{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:27:22Z","timestamp":1774686442361,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1998,4]]},"DOI":"10.1038\/nm0498-456","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T02:00:51Z","timestamp":1092880851000},"page":"456-459","source":"Crossref","is-referenced-by-count":62,"title":["Local paracrine effects of estradiol are central to parturition in the rhesus monkey"],"prefix":"10.1038","volume":"4","author":[{"given":"Peter W.","family":"Nathanielsz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Tame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Guller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino A.","family":"Giussani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnm0498456_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S0146-0005(95)80047-6","volume":"19","author":"DM Olson","year":"1995","unstructured":"Olson, D.M., Mijovic, J.E. & Sadowsky, D.W. Control of human parturition. Semin. Perinatal. 19, 52\u201363 (1995).","journal-title":"Semin. Perinatal."},{"key":"BFnm0498456_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1210\/endo-107-1-155","volume":"107","author":"DM Magyar","year":"1980","unstructured":"Magyar, D.M. et al. Time-trend analysis of plasma cortisol concentrations in the fetal sheep in relation to parturition. Endocrinology 107, 155\u2013159 (1980).","journal-title":"Endocrinology"},{"key":"BFnm0498456_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1677\/joe.0.0690239","volume":"69","author":"PW Steele","year":"1976","unstructured":"Steele, P.W., Flint, A.P.F. & Turnbull, A.C. Activity of steroid C-17,20 lyase in the ovine placenta: effect of exposure to foetal glucocorticoid. J. Endocrinol. 69, 239\u2013246 (1976).","journal-title":"J. Endocrinol."},{"key":"BFnm0498456_CR4","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1210\/endo-110-4-1402","volume":"110","author":"PW Nathanielsz","year":"1982","unstructured":"Nathanielsz, P.W. et al. Time trend analysis of plasma unconjugated and sulfocon-jugated estrone and 3\u03b2\u2013\u03945 - steroids in fetal and maternal sheep plasma in relation to spontaneous parturition at term. Endocrinology 110, 1402\u20131407 (1982).","journal-title":"Endocrinology"},{"key":"BFnm0498456_CR5","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/229208a0","volume":"229","author":"JRG Challis","year":"1971","unstructured":"Challis, J.R.G. Sharp increase in free circulating oestrogens immediately before parturition in sheep. Nature 229, 208 (1971).","journal-title":"Nature"},{"key":"BFnm0498456_CR6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1210\/endo-107-3-801","volume":"107","author":"CW Eisner","year":"1980","unstructured":"Eisner, C.W. et al. Time-trend analysis of plasma C-21 steroids in fetal and maternal sheep during the last 18 days of gestation. Endocrinology 107, 801\u2013808 (1980).","journal-title":"Endocrinology"},{"key":"BFnm0498456_CR7","volume-title":"Fetal Endocrinology","author":"MJ Novy","year":"1981","unstructured":"Novy, M.J. & Walsh, S.W. Regulation of fetoplacental steroidogenesis in rhesus macaques. In Fetal Endocrinology (Novy M.J. and Resko, J.A., eds), 66-94 (Academic Press, NY, (1981)."},{"key":"BFnm0498456_CR8","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/0002-9378(91)90396-9","volume":"165","author":"L Wilson","year":"1991","unstructured":"Wilson, L., Parsons, M.T. & Flouret, C. Forward shift in the initiation of the nocturnal estradiol surge in the pregnant baboon: Is this the genesis of labor?. Am. I. Obstet. Cynecol. 165, 1487\u20131498 (1991).","journal-title":"Am. I. Obstet. Cynecol."},{"key":"BFnm0498456_CR9","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1210\/jcem-48-1-133","volume":"48","author":"JE Buster","year":"1979","unstructured":"Buster, J.E. et al. Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies. I. C21 steroids: Progesterone, 16\u03b1-hydroxyproges-terone, 17\u03b1-hydroxyprogesterone, 20\u03b1-dihydroprogesterone, \u03945-pregnenolone, \u03945-pregnenolone sulfate, and 17-hydroxy \u03945-pregnenolone. J. Clin. Endo. Metab. 48, 133\u2013138 (1979).","journal-title":"J. Clin. Endo. Metab."},{"key":"BFnm0498456_CR10","volume-title":"Fetal Endocrinology","author":"PK Siiteri","year":"1981","unstructured":"Siiteri, P.K. & Seron-Ferre, M. Some new thoughts on the fetoplacental unit and parturition in primates. In Fetal Endocrinology. (Novy, M.J. and Resko, J.A, eds.), 1-34 (Academic Press, NY, 1981)."},{"key":"BFnm0498456_CR11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1210\/jcem-48-1-139","volume":"48","author":"JE Buster","year":"1979","unstructured":"Buster, J.E. et al. Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies II. C18 and C19 steroids: estradiol, estriol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, 5-androstenediol, 4-an-drostenedione, testosterone, and dihydrotestosterone. J. Clin. Endo. Metab. 48, 139\u2013142 (1979).","journal-title":"J. Clin. Endo. Metab."},{"key":"BFnm0498456_CR12","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1210\/endo.132.6.8389279","volume":"132","author":"SJ Lye","year":"1993","unstructured":"Lye, S.J., Nicholson, B.J., Mascarenhas, M., MacKenzie, L. & Petrocelli, T. Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen: Progesterone ratio. Endocrinology 132, 2380\u20132386 (1993).","journal-title":"Endocrinology"},{"key":"BFnm0498456_CR13","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1159\/000125389","volume":"51","author":"JA Amico","year":"1990","unstructured":"Amico, J.A., Janosky, J.E. & Cameron, J.L. Effect of estradiol and progesterone administration upon the circadian rhythm of oxytocin in the cerebrospinal fluid of rhesus monkeys. Neuroendocrinology 51, 543\u2013551 (1990).","journal-title":"Neuroendocrinology"},{"key":"BFnm0498456_CR14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1095\/biolreprod45.3.395","volume":"45","author":"PG Zhang","year":"1991","unstructured":"Zhang, P.G., Weston & Hixon, J.E. Influence of estradiol on the secretion of oxytocin and prostaglandin F2\u03b12 during luteolysis in the ewes. Biol. Reprod. 45, 395\u2013403 (1991).","journal-title":"Biol. Reprod."},{"issue":"1","key":"BFnm0498456_CR15","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1210\/endo.133.1.8391423","volume":"133","author":"T. Petrocelli","year":"1993","unstructured":"Petrocelli, T. & Lye, S.J. Regulation of transcripts encoding the myometrial gap junction protein, connexin-43, by estrogen and progesterone. Endocrinology 133, 284\u2013290(1993).","journal-title":"Endocrinology"},{"key":"BFnm0498456_CR16","first-page":"762","volume":"555","author":"WX Wu","year":"1996","unstructured":"Wu, W.X., Owiny, J.R., Zhang, Q., Ma, X.H. & Nathanielsz, P.W. Regulation of the estrogen receptor and its mRNA in the ovariectomized sheep myometrium and en-dometrium: The role of estradiol and progesterone. Biol. Reprod. 555, 762\u2013768 (1996).","journal-title":"Biol. Reprod."},{"key":"BFnm0498456_CR17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1136\/bmj.294.6567.270","volume":"294","author":"J Daren","year":"1987","unstructured":"J.,Daren, McGarrigl, C.L. & Lachelin,, G.C.L Increased saliva oestriol to progesterone ratio before idiopathic preterm delivery: a possible predictor for preterm labour. Br. Med. J. 294, 270\u2013272 (1987).","journal-title":"Br. Med. J."},{"key":"BFnm0498456_CR18","first-page":"57","volume":"1","author":"AM Germain","year":"1996","unstructured":"Germain, A.M., Kato, S., Villarroel, L.A., Valenzuela, G.J. & Seron-Ferre, M. Human term and preterm delivery is preceded by a rise in maternal plasma 17-estradiol. Prenatal & Neonatal Med. 1, 57\u201363 (1996).","journal-title":"Prenatal & Neonatal Med."},{"key":"BFnm0498456_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/S0002-9378(97)70570-2","volume":"176","author":"GJ Haluska","year":"1997","unstructured":"Haluska, G.J., Cook, M.J. & Novy, M.J. Inhibition and augmentation of progesterone production during pregnancy: Effects on parturition in rhesus monkeys. Am. J. Obstet. Cynecol. 176, 682\u2013691 (1997).","journal-title":"Am. J. Obstet. Cynecol."},{"issue":"4","key":"BFnm0498456_CR20","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nm0496-443","volume":"2","author":"Charles A. Mecenas","year":"1996","unstructured":"Mecenas, C.A. et al. Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nature Med. 2,(4) 443\u2013448 (1996).","journal-title":"Nature Medicine"},{"key":"BFnm0498456_CR21","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1159\/000125371","volume":"51","author":"JA Amico","year":"1990","unstructured":"Amico, J.A. & Hempel, J. An oxytocin precursor intermediate circulates in the plasma of humans and rhesus monkeys administered estrogen. Neuroendocrinology 51, 437\u2013443 (1990).","journal-title":"Neuroendocrinology"},{"key":"BFnm0498456_CR22","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/0002-9378(83)90841-4","volume":"145","author":"MJ Novy","year":"1983","unstructured":"Novy, M.J. & Walsh, S.W. Dexamethasone and estradiol treatment in pregnant rhesus macaques: Effects on gestational length, maternal plasma hormones, and fetal growth. Am. J. Obstet. Cynecol. 145, 920\u2013931 (1983).","journal-title":"Am. J. Obstet. Cynecol."},{"key":"BFnm0498456_CR23","first-page":"567","volume":"80","author":"R Cibbar","year":"1995","unstructured":"Cibbar, R., Wong, S., Miller, F.D. & Mitchell, B.F. Estrogen stimulates oxytocin gene expression in human chorio-decidua. J. Clin. Endo. Metab. 80, 567\u2013572 (1995).","journal-title":"J. Clin. Endo. Metab."},{"key":"BFnm0498456_CR24","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1210\/endo.134.6.8194483","volume":"134","author":"DL Lefebvre","year":"1994","unstructured":"Lefebvre, D.L., Farookhi, R., Giaid, A., Neculcea, J. & Zingg, H.H. Uterine oxytocin gene expression. II. induction by exogenous steroid administration. Endocrinology 134, 2562\u20132566 (1994).","journal-title":"Endocrinology"},{"key":"BFnm0498456_CR25","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1095\/biolreprod56.2.557","volume":"56","author":"DM Farber","year":"1997","unstructured":"Farber, D.M. et al Timing of the switch from myometrial contractures to contractions in late-gestation pregnant rhesus monkeys as recorded by myometrial electromyogram during spontaneous term and androstenedione-induced labor. Biol. Reprod. 56, 557\u2013562 (1997).","journal-title":"Biol. Reprod."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0498-456","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0498-456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0498-456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:21:35Z","timestamp":1684448495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0498-456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["BFnm0498456"],"URL":"https:\/\/doi.org\/10.1038\/nm0498-456","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}