{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:04:44Z","timestamp":1792670684401,"version":"4.5.0"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1038\/nm.3883","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T15:26:30Z","timestamp":1435591590000},"page":"688-697","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":511,"title":["The emerging role of resident memory T cells in protective immunity and inflammatory disease"],"prefix":"10.1038","volume":"21","author":[{"given":"Chang Ook","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S","family":"Kupper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"BFnm3883_CR1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","volume":"401","author":"F Sallusto","year":"1999","unstructured":"Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708\u2013712 (1999).","journal-title":"Nature"},{"key":"BFnm3883_CR2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/40166","volume":"389","author":"RC Fuhlbrigge","year":"1997","unstructured":"Fuhlbrigge, R.C., Kieffer, J.D., Armerding, D. & Kupper, T.S. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389, 978\u2013981 (1997).","journal-title":"Nature"},{"key":"BFnm3883_CR3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/eji.1830220402","volume":"22","author":"CR Mackay","year":"1992","unstructured":"Mackay, C.R. et al. Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. Eur. J. Immunol. 22, 887\u2013895 (1992).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3883_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature10851","volume":"483","author":"X Jiang","year":"2012","unstructured":"Jiang, X. et al. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 483, 227\u2013231 (2012).","journal-title":"Nature"},{"key":"BFnm3883_CR5","doi-asserted-by":"crossref","first-page":"269rv261","DOI":"10.1126\/scitranslmed.3010641","volume":"7","author":"RA Clark","year":"2015","unstructured":"Clark, R.A. Resident memory T cells in human health and disease. Sci. Transl. Med. 7, 269rv261 (2015).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3883_CR6","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","volume":"14","author":"LK Mackay","year":"2013","unstructured":"Mackay, L.K. et al. The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin. Nat. Immunol. 14, 1294\u20131301 (2013).","journal-title":"Nat. Immunol."},{"key":"BFnm3883_CR7","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.4049\/jimmunol.1201305","volume":"189","author":"LM Wakim","year":"2012","unstructured":"Wakim, L.M. et al. The molecular signature of tissue resident memory CD8 T cells isolated from the brain. J. Immunol. 189, 3462\u20133471 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nri1222","volume":"3","author":"UH von Andrian","year":"2003","unstructured":"von Andrian, U.H. & Mempel, T.R. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3, 867\u2013878 (2003).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3883_CR9","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.cell.2013.04.007","volume":"153","author":"NJ Tubo","year":"2013","unstructured":"Tubo, N.J. et al. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 153, 785\u2013796 (2013).","journal-title":"Cell"},{"key":"BFnm3883_CR10","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1056\/NEJM200010053431407","volume":"343","author":"UH von Andrian","year":"2000","unstructured":"von Andrian, U.H. & Mackay, C.R. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343, 1020\u20131034 (2000).","journal-title":"N. Engl. J. Med."},{"key":"BFnm3883_CR11","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.immuni.2006.06.019","volume":"25","author":"L Liu","year":"2006","unstructured":"Liu, L., Fuhlbrigge, R.C., Karibian, K., Tian, T. & Kupper, T.S. Dynamic programming of CD8+ T cell trafficking after live viral immunization. Immunity 25, 511\u2013520 (2006).","journal-title":"Immunity"},{"key":"BFnm3883_CR12","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/eji.200939722","volume":"39","author":"F Sallusto","year":"2009","unstructured":"Sallusto, F. & Lanzavecchia, A. Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity. Eur. J. Immunol. 39, 2076\u20132082 (2009).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3883_CR13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20011502","volume":"195","author":"DJ Campbell","year":"2002","unstructured":"Campbell, D.J. & Butcher, E.C. Rapid acquisition of tissue-specific homing phenotypes by CD4+ T cells activated in cutaneous or mucosal lymphoid tissues. J. Exp. Med. 195, 135\u2013141 (2002).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR14","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.150.3.1122","volume":"150","author":"LJ Picker","year":"1993","unstructured":"Picker, L.J. et al. Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J. Immunol. 150, 1122\u20131136 (1993).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR15","first-page":"859","volume":"7","author":"MJ Borowitz","year":"1993","unstructured":"Borowitz, M.J., Weidner, A., Olsen, E.A. & Picker, L.J. Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. Leukemia 7, 859\u2013863 (1993).","journal-title":"Leukemia"},{"key":"BFnm3883_CR16","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1084\/jem.174.6.1461","volume":"174","author":"EL Berg","year":"1991","unstructured":"Berg, E.L. et al. The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J. Exp. Med. 174, 1461\u20131466 (1991).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/23495","volume":"400","author":"JJ Campbell","year":"1999","unstructured":"Campbell, J.J. et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400, 776\u2013780 (1999).","journal-title":"Nature"},{"key":"BFnm3883_CR18","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.4049\/jimmunol.163.5.2353","volume":"163","author":"JJ Campbell","year":"1999","unstructured":"Campbell, J.J., Pan, J. & Butcher, E.C. Cutting edge: developmental switches in chemokine responses during T cell maturation. J. Immunol. 163, 2353\u20132357 (1999).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nm0202-157","volume":"8","author":"B Homey","year":"2002","unstructured":"Homey, B. et al. CCL27-CCR10 interactions regulate T cell\u2013mediated skin inflammation. Nat. Med. 8, 157\u2013165 (2002).","journal-title":"Nat. Med."},{"key":"BFnm3883_CR20","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/eji.200636575","volume":"37","author":"C Siewert","year":"2007","unstructured":"Siewert, C. et al. Induction of organ-selective CD4+ regulatory T cell homing. Eur. J. Immunol. 37, 978\u2013989 (2007).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3883_CR21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2004.08.011","volume":"21","author":"M Iwata","year":"2004","unstructured":"Iwata, M. et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 21, 527\u2013538 (2004).","journal-title":"Immunity"},{"key":"BFnm3883_CR22","first-page":"97","volume":"151","author":"M Briskin","year":"1997","unstructured":"Briskin, M. et al. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am. J. Pathol. 151, 97\u2013110 (1997).","journal-title":"Am. J. Pathol."},{"key":"BFnm3883_CR23","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.190.9.1241","volume":"190","author":"BA Zabel","year":"1999","unstructured":"Zabel, B.A. et al. Human G protein-coupled receptor GPR-9-6\/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J. Exp. Med. 190, 1241\u20131256 (1999).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR24","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.4049\/jimmunol.172.3.1575","volume":"172","author":"BF Chong","year":"2004","unstructured":"Chong, B.F., Murphy, J.E., Kupper, T.S. & Fuhlbrigge, R.C. E-selectin, thymus- and activation-regulated chemokine\/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system. J. Immunol. 172, 1575\u20131581 (2004).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nri1310","volume":"4","author":"TS Kupper","year":"2004","unstructured":"Kupper, T.S. & Fuhlbrigge, R.C. Immune surveillance in the skin: mechanisms and clinical consequences. Nat. Rev. Immunol. 4, 211\u2013222 (2004).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3883_CR26","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1126\/science.1059984","volume":"291","author":"CR Mackay","year":"2001","unstructured":"Mackay, C.R. & von Andrian, U.H. Immunology. Memory T cells\u2014local heroes in the struggle for immunity. Science 291, 2323\u20132324 (2001).","journal-title":"Science"},{"key":"BFnm3883_CR27","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJM199912093412407","volume":"341","author":"C Robert","year":"1999","unstructured":"Robert, C. & Kupper, T.S. Inflammatory skin diseases, T cells, and immune surveillance. N. Engl. J. Med. 341, 1817\u20131828 (1999).","journal-title":"N. Engl. J. Med."},{"key":"BFnm3883_CR28","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.166.3.1813","volume":"166","author":"RJ Hogan","year":"2001","unstructured":"Hogan, R.J. et al. Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections. J. Immunol. 166, 1813\u20131822 (2001).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR29","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.4049\/jimmunol.175.10.6615","volume":"175","author":"CH Wei","year":"2005","unstructured":"Wei, C.H. et al. Tissue-resident memory CD8+ T cells can be deleted by soluble, but not cross-presented antigen. J. Immunol. 175, 6615\u20136623 (2005).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1189\/jlb.0313180","volume":"95","author":"T Wu","year":"2014","unstructured":"Wu, T. et al. Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection. J. Leukoc. Biol. 95, 215\u2013224 (2014).","journal-title":"J. Leukoc. Biol."},{"key":"BFnm3883_CR31","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1172\/JCI10927","volume":"106","author":"NA Kuklin","year":"2000","unstructured":"Kuklin, N.A. et al. \u03b14\u03b27 independent pathway for CD8+ T cell-mediated intestinal immunity to rotavirus. J. Clin. Invest. 106, 1541\u20131552 (2000).","journal-title":"J. Clin. Invest."},{"key":"BFnm3883_CR32","doi-asserted-by":"crossref","first-page":"219ra218","DOI":"10.1126\/scitranslmed.3007828","volume":"6","author":"C Schlapbach","year":"2014","unstructured":"Schlapbach, C. et al. Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci. Transl. Med. 6, 219ra218 (2014).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3883_CR33","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.immuni.2012.03.018","volume":"36","author":"J Seneschal","year":"2012","unstructured":"Seneschal, J., Clark, R.A., Gehad, A., Baecher-Allan, C.M. & Kupper, T.S. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 36, 873\u2013884 (2012).","journal-title":"Immunity"},{"key":"BFnm3883_CR34","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nature08511","volume":"462","author":"Y Nakanishi","year":"2009","unstructured":"Nakanishi, Y., Lu, B., Gerard, C. & Iwasaki, A. CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help. Nature 462, 510\u2013513 (2009).","journal-title":"Nature"},{"key":"BFnm3883_CR35","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature11522","volume":"491","author":"H Shin","year":"2012","unstructured":"Shin, H. & Iwasaki, A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature 491, 463\u2013467 (2012).","journal-title":"Nature"},{"key":"BFnm3883_CR36","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1073\/pnas.1202288109","volume":"109","author":"LK Mackay","year":"2012","unstructured":"Mackay, L.K. et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc. Natl. Acad. Sci. USA 109, 7037\u20137042 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3883_CR37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1257530","volume":"346","author":"N Iijima","year":"2014","unstructured":"Iijima, N. & Iwasaki, A. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 346, 93\u201398 (2014).","journal-title":"Science"},{"key":"BFnm3883_CR38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nm.3860","volume":"21","author":"O Gaide","year":"2015","unstructured":"Gaide, O. et al. Common clonal origin of central and resident memory T cells following skin immunization. Nat. Med. 21, 647\u2013653 (2015).","journal-title":"Nat. Med."},{"key":"BFnm3883_CR39","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.4049\/jimmunol.1400074","volume":"193","author":"RT Sowell","year":"2014","unstructured":"Sowell, R.T., Rogozinska, M., Nelson, C.E., Vezys, V. & Marzo, A.L. Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR. J. Immunol. 193, 2067\u20132071 (2014).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2014.09.007","volume":"41","author":"BJ Laidlaw","year":"2014","unstructured":"Laidlaw, B.J. et al. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity 41, 633\u2013645 (2014).","journal-title":"Immunity"},{"key":"BFnm3883_CR41","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1126\/science.1058867","volume":"291","author":"D Masopust","year":"2001","unstructured":"Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413\u20132417 (2001).","journal-title":"Science"},{"key":"BFnm3883_CR42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1074-7613(04)00103-7","volume":"20","author":"KD Klonowski","year":"2004","unstructured":"Klonowski, K.D. et al. Dynamics of blood-borne CD8 memory T cell migration in vivo. Immunity 20, 551\u2013562 (2004).","journal-title":"Immunity"},{"key":"BFnm3883_CR43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-immunol-032712-095954","volume":"31","author":"SN Mueller","year":"2013","unstructured":"Mueller, S.N., Gebhardt, T., Carbone, F.R. & Heath, W.R. Memory T cell subsets, migration patterns, and tissue residence. Annu. Rev. Immunol. 31, 137\u2013161 (2013).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm3883_CR44","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/eji.201041377","volume":"41","author":"MJ Bevan","year":"2011","unstructured":"Bevan, M.J. Memory T cells as an occupying force. Eur. J. Immunol. 41, 1192\u20131195 (2011).","journal-title":"Eur. J. Immunol."},{"key":"BFnm3883_CR45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.it.2012.08.008","volume":"34","author":"T Gebhardt","year":"2013","unstructured":"Gebhardt, T., Mueller, S.N., Heath, W.R. & Carbone, F.R. Peripheral tissue surveillance and residency by memory T cells. Trends Immunol. 34, 27\u201332 (2013).","journal-title":"Trends Immunol."},{"key":"BFnm3883_CR46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.coi.2013.05.007","volume":"25","author":"FR Carbone","year":"2013","unstructured":"Carbone, F.R., Mackay, L.K., Heath, W.R. & Gebhardt, T. Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues. Curr. Opin. Immunol. 25, 329\u2013333 (2013).","journal-title":"Curr. Opin. Immunol."},{"key":"BFnm3883_CR47","first-page":"332","volume":"5","author":"SN Mueller","year":"2014","unstructured":"Mueller, S.N., Zaid, A. & Carbone, F.R. Tissue-resident T cells: dynamic players in skin immunity. Front. Immunol. 5, 332 (2014).","journal-title":"Front. Immunol."