{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:17:28Z","timestamp":1791206248790,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/nm.4315","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T15:07:20Z","timestamp":1492441640000},"page":"601-610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet"],"prefix":"10.1038","volume":"23","author":[{"given":"Meritxell","family":"Nus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P","family":"Sage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-9025","authenticated-orcid":false,"given":"Brian Y H","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Newland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsiantoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Raffort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00ebnne","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Finigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichola","family":"Figg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Schirmbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Kneilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles S H","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"de la Pompa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-7878","authenticated-orcid":false,"given":"Ziad","family":"Mallat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"BFnm4315_CR1","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.immuni.2013.06.009","volume":"38","author":"P Libby","year":"2013","unstructured":"Libby, P., Lichtman, A.H. & Hansson, G.K. Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity 38, 1092\u20131104 (2013).","journal-title":"Immunity"},{"key":"BFnm4315_CR2","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/CIRCRESAHA.114.302761","volume":"114","author":"H Ait-Oufella","year":"2014","unstructured":"Ait-Oufella, H., Sage, A.P., Mallat, Z. & Tedgui, A. Adaptive (T and B cells) immunity and control by dendritic cells in atherosclerosis. Circ. Res. 114, 1640\u20131660 (2014).","journal-title":"Circ. Res."},{"key":"BFnm4315_CR3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3109\/07853890.2014.900272","volume":"46","author":"AP Sage","year":"2014","unstructured":"Sage, A.P. & Mallat, Z. Multiple potential roles for B cells in atherosclerosis. Ann. Med. 46, 297\u2013303 (2014).","journal-title":"Ann. Med."},{"key":"BFnm4315_CR4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1161\/ATVBAHA.114.303569","volume":"35","author":"D Tsiantoulas","year":"2015","unstructured":"Tsiantoulas, D., Sage, A.P., Mallat, Z. & Binder, C.J. Targeting B cells in atherosclerosis: closing the gap from bench to bedside. Arterioscler. Thromb. Vasc. Biol. 35, 296\u2013302 (2015).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnm4315_CR5","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1084\/jem.20100155","volume":"207","author":"H Ait-Oufella","year":"2010","unstructured":"Ait-Oufella, H. et al. B cell depletion reduces the development of atherosclerosis in mice. J. Exp. Med. 207, 1579\u20131587 (2010).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR6","doi-asserted-by":"publisher","first-page":"4410","DOI":"10.4049\/jimmunol.1000033","volume":"185","author":"T Kyaw","year":"2010","unstructured":"Kyaw, T. et al. Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis. J. Immunol. 185, 4410\u20134419 (2010).","journal-title":"J. Immunol."},{"key":"BFnm4315_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tcm.2012.06.011","volume":"22","author":"T Kyaw","year":"2012","unstructured":"Kyaw, T., Tipping, P., Bobik, A. & Toh, B.H. Protective role of natural IgM-producing B1a cells in atherosclerosis. Trends Cardiovasc. Med. 22, 48\u201353 (2012).","journal-title":"Trends Cardiovasc. Med."},{"key":"BFnm4315_CR8","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1161\/ATVBAHA.111.244731","volume":"32","author":"AP Sage","year":"2012","unstructured":"Sage, A.P. et al. BAFF receptor deficiency reduces the development of atherosclerosis in mice\u2014brief report. Arterioscler. Thromb. Vasc. Biol. 32, 1573\u20131576 (2012).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnm4315_CR9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/imr.12176","volume":"259","author":"KM Candando","year":"2014","unstructured":"Candando, K.M., Lykken, J.M. & Tedder, T.F. B10 cell regulation of health and disease. Immunol. Rev. 259, 259\u2013272 (2014).","journal-title":"Immunol. Rev."},{"key":"BFnm4315_CR10","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.immuni.2015.04.005","volume":"42","author":"EC Rosser","year":"2015","unstructured":"Rosser, E.C. & Mauri, C. Regulatory B cells: origin, phenotype, and function. Immunity 42, 607\u2013612 (2015).","journal-title":"Immunity"},{"key":"BFnm4315_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.coi.2014.02.009","volume":"28","author":"VD Dang","year":"2014","unstructured":"Dang, V.D., Hilgenberg, E., Ries, S., Shen, P. & Fillatreau, S. From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets. Curr. Opin. Immunol. 