{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:12:15Z","timestamp":1792087935114,"version":"4.4.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/nm.4097","type":"journal-article","created":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T11:38:21Z","timestamp":1462189101000},"page":"672-678","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":352,"title":["Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins"],"prefix":"10.1038","volume":"22","author":[{"given":"Stanley Chun-Wei","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-0738","authenticated-orcid":false,"given":"Heidi","family":"Dvinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Micol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Rock","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Yoshimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-4921","authenticated-orcid":false,"given":"Camille","family":"Lobry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Krivtsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Palacino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Buonamici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-1063","authenticated-orcid":false,"given":"Robert K","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abdel-Wahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"BFnm4097_CR1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature10496","volume":"478","author":"K Yoshida","year":"2011","unstructured":"Yoshida, K. et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478, 64\u201369 (2011).","journal-title":"Nature"},{"key":"BFnm4097_CR2","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1056\/NEJMoa1103283","volume":"365","author":"E Papaemmanuil","year":"2011","unstructured":"Papaemmanuil, E. et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N. Engl. J. Med. 365, 1384\u20131395 (2011).","journal-title":"N. Engl. J. Med."},{"key":"BFnm4097_CR3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ng.1031","volume":"44","author":"TA Graubert","year":"2012","unstructured":"Graubert, T.A. et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat. Genet. 44, 53\u201357 (2012).","journal-title":"Nat. Genet."},{"key":"BFnm4097_CR4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ccell.2015.04.008","volume":"27","author":"CL Shirai","year":"2015","unstructured":"Shirai, C.L. et al. Mutant U2AF1 expression alters hematopoiesis and pre-mRNA splicing in vivo. Cancer Cell 27, 631\u2013643 (2015).","journal-title":"Cancer Cell"},{"key":"BFnm4097_CR5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ccell.2015.04.006","volume":"27","author":"E Kim","year":"2015","unstructured":"Kim, E. et al. SRSF2 mutations contribute to myelodysplasia by mutant-specific effects on exon recognition. Cancer Cell 27, 617\u2013630 (2015).","journal-title":"Cancer Cell"},{"key":"BFnm4097_CR6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1101\/gr.181016.114","volume":"25","author":"JO Ilagan","year":"2015","unstructured":"Ilagan, J.O. et al. U2AF1 mutations alter splice site recognition in hematological malignancies. Genome Res. 25, 14\u201326 (2015).","journal-title":"Genome Res."},{"key":"BFnm4097_CR7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1101\/gad.2009411","volume":"25","author":"EG Folco","year":"2011","unstructured":"Folco, E.G., Coil, K.E. & Reed, R. The antitumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region. Genes Dev. 25, 440\u2013444 (2011).","journal-title":"Genes Dev."},{"key":"BFnm4097_CR8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nchembio.2007.16","volume":"3","author":"Y Kotake","year":"2007","unstructured":"Kotake, Y. et al. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat. Chem. Biol. 3, 570\u2013575 (2007).","journal-title":"Nat. Chem. Biol."},{"key":"BFnm4097_CR9","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1182\/blood-2014-11-610543","volume":"125","author":"RC Lindsley","year":"2015","unstructured":"Lindsley, R.C. et al. Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Blood 125, 1367\u20131376 (2015).","journal-title":"Blood"},{"key":"BFnm4097_CR10","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1056\/NEJMc1500684","volume":"372","author":"G Genovese","year":"2015","unstructured":"Genovese, G., Jaiswal, S., Ebert, B.L. & McCarroll, S.A. Clonal hematopoiesis and blood-cancer risk. N. Engl. J. Med. 372, 1071\u20131072 (2015).","journal-title":"N. Engl. J. Med."},{"key":"BFnm4097_CR11","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","volume":"20","author":"M Xie","year":"2014","unstructured":"Xie, M. et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20, 1472\u20131478 (2014).","journal-title":"Nat. Med."},{"key":"BFnm4097_CR12","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","volume":"371","author":"G Genovese","year":"2014","unstructured":"Genovese, G. et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371, 2477\u20132487 (2014).","journal-title":"N. Engl. J. Med."},{"key":"BFnm4097_CR13","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nmeth.1528","volume":"7","author":"Y Katz","year":"2010","unstructured":"Katz, Y., Wang, E.T., Airoldi, E.M. & Burge, C.B. Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nat. Methods 7, 1009\u20131015 (2010).","journal-title":"Nat. Methods"},{"key":"BFnm4097_CR14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cogpsych.2009.12.001","volume":"60","author":"EJ Wagenmakers","year":"2010","unstructured":"Wagenmakers, E.J., Lodewyckx, T., Kuriyal, H. & Grasman, R. Bayesian hypothesis testing for psychologists: a tutorial on the Savage\u2013Dickey method. Cognit. Psychol. 60, 158\u2013189 (2010).","journal-title":"Cognit. Psychol."},{"key":"BFnm4097_CR15","doi-asserted-by":"crossref","first-page":"E4726","DOI":"10.1073\/pnas.1514105112","volume":"112","author":"J Zhang","year":"2015","unstructured":"Zhang, J. et al. Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities. Proc. Natl. Acad. Sci. USA 112, E4726\u2013E4734 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm4097_CR16","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/ng.3371","volume":"47","author":"VP Lavall\u00e9e","year":"2015","unstructured":"Lavall\u00e9e, V.P. et al. The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias. Nat. Genet. 47, 1030\u20131037 (2015).","journal-title":"Nat. Genet."},{"key":"BFnm4097_CR17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ccr.2011.06.009","volume":"20","author":"SR Daigle","year":"2011","unstructured":"Daigle, S.R. et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 20, 53\u201365 (2011).","journal-title":"Cancer Cell"},{"key":"BFnm4097_CR18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2011.06.010","volume":"20","author":"KM Bernt","year":"2011","unstructured":"Bernt, K.M. et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 20, 66\u201378 (2011).","journal-title":"Cancer Cell"},{"key":"BFnm4097_CR19","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1111\/j.1742-4658.2011.08387.x","volume":"278","author":"A Yokoi","year":"2011","unstructured":"Yokoi, A. et al. Biological validation that SF3b is a target of the antitumor macrolide pladienolide. FEBS J. 278, 4870\u20134880 (2011).","journal-title":"FEBS J."},{"key":"BFnm4097_CR20","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1182\/blood-2013-08-518886","volume":"122","author":"E Papaemmanuil","year":"2013","unstructured":"Papaemmanuil, E. et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood 122, 3616\u20133627, quiz 3699 (2013).","journal-title":"Blood"},{"key":"BFnm4097_CR21","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1200\/JCO.2011.40.7379","volume":"30","author":"R Bejar","year":"2012","unstructured":"Bejar, R. et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J. Clin. Oncol. 30, 3376\u20133382 (2012).","journal-title":"J. Clin. Oncol."},{"key":"BFnm4097_CR22","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1182\/blood-2011-11-390252","volume":"119","author":"SJ Zhang","year":"2012","unstructured":"Zhang, S.J. et al. Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome. Blood 119, 4480\u20134485 (2012).","journal-title":"Blood"},{"key":"BFnm4097_CR23","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/leu.2013.119","volume":"27","author":"AM Vannucchi","year":"2013","unstructured":"Vannucchi, A.M. et al. Mutations and prognosis in primary myelofibrosis. Leukemia 27, 1861\u20131869 (2013).","journal-title":"Leukemia"},{"key":"BFnm4097_CR24","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1261\/rna.053108.115","volume":"22","author":"KA Effenberger","year":"2016","unstructured":"Effenberger, K.A., Urabe, V.K., Prichard, B.E., Ghosh, A.K. & Jurica, M.S. Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages. RNA 22, 350\u2013359 (2016).","journal-title":"RNA"},{"key":"BFnm4097_CR25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrd3823","volume":"11","author":"S Bonnal","year":"2012","unstructured":"Bonnal, S., Vigevani, L. & Valc\u00e1rcel, J. The spliceosome as a target of novel antitumor drugs. Nat. Rev. Drug Discov. 11, 847\u2013859 (2012).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFnm4097_CR26","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1158\/1078-0432.CCR-13-0485","volume":"19","author":"FA Eskens","year":"2013","unstructured":"Eskens, F.A. et al. Phase 1 pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors. Clin. Cancer Res. 19, 6296\u20136304 (2013).","journal-title":"Clin. Cancer Res."},{"key":"BFnm4097_CR27","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s10637-013-0046-5","volume":"32","author":"DS Hong","year":"2014","unstructured":"Hong, D.S. et al. A phase 1, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor, administered intravenously on days 1 and 8 every 21 days to patients with solid tumors. Invest. New Drugs 32, 436\u2013444 (2014).","journal-title":"Invest. New Drugs"},{"key":"BFnm4097_CR28","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1093\/bioinformatics\/btv034","volume":"31","author":"Y Katz","year":"2015","unstructured":"Katz, Y. et al. Quantitative visualization of alternative exon expression from RNA-seq data. Bioinformatics 31, 2400\u20132402 (2015).","journal-title":"Bioinformatics"},{"key":"BFnm4097_CR29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","volume":"14","author":"H Thorvaldsd\u00f3ttir","year":"2013","unstructured":"Thorvaldsd\u00f3ttir, H., Robinson, J.T. & Mesirov, J.P. Integrative genomics viewer (IGV): high-performance genomics data visualization and exploration. Brief. Bioinform. 14, 178\u2013192 (2013).","journal-title":"Brief. Bioinform."