},{"key":"BFnm3883_CR48","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.immuni.2014.03.007","volume":"40","author":"BS Sheridan","year":"2014","unstructured":"Sheridan, B.S. et al. Oral infection drives a distinct population of intestinal resident memory CD8+ T cells with enhanced protective function. Immunity 40, 747\u2013757 (2014).","journal-title":"Immunity"},{"key":"BFnm3883_CR49","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.cell.2014.05.026","volume":"157","author":"LK Beura","year":"2014","unstructured":"Beura, L.K. & Masopust, D. SnapShot: resident memory T cells. Cell 157, 1488\u20131488 (2014).","journal-title":"Cell"},{"key":"BFnm3883_CR50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fimmu.2014.00331","volume":"5","author":"DL Turner","year":"2014","unstructured":"Turner, D.L. & Farber, D.L. Mucosal resident memory CD4 T cells in protection and immunopathology. Front. Immunol. 5, 331 (2014).","journal-title":"Front. Immunol."},{"key":"BFnm3883_CR51","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature04606","volume":"440","author":"LR Shiow","year":"2006","unstructured":"Shiow, L.R. et al. CD69 acts downstream of interferon-\u03b1\/\u03b2 to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440, 540\u2013544 (2006).","journal-title":"Nature"},{"key":"BFnm3883_CR52","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.4049\/jimmunol.1402256","volume":"194","author":"LK Mackay","year":"2015","unstructured":"Mackay, L.K. et al. Cutting Edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J. Immunol. 194, 2059\u20132063 (2015).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR53","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ni.2745","volume":"14","author":"CN Skon","year":"2013","unstructured":"Skon, C.N. et al. Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat. Immunol. 14, 1285\u20131293 (2013).","journal-title":"Nat. Immunol."},{"key":"BFnm3883_CR54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-immunol-020711-075011","volume":"30","author":"JG Cyster","year":"2012","unstructured":"Cyster, J.G. & Schwab, S.R. Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. Annu. Rev. Immunol. 30, 69\u201394 (2012).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm3883_CR55","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ni1240","volume":"6","author":"SK Bromley","year":"2005","unstructured":"Bromley, S.K., Thomas, S.Y. & Luster, A.D. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol. 6, 895\u2013901 (2005).","journal-title":"Nat. Immunol."},{"key":"BFnm3883_CR56","doi-asserted-by":"crossref","first-page":"970","DOI":"10.4049\/jimmunol.1202805","volume":"190","author":"SK Bromley","year":"2013","unstructured":"Bromley, S.K., Yan, S., Tomura, M., Kanagawa, O. & Luster, A.D. Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J. Immunol. 190, 970\u2013976 (2013).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR57","doi-asserted-by":"crossref","first-page":"279ra239","DOI":"10.1126\/scitranslmed.3010302","volume":"7","author":"R Watanabe","year":"2015","unstructured":"Watanabe, R. et al. Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci. Transl. Med. 7, 279ra239 (2015).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3883_CR58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-94-017-9153-3_7","volume":"819","author":"GA Hadley","year":"2014","unstructured":"Hadley, G.A. & Higgins, J.M. Integrin \u03b1E\u03b27: molecular features and functional significance in the immune system. Adv. Exp. Med. Biol. 819, 97\u2013110 (2014).","journal-title":"Adv. Exp. Med. Biol."},{"key":"BFnm3883_CR59","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI44675","volume":"121","author":"B Piet","year":"2011","unstructured":"Piet, B. et al. CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung. J. Clin. Invest. 121, 2254\u20132263 (2011).","journal-title":"J. Clin. Invest."},{"key":"BFnm3883_CR60","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","volume":"9","author":"FO Nestle","year":"2009","unstructured":"Nestle, F.O., Di Meglio, P., Qin, J.Z. & Nickoloff, B.J. Skin immune sentinels in health and disease. Nat. Rev. Immunol. 9, 679\u2013691 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm3883_CR61","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1242\/dev.116.4.1011","volume":"116","author":"K Shimamura","year":"1992","unstructured":"Shimamura, K. & Takeichi, M. Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis. Development 116, 1011\u20131019 (1992).","journal-title":"Development"},{"key":"BFnm3883_CR62","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/35065111","volume":"410","author":"RL Reinhardt","year":"2001","unstructured":"Reinhardt, R.L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M.K. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410, 101\u2013105 (2001).","journal-title":"Nature"},{"key":"BFnm3883_CR63","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","volume":"10","author":"T Gebhardt","year":"2009","unstructured":"Gebhardt, T. et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat. Immunol. 10, 524\u2013530 (2009).","journal-title":"Nat. Immunol."},{"key":"BFnm3883_CR64","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ni.3108","volume":"16","author":"T Bergsbaken","year":"2015","unstructured":"Bergsbaken, T. & Bevan, M.J. Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection. Nat. Immunol. 16, 406\u2013414 (2015).","journal-title":"Nat. Immunol."