{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:14:06Z","timestamp":1789629246432,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1038\/nm.4470","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T16:03:21Z","timestamp":1515427401000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury"],"prefix":"10.1038","volume":"24","author":[{"given":"Enrico","family":"Velardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2842-4820","authenticated-orcid":false,"given":"Stefan","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon V","family":"Argyropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shieh","family":"Jae-Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren F","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Lazrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette M","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Kreines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Shono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Wertheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Jenq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-3634","authenticated-orcid":false,"given":"Alan M","family":"Hanash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm A","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Kiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel R M","family":"van den Brink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6220-5632","authenticated-orcid":false,"given":"Jarrod A","family":"Dudakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"BFnm4470_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0301-472X(02)00802-0","volume":"30","author":"N Dainiak","year":"2002","unstructured":"Dainiak, N. Hematologic consequences of exposure to ionizing radiation. Exp. Hematol. 30, 513\u2013528 (2002).","journal-title":"Exp. Hematol."},{"key":"BFnm4470_CR2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/00004032-200305000-00001","volume":"84","author":"GH Anno","year":"2003","unstructured":"Anno, G.H., Young, R.W., Bloom, R.M. & Mercier, J.R. Dose response relationships for acute ionizing-radiation lethality. Health Phys. 84, 565\u2013575 (2003).","journal-title":"Health Phys."},{"key":"BFnm4470_CR3","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1089\/scd.2014.0546","volume":"24","author":"K Mierzejewska","year":"2015","unstructured":"Mierzejewska, K. et al. Hematopoietic stem\/progenitor cells express several functional sex hormone receptors-novel evidence for a potential developmental link between hematopoiesis and primordial germ cells. Stem Cells Dev. 24, 927\u2013937 (2015).","journal-title":"Stem Cells Dev."},{"key":"BFnm4470_CR4","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.stem.2014.11.002","volume":"15","author":"A S\u00e1nchez-Aguilera","year":"2014","unstructured":"S\u00e1nchez-Aguilera, A. et al. Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell Stem Cell 15, 791\u2013804 (2014).","journal-title":"Cell Stem Cell"},{"key":"BFnm4470_CR5","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nature12932","volume":"505","author":"D Nakada","year":"2014","unstructured":"Nakada, D. et al. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature 505, 555\u2013558 (2014).","journal-title":"Nature"},{"key":"BFnm4470_CR6","doi-asserted-by":"publisher","first-page":"7084","DOI":"10.4049\/jimmunol.0900196","volume":"183","author":"JA Dudakov","year":"2009","unstructured":"Dudakov, J.A. et al. Sex steroid ablation enhances hematopoietic recovery following cytotoxic antineoplastic therapy in aged mice. J. Immunol. 183, 7084\u20137094 (2009).","journal-title":"J. Immunol."},{"key":"BFnm4470_CR7","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.stemcr.2015.01.018","volume":"4","author":"DM Khong","year":"2015","unstructured":"Khong, D.M. et al. Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade. Stem Cell Rep. 4, 445\u2013458 (2015).","journal-title":"Stem Cell Rep."},{"key":"BFnm4470_CR8","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1667\/RR1880.1","volume":"173","author":"JP Williams","year":"2010","unstructured":"Williams, J.P. et al. Animal models for medical countermeasures to radiation exposure. Radiat. Res. 173, 557\u2013578 (2010).","journal-title":"Radiat. Res."},{"key":"BFnm4470_CR9","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1259\/bjr\/16386034","volume":"85","author":"MI Koukourakis","year":"2012","unstructured":"Koukourakis, M.I. Radiation damage and radioprotectants: new concepts in the era of molecular medicine. Br. J. Radiol. 