":"Endocrinology"},{"key":"BFnm3580_CR29","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.juro.2007.01.014","volume":"177","author":"Z Wang","year":"2007","unstructured":"Wang, Z. et al. Up-regulation of estrogen responsive genes in hypospadias: microarray analysis. J. Urol. 177, 1939\u20131946 (2007).","journal-title":"J. Urol."},{"key":"BFnm3580_CR30","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2350\/06-04-0079.1","volume":"10","author":"B Liu","year":"2007","unstructured":"Liu, B. et al. Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias. Pediatr. Dev. Pathol. 10, 446\u2013454 (2007).","journal-title":"Pediatr. Dev. Pathol."},{"key":"BFnm3580_CR31","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1203\/01.pdr.0000187796.28007.2d","volume":"58","author":"B Liu","year":"2005","unstructured":"Liu, B. et al. Activating transcription factor 3 is up-regulated in patients with hypospadias. Pediatr. Res. 58, 1280\u20131283 (2005).","journal-title":"Pediatr. Res."},{"key":"BFnm3580_CR32","first-page":"217","volume":"65","author":"B Liu","year":"2006","unstructured":"Liu, B., Agras, K., Willingham, E., Vilela, M.L. & Baskin, L.S. Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiation. Horm. Res. 65, 217\u2013222 (2006).","journal-title":"Horm. Res."},{"key":"BFnm3580_CR33","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4111\/kju.2010.51.8.561","volume":"51","author":"C Gurbuz","year":"2010","unstructured":"Gurbuz, C. et al. Is activating transcription factor 3 up-regulated in patients with hypospadias? Korean J. Urol. 51, 561\u2013564 (2010).","journal-title":"Korean J. Urol."},{"key":"BFnm3580_CR34","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.juro.2008.07.066","volume":"180","author":"N Kalfa","year":"2008","unstructured":"Kalfa, N. et al. Genomic variants of ATF3 in patients with hypospadias. J. Urol. 180, 2183\u20132188, discussion 2188 (2008).","journal-title":"J. Urol."},{"key":"BFnm3580_CR35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1530\/EJE-07-0793","volume":"158","author":"A Beleza-Meireles","year":"2008","unstructured":"Beleza-Meireles, A. et al. Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. Eur. J. Endocrinol. 158, 729\u2013739 (2008).","journal-title":"Eur. J. Endocrinol."},{"key":"BFnm3580_CR36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0303-7207(99)00139-2","volume":"156","author":"S Thenot","year":"1999","unstructured":"Thenot, S., Charpin, M., Bonnet, S. & Cavailles, V. Estrogen receptor cofactors expression in breast and endometrial human cancer cells. Mol. Cell. Endocrinol. 156, 85\u201393 (1999).","journal-title":"Mol. Cell. Endocrinol."},{"key":"BFnm3580_CR37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jsbmb.2005.04.020","volume":"95","author":"S Lambard","year":"2005","unstructured":"Lambard, S. et al. Aromatase in testis: expression and role in male reproduction. J. Steroid Biochem. Mol. Biol. 95, 63\u201369 (2005).","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"BFnm3580_CR38","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1210\/endo.138.11.5512","volume":"138","author":"WC Song","year":"1997","unstructured":"Song, W.C., Qian, Y., Sun, X. & Negishi, M. Cellular localization and regulation of expression of testicular estrogen sulfotransferase. Endocrinology 138, 5006\u20135012 (1997).","journal-title":"Endocrinology"},{"key":"BFnm3580_CR39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/ar.1091360402","volume":"136","author":"S Hazary","year":"1960","unstructured":"Hazary, S. & Gardner, W.U. Influence of sex hormones on abdominal musculature and the formation of inguinal and scrotal hernias in mice. Anat. Rec. 136, 437\u2013443 (1960).","journal-title":"Anat. Rec."},{"key":"BFnm3580_CR40","doi-asserted-by":"crossref","first-page":"e33529","DOI":"10.1371\/journal.pone.0033529","volume":"7","author":"RB Reinert","year":"2012","unstructured":"Reinert, R.B. et al. Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice. PLoS ONE 7, e33529 (2012).","journal-title":"PLoS ONE"},{"key":"BFnm3580_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygcen.2008.07.025","volume":"159","author":"X Li","year":"2008","unstructured":"Li, X. & Rahman, N. Impact of androgen\/estrogen ratio: lessons learned from the aromatase over-expression mice. Gen. Comp. Endocrinol. 159, 1\u20139 (2008).","journal-title":"Gen. Comp. Endocrinol."},{"key":"BFnm3580_CR42","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1128\/MCB.00159-12","volume":"32","author":"H Wang","year":"2012","unstructured":"Wang, H. et al. The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol. Cell. Biol. 32, 3190\u20133202 (2012).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm3580_CR43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-genet-102209-163544","volume":"45","author":"S Girirajan","year":"2011","unstructured":"Girirajan, S., Campbell, C.D. & Eichler, E.E. Human copy number variation and complex genetic disease. Annu. Rev. Genet. 45, 203\u2013226 (2011).","journal-title":"Annu. Rev. Genet."},{"key":"BFnm3580_CR44","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1001\/jama.2008.668","volume":"300","author":"A Ferlin","year":"2008","unstructured":"Ferlin, A. et al. Genetic alterations associated with cryptorchidism. J. Am. Med. Assoc. 300, 2271\u20132276 (2008).","journal-title":"J. Am. Med. Assoc."},{"key":"BFnm3580_CR45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000249147","volume":"3","author":"F Hadziselimovic","year":"2009","unstructured":"Hadziselimovic, F. et al. EGR4 is a master gene responsible for fertility in cryptorchidism. Sex Dev. 3, 253\u2013263 (2009).","journal-title":"Sex Dev."},{"key":"BFnm3580_CR46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000323955","volume":"5","author":"F Hadziselimovic","year":"2011","unstructured":"Hadziselimovic, F., Hadziselimovic, N.O., Demougin, P. & Oakeley, E.J. Testicular gene expression in cryptorchid boys at risk of azoospermia. Sex Dev. 5, 49\u201359 (2011).","journal-title":"Sex Dev."