},{"key":"BFnm3883_CR65","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10339","volume":"477","author":"T Gebhardt","year":"2011","unstructured":"Gebhardt, T. et al. Different patterns of peripheral migration by memory CD4 and CD8 T cells. Nature 477, 216\u2013219 (2011).","journal-title":"Nature"},{"key":"BFnm3883_CR66","doi-asserted-by":"crossref","first-page":"117ra117","DOI":"10.1126\/scitranslmed.3003008","volume":"4","author":"RA Clark","year":"2012","unstructured":"Clark, R.A. et al. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci. Transl. Med. 4, 117ra117 (2012).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3883_CR67","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.1200402","volume":"188","author":"KA Casey","year":"2012","unstructured":"Casey, K.A. et al. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J. Immunol. 188, 4866\u20134875 (2012).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR68","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.4049\/jimmunol.1100912","volume":"187","author":"S Kadow","year":"2011","unstructured":"Kadow, S. et al. Aryl hydrocarbon receptor is critical for homeostasis of invariant \u03b3\u03b4 T cells in the murine epidermis. J. Immunol. 187, 3104\u20133110 (2011).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR69","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1073\/pnas.1322292111","volume":"111","author":"A Zaid","year":"2014","unstructured":"Zaid, A. et al. Persistence of skin-resident memory T cells within an epidermal niche. Proc. Natl. Acad. Sci. USA 111, 5307\u20135312 (2014).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3883_CR70","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1254536","volume":"346","author":"JM Schenkel","year":"2014","unstructured":"Schenkel, J.M. et al. T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science 346, 98\u2013101 (2014).","journal-title":"Science"},{"key":"BFnm3883_CR71","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1126\/science.1254803","volume":"346","author":"S Ariotti","year":"2014","unstructured":"Ariotti, S. et al. T cell memory. Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert. Science 346, 101\u2013105 (2014).","journal-title":"Science"},{"key":"BFnm3883_CR72","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/jid.2009.247","volume":"130","author":"RA Clark","year":"2010","unstructured":"Clark, R.A. Skin-resident T cells: the ups and downs of on site immunity. J. Invest. Dermatol. 130, 362\u2013370 (2010).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR73","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.176.7.4431","volume":"176","author":"RA Clark","year":"2006","unstructured":"Clark, R.A. et al. The vast majority of CLA+ T cells are resident in normal skin. J. Immunol. 176, 4431\u20134439 (2006).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR74","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.jid.5700199","volume":"126","author":"RA Clark","year":"2006","unstructured":"Clark, R.A. et al. A novel method for the isolation of skin resident T cells from normal and diseased human skin. J. Invest. Dermatol. 126, 1059\u20131070 (2006).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR75","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1182\/blood-2006-02-002873","volume":"109","author":"RA Clark","year":"2007","unstructured":"Clark, R.A. & Kupper, T.S. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 109, 194\u2013202 (2007).","journal-title":"Blood"},{"key":"BFnm3883_CR76","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/jid.2012.456","volume":"133","author":"D Hijnen","year":"2013","unstructured":"Hijnen, D. et al. CD8+ T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-\u03b3, IL-13, IL-17, and IL-22. J. Invest. Dermatol. 133, 973\u2013979 (2013).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR77","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm.2078","volume":"16","author":"L Liu","year":"2010","unstructured":"Liu, L. et al. Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat. Med. 16, 224\u2013227 (2010).","journal-title":"Nat. Med."},{"key":"BFnm3883_CR78","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature12110","volume":"497","author":"J Zhu","year":"2013","unstructured":"Zhu, J. et al. Immune surveillance by CD8\u03b1\u03b1+ skin-resident T cells in human herpes virus infection. Nature 497, 494\u2013497 (2013).","journal-title":"Nature"},{"key":"BFnm3883_CR79","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1172\/JCI40926","volume":"120","author":"M Tomura","year":"2010","unstructured":"Tomura, M. et al. Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J. Clin. Invest. 120, 883\u2013893 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnm3883_CR80","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1084\/jem.20090858","volume":"207","author":"D Masopust","year":"2010","unstructured":"Masopust, D. et al. Dynamic T cell migration program provides resident memory within intestinal epithelium. J. Exp. Med. 207, 553\u2013564 (2010).