28, 77\u201383 (2014).","journal-title":"Curr. Opin. Immunol."},{"key":"BFnm4315_CR12","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1161\/ATVBAHA.115.305568","volume":"35","author":"AP Sage","year":"2015","unstructured":"Sage, A.P. et al. Regulatory B cell\u2013specific interleukin-10 is dispensable for atherosclerosis development in mice. Arterioscler. Thromb. Vasc. Biol. 35, 1770\u20131773 (2015).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnm4315_CR13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1160\/TH14-12-1084","volume":"114","author":"AC Strom","year":"2015","unstructured":"Strom, A.C. et al. B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10. Thromb. Haemost. 114, 835\u2013847 (2015).","journal-title":"Thromb. Haemost."},{"key":"BFnm4315_CR14","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nri2656","volume":"9","author":"S Pillai","year":"2009","unstructured":"Pillai, S. & Cariappa, A. The follicular versus marginal zone B lymphocyte cell fate decision. Nat. Rev. Immunol. 9, 767\u2013777 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm4315_CR15","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.114.010988","volume":"131","author":"M Clement","year":"2015","unstructured":"Clement, M. et al. Control of the T follicular helper\u2013germinal center B-cell axis by CD8+ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development. Circulation 131, 560\u2013570 (2015).","journal-title":"Circulation"},{"key":"BFnm4315_CR16","doi-asserted-by":"publisher","first-page":"E2030","DOI":"10.1073\/pnas.1421227112","volume":"112","author":"EK Grasset","year":"2015","unstructured":"Grasset, E.K. et al. Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response. Proc. Natl. Acad. Sci. USA 112, E2030\u2013E2038 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm4315_CR17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S1074-7613(03)00111-0","volume":"18","author":"T Saito","year":"2003","unstructured":"Saito, T. et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18, 675\u2013685 (2003).","journal-title":"Immunity"},{"key":"BFnm4315_CR18","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/ni793","volume":"3","author":"K Tanigaki","year":"2002","unstructured":"Tanigaki, K. et al. Notch\u2013RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat. Immunol. 3, 443\u2013450 (2002).","journal-title":"Nat. Immunol."},{"key":"BFnm4315_CR19","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.4049\/jimmunol.171.6.2783","volume":"171","author":"CM Witt","year":"2003","unstructured":"Witt, C.M., Won, W.J., Hurez, V. & Klug, C.A. Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J. Immunol. 171, 2783\u20132788 (2003).","journal-title":"J. Immunol."},{"key":"BFnm4315_CR20","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1084\/jem.20111202","volume":"209","author":"ES Gold","year":"2012","unstructured":"Gold, E.S. et al. ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. J. Exp. Med. 209, 807\u2013817 (2012).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nature04768","volume":"441","author":"M Gilchrist","year":"2006","unstructured":"Gilchrist, M. et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441, 173\u2013178 (2006).","journal-title":"Nature"},{"key":"BFnm4315_CR22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ni.2784","volume":"15","author":"D De Nardo","year":"2014","unstructured":"De Nardo, D. et al. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat. Immunol. 15, 152\u2013160 (2014).","journal-title":"Nat. Immunol."},{"key":"BFnm4315_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nm.2557","volume":"18","author":"W Hoetzenecker","year":"2011","unstructured":"Hoetzenecker, W. et al. ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat. Med. 18, 128\u2013134 (2011).","journal-title":"Nat. Med."},{"key":"BFnm4315_CR24","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/mnfr.201300104","volume":"58","author":"M Herieka","year":"2014","unstructured":"Herieka, M. & Erridge, C. High-fat meal induced postprandial inflammation. Mol. Nutr. Food Res. 58, 136\u2013146 (2014).","journal-title":"Mol. Nutr. Food Res."},{"key":"BFnm4315_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/ni.1877","volume":"11","author":"KL Good-Jacobson","year":"2010","unstructured":"Good-Jacobson, K.L. et al. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat. Immunol. 11, 535\u2013542 (2010).","journal-title":"Nat. Immunol."},{"key":"BFnm4315_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/ni1542","volume":"9","author":"G Cinamon","year":"2008","unstructured":"Cinamon, G., Zachariah, M.A., Lam, O.M., Foss, F.W. Jr. & Cyster, J.G. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat. Immunol. 9, 54\u201362 (2008).","journal-title":"Nat. Immunol."