{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:41:55Z","timestamp":1791330115787,"version":"4.3.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1038\/nm.3842","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T16:45:07Z","timestamp":1429548307000},"page":"467-475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Homeostatic regulation of T cell trafficking by a B cell\u2013derived peptide is impaired in autoimmune and chronic inflammatory disease"],"prefix":"10.1038","volume":"21","author":[{"given":"Myriam","family":"Chimen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M","family":"McGettrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita","family":"Apta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahithi J","family":"Kuravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara M","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Odedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alassiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Nayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Hitchcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam F","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Copland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy S K","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard B","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Narendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Ed","family":"Rainger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"BFnm3842_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1034\/j.1600-065X.2003.00075.x","volume":"195","author":"JG Cyster","year":"2003","unstructured":"Cyster, J.G. Lymphoid organ development and cell migration. Immunol. Rev. 195, 5\u201314 (2003).","journal-title":"Immunol. Rev."},{"key":"BFnm3842_CR2","doi-asserted-by":"publisher","first-page":"13074","DOI":"10.1073\/pnas.0705863104","volume":"104","author":"M Koulmanda","year":"2007","unstructured":"Koulmanda, M. et al. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc. Natl. Acad. Sci. USA 104, 13074\u201313079 (2007).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3842_CR3","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1097\/00007890-199010000-00001","volume":"50","author":"JS Pober","year":"1990","unstructured":"Pober, J.S. & Cotran, R.S. The role of endothelial cells in inflammation. Transplantation 50, 537\u2013544 (1990).","journal-title":"Transplantation"},{"key":"BFnm3842_CR4","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1172\/JCI29126","volume":"116","author":"T Kadowaki","year":"2006","unstructured":"Kadowaki, T. et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 116, 1784\u20131792 (2006).","journal-title":"J. Clin. Invest."},{"key":"BFnm3842_CR5","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1172\/JCI29623","volume":"117","author":"R Ouedraogo","year":"2007","unstructured":"Ouedraogo, R. et al. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J. Clin. Invest. 117, 1718\u20131726 (2007).","journal-title":"J. Clin. Invest."},{"key":"BFnm3842_CR6","doi-asserted-by":"publisher","first-page":"E418","DOI":"10.1210\/jc.2012-3516","volume":"98","author":"TT Pang","year":"2013","unstructured":"Pang, T.T. et al. Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes. J. Clin. Endocrinol. Metab. 98, E418\u2013E428 (2013).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnm3842_CR7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1196\/annals.1447.021","volume":"1150","author":"TT Pang","year":"2008","unstructured":"Pang, T.T. & Narendran, P. The distribution of adiponectin receptors on human peripheral blood mononuclear cells. Ann. NY Acad. Sci. 1150, 143\u2013145 (2008).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnm3842_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1046\/j.1440-1711.2002.01062.x","volume":"80","author":"PF Lalor","year":"2002","unstructured":"Lalor, P.F., Shields, P., Grant, A. & Adams, D.H. Recruitment of lymphocytes to the human liver. Immunol. Cell Biol. 80, 52\u201364 (2002).","journal-title":"Immunol. Cell Biol."},{"key":"BFnm3842_CR9","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.biocel.2006.02.004","volume":"38","author":"R Olsson","year":"2006","unstructured":"Olsson, R. & Carlsson, P.O. The pancreatic islet endothelial cell: emerging roles in islet function and disease. Int. J. Biochem. Cell Biol. 38, 710\u2013714 (2006).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"BFnm3842_CR10","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1959::AID-IMMU1959>3.0.CO;2-4","volume":"28","author":"DP Andrew","year":"1998","unstructured":"Andrew, D.P. et al. Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice. Eur. J. Immunol. 28, 1959\u20131969 (1998).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3842_CR11","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.4049\/jimmunol.154.7.3062","volume":"154","author":"RI Brezinschek","year":"1995","unstructured":"Brezinschek, R.I., Lipsky, P.E., Galea, P., Vita, R. & Oppenheimer-Marks, N. Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity. J. Immunol. 154, 3062\u20133077 (1995).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR12","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/88710","volume":"2","author":"G Cinamon","year":"2001","unstructured":"Cinamon, G., Shinder, V. & Alon, R. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines. Nat. Immunol. 2, 515\u2013522 (2001).","journal-title":"Nat. Immunol."},{"key":"BFnm3842_CR13","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nri2156","volume":"7","author":"K Ley","year":"2007","unstructured":"Ley, K., Laudanna, C., Cybulsky, M.I. & Nourshargh, S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 7, 678\u2013689 (2007).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3842_CR14","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.4049\/jimmunol.1201739","volume":"189","author":"L Ma","year":"2012","unstructured":"Ma, L. et al. CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo. J. Immunol. 189, 4104\u20134111 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR15","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.immuni.2008.12.020","volume":"30","author":"Z Shulman","year":"2009","unstructured":"Shulman, Z. et al. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity 30, 384\u2013396 (2009).","journal-title":"Immunity"},{"key":"BFnm3842_CR16","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1146\/annurev.ph.57.030195.004143","volume":"57","author":"TA Springer","year":"1995","unstructured":"Springer, T.A. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu. Rev. Physiol. 57, 827\u2013872 (1995).","journal-title":"Annu. Rev. Physiol."},{"key":"BFnm3842_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1189\/jlb.0508301","volume":"85","author":"HM McGettrick","year":"2009","unstructured":"McGettrick, H.M. et al. Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration. J. Leukoc. Biol. 85, 98\u2013107 (2009).","journal-title":"J. Leukoc. Biol."},{"key":"BFnm3842_CR18","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<961::AID-IMMU961>3.0.CO;2-4","volume":"28","author":"L Piali","year":"1998","unstructured":"Piali, L. et al. The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur. J. Immunol. 28, 961\u2013972 (1998).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3842_CR19","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nri2974","volume":"11","author":"S Spiegel","year":"2011","unstructured":"Spiegel, S. & Milstien, S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 11, 403\u2013415 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3842_CR20","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1172\/JCI117612","volume":"94","author":"DA Jones","year":"1994","unstructured":"Jones, D.A., McIntire, L.V., Smith, C.W. & Picker, L.J. A two-step adhesion cascade for T cell\/endothelial cell interactions under flow conditions. J. Clin. Invest. 94, 2443\u20132450 (1994).","journal-title":"J. Clin. Invest."},{"key":"BFnm3842_CR21","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1084\/jem.181.3.1179","volume":"181","author":"FW Luscinskas","year":"1995","unstructured":"Luscinskas, F.W., Ding, H. & Lichtman, A.H. P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor \u03b1\u2013activated vascular endothelium under flow. J. Exp. Med. 181, 1179\u20131186 (1995).","journal-title":"J. Exp. Med."},{"key":"BFnm3842_CR22","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.4049\/jimmunol.154.3.1216","volume":"154","author":"T Yago","year":"1995","unstructured":"Yago, T. et al. Analysis of an initial step of T cell adhesion to endothelial monolayers under flow conditions. J. Immunol. 154, 1216\u20131222 (1995).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR23","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.4049\/jimmunol.1100299","volume":"187","author":"SR Ahmed","year":"2011","unstructured":"Ahmed, S.R. et al. Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. J. Immunol. 187, 1432\u20131439 (2011).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR24","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1172\/JCI60746","volume":"122","author":"S Fukuhara","year":"2012","unstructured":"Fukuhara, S. et al. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J. Clin. Invest. 122, 1416\u20131426 (2012).","journal-title":"J. Clin. Invest."},{"key":"BFnm3842_CR25","doi-asserted-by":"publisher","first-page":"e38941","DOI":"10.1371\/journal.pone.0038941","volume":"7","author":"Y Hisano","year":"2012","unstructured":"Hisano, Y., Kobayashi, N., Yamaguchi, A. & Nishi, T. Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. PLoS ONE 7, e38941 (2012).","journal-title":"PLoS ONE"},{"key":"BFnm3842_CR26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.4049\/jimmunol.1200282","volume":"189","author":"A Nijnik","year":"2012","unstructured":"Nijnik, A. et al. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J. Immunol. 189, 102\u2013111 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/ni1534","volume":"9","author":"LG Ledgerwood","year":"2008","unstructured":"Ledgerwood, L.G. et al. