{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:15:06Z","timestamp":1791220506843,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1996,5]]},"DOI":"10.1038\/nm0596-529","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T01:30:57Z","timestamp":1092879057000},"page":"529-533","source":"Crossref","is-referenced-by-count":244,"title":["Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor\u2013type integrins inhibits retinal neovascularization"],"prefix":"10.1038","volume":"2","author":[{"given":"Hans-Peter","family":"Hammes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brownlee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Jonczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus T.","family":"Preissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnm0596529_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1136\/bjo.72.5.363","volume":"72","author":"M Prost","year":"1988","unstructured":"Prost, M. Experimental studies on the pathogensis of retinopathy of prematurity. Br. J. Ophthalmol. 72, 363\u2013367 (1988).","journal-title":"Br. J. Ophthalmol."},{"key":"BFnm0596529_CR2","first-page":"115","volume":"73","author":"B Thylefors","year":"1995","unstructured":"Thylefors, B., Negrel, A.D., Pararajasegaram, R. & Dadzie, K.Y. Global data on blindness. Bull. World. Health. Organ. 73, 115\u2013121 (1995).","journal-title":"Bull. World. Health. Organ."},{"key":"BFnm0596529_CR3","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/S0161-6420(94)31217-6","volume":"101","author":"SE Moss","year":"1994","unstructured":"Moss, S.E., Klein, R. & Klein, B.E. Ten-year incidence of visual loss in a diabetic population. Ophthalmology 101, 1061\u20131070 (1994).","journal-title":"Ophthalmology"},{"key":"BFnm0596529_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/BF02027896","volume":"11","author":"GC Brown","year":"1987","unstructured":"Brown, G.C., Brown, R.H. & Brown, M.M. Peripheral proliferative retinopathies. Int. Ophthalmol. 11, 41\u201350 (1987).","journal-title":"Int. Ophthalmol."},{"key":"BFnm0596529_CR5","doi-asserted-by":"crossref","unstructured":"The Diabetic retinopathy Study Group. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of DRS findings. Ophthalmology 88, 583\u2013600 (1981).","DOI":"10.1016\/S0161-6420(81)34978-1"},{"key":"BFnm0596529_CR6","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","volume":"15","author":"J Stone","year":"1995","unstructured":"Stone, J. et al. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J. Neurosci. 15, 4738\u20134747 (1995).","journal-title":"J. Neurosci."},{"key":"BFnm0596529_CR7","first-page":"638","volume":"72","author":"J Pe\u00e8r","year":"1995","unstructured":"Pe\u00e8r, J. et al. Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. Lab. Invest. 72, 638\u2013645 (1995).","journal-title":"Lab. Invest."},{"key":"BFnm0596529_CR8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0962-8924(00)88949-7","volume":"5","author":"J Bischoff","year":"1995","unstructured":"Bischoff, J. Approaches to studying cell adhesion molecules in angiogenesis. Trends Cell Biol. 5, 69\u201374 (1995).","journal-title":"Trends Cell Biol."},{"key":"BFnm0596529_CR9","doi-asserted-by":"publisher","first-page":"10686","DOI":"10.1073\/pnas.89.22.10686","volume":"89","author":"E Bacharach","year":"1992","unstructured":"Bacharach, E., Itin, A. & Keshet, E. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc. Natl. Acad. Sci. USA 89, 10686\u201310690 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0596529_CR10","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1073\/pnas.92.3.905","volume":"92","author":"EA Pierce","year":"1995","unstructured":"Pierce, E.A., Avery, R.L., Foley, E.D., Aiello, L.P. & Smith, L.E.H. Vascular endothelial growth factor\/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc. Natl. Acad. Sci. USA 92, 905\u2013909 (1995).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0596529_CR11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/eye.1991.31","volume":"5","author":"GS Schultz","year":"1991","unstructured":"Schultz, G.S. & Grant, M.B. Neovascular growth factors. Eye 5, 170\u2013180 (1991).","journal-title":"Eye"},{"key":"BFnm0596529_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1055\/s-0029-1211323","volume":"103","author":"A Pfeiffer","year":"1995","unstructured":"Pfeiffer, A. & Schatz, H. Diabetic microvascular complications and growth factors. Exp. Clin. Endocrinol. Diabetes 103, 7\u201314 (1995).","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"BFnm0596529_CR13","first-page":"1450","volume":"36","author":"JL Berka","year":"1995","unstructured":"Berka, J.L. et al. Renin-containing Mueller cells of the retina display endocrine features. Invest. Ophthalmol. Vis. Sci. 36, 1450\u20131458 (1995).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm0596529_CR14","first-page":"3649","volume":"35","author":"SG Robbins","year":"1994","unstructured":"Robbins, S.G. et al. Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseases. Invest. Ophthalmol. Vis. Sci. 35, 3649\u20133663 (1994).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm0596529_CR15","first-page":"134","volume":"90","author":"J Spranger","year":"1995","unstructured":"Spranger, J., Meyer-Schwickerath, R., Klein, M., Schatz, H. & Pfeiffer, A. TNF-\u03b1 level in the vitreous body: Increase in neovascular eye diseases and proliferative diabetic retinopathy. Med. Klin. 90, 134\u2013137 (1995).","journal-title":"Med. Klin."},{"key":"BFnm0596529_CR16","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1083\/jcb.117.5.1101","volume":"117","author":"DI Leavesley","year":"1992","unstructured":"Leavesley, D.I., Ferguson, G.D., Wayner, E.A. & Cheresh, D.A. Requirement of the integrin \u03b23 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J. Cell Biol. 117, 1101\u20131107 (1992).","journal-title":"J. Cell Biol."},{"key":"BFnm0596529_CR17","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/0955-0674(93)90036-P","volume":"5","author":"B Felding-Habermann","year":"1993","unstructured":"Felding-Habermann, B. & Cheresh, D.A. Vitronectin and its receptors. Curt. Opin. Cell Biol. 5, 864\u2013868 (1993).","journal-title":"Curt. Opin. Cell Biol."