},{"key":"BFnm4315_CR27","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/intimm\/dxq047","volume":"22","author":"JP Pereira","year":"2010","unstructured":"Pereira, J.P., Kelly, L.M. & Cyster, J.G. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int. Immunol. 22, 413\u2013419 (2010).","journal-title":"Int. Immunol."},{"key":"BFnm4315_CR28","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nri3755","volume":"14","author":"JG Cyster","year":"2014","unstructured":"Cyster, J.G., Dang, E.V., Reboldi, A. & Yi, T. 25-Hydroxycholesterols in innate and adaptive immunity. Nat. Rev. Immunol. 14, 731\u2013743 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm4315_CR29","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1084\/jem.20120994","volume":"209","author":"CS Ma","year":"2012","unstructured":"Ma, C.S., Deenick, E.K., Batten, M. & Tangye, S.G. The origins, function, and regulation of T follicular helper cells. J. Exp. Med. 209, 1241\u20131253 (2012).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR30","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1084\/jem.20121416","volume":"210","author":"BH Zinselmeyer","year":"2013","unstructured":"Zinselmeyer, B.H. et al. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J. Exp. Med. 210, 757\u2013774 (2013).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR31","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.immunol.021908.132607","volume":"27","author":"JC Weill","year":"2009","unstructured":"Weill, J.C., Weller, S. & Reynaud, C.A. Human marginal zone B cells. Annu. Rev. Immunol. 27, 267\u2013285 (2009).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm4315_CR32","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1084\/jem.20132203","volume":"211","author":"M Descatoire","year":"2014","unstructured":"Descatoire, M. et al. Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties. J. Exp. Med. 211, 987\u20131000 (2014).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR33","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1084\/jem.20091777","volume":"207","author":"D Zotos","year":"2010","unstructured":"Zotos, D. et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell\u2013intrinsic mechanism. J. Exp. Med. 207, 365\u2013378 (2010).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.immuni.2015.01.013","volume":"42","author":"JY Lee","year":"2015","unstructured":"Lee, J.Y. et al. The transcription factor KLF2 restrains CD4+ T follicular helper cell differentiation. Immunity 42, 252\u2013264 (2015).","journal-title":"Immunity"},{"key":"BFnm4315_CR35","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1084\/jem.20131666","volume":"211","author":"S Moriyama","year":"2014","unstructured":"Moriyama, S. et al. Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers. J. Exp. Med. 211, 1297\u20131305 (2014).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1084\/jem.20141432","volume":"212","author":"JP Weber","year":"2015","unstructured":"Weber, J.P. et al. ICOS maintains the T follicular helper cell phenotype by down-regulating Kr\u00fcppel-like factor 2. J. Exp. Med. 212, 217\u2013233 (2015).","journal-title":"J. Exp. Med."},{"key":"BFnm4315_CR37","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.4049\/jimmunol.1103246","volume":"188","author":"MA Kroenke","year":"2012","unstructured":"Kroenke, M.A. et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J. Immunol. 188, 3734\u20133744 (2012).","journal-title":"J. Immunol."},{"key":"BFnm4315_CR38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature12910","volume":"507","author":"X Liu","year":"2014","unstructured":"Liu, X. et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature 507, 513\u2013518 (2014).","journal-title":"Nature"},{"key":"BFnm4315_CR39","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.immuni.2011.03.023","volume":"34","author":"YS Choi","year":"2011","unstructured":"Choi, Y.S. et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34, 932\u2013946 (2011).","journal-title":"Immunity"},{"key":"BFnm4315_CR40","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.4049\/jimmunol.1500999","volume":"197","author":"SY Soh","year":"2016","unstructured":"Soh, S.Y. et al. NKT cell hyporesponsiveness leads to unrestrained accumulation of marginal zone B cells in hypercholesterolemic apolipoprotein E\u2013deficient mice. J. Immunol. 197, 3894\u20133904 (2016).","journal-title":"J. Immunol."},{"key":"BFnm4315_CR41","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1038\/nm.3680","volume":"20","author":"EC Rosser","year":"2014","unstructured":"Rosser, E.C. et al. Regulatory B cells are induced by gut microbiota\u2013driven interleukin-1\u03b2 and interleukin-6 production. Nat. Med. 20, 1334\u20131339 (2014).","journal-title":"Nat. Med."