{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:17:31Z","timestamp":1773155851651,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1997,7]]},"DOI":"10.1038\/nm0797-771","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T02:09:35Z","timestamp":1092881375000},"page":"771-774","source":"Crossref","is-referenced-by-count":135,"title":["Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of \u03b2-glucuronidase"],"prefix":"10.1038","volume":"3","author":[{"given":"Rosanne M","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFnm0797771_CR1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0022-3476(73)80162-3","volume":"82","author":"WS Sly","year":"1973","unstructured":"Sly, W.S., Quinton, B.A., McAlister, W.H. & Rimoin, D.L. Beta glucuronidase deficiency: Report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis. J. Pediatr. 82, 249\u2013257 (1973).","journal-title":"J. Pediatr."},{"key":"BFnm0797771_CR2","first-page":"2465","volume-title":"Metabolic Basis of Inherited Disease","author":"EF Neufeld","year":"1995","unstructured":"Neufeld, E.F. & Muenzer, J. The mucopolysaccharidoses. in Metabolic Basis of Inherited Disease, 7th edn. (eds. Scriver, C.R., Beaudet, A.L, Sly, W.S. & Valle, D.) 2465\u20132494 (McCraw Hill, NY, 1995)."},{"key":"BFnm0797771_CR3","first-page":"980","volume":"18","author":"ME Haskins","year":"1984","unstructured":"Haskins, M.E., Desnick, R.J., DiFerrante, N., Jezyk, P.F. & Patterson, D.F. Beta-glucuronidase deficiency in a dog: A model of mucopolysaccharidosis VII. Pediatr. Res. 18, 980\u2013984 (1984).","journal-title":"Pediatr. Res."},{"key":"BFnm0797771_CR4","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1172\/JCI114010","volume":"83","author":"EH Birkenmeier","year":"1989","unstructured":"Birkenmeier, E.H. et al. Murine mucopolysaccharidosis type VII: Characterization of a mouse with beta-glucuronidase deficiency. J. Clin. Invest. 83, 1258\u20131256 (1989).","journal-title":"J. Clin. Invest."},{"key":"BFnm0797771_CR5","unstructured":"Wolfe, J.H. & Sands, M.S. Murine mucopolysaccharidosis type VII: A model system for somatic gene therapy of the central nervous system, in Protocols for Gene Transfer in Neuroscience: Towards Gene Therapy of Neurologic Disorders . (eds. P.R. Lowenstein & L.W. Enquist) 263\u2013274 (John Wiley and Sons, Essex, England, 1996)."},{"key":"BFnm0797771_CR6","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/360749a0","volume":"360","author":"JH Wolfe","year":"1992","unstructured":"Wolfe, J.H. et al. Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer. Nature 360, 749\u2013753 (1992).","journal-title":"Nature"},{"key":"BFnm0797771_CR7","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/ng0892-379","volume":"1","author":"JH Wolfe","year":"1992","unstructured":"Wolfe, J.H., Deshmane, S.L. & Fraser, N.W. Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. Nature Genet. 1, 379\u2013384 (1992).","journal-title":"Nature Genet."},{"key":"BFnm0797771_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/ng0693-154","volume":"4","author":"P Moullier","year":"1993","unstructured":"Moullier, P., Bohl, D., Heard, J.-M. & Danos, O. Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts. Nature Genet. 4, 154\u2013159 (1993).","journal-title":"Nature Genet."},{"key":"BFnm0797771_CR9","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1172\/JCI117237","volume":"93","author":"MS Sands","year":"1994","unstructured":"Sands, M.S. et al. Enzyme replacement therapy for murine mucopolysaccharidosis type VII. J. Clin. Invest 93, 2324\u20132331 (1994).","journal-title":"J. Clin. Invest"},{"key":"BFnm0797771_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/374367a0","volume":"374","author":"EY Snyder","year":"1995","unstructured":"Snyder, E.Y., Taylor, R.M. & Wolfe, J.H. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 374, 367\u2013370 (1995).","journal-title":"Nature"},{"key":"BFnm0797771_CR11","first-page":"2427","volume-title":"Metabolic Basis of Inherited Disease","author":"CR Scriver","year":"1995","unstructured":"Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D. Metabolic Basis of Inherited Disease, 7th edn., Part 12, Lysosomal Enzymes, 2427\u20132839 (McGraw Hill, New York, 1995)."},{"key":"BFnm0797771_CR12","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1006\/excr.1994.1298","volume":"214","author":"RM Taylor","year":"1994","unstructured":"Taylor, R.M. & Wolfe, J.H. Cross-correction of beta-glucuronidase deficiency by retroviral vector-mediated gene transfer. Exp. Cell Res. 214, 606\u2013613 (1994).","journal-title":"Exp. Cell Res."},{"key":"BFnm0797771_CR13","first-page":"70","volume":"2","author":"JH Wolfe","year":"1995","unstructured":"Wolfe, J.H. et al. High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector. Gene Ther. 2, 70\u201378 (1995).","journal-title":"Gene Ther."},{"key":"BFnm0797771_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1152\/physrev.1993.73.3.583","volume":"73","author":"LJ Fisher","year":"1993","unstructured":"Fisher, L.J. & Gage, F.H. Grafting in the mammalian central nervous system. Physiol. Rev. 73, 583\u2013616 (1993).","journal-title":"Physiol. Rev."},{"key":"BFnm0797771_CR15","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1128\/MCB.12.1.38","volume":"12","author":"JR Flanagan","year":"1992","unstructured":"Flanagan, J.R. et al. Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. Mol. Cell. Biol. 12, 38\u201344 (1992).","journal-title":"Mol. Cell. Biol."},{"key":"BFnm0797771_CR16","doi-asserted-by":"publisher","first-page":"11332","DOI":"10.1073\/pnas.89.23.11332","volume":"89","author":"T Ohashi","year":"1992","unstructured":"Ohashi, T. et al. Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector. Proc. Natl. Acad. Sci. USA 89, 11332\u201311336 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0797771_CR17","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1073\/pnas.87.8.2877","volume":"87","author":"JH Wolfe","year":"1990","unstructured":"Wolfe, J.H. et al. Restoration of normal lysosomal function in mucopolysaccharidosis type VII cells by gene transfer. Proc. Natl. Acad. Sci. USA 87, 2877\u20132881 (1990).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0797771_CR18","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1073\/pnas.87.10.3914","volume":"87","author":"JW Kyle","year":"1990","unstructured":"Kyle, J.W. et al. Correction of murine mucopolysaccharidosis VII by a human \u03b2-glucuronidase transgene. Proc. Natl. Acad. Sci. USA 87, 3914\u20133918 (1990).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0797771_CR19","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1046\/j.1471-4159.1997.68052079.x","volume":"68","author":"RM Taylor","year":"1997","unstructured":"Taylor, R.M. & Wolfe, J.H. Glycosaminoglycan storage in neonatal murine mucopolysaccharidosis type VII neurogltal cells and correction by |\u03b2-glucuronidase gene transfer. J. Neurochem. 68, 2079\u20132085 (1997).","journal-title":"J. Neurochem."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0797-771","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0797-771.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0797-771.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T23:26:18Z","timestamp":1684452378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0797-771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["BFnm0797771"],"URL":"https:\/\/doi.org\/10.1038\/nm0797-771","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}