{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:27:56Z","timestamp":1790886476125,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1038\/nm.4075","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T15:08:49Z","timestamp":1460387329000},"page":"524-530","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin"],"prefix":"10.1038","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-2213","authenticated-orcid":false,"given":"Donghyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Gi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Uk","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Chamaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana J","family":"Philpott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Inohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,11]]},"reference":[{"key":"BFnm4075_CR1","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1016\/j.vaccine.2004.11.010","volume":"23","author":"LC Freytag","year":"2005","unstructured":"Freytag, L.C. & Clements, J.D. Mucosal adjuvants. Vaccine 23, 1804\u20131813 (2005).","journal-title":"Vaccine"},{"key":"BFnm4075_CR2","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.4049\/jimmunol.132.6.2736","volume":"132","author":"CO Elson","year":"1984","unstructured":"Elson, C.O. & Ealding, W. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J. Immunol. 132, 2736\u20132741 (1984).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR3","doi-asserted-by":"publisher","first-page":"5876","DOI":"10.1128\/IAI.66.12.5876-5881.1998","volume":"66","author":"A Porgador","year":"1998","unstructured":"Porgador, A., Staats, H.F., Itoh, Y. & Kelsall, B.L. Intranasal immunization with cytotoxic T lymphocyte epitope peptide and mucosal adjuvant cholera toxin: selective augmentation of peptide-presenting dendritic cells in nasal-mucosa-associated lymphoid tissue. Infect. Immun. 66, 5876\u20135881 (1998).","journal-title":"Infect. Immun."},{"key":"BFnm4075_CR4","doi-asserted-by":"publisher","first-page":"22265","DOI":"10.1074\/jbc.272.35.22265","volume":"272","author":"RK Sunahara","year":"1997","unstructured":"Sunahara, R.K., Dessauer, C.W., Whisnant, R.E., Kleuss, C. & Gilman, A.G. Interaction of Gs\u03b1 with the cytosolic domains of mammalian adenylyl cyclase. J. Biol. Chem. 272, 22265\u201322271 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnm4075_CR5","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1002\/eji.1830220915","volume":"22","author":"N Lycke","year":"1992","unstructured":"Lycke, N., Tsuji, T. & Holmgren, J. The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur. J. Immunol. 22, 2277\u20132281 (1992).","journal-title":"Eur. J. Immunol."},{"key":"BFnm4075_CR6","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.163.7.3668","volume":"163","author":"E Williamson","year":"1999","unstructured":"Williamson, E., Westrich, G.M. & Viney, J.L. Modulating dendritic cells to optimize mucosal immunization protocols. J. Immunol. 163, 3668\u20133675 (1999).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR7","doi-asserted-by":"publisher","first-page":"10638","DOI":"10.1073\/pnas.1002348107","volume":"107","author":"SK Datta","year":"2010","unstructured":"Datta, S.K. et al. Mucosal adjuvant activity of cholera toxin requires TH17 cells and protects against inhalation anthrax. Proc. Natl. Acad. Sci. USA 107, 10638\u201310643 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm4075_CR8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1084\/jem.189.3.541","volume":"189","author":"MC Braun","year":"1999","unstructured":"Braun, M.C., He, J., Wu, C.Y. & Kelsall, B.L. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor \u03b21 and \u03b22 chain expression. J. Exp. Med. 189, 541\u2013552 (1999).","journal-title":"J. Exp. Med."},{"key":"BFnm4075_CR9","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1084\/jem.178.4.1309","volume":"178","author":"J Xu-Amano","year":"1993","unstructured":"Xu-Amano, J. et al. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces TH2 cells in mucosa-associated tissues. J. Exp. Med. 178, 1309\u20131320 (1993).","journal-title":"J. Exp. Med."},{"key":"BFnm4075_CR10","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1073\/pnas.94.10.5267","volume":"94","author":"S Yamamoto","year":"1997","unstructured":"Yamamoto, S. et al. A nontoxic mutant of cholera toxin elicits TH2-type responses for enhanced mucosal immunity. Proc. Natl. Acad. Sci. USA 94, 5267\u20135272 (1997).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm4075_CR11","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1084\/jem.20080912","volume":"206","author":"A la Sala","year":"2009","unstructured":"la Sala, A. et al. Cholera toxin inhibits IL-12 production and CD8-\u03b1+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function. J. Exp. Med. 206, 1227\u20131235 (2009).","journal-title":"J. Exp. Med."},{"key":"BFnm4075_CR12","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1172\/JCI59097","volume":"122","author":"X Li","year":"2012","unstructured":"Li, X. et al. Divergent requirement for G\u03b1s and cAMP in the differentiation and inflammatory profile of distinct mouse TH subsets. J. Clin. Invest. 