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat. Immunol. 9, 42\u201353 (2008).","journal-title":"Nat. Immunol."},{"key":"BFnm3842_CR28","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1126\/science.1070238","volume":"296","author":"S Mandala","year":"2002","unstructured":"Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346\u2013349 (2002).","journal-title":"Science"},{"key":"BFnm3842_CR29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature02284","volume":"427","author":"M Matloubian","year":"2004","unstructured":"Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355\u2013360 (2004).","journal-title":"Nature"},{"key":"BFnm3842_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1126\/science.1139221","volume":"316","author":"R Pappu","year":"2007","unstructured":"Pappu, R. et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316, 295\u2013298 (2007).","journal-title":"Science"},{"key":"BFnm3842_CR31","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.immuni.2007.11.017","volume":"28","author":"TH Pham","year":"2008","unstructured":"Pham, T.H., Okada, T., Matloubian, M., Lo, C.G. & Cyster, J.G. S1P1 receptor signaling overrides retention mediated by G\u03b1i-coupled receptors to promote T cell egress. Immunity 28, 122\u2013133 (2008).","journal-title":"Immunity"},{"key":"BFnm3842_CR32","doi-asserted-by":"publisher","first-page":"180705","DOI":"10.1155\/2012\/180705","volume":"2012","author":"SM Hammad","year":"2012","unstructured":"Hammad, S.M., Al Gadban, M.A., Semler, A.J. & Klein, R.L. Sphingosine 1-phosphate distribution in human plasma: associations with lipid profiles. J. Lipids 2012, 180705 (2012).","journal-title":"J. Lipids"},{"key":"BFnm3842_CR33","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1042\/bj3520809","volume":"352","author":"N Murata","year":"2000","unstructured":"Murata, N. et al. Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem. J. 352, 809\u2013815 (2000).","journal-title":"Biochem. J."},{"key":"BFnm3842_CR34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/cvr\/cvp070","volume":"82","author":"K Sattler","year":"2009","unstructured":"Sattler, K. & Levkau, B. Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection. Cardiovasc. Res. 82, 201\u2013211 (2009).","journal-title":"Cardiovasc. Res."},{"key":"BFnm3842_CR35","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1093\/intimm\/5.6.647","volume":"5","author":"J Chen","year":"1993","unstructured":"Chen, J. et al. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol. 5, 647\u2013656 (1993).","journal-title":"Int. Immunol."},{"key":"BFnm3842_CR36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.micpath.2006.03.004","volume":"41","author":"C Johansson","year":"2006","unstructured":"Johansson, C. et al. Elevated neutrophil, macrophage and dendritic cell numbers characterize immune cell populations in mice chronically infected with Salmonella. Microb. Pathog. 41, 49\u201358 (2006).","journal-title":"Microb. Pathog."},{"key":"BFnm3842_CR37","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.3748\/wjg.v12.i34.5429","volume":"12","author":"PF Lalor","year":"2006","unstructured":"Lalor, P.F., Lai, W.K., Curbishley, S.M., Shetty, S. & Adams, D.H. Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo. World J. Gastroenterol. 12, 5429\u20135439 (2006).","journal-title":"World J. Gastroenterol."},{"key":"BFnm3842_CR38","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1172\/JCI119468","volume":"99","author":"J Wong","year":"1997","unstructured":"Wong, J. et al. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J. Clin. Invest. 99, 2782\u20132790 (1997).","journal-title":"J. Clin. Invest."},{"key":"BFnm3842_CR39","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.4049\/jimmunol.1201216","volume":"189","author":"M Bombardieri","year":"2012","unstructured":"Bombardieri, M. et al. Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL\/6 mice. J. Immunol. 189, 3767\u20133776 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR40","doi-asserted-by":"crossref","first-page":"re10","DOI":"10.1126\/stke.2962005re10","volume":"2005","author":"D Bridges","year":"2005","unstructured":"Bridges, D. & Moorhead, G.B. 14\u20133-3 proteins: a number of functions for a numbered protein. Sci. STKE 2005, re10 (2005).","journal-title":"Sci. STKE"},{"key":"BFnm3842_CR41","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1242\/jcs.01171","volume":"117","author":"MK Dougherty","year":"2004","unstructured":"Dougherty, M.K. & Morrison, D.K. Unlocking the code of 14\u20133-3. J. Cell Sci. 117, 1875\u20131884 (2004).","journal-title":"J. Cell Sci."},{"key":"BFnm3842_CR42","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1146\/annurev.pharmtox.40.1.617","volume":"40","author":"H Fu","year":"2000","unstructured":"Fu, H., Subramanian, R.R. & Masters, S.C. 14\u20133-3 proteins: structure, function, and regulation. Annu. Rev. Pharmacol. Toxicol. 40, 617\u2013647 (2000).