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fimmu.2011.00025","volume":"2","author":"DT Ruane","year":"2011","unstructured":"Ruane, D.T. & Lavelle, E.C. The role of CD103+ dendritic cells in the intestinal mucosal immune system. Front. Immunol. 2, 25 (2011).","journal-title":"Front. Immunol."},{"key":"BFnm3883_CR82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","volume":"38","author":"T Sathaliyawala","year":"2013","unstructured":"Sathaliyawala, T. et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38, 187\u2013197 (2013).","journal-title":"Immunity"},{"key":"BFnm3883_CR83","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/gene.2013.20","volume":"14","author":"SW Tse","year":"2013","unstructured":"Tse, S.W., Cockburn, I.A., Zhang, H., Scott, A.L. & Zavala, F. Unique transcriptional profile of liver-resident memory CD8+ T cells induced by immunization with malaria sporozoites. Genes Immun. 14, 302\u2013309 (2013).","journal-title":"Genes Immun."},{"key":"BFnm3883_CR84","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/jvh.12081","volume":"20","author":"K Yanagisawa","year":"2013","unstructured":"Yanagisawa, K. et al. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J. Viral Hepat. 20, 556\u2013565 (2013).","journal-title":"J. Viral Hepat."},{"key":"BFnm3883_CR85","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/mi.2013.67","volume":"7","author":"DL Turner","year":"2014","unstructured":"Turner, D.L. et al. Lung niches for the generation and maintenance of tissue-resident memory T cells. Mucosal Immunol. 7, 501\u2013510 (2014).","journal-title":"Mucosal Immunol."},{"key":"BFnm3883_CR86","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.1402369","volume":"194","author":"Y Hu","year":"2015","unstructured":"Hu, Y., Lee, Y.T., Kaech, S.M., Garvy, B. & Cauley, L.S. Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells. J. Immunol. 194, 2407\u20132414 (2015).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR87","doi-asserted-by":"crossref","first-page":"e16245","DOI":"10.1371\/journal.pone.0016245","volume":"6","author":"R Purwar","year":"2011","unstructured":"Purwar, R. et al. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One 6, e16245 (2011).","journal-title":"PLoS One"},{"key":"BFnm3883_CR88","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/jid.2011.400","volume":"132","author":"TS Kupper","year":"2012","unstructured":"Kupper, T.S. Old and new: recent innovations in vaccine biology and skin T cells. J. Invest. Dermatol. 132, 829\u2013834 (2012).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR89","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1257530","volume":"346","author":"N Iijima","year":"2014","unstructured":"Iijima, N. & Iwasaki, A. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 346, 93\u201398 (2014).","journal-title":"Science"},{"key":"BFnm3883_CR90","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1172\/JCI63287","volume":"122","author":"N Cuburu","year":"2012","unstructured":"Cuburu, N. et al. Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses. J. Clin. Invest. 122, 4606\u20134620 (2012).","journal-title":"J. Clin. Invest."},{"key":"BFnm3883_CR91","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/JVI.02380-14","volume":"89","author":"N Cuburu","year":"2015","unstructured":"Cuburu, N. et al. Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB\/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge. J. Virol. 89, 83\u201396 (2015).","journal-title":"J. Virol."},{"key":"BFnm3883_CR92","doi-asserted-by":"crossref","first-page":"221ra213","DOI":"10.1126\/scitranslmed.3007323","volume":"6","author":"L Maldonado","year":"2014","unstructured":"Maldonado, L. et al. Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions. Sci. Transl. Med. 6, 221ra213 (2014).","journal-title":"Sci. Transl. Med."},{"key":"BFnm3883_CR93","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/ACI.0b013e32832cda4c","volume":"9","author":"T Shiohara","year":"2009","unstructured":"Shiohara, T. Fixed drug eruption: pathogenesis and diagnostic tests. Curr. Opin. Allergy Clin. Immunol. 9, 316\u2013321 (2009).","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"BFnm3883_CR94","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/jid.2010.280","volume":"131","author":"M Suarez-Farinas","year":"2011","unstructured":"Suarez-Farinas, M., Fuentes-Duculan, J., Lowes, M.A. & Krueger, J.G. Resolved psoriasis lesions retain expression of a subset of disease-related genes. J. Invest. Dermatol. 131, 391\u2013400 (2011).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/jid.2010.374","volume":"131","author":"RA Clark","year":"2011","unstructured":"Clark, R.A. Gone but not forgotten: lesional memory in psoriatic skin. J. Invest. Dermatol. 131, 283\u2013285 (2011).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR96","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","volume":"192","author":"S Cheuk","year":"2014","unstructured":"Cheuk, S. et al. Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis. J. Immunol. 192, 3111\u20133120 (2014).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR97","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/jid.2012.284","volume":"133","author":"T Honda","year":"2013","unstructured":"Honda, T., Egawa, G., Grabbe, S. & Kabashima, K. Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis. J. Invest. Dermatol. 133, 303\u2013315 (2013).","journal-title":"J. Invest. Dermatol."},{"key":"BFnm3883_CR98","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1182\/blood-2009-11-251926","volume":"116","author":"JJ Campbell","year":"2010","unstructured":"Campbell, J.J., Clark, R.A., Watanabe, R. & Kupper, T.S. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood 116, 767\u2013771 (2010).","journal-title":"Blood"},{"key":"BFnm3883_CR99","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.20081712","volume":"206","author":"MA Kleinschek","year":"2009","unstructured":"Kleinschek, M.A. et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J. Exp. Med. 206, 525\u2013534 (2009).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR100","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.4049\/jimmunol.1302911","volume":"192","author":"K Sasaki","year":"2014","unstructured":"Sasaki, K. et al. Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. J. Immunol. 192, 3029\u20133042 (2014).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR101","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/schbul\/sbu049","volume":"40","author":"M Debnath","year":"2014","unstructured":"Debnath, M. & Berk, M. Th17 pathway-mediated immunopathogenesis of schizophrenia: mechanisms and implications. Schizophr. Bull. 40, 1412\u20131421 (2014).","journal-title":"Schizophr. Bull."},{"key":"BFnm3883_CR102","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nm.2817","volume":"18","author":"JP Sherlock","year":"2012","unstructured":"Sherlock, J.P. et al. IL-23 induces spondyloarthropathy by acting on ROR-\u03b3t+ CD3+CD4\u2212CD8\u2212 entheseal resident T cells. Nat. Med. 18, 1069\u20131076 (2012).","journal-title":"Nat. Med."},{"issue":"suppl. 11","key":"BFnm3883_CR103","first-page":"S209","volume":"66","author":"LA Henderson","year":"2014","unstructured":"Henderson, L.A. et al. A161: novel 3-dimensional explant method facilitates the study of lymphocyte populations in the synovium and reveals a large population of resident memory T cells in rheumatoid arthritis. Arthritis Rheum. 66 (suppl. 11), S209 (2014).","journal-title":"Arthritis Rheum."},{"key":"BFnm3883_CR104","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1365-2249.2004.02473.x","volume":"136","author":"G Zhou","year":"2004","unstructured":"Zhou, G. et al. Identification of systemically expanded activated T cell clones in MRL\/lpr and NZB\/W F1 lupus model mice. Clin. Exp. Immunol. 136, 448\u2013455 (2004).","journal-title":"Clin. Exp. Immunol."},{"key":"BFnm3883_CR105","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1084\/jem.20020178","volume":"196","author":"Y Feng","year":"2002","unstructured":"Feng, Y. et al. CD103 expression is required for destruction of pancreatic islet allografts by CD8+ T cells. J. Exp. Med. 196, 877\u2013886 (2002).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR106","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4049\/jimmunol.172.1.214","volume":"172","author":"D Wang","year":"2004","unstructured":"Wang, D. et al. Regulation of CD103 expression by CD8+ T cells responding to renal allografts. J. Immunol. 172, 214\u2013221 (2004).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR107","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/01.TP.0000064210.92444.B5","volume":"75","author":"R Ding","year":"2003","unstructured":"Ding, R. et al. CD103 mRNA levels in urinary cells predict acute rejection of renal allografts. Transplantation 75, 1307\u20131312 (2003).","journal-title":"Transplantation"},{"key":"BFnm3883_CR108","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.4049\/jimmunol.1301390","volume":"192","author":"J Boldison","year":"2014","unstructured":"Boldison, J. et al. Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis. J. Immunol. 192, 4541\u20134550 (2014).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR109","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","volume":"192","author":"GJ Freeman","year":"2000","unstructured":"Freeman, G.J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027\u20131034 (2000).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR110","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1158\/1078-0432.CCR-13-1877","volume":"20","author":"JR Webb","year":"2014","unstructured":"Webb, J.R., Milne, K., Watson, P., Deleeuw, R.J. & Nelson, B.H. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. Clin. Cancer Res. 20, 434\u2013444 (2014).","journal-title":"Clin. Cancer Res."},{"key":"BFnm3883_CR111","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1056\/NEJMoa1305133","volume":"369","author":"O Hamid","year":"2013","unstructured":"Hamid, O. et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369, 134\u2013144 (2013).","journal-title":"N. Engl. J. Med."},{"key":"BFnm3883_CR112","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMoa1412082","volume":"372","author":"C Robert","year":"2015","unstructured":"Robert, C. et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 372, 320\u2013330 (2015).","journal-title":"N. Engl. J. Med."