},{"key":"BFnm0596529_CR18","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.7512751","volume":"264","author":"PC Brooks","year":"1994","unstructured":"Brooks, P.C., Clark, R.A.F. & Cheresh, D.A. Requirement of vascular integrin \u03b1v\u03b23 for angiogenesis. Science 264, 569\u2013571 (1994).","journal-title":"Science"},{"key":"BFnm0596529_CR19","first-page":"2791","volume":"35","author":"RP Casaroli Marano","year":"1994","unstructured":"Casaroli Marano, R.P. & Vilaro, S. The role of fibronectin, laminin, vitronectin and their receptors on cellular adhesion in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 35, 2791\u20132903 (1994).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm0596529_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0014-4835(05)80079-X","volume":"60","author":"RP Casaroli Marano","year":"1995","unstructured":"Casaroli Marano, R.P., Preissner, K.T. & Vilaro, S., Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. Exp. Eye Res. 60, 5\u201317 (1995).","journal-title":"Exp. Eye Res."},{"key":"BFnm0596529_CR21","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/0092-8674(94)90007-8","volume":"79","author":"PC Brooks","year":"1994","unstructured":"Brooks, P.C. et al. Integrin \u03b1v\u03b23 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157\u20131164 (1994).","journal-title":"Cell"},{"key":"BFnm0596529_CR22","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1126\/science.270.5241.1500","volume":"270","author":"M Friedlander","year":"1995","unstructured":"Friedlander, M. et al. Definition of two angiogenic pathways by distinct \u03b1v integrins. Science 270, 1500\u20131502 (1995).","journal-title":"Science"},{"key":"BFnm0596529_CR23","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/367576a0","volume":"367","author":"B Millauer","year":"1994","unstructured":"Millauer, B., Shawver, L.K., Plate, K.H., Risau, W. & Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367, 576\u2013579 (1994).","journal-title":"Nature"},{"key":"BFnm0596529_CR24","first-page":"101","volume":"35","author":"LEH Smith","year":"1994","unstructured":"Smith, L.E.H. et al. Vascular endothelial growth factor\/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Invest. Ophthalmol. Vis. Sci. 35, 101\u2013111 (1994).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnm0596529_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/0014-5793(91)81101-D","volume":"291","author":"M Aumailley","year":"1991","unstructured":"Aumailley, M. et al. Arg-Gly-Asp constrained within cyclic pentapeptides: Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1. FEBS Lett. 291, 50\u201354 (1991).","journal-title":"FEBS Lett."},{"key":"BFnm0596529_CR26","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1073\/pnas.91.4.1524","volume":"91","author":"R Sasisekharan","year":"1994","unstructured":"Sasisekharan, R., Moses, M.A., Nugent, M.A., Cooney, C.L. & Langer, R. Heparinase inhibits neovascularization. Proc. Natl. Acad. Sci. USA 91, 1524\u20131528 (1994).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0596529_CR27","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1073\/pnas.88.11.5026","volume":"88","author":"ML Iruela-Arispe","year":"1991","unstructured":"Iruela-Arispe, M.L., Bornstein, P. & Sage, H. Thrombospondin exerts an anti-angiogenic effect on cord formation by endothelial cells in vitro. Proc. Natl. Acad. Sci. USA 88, 5026\u20135030 (1991).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0596529_CR28","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1126\/science.7521539","volume":"265","author":"KM Dameron","year":"1994","unstructured":"Dameron, K.M., Volpert, O.V., Tainsky, M.A. & Bouck, N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265, 1582\u20131584 (1994).","journal-title":"Science"},{"key":"BFnm0596529_CR29","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1126\/science.1694043","volume":"248","author":"MA Moses","year":"1990","unstructured":"Moses, M.A., Sudhalter, J. & Langer, R. Identification of an inhibitor of neovascularization from cartilage. Science 248, 1408\u20131410 (1990).","journal-title":"Science"},{"key":"BFnm0596529_CR30","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/jcp.1041600122","volume":"160","author":"MD Johnson","year":"1994","unstructured":"Johnson, M.D. et al. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J. Cell. Physiol. 160, 194\u2013202 (1994).","journal-title":"J. Cell. Physiol."},{"key":"BFnm0596529_CR31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0092-8674(94)90200-3","volume":"79","author":"MS O'Reilly","year":"1994","unstructured":"O'Reilly, M.S. et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315\u2013328 (1994).","journal-title":"Cell"},{"key":"BFnm0596529_CR32","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","volume":"331","author":"LP Aiello","year":"1994","unstructured":"Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480\u20131487 (1994).","journal-title":"N. Engl. J. Med."},{"key":"BFnm0596529_CR33","unstructured":"Jonczyk, A. et al. Zyklische Adh\u00e4sionsinhibitoren. EP 0 632 053 (1993)."},{"key":"BFnm0596529_CR34","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1182\/blood.V71.6.1581.1581","volume":"71","author":"KT Preissner","year":"1988","unstructured":"Preissner, K.T., Anders, E., Grulich-Henn, J. & M\u00fcller-Berghaus, G. Attachment of cultured human endothelial cells is promoted by specific association with S protein (vitronectin) as well as with the ternary S protein-thrombin-antithrombin III complex. Blood 71, 1581\u20131589 (1988).","journal-title":"Blood"}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0596-529","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0596-529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0596-529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T22:38:23Z","timestamp":1684449503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0596-529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["BFnm0596529"],"URL":"https:\/\/doi.org\/10.1038\/nm0596-529","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}