{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:49:45Z","timestamp":1791161385129,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T00:00:00Z","timestamp":1410048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T00:00:00Z","timestamp":1410048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/nm.3702","type":"journal-article","created":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T15:28:43Z","timestamp":1410103723000},"page":"1126-1129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":315,"title":["Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge"],"prefix":"10.1038","volume":"20","author":[{"given":"Daphne A","family":"Stanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N","family":"Honko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Asiedu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Trefry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie W","family":"Lau-Kilby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hensley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Ammendola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Grazioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E","family":"Foulds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitzi M","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Colloca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Folgori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-7040","authenticated-orcid":false,"given":"Mario","family":"Roederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J","family":"Nabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mascola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Nicosia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Koup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,7]]},"reference":[{"key":"BFnm3702_CR1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/35046108","volume":"408","author":"NJ Sullivan","year":"2000","unstructured":"Sullivan, N.J., Sanchez, A., Rollin, P.E., Yang, Z.Y. & Nabel, G.J. Nature 408, 605\u2013609 (2000).","journal-title":"Nature"},{"key":"BFnm3702_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/415331a","volume":"415","author":"JW Shiver","year":"2002","unstructured":"Shiver, J.W. et al. Nature 415, 331\u2013335 (2002).","journal-title":"Nature"},{"key":"BFnm3702_CR3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3390\/v2020435","volume":"2","author":"SA Brown","year":"2010","unstructured":"Brown, S.A. et al. Viruses 2, 435\u2013467 (2010).","journal-title":"Viruses"},{"key":"BFnm3702_CR4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.vaccine.2010.10.037","volume":"29","author":"JE Ledgerwood","year":"2010","unstructured":"Ledgerwood, J.E. et al. Vaccine 29, 304\u2013313 (2010).","journal-title":"Vaccine"},{"key":"BFnm3702_CR5","doi-asserted-by":"publisher","first-page":"115ra1","DOI":"10.1126\/scitranslmed.3003155","volume":"4","author":"E Barnes","year":"2012","unstructured":"Barnes, E. et al. Sci. Transl. Med. 4, 115ra1 (2012).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3702_CR6","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.4049\/jimmunol.1202861","volume":"190","author":"KM Quinn","year":"2013","unstructured":"Quinn, K.M. et al. J. Immunol. 190, 2720\u20132735 (2013).","journal-title":"J. Immunol."},{"key":"BFnm3702_CR7","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1038\/nm.2447","volume":"17","author":"NJ Sullivan","year":"2011","unstructured":"Sullivan, N.J. et al. Nat. Med. 17, 1128\u20131131 (2011).","journal-title":"Nat. Med."},{"key":"BFnm3702_CR8","doi-asserted-by":"publisher","first-page":"4222","DOI":"10.1128\/JVI.02407-10","volume":"85","author":"TW Geisbert","year":"2011","unstructured":"Geisbert, T.W. et al. J. Virol. 85, 4222\u20134233 (2011).","journal-title":"J. Virol."},{"key":"BFnm3702_CR9","doi-asserted-by":"publisher","first-page":"6290","DOI":"10.4049\/jimmunol.172.10.6290","volume":"172","author":"DH Barouch","year":"2004","unstructured":"Barouch, D.H. et al. J. Immunol. 172, 6290\u20136297 (2004).","journal-title":"J. Immunol."},{"key":"BFnm3702_CR10","doi-asserted-by":"publisher","first-page":"115ra2","DOI":"10.1126\/scitranslmed.3002925","volume":"4","author":"S Colloca","year":"2012","unstructured":"Colloca, S. et al. Sci. Transl. Med. 4, 115ra2 (2012).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3702_CR11","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.virol.2005.10.042","volume":"346","author":"GP Kobinger","year":"2006","unstructured":"Kobinger, G.P. et al. Virology 346, 394\u2013401 (2006).","journal-title":"Virology"},{"key":"BFnm3702_CR12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1128\/IAI.00740-09","volume":"78","author":"A Reyes-Sandoval","year":"2010","unstructured":"Reyes-Sandoval, A. et al. Infect. Immun. 78, 145\u2013153 (2010).","journal-title":"Infect. Immun."