{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:56:25Z","timestamp":1770702985870,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1038\/nm0398-333","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T01:57:35Z","timestamp":1092880655000},"page":"333-335","source":"Crossref","is-referenced-by-count":85,"title":["An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow"],"prefix":"10.1038","volume":"4","author":[{"given":"James F.","family":"George","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Kirklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnm0398333_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/172603a0","volume":"172","author":"RE Billingham","year":"1953","unstructured":"Billingham, R.E., Brent, L. & Medawar, P.B. \u2018Actively acquired tolerance\u2018 of foreign cells. Nature 172, 603\u2013606 (1953).","journal-title":"Nature"},{"key":"BFnm0398333_CR2","first-page":"476","volume":"19","author":"WC Hartner","year":"1987","unstructured":"Hartner, W.C. et al. Specific tolerance to canine renal allografts following treatment with fractionated bone marrow and antilymphocyte serum. Transplant. Proc. 19, 476\u2013477 (1987).","journal-title":"Transplant. Proc."},{"key":"BFnm0398333_CR3","first-page":"281","volume":"21","author":"JJ Gozzo","year":"1970","unstructured":"Gozzo, J.J., Wood, M.L. & Monaco, A.P. Use of allogenic, homozygous bone marrow cells for the induction of specific immunologic tolerance in mice treated with antilymphocyte serum. Surg. Forum 21, 281\u2013284 (1970).","journal-title":"Surg. Forum"},{"key":"BFnm0398333_CR4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/00007890-198307000-00021","volume":"36","author":"JM Thomas","year":"1983","unstructured":"Thomas, J.M. et al. Renal allograft tolerance induced with ATG and donor bone marrow in outbred rhesus monkeys. Transplantation 36, 104\u2013106 (1983).","journal-title":"Transplantation"},{"key":"BFnm0398333_CR5","first-page":"99","volume-title":"The use of donor-specific bone marrow to induce specific unresponsiveness (tolerance) to tissue allografts","author":"AP Monaco","year":"1995","unstructured":"Monaco, A.P., Wood, M.L., Maki, T. & Gozzo, J.J. The use of donor-specific bone marrow to induce specific unresponsiveness (tolerance) to tissue allografts. Chimerism and Tolerance (ed. lldstad, K.J.) 99\u2013113 (Landes, Austin, 1995)."},{"key":"BFnm0398333_CR6","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/0092-8674(94)90375-1","volume":"76","author":"T Takahashi","year":"1994","unstructured":"Takahashi, T. et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76, 969\u2013976 (1994).","journal-title":"Cell"},{"key":"BFnm0398333_CR7","first-page":"191","volume":"9","author":"Y Sharabi","year":"1992","unstructured":"Sharabi, Y., Abraham, V.S., Sykes, M. & Sachs, D.H. Mixed allogeneic chimeras prepared by a non-myelablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant 9, 191\u2013197 (1992).","journal-title":"Bone Marrow Transplant"},{"key":"BFnm0398333_CR8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/00007890-199408000-00013","volume":"58","author":"JP Smith","year":"1994","unstructured":"Smith, J.P., Kasten-jolly, J., >Field, L.J. & Thomas, J.M. Assessment of donor bone marrow cell-derived chimerism in transplantation tolerance using transgenic mice. Transplantation 58, 324\u2013329 (1994).","journal-title":"Transplantation"},{"key":"BFnm0398333_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/S0167-5699(96)10070-0","volume":"17","author":"TE Starzl","year":"1996","unstructured":"Starzl, T.E. et al. The lost chord: Microchimerism and allograft survival [review]. Immunol. Today 17, 577\u201384; discussion 588 (1996).","journal-title":"Immunol. Today"},{"key":"BFnm0398333_CR10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4049\/jimmunol.111.1.65","volume":"111","author":"DM Lubaroff","year":"1973","unstructured":"Lubaroff, D.M. & Silvers, W.K. Importance of chimerism in maintaining tolerance of skin allografts in mice. J. Immunol. 111, 65\u201371 (1973).","journal-title":"J. Immunol."},{"key":"BFnm0398333_CR11","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s003359900486","volume":"8","author":"DE Bergstrom","year":"1997","unstructured":"Bergstrom, D.E. et al. An expanded collection of mouse Y chromosome RDA clones. Mammal. Genome 8, 510\u2013512 (1997).","journal-title":"Mammal. Genome"},{"key":"BFnm0398333_CR12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0167-5699(95)80069-7","volume":"16","author":"S Nagata","year":"1995","unstructured":"Nagata, S. & Suda, T. Fas and Fas ligand: lpr and gld mutations [review]. Immunol. Today 16, 39\u201343 (1995).","journal-title":"Immunol. Today"},{"key":"BFnm0398333_CR13","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1097\/00007890-199403270-00022","volume":"57","author":"KM Verbanac","year":"1994","unstructured":"Verbanac, K.M., Carver, F.M., Haisch, C.E. & Thomas, J.M. A role for transforming growth factor-beta in the veto mechanism in transplant tolerance. Transplantation 57, 893\u2013900 (1994).","journal-title":"Transplantation"},{"key":"BFnm0398333_CR14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/00007890-199401000-00018","volume":"57","author":"JM Thomas","year":"1994","unstructured":"Thomas, J.M. et al. Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation 57, 101\u2013115 (1994).","journal-title":"Transplantation"},{"key":"BFnm0398333_CR15","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.4049\/jimmunol.155.7.3464","volume":"155","author":"L Zhang","year":"1995","unstructured":"Zhang, L., Fung-Leung, W. & Miller, R.G. Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance. J. Immunol. 155, 3464\u20133471 (1995).","journal-title":"J. Immunol."},{"key":"BFnm0398333_CR16","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1084\/jem.178.2.703","volume":"178","author":"PJ Martin","year":"1993","unstructured":"Martin, P.J. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: Potential implications for marrow transplantation in humans. J. Exp. Med. 178, 703\u2013712 (1993).","journal-title":"J. Exp. Med."},{"key":"BFnm0398333_CR17","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1182\/blood.V84.8.2436.2436","volume":"84","author":"CL Kaufman","year":"1994","unstructured":"Kaufman, C.L. et al. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84, 2436\u20132446 (1994).","journal-title":"Blood"},{"key":"BFnm0398333_CR18","unstructured":"Wood, K.J. Antigen induced tolerance. Chimerism and Tolerance (ed. lldstad, K.J.) 15\u201329 (Landes, Austin, 1995)."},{"key":"BFnm0398333_CR19","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1681\/ASN.V641143","volume":"6","author":"MH Sayegh","year":"1995","unstructured":"Sayegh, M.H. & Turka, L.A. T cell costimulatory pathways: Promising novel targets for immunosuppression and tolerance induction [editorial]. J. Am. Soc. Nephrol. 6, 1143\u20131150 (1995).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnm0398333_CR20","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/373444a0","volume":"373","author":"ST Ju","year":"1995","unstructured":"Ju, S.T., et al. Fas(CD95)\/FasL interactions required for programmed cell death after T-cell activation [see comments]. Nature 373, 444\u2013448 (1995).","journal-title":"Nature"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0398-333","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0398-333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0398-333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T06:15:09Z","timestamp":1705212909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0398-333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["BFnm0398333"],"URL":"https:\/\/doi.org\/10.1038\/nm0398-333","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}