{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:45:28Z","timestamp":1790153128646,"version":"4.0.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1995,4]]},"DOI":"10.1038\/nm0495-342","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T01:11:39Z","timestamp":1092877899000},"page":"342-347","source":"Crossref","is-referenced-by-count":311,"title":["In utero surgery rescues neurological function at birth in sheep with spina bifida"],"prefix":"10.1038","volume":"1","author":[{"given":"Martin","family":"Meuli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Meuli-Simmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grover M.","family":"Hutchins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Yingling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen McBiles","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Scott","family":"Adzick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnm0495342_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/tera.1420490210","volume":"49","author":"GM Shaw","year":"1994","unstructured":"Shaw, G.M., Jensvold, N.G., Wasserman, C.R. & Lammer, E.J. Epidemiologic characteristics of phenotypically distinct neural tube defects among 0.7 million California births. Teratology 49, 143\u2013149 (1994).","journal-title":"Teratology"},{"key":"BFnm0495342_CR2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/0166-2236(93)90001-3","volume":"16","author":"AJ Copp","year":"1993","unstructured":"Copp, A.J. Neural tube defects. Trends. Neurosci. 16, 381\u2013383 (1993).","journal-title":"Trends. Neurosci."},{"key":"BFnm0495342_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/0301-0082(90)90037-H","volume":"35","author":"AJ Copp","year":"1990","unstructured":"Copp, A.J., Brook, F.A., Estibeiro, J.P., Shum, A.S.W. & Cockroft, D.L. The embryonic development of mammalian neural tube defects. Progr. Neurobiol. 35, 363\u2013403 (1990).","journal-title":"Progr. Neurobiol."},{"key":"BFnm0495342_CR4","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1001\/jama.1988.03720040050026","volume":"259","author":"RJ Lemire","year":"1988","unstructured":"Lemire, R.J. Neural tube defects. J. Am. Med. Assoc. 259, 558\u2013562 (1988).","journal-title":"J. Am. Med. Assoc."},{"key":"BFnm0495342_CR5","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1056\/NEJM198506203122501","volume":"312","author":"JF McLaughlin","year":"1985","unstructured":"McLaughlin, J.F. Influence of prognosis on decisions regarding the care of newborns with myelodysplasia. New Engl. J. Med. 312, 1589\u20131594 (1985).","journal-title":"New Engl. J. Med."},{"key":"BFnm0495342_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/tera.1420340206","volume":"34","author":"LR Campbell","year":"1986","unstructured":"Campbell, L.R., Dayton, D.H. & Sohal, G.S. A review of human and animal studies on the etiology of neural tube defects. Teratology 34, 171\u2013187 (1986).","journal-title":"Teratology"},{"key":"BFnm0495342_CR7","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3171\/jns.1978.49.5.0711","volume":"49","author":"K Osaka","year":"1978","unstructured":"Osaka, K., Tanimura, T., Hirayama, A. & Matsumoto, S. Myelomeningocele before birth. J. Neurosurg. 49, 711\u2013724 (1978).","journal-title":"J. Neurosurg."},{"key":"BFnm0495342_CR8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/aja.1000930304","volume":"93","author":"BM Patten","year":"1953","unstructured":"Patten, B.M. Embryological stages in the establishing of myeloschisis with spina bifida. Am. J. Anat. 93, 365\u2013395 (1953).","journal-title":"Am. J. Anat."},{"key":"BFnm0495342_CR9","first-page":"181","volume":"19","author":"C Keller-Peck","year":"1993","unstructured":"Keller-Peck, C. & Mullen, R.J. Evidence for late neuronal degeneration in the open neural tube of curly tail mutant mice. Soc. Neurosci. Abst. 19, 181 (1993).","journal-title":"Soc. Neurosci. Abst."},{"key":"BFnm0495342_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/path.1711100110","volume":"110","author":"JL Emery","year":"1973","unstructured":"Emery, J.L. & Lendon, R.G. The local cord lesion in neurospinal dysraphism (meningomyelocele). J. Pathol. 110, 83\u201396 (1973).","journal-title":"J. Pathol."},{"key":"BFnm0495342_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0140-6736(56)91696-8","volume":"2","author":"AH Cameron","year":"1956","unstructured":"Cameron, A.H. The spinal cord lesion in spina bifida cystica. Lancet 2, 171\u2013174 (1956).","journal-title":"Lancet"},{"key":"BFnm0495342_CR12","first-page":"472","volume":"43","author":"MA Jordan","year":"1991","unstructured":"Jordan, M.A., Heffez, D.S. & Hutchins, G.M. The relationships of the spinal cord and meninges in meningocele, meningomyelocele and iniencephaly. Teratology 43, 472 (1991).","journal-title":"Teratology"},{"key":"BFnm0495342_CR13","first-page":"1","volume-title":"Advances in Anatomy Embryology and Cell Biology","author":"W Schmidt","year":"1992","unstructured":"Schmidt, W. The amniotic fluid compartment: The fetal habitat in Advances in Anatomy Embryology and Cell Biology, (eds Beck, F et al.) 1\u2013100 (Springer, Berlin, New York, 1992)."},{"key":"BFnm0495342_CR14","first-page":"94","volume":"10","author":"FK Lotgering","year":"1986","unstructured":"Lotgering, F.K. & Wallenburg, H.C.S. Mechanisms of production and clearance of amniotic fluid. Semin. Perinatal. 10, 94\u2013102 (1986).","journal-title":"Semin. Perinatal."},{"key":"BFnm0495342_CR15","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/S0022-3468(89)80200-3","volume":"24","author":"JC Langer","year":"1989","unstructured":"Langer, J.C. Etiology of intestinal damage in gastroschisis. I. Effects of amniotic fluid exposure and bowel constriction in a fetal lamb model. J. Pediatr. Surg. 24, 992\u2013997 (1989).","journal-title":"J. Pediatr. Surg."