122, 963\u2013973 (2012).","journal-title":"J. Clin. Invest."},{"key":"BFnm4075_CR13","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/mi.2014.111","volume":"8","author":"J Mattsson","year":"2015","unstructured":"Mattsson, J. et al. Cholera toxin adjuvant promotes a balanced TH1\u2013TH2\u2013TH17 response independently of IL-12 and IL-17 by acting on Gs\u03b1 in CD11b+ DCs. Mucosal Immunol. 8, 815\u2013827 (2015).","journal-title":"Mucosal Immunol."},{"key":"BFnm4075_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.coi.2008.06.001","volume":"20","author":"MH Shaw","year":"2008","unstructured":"Shaw, M.H., Reimer, T., Kim, Y.G. & Nu\u00f1ez, G. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr. Opin. Immunol. 20, 377\u2013382 (2008).","journal-title":"Curr. Opin. Immunol."},{"key":"BFnm4075_CR15","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","volume":"278","author":"N Inohara","year":"2003","unstructured":"Inohara, N. et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 278, 5509\u20135512 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm4075_CR16","doi-asserted-by":"publisher","first-page":"8869","DOI":"10.1074\/jbc.C200651200","volume":"278","author":"SE Girardin","year":"2003","unstructured":"Girardin, S.E. et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869\u20138872 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnm4075_CR17","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.4049\/jimmunol.178.4.2380","volume":"178","author":"JH Park","year":"2007","unstructured":"Park, J.H. et al. RICK (RIP2) mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J. Immunol. 178, 2380\u20132386 (2007).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR18","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/sj.emboj.7601962","volume":"27","author":"M Hasegawa","year":"2008","unstructured":"Hasegawa, M. et al. A critical role of RICK (RIP2) polyubiquitination in Nod-induced NF-\u03baB activation. EMBO J. 27, 373\u2013383 (2008).","journal-title":"EMBO J."},{"key":"BFnm4075_CR19","doi-asserted-by":"publisher","first-page":"5781","DOI":"10.4049\/jimmunol.1402184","volume":"193","author":"V Pavot","year":"2014","unstructured":"Pavot, V. et al. Cutting edge: new chimeric NOD2\u2013TLR2 adjuvant drastically increases vaccine immunogenicity. J. Immunol. 193, 5781\u20135785 (2014).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR20","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.4049\/jimmunol.181.11.7925","volume":"181","author":"JG Magalhaes","year":"2008","unstructured":"Magalhaes, J.G. et al. Nod2-dependent TH2 polarization of antigen-specific immunity. J. Immunol. 181, 7925\u20137935 (2008).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.immuni.2007.03.009","volume":"26","author":"JH Fritz","year":"2007","unstructured":"Fritz, J.H. et al. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 26, 445\u2013459 (2007).","journal-title":"Immunity"},{"key":"BFnm4075_CR22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/2049-2618-2-22","volume":"2","author":"EK Allen","year":"2014","unstructured":"Allen, E.K. et al. Characterization of the nasopharyngeal microbiota in health and during rhinovirus challenge. Microbiome 2, 22 (2014).","journal-title":"Microbiome"},{"key":"BFnm4075_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4049\/jimmunol.1203103","volume":"190","author":"N Warner","year":"2013","unstructured":"Warner, N. & N\u00fa\u00f1ez, G. MyD88: a critical adaptor protein in innate immunity signal transduction. J. Immunol. 190, 3\u20134 (2013).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR24","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","volume":"34","author":"T Kawai","year":"2011","unstructured":"Kawai, T. & Akira, S. Toll-like receptors and their cross-talk with other innate receptors in infection and immunity. Immunity 34, 637\u2013650 (2011).","journal-title":"Immunity"},{"key":"BFnm4075_CR25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/ni.1715","volume":"10","author":"RL Reinhardt","year":"2009","unstructured":"Reinhardt, R.L., Liang, H.E. & Locksley, R.M. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10, 385\u2013393 (2009).","journal-title":"Nat. Immunol."},{"key":"BFnm4075_CR26","doi-asserted-by":"publisher","first-page":"e17739","DOI":"10.1371\/journal.pone.0017739","volume":"6","author":"D Eto","year":"2011","unstructured":"Eto, D. et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (TFH) differentiation. PLoS One 6, e17739 (2011).","journal-title":"PLoS One"},{"key":"BFnm4075_CR27","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1084\/jem.20111504","volume":"209","author":"A Karnowski","year":"2012","unstructured":"Karnowski, A. et al. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J. Exp. Med. 209, 2049\u20132064 (2012).","journal-title":"J. Exp. Med."