},{"key":"BFnm3580_CR47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1083\/jcb.200503106","volume":"170","author":"IG Mills","year":"2005","unstructured":"Mills, I.G. et al. Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J. Cell Biol. 170, 191\u2013200 (2005).","journal-title":"J. Cell Biol."},{"key":"BFnm3580_CR48","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/ijc.21469","volume":"118","author":"MR Ray","year":"2006","unstructured":"Ray, M.R. et al. Cyclin G\u2013associated kinase: a novel androgen receptor\u2013interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer. Int. J. Cancer 118, 1108\u20131119 (2006).","journal-title":"Int. J. Cancer"},{"key":"BFnm3580_CR49","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1074\/mcp.M600169-MCP200","volume":"6","author":"R Jasavala","year":"2007","unstructured":"Jasavala, R. et al. Identification of putative androgen receptor interaction protein modules: cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells. Mol. Cell. Proteomics 6, 252\u2013271 (2007).","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnm3580_CR50","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2005.09.011","volume":"123","author":"J Kang","year":"2005","unstructured":"Kang, J. et al. A nuclear function of \u03b2-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123, 833\u2013847 (2005).","journal-title":"Cell"},{"key":"BFnm3580_CR51","doi-asserted-by":"crossref","first-page":"16820","DOI":"10.1074\/jbc.M213163200","volume":"278","author":"L Yang","year":"2003","unstructured":"Yang, L. et al. APPL suppresses androgen receptor transactivation via potentiating Akt activity. J. Biol. Chem. 278, 16820\u201316827 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm3580_CR52","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1101\/gad.1381906","volume":"20","author":"M Enari","year":"2006","unstructured":"Enari, M., Ohmori, K., Kitabayashi, I. & Taya, Y. Requirement of clathrin heavy chain for p53-mediated transcription. Genes Dev. 20, 1087\u20131099 (2006).","journal-title":"Genes Dev."},{"key":"BFnm3580_CR53","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.molcel.2005.11.030","volume":"21","author":"X Wei","year":"2006","unstructured":"Wei, X., Xu, H. & Kufe, D. MUC1 oncoprotein stabilizes and activates estrogen receptor \u03b1. Mol. Cell 21, 295\u2013305 (2006).","journal-title":"Mol. Cell"},{"key":"BFnm3580_CR54","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S1097-2765(03)00090-X","volume":"11","author":"G Reid","year":"2003","unstructured":"Reid, G. et al. Cyclic, proteasome-mediated turnover of unliganded and liganded ER\u03b1 on responsive promoters is an integral feature of estrogen signaling. Mol. Cell 11, 695\u2013707 (2003).","journal-title":"Mol. Cell"},{"key":"BFnm3580_CR55","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1097-2765(00)80259-2","volume":"5","author":"DM Lonard","year":"2000","unstructured":"Lonard, D.M., Nawaz, Z., Smith, C.L. & O'Malley, B.W. The 26S proteasome is required for estrogen receptor-\u03b1 and coactivator turnover and for efficient estrogen receptor-\u03b1 transactivation. Mol. Cell 5, 939\u2013948 (2000).","journal-title":"Mol. Cell"},{"key":"BFnm3580_CR56","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.96.5.1858","volume":"96","author":"Z Nawaz","year":"1999","unstructured":"Nawaz, Z., Lonard, D.M., Dennis, A.P., Smith, C.L. & O'Malley, B.W. Proteasome-dependent degradation of the human estrogen receptor. Proc. Natl. Acad. Sci. USA 96, 1858\u20131862 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3580_CR57","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.febslet.2009.12.047","volume":"584","author":"VI Korolchuk","year":"2010","unstructured":"Korolchuk, V.I., Menzies, F.M. & Rubinsztein, D.C. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett. 584, 1393\u20131398 (2010).","journal-title":"FEBS Lett."},{"key":"BFnm3580_CR58","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.molcel.2009.01.021","volume":"33","author":"VI Korolchuk","year":"2009","unstructured":"Korolchuk, V.I., Mansilla, A., Menzies, F.M. & Rubinsztein, D.C. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol. Cell 33, 517\u2013527 (2009).","journal-title":"Mol. Cell"},{"key":"BFnm3580_CR59","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1002\/ajmg.a.32398","volume":"146A","author":"Z Ou","year":"2008","unstructured":"Ou, Z. et al. Branchiootorenal syndrome and oculoauriculovertebral spectrum features associated with duplication of SIX1, SIX6, and OTX2 resulting from a complex chromosomal rearrangement. Am. J. Med. Genet. A 146A, 2480\u20132489 (2008).","journal-title":"Am. J. Med. Genet. A"},{"key":"BFnm3580_CR60","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/GIM.0b013e31816b4420","volume":"10","author":"Z Ou","year":"2008","unstructured":"Ou, Z. et al. Bacterial artificial chromosome-emulation oligonucleotide arrays for targeted clinical array-comparative genomic hybridization analyses. Genet. Med. 10, 278\u2013289 (2008).","journal-title":"Genet. Med."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.3580.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3580","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3580.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:46:06Z","timestamp":1684435566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.3580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["BFnm3580"],"URL":"https:\/\/doi.org\/10.1038\/nm.3580","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718426568.793495909","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,1]]},"assertion":[{"value":"2 February 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}