},{"key":"BFnm4097_CR30","unstructured":"National Research Council. Guide for the Care and Use of Laboratory Animals 8th edn. (The National Academies Press, 2011)."},{"key":"BFnm4097_CR31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1097-2765(01)00181-2","volume":"7","author":"HY Wang","year":"2001","unstructured":"Wang, H.Y., Xu, X., Ding, J.H., Bermingham, J.R. Jr. & Fu, X.D. SC35 plays a role in T cell development and alternative splicing of CD45. Mol. Cell 7, 331\u2013342 (2001).","journal-title":"Mol. Cell"},{"key":"BFnm4097_CR32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/gene.10161","volume":"34","author":"P Georgiades","year":"2002","unstructured":"Georgiades, P. et al. Vav-Cre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages. Genesis 34, 251\u2013256 (2002).","journal-title":"Genesis"},{"key":"BFnm4097_CR33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","volume":"17","author":"DT Cheng","year":"2015","unstructured":"Cheng, D.T. et al. Memorial Sloan Kettering\u2013integrated mutation profiling of actionable cancer targets (MSK-IMPACT): a hybridization-capture-based next-generation sequencing clinical assay for solid tumor molecular oncology. J. Mol. Diagn. 17, 251\u2013264 (2015).","journal-title":"J. Mol. Diagn."},{"key":"BFnm4097_CR34","doi-asserted-by":"crossref","first-page":"D64","DOI":"10.1093\/nar\/gks1048","volume":"41","author":"LR Meyer","year":"2013","unstructured":"Meyer, L.R. et al. The UCSC Genome Browser database: extensions and updates 2013. Nucleic Acids Res. 41, D64\u2013D69 (2013).","journal-title":"Nucleic Acids Res."},{"key":"BFnm4097_CR35","doi-asserted-by":"crossref","first-page":"D48","DOI":"10.1093\/nar\/gks1236","volume":"41","author":"P Flicek","year":"2013","unstructured":"Flicek, P. et al. Ensembl 2013. Nucleic Acids Res. 41, D48\u2013D55 (2013).","journal-title":"Nucleic Acids Res."},{"key":"BFnm4097_CR36","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1101\/gad.212548.112","volume":"27","author":"CG Hubert","year":"2013","unstructured":"Hubert, C.G. et al. Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. Genes Dev. 27, 1032\u20131045 (2013).","journal-title":"Genes Dev."},{"key":"BFnm4097_CR37","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","volume":"10","author":"B Langmead","year":"2009","unstructured":"Langmead, B., Trapnell, C., Pop, M. & Salzberg, S.L. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).","journal-title":"Genome Biol."},{"key":"BFnm4097_CR38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li, B. & Dewey, C.N. RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).","journal-title":"BMC Bioinformatics"},{"key":"BFnm4097_CR39","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).","journal-title":"Genome Biol."},{"key":"BFnm4097_CR40","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell, C., Pachter, L. & Salzberg, S.L. TopHat: discovering splice junctions with RNA-seq. Bioinformatics 25, 1105\u20131111 (2009).","journal-title":"Bioinformatics"},{"key":"BFnm4097_CR41","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","volume":"11","author":"MD Robinson","year":"2010","unstructured":"Robinson, M.D. & Oshlack, A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 11, R25 (2010).","journal-title":"Genome Biol."},{"key":"BFnm4097_CR42","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","volume":"11","author":"MD Young","year":"2010","unstructured":"Young, M.D., Wakefield, M.J., Smyth, G.K. & Oshlack, A. Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol. 11, R14 (2010).","journal-title":"Genome Biol."},{"key":"BFnm4097_CR43","doi-asserted-by":"crossref","first-page":"bar041","DOI":"10.1093\/database\/bar041","volume":"2011","author":"JM Guberman","year":"2011","unstructured":"Guberman, J.M. et al. BioMart central portal: an open database network for the biological community. Database 2011, bar041 (2011).","journal-title":"Database"}],"updated-by":[{"DOI":"10.1038\/nm0616-692d","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:00:00Z","timestamp":1465257600000}}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.4097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.4097","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.4097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:56:53Z","timestamp":1684436213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.4097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,2]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFnm4097"],"URL":"https:\/\/doi.org\/10.1038\/nm.4097","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726325845.793520962","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726325845.793549682","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,2]]},"assertion":[{"value":"2 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Erratum","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the version of this article initially published online, the graphs in Figure 3b\u2013d were laid out incorrectly and were not consistent with the figure legend and text. The error has been corrected for the print, PDF and HTML versions of this article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.T., J.P., S.B., and P.G.S. are employees of H3 Biomedicine, Inc.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}