},{"key":"BFnm4075_CR28","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/24884","volume":"396","author":"J de Rooij","year":"1998","unstructured":"de Rooij, J. et al. Epac is a Rap1 guanine-nucleotide exchange factor directly activated by cyclic AMP. Nature 396, 474\u2013477 (1998).","journal-title":"Nature"},{"key":"BFnm4075_CR29","doi-asserted-by":"publisher","first-page":"rs3","DOI":"10.1126\/scisignal.2003305","volume":"6","author":"N Warner","year":"2013","unstructured":"Warner, N. et al. A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-\u03baB signaling pathways. Sci. Signal. 6, rs3 (2013).","journal-title":"Sci. Signal."},{"key":"BFnm4075_CR30","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","volume":"4","author":"II Ivanov","year":"2008","unstructured":"Ivanov, I.I. et al. Specific microbiota direct the differentiation of IL-17-producing T helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337\u2013349 (2008).","journal-title":"Cell Host Microbe"},{"key":"BFnm4075_CR31","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/nm.2505","volume":"17","author":"N Shulzhenko","year":"2011","unstructured":"Shulzhenko, N. et al. Cross-talk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat. Med. 17, 1585\u20131593 (2011).","journal-title":"Nat. Med."},{"key":"BFnm4075_CR32","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.immuni.2012.04.011","volume":"37","author":"MC Abt","year":"2012","unstructured":"Abt, M.C. et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 37, 158\u2013170 (2012).","journal-title":"Immunity"},{"key":"BFnm4075_CR33","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nature07008","volume":"453","author":"SK Mazmanian","year":"2008","unstructured":"Mazmanian, S.K., Round, J.L. & Kasper, D.L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453, 620\u2013625 (2008).","journal-title":"Nature"},{"key":"BFnm4075_CR34","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/0006-291X(74)90458-6","volume":"59","author":"F Ellouz","year":"1974","unstructured":"Ellouz, F., Adam, A., Ciorbaru, R. & Lederer, E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem. Biophys. Res. Commun. 59, 1317\u20131325 (1974).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnm4075_CR35","doi-asserted-by":"publisher","first-page":"14896","DOI":"10.1073\/pnas.1015063108","volume":"108","author":"JG Magalhaes","year":"2011","unstructured":"Magalhaes, J.G. et al. Nucleotide-oligomerization-domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc. Natl. Acad. Sci. USA 108, 14896\u201314901 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm4075_CR36","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.jaci.2010.09.021","volume":"126","author":"W Duan","year":"2010","unstructured":"Duan, W. et al. Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation. J. Allergy Clin. Immunol. 126, 1284\u20131293.e10 (2010).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFnm4075_CR37","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/icb.2009.64","volume":"87","author":"CS Ma","year":"2009","unstructured":"Ma, C.S. et al. Early commitment of naive human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL-12. Immunol. Cell Biol. 87, 590\u2013600 (2009).","journal-title":"Immunol. Cell Biol."},{"key":"BFnm4075_CR38","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.immuni.2009.04.016","volume":"31","author":"N Schmitt","year":"2009","unstructured":"Schmitt, N. et al. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 31, 158\u2013169 (2009).","journal-title":"Immunity"},{"key":"BFnm4075_CR39","doi-asserted-by":"publisher","first-page":"532","DOI":"10.4161\/hv.6.7.11278","volume":"6","author":"V Jiang","year":"2010","unstructured":"Jiang, V., Jiang, B., Tate, J., Parashar, U.D. & Patel, M.M. Performance of rotavirus vaccines in developed and developing countries. Hum. Vaccin. 6, 532\u2013542 (2010).","journal-title":"Hum. Vaccin."},{"key":"BFnm4075_CR40","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1741-7007-8-129","volume":"8","author":"MM Levine","year":"2010","unstructured":"Levine, M.M. Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine. BMC Biol. 8, 129 (2010).","journal-title":"BMC Biol."},{"key":"BFnm4075_CR41","doi-asserted-by":"publisher","first-page":"e41720","DOI":"10.1371\/journal.pone.0041720","volume":"7","author":"BA Lopman","year":"2012","unstructured":"Lopman, B.A. et al. Understanding reduced rotavirus vaccine efficacy in low socio-economic settings. PLoS One 7, e41720 (2012).","journal-title":"PLoS One"},{"key":"BFnm4075_CR42","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1086\/605330","volume":"200","author":"NC Grassly","year":"2009","unstructured":"Grassly, N.C. et al. Mucosal immunity after vaccination with monovalent and trivalent oral poliovirus vaccine in India. J. Infect. Dis. 200, 794\u2013801 (2009).","journal-title":"J. Infect. Dis."},{"key":"BFnm4075_CR43","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1128\/CVI.00321-12","volume":"19","author":"RA Johnson","year":"2012","unstructured":"Johnson, R.A. et al. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Clin. Vaccine Immunol. 19, 1712\u20131721 (2012).","journal-title":"Clin. Vaccine Immunol."},{"key":"BFnm4075_CR44","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1128\/CVI.05124-11","volume":"18","author":"DT Leung","year":"2011","unstructured":"Leung, D.T. et al. Comparison of memory B cell, antibody-secreting cell and plasma antibody responses in young children, older children and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Clin. Vaccine Immunol. 18, 1317\u20131325 (2011).","journal-title":"Clin. Vaccine Immunol."},{"key":"BFnm4075_CR45","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature11053","volume":"486","author":"T Yatsunenko","year":"2012","unstructured":"Yatsunenko, T. et al. Human gut microbiome viewed across age and geography. Nature 486, 222\u2013227 (2012).","journal-title":"Nature"},{"key":"BFnm4075_CR46","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.molmed.2012.04.007","volume":"18","author":"PS Korpe","year":"2012","unstructured":"Korpe, P.S. & Petri, W.A. Jr. Environmental enteropathy: critical implications of a poorly understood condition. Trends Mol. Med. 18, 328\u2013336 (2012).","journal-title":"Trends Mol. Med."},{"key":"BFnm4075_CR47","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.4049\/jimmunol.1300678","volume":"191","author":"KS Chattha","year":"2013","unstructured":"Chattha, K.S., Vlasova, A.N., Kandasamy, S., Rajashekara, G. & Saif, L.J. Divergent immunomodulating effects of probiotics on T cell responses to oral attenuated human rotavirus vaccine and virulent human rotavirus infection in a neonatal gnotobiotic piglet disease model. J. Immunol. 191, 2446\u20132456 (2013).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR48","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.immuni.2014.08.009","volume":"41","author":"JZ Oh","year":"2014","unstructured":"Oh, J.Z. et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity 41, 478\u2013492 (2014).","journal-title":"Immunity"},{"key":"BFnm4075_CR49","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1159\/000218119","volume":"150","author":"D Kim","year":"2009","unstructured":"Kim, D. et al. Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int. Arch. Allergy Immunol. 150, 164\u2013171 (2009).","journal-title":"Int. Arch. Allergy Immunol."},{"key":"BFnm4075_CR50","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1046\/j.1365-3083.1997.d01-159.x","volume":"46","author":"HY Wu","year":"1997","unstructured":"Wu, H.Y., Nguyen, H.H. & Russell, M.W. Nasal lymphoid tissue (NALT) as a mucosal immune-inductive site. Scand. J. Immunol. 46, 506\u2013513 (1997).","journal-title":"Scand. J. Immunol."},{"key":"BFnm4075_CR51","doi-asserted-by":"publisher","first-page":"792","DOI":"10.4049\/jimmunol.0900173","volume":"183","author":"L Franchi","year":"2009","unstructured":"Franchi, L., Eigenbrod, T. & N\u00fa\u00f1ez, G. Cutting edge: TNF-\u03b1 mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J. Immunol. 183, 792\u2013796 (2009).","journal-title":"J. Immunol."},{"key":"BFnm4075_CR52","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1128\/IAI.01043-09","volume":"78","author":"M Hasegawa","year":"2010","unstructured":"Hasegawa, M. et al. Transitions in oral and intestinal microflora composition and innate-immune-receptor-dependent stimulation during mouse development. Infect. Immun. 78, 639\u2013650 (2010).","journal-title":"Infect. Immun."},{"key":"BFnm4075_CR53","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.1172\/JCI43918","volume":"120","author":"C Ubeda","year":"2010","unstructured":"Ubeda, C. et al. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J. Clin. Invest. 120, 4332\u20134341 (2010).","journal-title":"J. Clin. Invest."}],"updated-by":[{"DOI":"10.1038\/nm0816-961","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T00:00:00Z","timestamp":1470268800000}}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nm.4075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.4075","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.4075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:34:55Z","timestamp":1692286495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.4075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,11]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["BFnm4075"],"URL":"https:\/\/doi.org\/10.1038\/nm.4075","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/nm0816-961","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,11]]},"assertion":[{"value":"17 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2016","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Corrigendum","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the version of this article initially published, Mathias Chamaillard was inadvertently omitted from the list of authors and from the Author Contributions section. The error has been corrected in the HTML and PDF versions of the article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}