85, 313\u2013330 (2012).","journal-title":"Br. J. Radiol."},{"key":"BFnm4470_CR10","doi-asserted-by":"publisher","first-page":"6014","DOI":"10.4049\/jimmunol.0802445","volume":"184","author":"GL Goldberg","year":"2010","unstructured":"Goldberg, G.L. et al. Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice. J. Immunol. 184, 6014\u20136024 (2010).","journal-title":"J. Immunol."},{"key":"BFnm4470_CR11","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.4049\/jimmunol.0802446","volume":"182","author":"JA Dudakov","year":"2009","unstructured":"Dudakov, J.A., Goldberg, G.L., Reiseger, J.J., Chidgey, A.P. & Boyd, R.L. Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis. J. Immunol. 182, 6247\u20136260 (2009).","journal-title":"J. Immunol."},{"key":"BFnm4470_CR12","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1084\/jem.20131289","volume":"211","author":"E Velardi","year":"2014","unstructured":"Velardi, E. et al. Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. J. Exp. Med. 211, 2341\u20132349 (2014).","journal-title":"J. Exp. Med."},{"key":"BFnm4470_CR13","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1182\/blood.V82.8.2353.2353","volume":"82","author":"N Katayama","year":"1993","unstructured":"Katayama, N. et al. Stage-specific expression of c-kit protein by murine hematopoietic progenitors. Blood 82, 2353\u20132360 (1993).","journal-title":"Blood"},{"key":"BFnm4470_CR14","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.exphem.2004.07.015","volume":"32","author":"W Li","year":"2004","unstructured":"Li, W., Wang, G., Cui, J., Xue, L. & Cai, L. Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation. Exp. Hematol. 32, 1088\u20131096 (2004).","journal-title":"Exp. Hematol."},{"key":"BFnm4470_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/pbc.22004","volume":"53","author":"ML Meistrich","year":"2009","unstructured":"Meistrich, M.L. Male gonadal toxicity. Pediatr. Blood Cancer 53, 261\u2013266 (2009).","journal-title":"Pediatr. Blood Cancer"},{"key":"BFnm4470_CR16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1126\/science.1201219","volume":"333","author":"F Notta","year":"2011","unstructured":"Notta, F. et al. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 333, 218\u2013221 (2011).","journal-title":"Science"},{"key":"BFnm4470_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.mce.2013.12.009","volume":"383","author":"J Choi","year":"2014","unstructured":"Choi, J. & Smitz, J. Luteinizing hormone and human chorionic gonadotropin: origins of difference. Mol. Cell. Endocrinol. 383, 203\u2013213 (2014).","journal-title":"Mol. Cell. Endocrinol."},{"key":"BFnm4470_CR18","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/ncb2699","volume":"15","author":"JJ Tsai","year":"2013","unstructured":"Tsai, J.J. et al. Nrf2 regulates haematopoietic stem cell function. Nat. Cell Biol. 15, 309\u2013316 (2013).","journal-title":"Nat. Cell Biol."},{"key":"BFnm4470_CR19","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1182\/blood-2009-06-229443","volume":"115","author":"MG Kharas","year":"2010","unstructured":"Kharas, M.G. et al. Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice. Blood 115, 1406\u20131415 (2010).","journal-title":"Blood"},{"key":"BFnm4470_CR20","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1101\/gad.2024411","volume":"25","author":"YV Wang","year":"2011","unstructured":"Wang, Y.V. et al. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 25, 1426\u20131438 (2011).","journal-title":"Genes Dev."},{"key":"BFnm4470_CR21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1182\/blood-2005-04-1418","volume":"107","author":"Y Wang","year":"2006","unstructured":"Wang, Y., Schulte, B.A., LaRue, A.C., Ogawa, M. & Zhou, D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 107, 358\u2013366 (2006).","journal-title":"Blood"},{"key":"BFnm4470_CR22","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1126\/science.287.5459.1804","volume":"287","author":"T Cheng","year":"2000","unstructured":"Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1\/waf1. Science 287, 1804\u20131808 (2000).","journal-title":"Science"},{"key":"BFnm4470_CR23","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1172\/JCI41402","volume":"120","author":"SM Johnson","year":"2010","unstructured":"Johnson, S.M. et al. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4\/6 inhibition. J. Clin. Invest. 120, 2528\u20132536 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnm4470_CR24","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1084\/jem.20081297","volume":"205","author":"C Chen","year":"2008","unstructured":"Chen, C. et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397\u20132408 (2008).","journal-title":"J. Exp. Med."