},{"key":"BFnm3702_CR13","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/infdis\/jir850","volume":"205","author":"GA O'Hara","year":"2012","unstructured":"O'Hara, G.A. et al. J. Infect. Dis. 205, 772\u2013781 (2012).","journal-title":"J. Infect. Dis."},{"key":"BFnm3702_CR14","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1038\/mt.2012.223","volume":"20","author":"SH Sheehy","year":"2012","unstructured":"Sheehy, S.H. et al. Mol. Ther. 20, 2355\u20132368 (2012).","journal-title":"Mol. Ther."},{"key":"BFnm3702_CR15","doi-asserted-by":"publisher","first-page":"e94355","DOI":"10.1371\/journal.pone.0094355","volume":"9","author":"CE Mire","year":"2014","unstructured":"Mire, C.E. et al. PLoS ONE 9, e94355 (2014).","journal-title":"PLoS ONE"},{"key":"BFnm3702_CR16","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1371\/journal.pmed.0030177","volume":"3","author":"NJ Sullivan","year":"2006","unstructured":"Sullivan, N.J. et al. PLoS Med. 3, e177 (2006).","journal-title":"PLoS Med."},{"key":"BFnm3702_CR17","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nrmicro2129","volume":"7","author":"NJ Sullivan","year":"2009","unstructured":"Sullivan, N.J., Martin, J.E., Graham, B.S. & Nabel, G.J. Nat. Rev. Microbiol. 7, 393\u2013400 (2009).","journal-title":"Nat. Rev. Microbiol."},{"key":"BFnm3702_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nri2274","volume":"8","author":"RA Seder","year":"2008","unstructured":"Seder, R.A., Darrah, P.A. & Roederer, M. Nat. Rev. Immunol. 8, 247\u2013258 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3702_CR19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1182\/blood-2003-12-4341","volume":"104","author":"M Lichterfeld","year":"2004","unstructured":"Lichterfeld, M. et al. Blood 104, 487\u2013494 (2004).","journal-title":"Blood"},{"key":"BFnm3702_CR20","doi-asserted-by":"publisher","first-page":"e1000904","DOI":"10.1371\/journal.ppat.1000904","volume":"6","author":"LE Hensley","year":"2010","unstructured":"Hensley, L.E. et al. PLoS Pathog. 6, e1000904 (2010).","journal-title":"PLoS Pathog."},{"key":"BFnm3702_CR21","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nm1592","volume":"13","author":"PA Darrah","year":"2007","unstructured":"Darrah, P.A. et al. Nat. Med. 13, 843\u2013850 (2007).","journal-title":"Nat. Med."},{"key":"BFnm3702_CR22","doi-asserted-by":"publisher","first-page":"10386","DOI":"10.1128\/JVI.00594-10","volume":"84","author":"TW Geisbert","year":"2010","unstructured":"Geisbert, T.W. et al. J. Virol. 84, 10386\u201310394 (2010).","journal-title":"J. Virol."},{"key":"BFnm3702_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jviromet.2009.09.016","volume":"163","author":"G Di Lullo","year":"2010","unstructured":"Di Lullo, G. et al. J. Virol. Methods 163, 195\u2013204 (2010).","journal-title":"J. Virol. Methods"},{"key":"BFnm3702_CR24","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1128\/jvi.70.7.4805-4810.1996","volume":"70","author":"C Chartier","year":"1996","unstructured":"Chartier, C. et al. J. Virol. 70, 4805\u20134810 (1996).","journal-title":"J. Virol."},{"key":"BFnm3702_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/cyto.a.21015","volume":"79","author":"M Roederer","year":"2011","unstructured":"Roederer, M., Nozzi, J.L. & Nason, M.C. Cytometry A. 79, 167\u2013174 (2011).","journal-title":"Cytometry A."},{"key":"BFnm3702_CR26","doi-asserted-by":"publisher","first-page":"e2171","DOI":"10.1371\/journal.pntd.0002171","volume":"7","author":"S Malhotra","year":"2013","unstructured":"Malhotra, S. et al. PLoS Negl. Trop. Dis. 7, e2171 (2013).","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nm.3702.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.3702","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.3702.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T03:36:46Z","timestamp":1744342606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.3702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,7]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["BFnm3702"],"URL":"https:\/\/doi.org\/10.1038\/nm.3702","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,7]]},"assertion":[{"value":"18 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"N.J.S., G.J.N., S.C., A.F., A.N. and R.C. claim intellectual property on gene-based vaccines for ebolavirus. S. C. and A.N. are named inventors in patents issued in the US Patent and Trademark Office and European, Australian, Chinese, Indian,and Japanese Patent Offices, and pending in the Canadian and Hong Kong Patent Offices, on chimpanzee adenovirus 3 (ChAd3). S. C., A.N, V.A. and R.C. are named inventors in a patent application with patents pending with the US Patent and Trademark Office and European Patent Office on filovirus vaccine.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}