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AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem. J. 338, 783\u2013791 (1999).","journal-title":"Biochem. J."},{"key":"BFnm3699_CR64","doi-asserted-by":"crossref","first-page":"19860","DOI":"10.1073\/pnas.0906048106","volume":"106","author":"Y Zhang","year":"2009","unstructured":"Zhang, Y. et al. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc. Natl. Acad. Sci. USA 106, 19860\u201319865 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3699_CR65","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-1-4614-7411-1_43","volume":"789","author":"A Prince","year":"2013","unstructured":"Prince, A., Zhang, Y., Croniger, C. & Puchowicz, M. Oxidative metabolism: glucose versus ketones. Adv. Exp. Med. Biol. 789, 323\u2013328 (2013).","journal-title":"Adv. Exp. 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