},{"key":"BFnm4470_CR25","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1172\/JCI76838","volume":"124","author":"HA Himburg","year":"2014","unstructured":"Himburg, H.A. et al. Pleiotrophin mediates hematopoietic regeneration via activation of RAS. J. Clin. Invest. 124, 4753\u20134758 (2014).","journal-title":"J. Clin. Invest."},{"key":"BFnm4470_CR26","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1210\/en.2007-0160","volume":"148","author":"K Shiraishi","year":"2007","unstructured":"Shiraishi, K. & Ascoli, M. Lutropin\/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1\/2 cascade. Endocrinology 148, 3214\u20133225 (2007).","journal-title":"Endocrinology"},{"key":"BFnm4470_CR27","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1210\/en.2012-2179","volume":"154","author":"SR McGee","year":"2013","unstructured":"McGee, S.R. & Narayan, P. Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene. Endocrinology 154, 3900\u20133913 (2013).","journal-title":"Endocrinology"},{"key":"BFnm4470_CR28","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1084\/jem.20121610","volume":"210","author":"F Brenet","year":"2013","unstructured":"Brenet, F., Kermani, P., Spektor, R., Rafii, S. & Scandura, J.M. TGF\u03b2 restores hematopoietic homeostasis after myelosuppressive chemotherapy. J. Exp. Med. 210, 623\u2013639 (2013).","journal-title":"J. Exp. Med."},{"key":"BFnm4470_CR29","doi-asserted-by":"publisher","first-page":"9464","DOI":"10.1073\/pnas.89.20.9464","volume":"89","author":"KM Zsebo","year":"1992","unstructured":"Zsebo, K.M. et al. Radioprotection of mice by recombinant rat stem cell factor. Proc. Natl. Acad. Sci. USA 89, 9464\u20139468 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm4470_CR30","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cell.2016.06.042","volume":"166","author":"KA Goncalves","year":"2016","unstructured":"Goncalves, K.A. et al. Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells. Cell 166, 894\u2013906 (2016).","journal-title":"Cell"},{"key":"BFnm4470_CR31","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1634\/stemcells.2005-0598","volume":"24","author":"X Yu","year":"2006","unstructured":"Yu, X. et al. HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells 24, 876\u2013888 (2006).","journal-title":"Stem Cells"},{"key":"BFnm4470_CR32","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1126\/science.1106114","volume":"307","author":"JT Opferman","year":"2005","unstructured":"Opferman, J.T. et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science 307, 1101\u20131104 (2005).","journal-title":"Science"},{"key":"BFnm4470_CR33","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1182\/blood-2013-08-521716","volume":"123","author":"Y Qing","year":"2014","unstructured":"Qing, Y., Wang, Z., Bunting, K.D. & Gerson, S.L. Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. Blood 123, 1002\u20131011 (2014).","journal-title":"Blood"},{"key":"BFnm4470_CR34","doi-asserted-by":"publisher","first-page":"eaal3986","DOI":"10.1126\/scitranslmed.aal3986","volume":"9","author":"S He","year":"2017","unstructured":"He, S. et al. Transient CDK4\/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion. Sci. Transl. Med. 9, eaal3986 (2017).","journal-title":"Sci. Transl. Med."},{"key":"BFnm4470_CR35","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/nm.2969","volume":"18","author":"IG Winkler","year":"2012","unstructured":"Winkler, I.G. et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat. Med. 18, 1651\u20131657 (2012).","journal-title":"Nat. Med."},{"key":"BFnm4470_CR36","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1634\/stemcells.2006-0631","volume":"25","author":"R van Os","year":"2007","unstructured":"van Os, R. et al. A limited role for p21Cip1\/Waf1 in maintaining normal hematopoietic stem cell functioning. Stem Cells 25, 836\u2013843 (2007).","journal-title":"Stem Cells"},{"key":"BFnm4470_CR37","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nbt.1517","volume":"27","author":"A Foudi","year":"2009","unstructured":"Foudi, A. et al. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat. Biotechnol. 27, 84\u201390 (2009).","journal-title":"Nat. Biotechnol."},{"key":"BFnm4470_CR38","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1182\/blood-2013-07-515619","volume":"123","author":"L Shao","year":"2014","unstructured":"Shao, L. et al. Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood 123, 3105\u20133115 (2014).","journal-title":"Blood"},{"key":"BFnm4470_CR39","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nri3433","volume":"13","author":"H Geiger","year":"2013","unstructured":"Geiger, H., de Haan, G. & Florian, M.C. The ageing haematopoietic stem cell compartment. Nat. Rev. Immunol. 13, 376\u2013389 (2013).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnm4470_CR40","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/nature07815","volume":"458","author":"MA Essers","year":"2009","unstructured":"Essers, M.A. et al. IFN\u03b1 activates dormant haematopoietic stem cells in vivo. Nature 458, 904\u2013908 (2009).","journal-title":"Nature"},{"key":"BFnm4470_CR41","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nm.3070","volume":"19","author":"PL Doan","year":"2013","unstructured":"Doan, P.L. et al. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat. Med. 19, 295\u2013304 (2013).","journal-title":"Nat. Med."},{"key":"BFnm4470_CR42","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1182\/blood.V89.10.3596","volume":"89","author":"TD Randall","year":"1997","unstructured":"Randall, T.D. & Weissman, I.L. Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment. Blood 89, 3596\u20133606 (1997).","journal-title":"Blood"},{"key":"BFnm4470_CR43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1172\/JCI7954","volume":"105","author":"DY Jo","year":"2000","unstructured":"Jo, D.Y., Rafii, S., Hamada, T. & Moore, M.A. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J. Clin. Invest. 105, 101\u2013111 (2000).","journal-title":"J. Clin. Invest."},{"key":"BFnm4470_CR44","first-page":"145","volume":"17","author":"K Itoh","year":"1989","unstructured":"Itoh, K. et al. Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow. Exp. Hematol. 17, 145\u2013153 (1989).","journal-title":"Exp. Hematol."},{"key":"BFnm4470_CR45","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.exphem.2016.02.011","volume":"44","author":"S Radtke","year":"2016","unstructured":"Radtke, S., Haworth, K.G. & Kiem, H.P. The frequency of multipotent CD133+CD45RA\u2212CD34+ hematopoietic stem cells is not increased in fetal liver compared with adult stem cell sources. Exp. Hematol. 44, 502\u2013507 (2016).","journal-title":"Exp. Hematol."},{"key":"BFnm4470_CR46","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","volume":"41","author":"F Faul","year":"2009","unstructured":"Faul, F., Erdfelder, E., Buchner, A. & Lang, A.G. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav. Res. Methods 41, 1149\u20131160 (2009).","journal-title":"Behav. Res. Methods"}],"updated-by":[{"DOI":"10.1038\/nm0418-525b","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000}}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nm.4470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nm.4470","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nm.4470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/nm.4470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:22:40Z","timestamp":1739355760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm.4470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2,1]]}},"alternative-id":["BFnm4470"],"URL":"https:\/\/doi.org\/10.1038\/nm.4470","relation":{"correction":[{"id-type":"doi","id":"10.1038\/nm0418-525b","asserted-by":"object"}]},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,8]]},"assertion":[{"value":"21 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2018","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Corrigendum","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the version of this article initially published online, the phrase \"<i>ex vitro<\/i>\" appears in the abstract. This should be \"<i>ex vivo<\/i>\". The error has been corrected in the print, PDF and HTML versions of this article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2018","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/nm0418-525b","URL":"https:\/\/doi.org\/10.1038\/nm0418-525b","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A provisional patent application has been filed on the use of LHRH-Ant as a treatment for hematopoietic recovery from radiation injury (US 15\/033,178), with E.V., J.A.D., and M.R.M.v.d.B. listed as inventors. A provisional patent application has been filed on the use of LH to create, ablate, and modify primitive stem cell populations (US 62\/566,897), with E.V., J.A.D., S.R., H.-P.K., and M.R.M.v.d.B. listed as inventors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}