},{"key":"BFnm3883_CR113","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ni.2029","volume":"12","author":"BS Sheridan","year":"2011","unstructured":"Sheridan, B.S. & Lefran\u00e7ois, L. Regional and mucosal memory T cells. Nat. Immunol. 12, 485\u2013491 (2011).","journal-title":"Nat. Immunol."},{"key":"BFnm3883_CR114","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.0912943107","volume":"107","author":"X Jiang","year":"2010","unstructured":"Jiang, X., Campbell, J.J. & Kupper, T.S. Embryonic trafficking of \u03b3\u03b4 T cells to skin is dependent on E\/P selectin ligands and CCR4. Proc. Natl. Acad. Sci. USA 107, 7443\u20137448 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm3883_CR115","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.4049\/jimmunol.1100427","volume":"186","author":"EE Gray","year":"2011","unstructured":"Gray, E.E., Suzuki, K. & Cyster, J.G. Cutting edge: identification of a motile IL-17-producing \u03b3\u03b4 T cell population in the dermis. J. Immunol. 186, 6091\u20136095 (2011).","journal-title":"J. Immunol."},{"key":"BFnm3883_CR116","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1084\/jem.20101824","volume":"208","author":"N Sumaria","year":"2011","unstructured":"Sumaria, N. et al. Cutaneous immunosurveillance by self-renewing dermal \u03b3\u03b4 T cells. J. Exp. Med. 208, 505\u2013518 (2011).","journal-title":"J. Exp. Med."},{"key":"BFnm3883_CR117","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","volume":"35","author":"Y Cai","year":"2011","unstructured":"Cai, Y. et al. Pivotal role of dermal IL-17-producing \u03b3\u03b4 T cells in skin inflammation. Immunity 35, 596\u2013610 (2011).","journal-title":"Immunity"},{"key":"BFnm3883_CR118","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1172\/JCI72932","volume":"124","author":"R Sanchez Rodriguez","year":"2014","unstructured":"Sanchez Rodriguez, R. et al. Memory regulatory T cells reside in human skin. J. Clin. Invest. 124, 1027\u20131036 (2014).","journal-title":"J. Clin. Invest."},{"key":"BFnm3883_CR119","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","volume":"473","author":"SG Hansen","year":"2011","unstructured":"Hansen, S.G. et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523\u2013527 (2011).","journal-title":"Nature"},{"key":"BFnm3883_CR120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/CCO.0b013e3283253190","volume":"21","author":"JM Gardner","year":"2009","unstructured":"Gardner, J.M., Evans, K.G., Musiek, A., Rook, A.H. & Kim, E.J. Update on treatment of cutaneous T-cell lymphoma. Curr. Opin. Oncol. 21, 131\u2013137 (2009).","journal-title":"Curr. Opin. Oncol."},{"key":"BFnm3883_CR121","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/jamadermatol.2013.10099","volume":"150","author":"R Watanabe","year":"2014","unstructured":"Watanabe, R., Teague, J.E., Fisher, D.C., Kupper, T.S. & Clark, R.A. Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission. JAMA Dermatol. 150, 776\u2013779 (2014).","journal-title":"JAMA Dermatol."},{"key":"BFnm3883_CR122","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1309\/AJCPTXMEFOVYWDA6","volume":"133","author":"UN Rao","year":"2010","unstructured":"Rao, U.N., Lee, S.J., Luo, W., Mihm, M.C. Jr. & Kirkwood, J.M. Presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials. Am. J. Clin. Pathol. 133, 646\u2013653 (2010).","journal-title":"Am. J. Clin. Pathol."},{"key":"BFnm3883_CR123","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nature13954","volume":"515","author":"PC Tumeh","year":"2014","unstructured":"Tumeh, P.C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568\u2013571 (2014).","journal-title":"Nature"},{"key":"BFnm3883_CR124","doi-asserted-by":"crossref","first-page":"e27668","DOI":"10.4161\/onci.27668","volume":"3","author":"JR Webb","year":"2014","unstructured":"Webb, J.R., Milne, K. & Nelson, B.H. Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8 tumor-infiltrating lymphocytes in ovarian cancer. Oncoimmunology 3, e27668 (2014).","journal-title":"Oncoimmunology"},{"key":"BFnm3883_CR125","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.4049\/jimmunol.1402711","volume":"194","author":"F Djenidi","year":"2015","unstructured":"Djenidi, F. et al. CD8+CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients. J. Immunol. 194, 3475\u20133486 (2015).","journal-title":"J. Immunol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nm.3883.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.3883","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.3883.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T14:02:15Z","timestamp":1744293735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.3883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,29]]},"references-count":125,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["BFnm3883"],"URL":"https:\/\/doi.org\/10.1038\/nm.3883","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,29]]},"assertion":[{"value":"6 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"T.S.K. is an inventor on US Patent 8691502, assigned to TremRx, Inc.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}