},{"key":"BFnm0495342_CR16","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/tera.1420330303","volume":"33","author":"D Tibboel","year":"1986","unstructured":"Tibboel, D. The natural history of gastroschisis during fetal life: Development of the fibrous coating on the bowel loops. Teratology 33, 267\u2013272 (1986).","journal-title":"Teratology"},{"key":"BFnm0495342_CR17","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/S0022-5347(17)32648-4","volume":"152","author":"SD Niku","year":"1994","unstructured":"Niku, S.D., Stein, P.C., Scherz, H.C. & Parsons, C.L. A new method for cytodestruction of bladder epithelium using protamine sulfate and urea. J. Urol. 152, 1025\u20131028 (1994","journal-title":"J. Urol."},{"key":"BFnm0495342_CR18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0006-2952(93)90360-9","volume":"46","author":"M Matsuoka","year":"1993","unstructured":"Matsuoka, M. & Igisu, H. Comparison of the effects of L-carnitine, D-carnitine and acetyl-L-carnitine on the neurotoxicity of ammonia. Biochem. Pharmacol. 46, 159\u2013164 (1993).","journal-title":"Biochem. Pharmacol."},{"key":"BFnm0495342_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF00402868","volume":"195","author":"A Th\u00e9venet","year":"1986","unstructured":"Th\u00e9venet, A. & Sengel, P. Naturally occurring wounds and wound healing in chick embryo wings. Roux's Arch. Dev. Biol. 195, 345\u2013354 (1986).","journal-title":"Roux's Arch. Dev. Biol."},{"key":"BFnm0495342_CR20","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1227\/00006123-199306000-00021","volume":"32","author":"DS Heffez","year":"1993","unstructured":"Heffez, D.S., Aryanpur, J., Cuello Rotellini, N.A., Hutchins, G.M. & Freeman, J.M. Intrauterine repair of experimental surgically created dysraphism. Neurosurg. 32, 1005\u20131010 (1993).","journal-title":"Neurosurg."},{"key":"BFnm0495342_CR21","first-page":"259","volume":"39","author":"M Micheida","year":"1984","unstructured":"Micheida, M. Intrauterine treatment of spina bifida. Z. Kinderchir. 39, 259\u2013261 (1984).","journal-title":"Z. Kinderchir."},{"key":"BFnm0495342_CR22","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S0140-6736(94)90012-4","volume":"343","author":"NS Adzick","year":"1994","unstructured":"Adzick, N.S. & Harrison, M.R. Fetal surgical therapy. Lancet 343, 897\u2013902 (1994).","journal-title":"Lancet"},{"key":"BFnm0495342_CR23","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1227\/00006123-198605000-00008","volume":"18","author":"JN Gilbert","year":"1986","unstructured":"Gilbert, J.N., Jones, K.L., Rorke, L.B., Chernoff, G.F. & James, H.E. Central nervous system anomalies associated with meningomyelocele, hydrocephalus, and the Arnold-Chiari malformation: Reappraisal of theories regarding the pathogenesis of posterior neural tube closure defects. Neurosurgery 18, 559\u2013564 (1986).","journal-title":"Neurosurgery"},{"key":"BFnm0495342_CR24","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1126\/science.7089581","volume":"217","author":"B Bregman","year":"1982","unstructured":"Bregman, B. & Goldberger, M.E. Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats. Science 217, 553\u2013555 (1982).","journal-title":"Science"},{"key":"BFnm0495342_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0014-4886(91)90113-Q","volume":"112","author":"B Sypniewski Bregman","year":"1991","unstructured":"Sypniewski Bregman, B. & Bernstein-Goral, H. Both regenerating and late-developing pathways contribute to transplant-induced anatomical plasticity after spinal cord lesions at birth. Exp. Neural. 112, 49\u201363 (1991).","journal-title":"Exp. Neural."},{"key":"BFnm0495342_CR26","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/367167a0","volume":"367","author":"Y Iwashita","year":"1994","unstructured":"Iwashita, Y., Kawaguchi, S. & Murata, M. Restoration of function by replacement of spinal cord segments in the rat. Nature 367, 167\u2013170 (1994).","journal-title":"Nature"},{"key":"BFnm0495342_CR27","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/S0140-6736(86)91022-6","volume":"1","author":"MJ Korenromp","year":"1986","unstructured":"Korenromp, M.J., Van Gool, J.D., Bruinse, H.W. & Kriek, R. Early fetal leg movements in myelomeningocele. Lancet 1, 917\u2013918 (1986).","journal-title":"Lancet"},{"key":"BFnm0495342_CR28","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1056\/NEJM199103073241004","volume":"324","author":"DA Luthy","year":"1991","unstructured":"Luthy, D.A. Cesarean section before the onset of labor and subsequent motor function in infants with meningomyelocele diagnosed antenatally. New Engl. J. Med. 324, 662\u2013666 (1991).","journal-title":"New Engl. J. Med."},{"key":"BFnm0495342_CR29","first-page":"174","volume":"88","author":"MR Harrison","year":"1980","unstructured":"Harrison, M.R., Jester, J.A. & Ross, N.A. Correction of congenital diaphragmatic hernia in utero. I. The model: Intrathoracic balloon produces fatal pulmonary hypoplasia. Surgery 88, 174\u2013182 (1980).","journal-title":"Surgery"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0495-342","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0495-342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0495-342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:19:22Z","timestamp":1684448362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0495-342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["BFnm0495342"],"URL":"https:\/\/doi.org\/10.1038\/nm0495-342","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,4]]}}}