},{"key":"BFnm4315_CR42","doi-asserted-by":"publisher","first-page":"22328","DOI":"10.1074\/jbc.M110.123299","volume":"285","author":"AJ Bankovich","year":"2010","unstructured":"Bankovich, A.J., Shiow, L.R. & Cyster, J.G. CD69 suppresses sphingosine 1\u2013phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. J. Biol. Chem. 285, 22328\u201322337 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnm4315_CR43","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature10280","volume":"475","author":"S Hannedouche","year":"2011","unstructured":"Hannedouche, S. et al. Oxysterols direct immune cell migration via EBI2. Nature 475, 524\u2013527 (2011).","journal-title":"Nature"},{"key":"BFnm4315_CR44","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature10226","volume":"475","author":"C Liu","year":"2011","unstructured":"Liu, C. et al. Oxysterols direct B-cell migration through EBI2. Nature 475, 519\u2013523 (2011).","journal-title":"Nature"},{"key":"BFnm4315_CR45","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature12058","volume":"496","author":"H Xu","year":"2013","unstructured":"Xu, H. et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496, 523\u2013527 (2013).","journal-title":"Nature"},{"key":"BFnm4315_CR46","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.1172\/JCI31344","volume":"117","author":"I Gotsman","year":"2007","unstructured":"Gotsman, I. et al. Proatherogenic immune responses are regulated by the PD-1\/PD-L pathway in mice. J. Clin. Invest. 117, 2974\u20132982 (2007).","journal-title":"J. Clin. Invest."},{"key":"BFnm4315_CR47","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1161\/ATVBAHA.111.224709","volume":"31","author":"DX Bu","year":"2011","unstructured":"Bu, D.X. et al. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler. Thromb. Vasc. Biol. 31, 1100\u20131107 (2011).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnm4315_CR48","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1038\/ncomms6997","volume":"6","author":"AR Khan","year":"2015","unstructured":"Khan, A.R. et al. PD-L1hi B cells are critical regulators of humoral immunity. Nat. Commun. 6, 5997 (2015).","journal-title":"Nat. Commun."},{"key":"BFnm4315_CR49","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1126\/science.1175870","volume":"325","author":"RJ Johnston","year":"2009","unstructured":"Johnston, R.J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006\u20131010 (2009).","journal-title":"Science"},{"key":"BFnm4315_CR50","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ni.2496","volume":"14","author":"PT Sage","year":"2013","unstructured":"Sage, P.T., Francisco, L.M., Carman, C.V. & Sharpe, A.H. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat. Immunol. 14, 152\u2013161 (2013).","journal-title":"Nat. Immunol."},{"key":"BFnm4315_CR51","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S1074-7613(04)00050-0","volume":"20","author":"H Dong","year":"2004","unstructured":"Dong, H. et al. B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes. Immunity 20, 327\u2013336 (2004).","journal-title":"Immunity"},{"key":"BFnm4315_CR52","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1128\/MCB.24.13.5721-5732.2004","volume":"24","author":"MG Hartman","year":"2004","unstructured":"Hartman, M.G. et al. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol. Cell. Biol. 24, 5721\u20135732 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm4315_CR53","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/nm876","volume":"9","author":"CJ Binder","year":"2003","unstructured":"Binder, C.J. et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat. Med. 9, 736\u2013743 (2003).","journal-title":"Nat. Med."},{"key":"BFnm4315_CR54","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1172\/JCI36800","volume":"119","author":"MY Chou","year":"2009","unstructured":"Chou, M.Y. et al. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J. Clin. Invest. 119, 1335\u20131349 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFnm4315_CR55","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).","journal-title":"Genome Biol."},{"key":"BFnm4315_CR56","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nbt.2450","volume":"31","author":"C Trapnell","year":"2013","unstructured":"Trapnell, C. et al. Differential analysis of gene regulation at transcript resolution with RNA\u2013seq. Nat. Biotechnol. 31, 46\u201353 (2013).","journal-title":"Nat. Biotechnol."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm.4315.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm.4315","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nm.4315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nm.4315.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:01:13Z","timestamp":1684450873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.4315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFnm4315"],"URL":"https:\/\/doi.org\/10.1038\/nm.4315","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]},"assertion":[{"value":"4 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}