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"BFnm3842_CR43","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0304-3940(96)12598-2","volume":"209","author":"R Layfield","year":"1996","unstructured":"Layfield, R. et al. Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins. Neurosci. Lett. 209, 57\u201360 (1996).","journal-title":"Neurosci. Lett."},{"key":"BFnm3842_CR44","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/sj.cr.7290292","volume":"15","author":"D Lodygin","year":"2005","unstructured":"Lodygin, D. & Hermeking, H. The role of epigenetic inactivation of 14-3-3\u03c3 in human cancer. Cell Res. 15, 237\u2013246 (2005).","journal-title":"Cell Res."},{"key":"BFnm3842_CR45","doi-asserted-by":"publisher","first-page":"5762","DOI":"10.1074\/jbc.274.9.5762","volume":"274","author":"M Garcia-Guzman","year":"1999","unstructured":"Garcia-Guzman, M., Dolfi, F., Russello, M. & Vuori, K. Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. J. Biol. Chem. 274, 5762\u20135768 (1999).","journal-title":"J. Biol. Chem."},{"key":"BFnm3842_CR46","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/sj.onc.1204068","volume":"20","author":"DC Han","year":"2001","unstructured":"Han, D.C., Rodriguez, L.G. & Guan, J.L. Identification of a novel interaction between integrin beta1 and 14-3-3\u03b2. Oncogene 20, 346\u2013357 (2001).","journal-title":"Oncogene"},{"key":"BFnm3842_CR47","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/sj.cr.7290291","volume":"15","author":"P Mhawech","year":"2005","unstructured":"Mhawech, P. 14-3-3 proteins\u2013an update. Cell Res. 15, 228\u2013236 (2005).","journal-title":"Cell Res."},{"key":"BFnm3842_CR48","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/jcp.20122","volume":"202","author":"LG Rodriguez","year":"2005","unstructured":"Rodriguez, L.G. & Guan, J.L. 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove. J. Cell. Physiol. 202, 285\u2013294 (2005).","journal-title":"J. Cell. Physiol."},{"key":"BFnm3842_CR49","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1182\/blood-2007-07-103077","volume":"111","author":"EY Choi","year":"2008","unstructured":"Choi, E.Y. et al. Regulation of LFA-1\u2013dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Blood 111, 3607\u20133614 (2008).","journal-title":"Blood"},{"key":"BFnm3842_CR50","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1083\/jcb.200504016","volume":"171","author":"SC Fagerholm","year":"2005","unstructured":"Fagerholm, S.C., Hilden, T.J., Nurmi, S.M. & Gahmberg, C.G. Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms. J. Cell Biol. 171, 705\u2013715 (2005).","journal-title":"J. Cell Biol."},{"key":"BFnm3842_CR51","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1161\/CIRCRESAHA.109.204669","volume":"105","author":"Y Yuan","year":"2009","unstructured":"Yuan, Y. et al. Identification of a novel 14-3-3\u03b6 binding site within the cytoplasmic domain of platelet glycoprotein Ib\u03b1 that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX. Circ. Res. 105, 1177\u20131185 (2009).","journal-title":"Circ. Res."},{"key":"BFnm3842_CR52","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1124\/jpet.111.179168","volume":"337","author":"F Roviezzo","year":"2011","unstructured":"Roviezzo, F. et al. Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo. J. Pharmacol. Exp. Ther. 337, 830\u2013837 (2011).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnm3842_CR53","doi-asserted-by":"publisher","first-page":"17320","DOI":"10.1074\/jbc.M411674200","volume":"280","author":"D Mehta","year":"2005","unstructured":"Mehta, D., Konstantoulaki, M., Ahmmed, G.U. & Malik, A.B. Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates Rac activation and adherens junction assembly in endothelial cells. J. Biol. Chem. 280, 17320\u201317328 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFnm3842_CR54","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","volume":"112","author":"TW LeBien","year":"2008","unstructured":"LeBien, T.W. & Tedder, T.F. B lymphocytes: how they develop and function. Blood 112, 1570\u20131580 (2008).","journal-title":"Blood"},{"key":"BFnm3842_CR55","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1084\/jem.184.5.2049","volume":"184","author":"DV Serreze","year":"1996","unstructured":"Serreze, D.V. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new 'speed congenic' stock of NOD.Ig mu null mice. J. Exp. Med. 184, 2049\u20132053 (1996).","journal-title":"J. Exp. Med."},{"key":"BFnm3842_CR56","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3109\/08916934.2012.665526","volume":"45","author":"A Finnegan","year":"2012","unstructured":"Finnegan, A., Ashaye, S. & Hamel, K.M. B effector cells in rheumatoid arthritis and experimental arthritis. Autoimmunity 45, 353\u2013363 (2012).","journal-title":"Autoimmunity"},{"key":"BFnm3842_CR57","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1056\/NEJMoa0904452","volume":"361","author":"MD Pescovitz","year":"2009","unstructured":"Pescovitz, M.D. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N. Engl. J. Med. 361, 2143\u20132152 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFnm3842_CR58","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/art.10467","volume":"46","author":"S De Vita","year":"2002","unstructured":"De Vita, S. et al. Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis. Evidence of a pathogenic role for B cells. Arthritis Rheum. 46, 2029\u20132033 (2002).","journal-title":"Arthritis Rheum."},{"key":"BFnm3842_CR59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0022-1759(01)00427-6","volume":"255","author":"GE Rainger","year":"2001","unstructured":"Rainger, G.E., Stone, P., Morland, C.M. & Nash, G.B. A novel system for investigating the ability of smooth muscle cells and fibroblasts to regulate adhesion of flowing leukocytes to endothelial cells. J. Immunol. Methods 255, 73\u201382 (2001).","journal-title":"J. Immunol. Methods"},{"key":"BFnm3842_CR60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1006\/mvre.1993.1004","volume":"45","author":"BM Cooke","year":"1993","unstructured":"Cooke, B.M., Usami, S., Perry, I. & Nash, G.B. A simplified method for culture of endothelial cells and analysis of adhesion of blood cells under conditions of flow. Microvasc. Res. 45, 33\u201345 (1993).","journal-title":"Microvasc. Res."},{"key":"BFnm3842_CR61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.yexcr.2005.07.001","volume":"310","author":"LM Butler","year":"2005","unstructured":"Butler, L.M., Rainger, G.E., Rahman, M. & Nash, G.B. Prolonged culture of endothelial cells and deposition of basement membrane modify the recruitment of neutrophils. Exp. Cell Res. 310, 22\u201332 (2005).","journal-title":"Exp. Cell Res."},{"key":"BFnm3842_CR62","doi-asserted-by":"crossref","unstructured":"Eidhammer, I. et al. Computational and Statistical Methods for Protein Quantification by Mass Spectrometry (John Wiley & Sons, 2012).","DOI":"10.1002\/9781118494042"},{"key":"BFnm3842_CR63","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1182\/blood-2007-08-108936","volume":"111","author":"R Rajakariar","year":"2008","unstructured":"Rajakariar, R. et al. Novel biphasic role for lymphocytes revealed during resolving inflammation. Blood 111, 4184\u20134192 (2008).","journal-title":"Blood"},{"key":"BFnm3842_CR64","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/291238a0","volume":"291","author":"SK Hoiseth","year":"1981","unstructured":"Hoiseth, S.K. & Stocker, B.A. Aromatic-dependent Salmonella Typhimurium are non-virulent and effective as live vaccines. Nature 291, 238\u2013239 (1981).","journal-title":"Nature"},{"key":"BFnm3842_CR65","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1002\/eji.200425403","volume":"34","author":"AF Cunningham","year":"2004","unstructured":"Cunningham, A.F. et al. Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1. Eur. J. Immunol. 34, 2986\u20132995 (2004).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3842_CR66","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1126\/science.272.5268.1649","volume":"272","author":"M Cascalho","year":"1996","unstructured":"Cascalho, M. et al. A quasi-monoclonal mouse. Science 272, 1649\u20131652 (1996).","journal-title":"Science"},{"key":"BFnm3842_CR67","doi-asserted-by":"publisher","first-page":"5745","DOI":"10.4049\/jimmunol.1202283","volume":"189","author":"A Flores-Langarica","year":"2012","unstructured":"Flores-Langarica, A. et al. Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node. J. Immunol. 189, 5745\u20135754 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3842_CR68","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.jaut.2008.08.006","volume":"31","author":"EC Kerr","year":"2008","unstructured":"Kerr, E.C. et al. Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations. J. Autoimmun. 31, 354\u2013361 (2008).","journal-title":"J. Autoimmun."},{"key":"BFnm3842_CR69","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","volume":"15","author":"KG Alberti","year":"1998","unstructured":"Alberti, K.G. & Zimmet, P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15, 539\u2013553 (1998).","journal-title":"Diabet. Med."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.3842.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3842","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.3842.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T16:41:22Z","timestamp":1691599282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.3842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["BFnm3842"],"URL":"https:\/\/doi.org\/10.1038\/nm.3842","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]},"assertion":[{"value":"14 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.C., H.M.M., P.N. and G.E.R. hold patents for the therapeutic and diagnostic use of PEPITEM (WO2013\/104928) and cadherin-15 (WO2015\/001356) in autoimmune disease, chronic inflammatory disease and other diseases in which T cells contribute to pathogenesis, as well as for the use of adipoRs expression as a biomarker for rheumatoid arthritis (WO2014\/080204). The other authors have no competing financial interests to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}