{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:52:16Z","timestamp":1792900336477,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1038\/nm0798-808","type":"journal-article","created":{"date-parts":[[2004,8,19]],"date-time":"2004-08-19T02:15:09Z","timestamp":1092881709000},"page":"808-813","source":"Crossref","is-referenced-by-count":354,"title":["Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury"],"prefix":"10.1038","volume":"4","author":[{"given":"Christian","family":"Woiciechowsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khusru","family":"Asadullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Nestler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Platzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Sch\u00f6ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Gl\u00f6ckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang R.","family":"Lanksch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Dieter","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Diatrich","family":"D\u00f6cke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnm0798808_CR1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1097\/00005373-199107000-00005","volume":"31","author":"JL Rodriguez","year":"1991","unstructured":"Rodriguez, J.L. et al. Pneumonia: incidence, risk factors, and outcome in injured patients. I. Trauma. 31, 907\u2013912 (1991).","journal-title":"I. Trauma."},{"key":"BFnm0798808_CR2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1164\/ajrccm\/146.2.290","volume":"146","author":"AH Hsieh","year":"1992","unstructured":"Hsieh, A.H., Bishop, M.J., Kubilis, P.S., Newell, D.W. & Pierson, D.J. Pneumonia following closed head injury. Am. Rev. Respir. Dis. 146, 290\u2013294 (1992).","journal-title":"Am. Rev. Respir. Dis."},{"key":"BFnm0798808_CR3","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/00003246-199304000-00015","volume":"21","author":"MJ Jarek","year":"1993","unstructured":"Jarek, M.J., Legare, E.J., McDermott, M.T., Merenich, J.A. & Kollef, M.H. Endocrine profiles for outcome prediction from the intensive care unit. Crit. Care Med. 21, 543\u2013550 (1993).","journal-title":"Crit. Care Med."},{"key":"BFnm0798808_CR4","first-page":"432","volume":"2","author":"R Chiolero","year":"1994","unstructured":"Chiolero, R. & Berger, M. Endocrine response to brain injury. New Horiz. 2, 432\u2013442 (1994).","journal-title":"New Horiz."},{"key":"BFnm0798808_CR5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/00003246-199501000-00015","volume":"23","author":"PM Rothwell","year":"1995","unstructured":"Rothwell, P.M. & Lawler, P.G. Prediction of outcome in intensive care patients using endocrine parameters [see comments]. Crit. Care Med. 23, 78\u201383 (1995).","journal-title":"Crit. Care Med."},{"key":"BFnm0798808_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1749-6632.1995.tb44699.x","volume":"771","author":"LP Kapcala","year":"1995","unstructured":"Kapcala, L.P., Chautard, T. & Eskay, R.L. The protective role of the hypothalamic-pituitary-adrenal axis against lethality produced by immune, infectious, and inflammatory stress. Ann. NY Acad. Sci. 771, 419\u2013437 (1995).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnm0798808_CR7","doi-asserted-by":"publisher","first-page":"C331","DOI":"10.1152\/ajpcell.1995.268.2.C331","volume":"268","author":"IM Adcock","year":"1995","unstructured":"Adcock, I.M. et al. Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. Am. J. Physiol. 268, C331\u20138 (1995).","journal-title":"Am. J. Physiol."},{"key":"BFnm0798808_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1159\/000184268","volume":"43","author":"EM Sternberg","year":"1995","unstructured":"Sternberg, E.M. Neuroendocrine factors in susceptibility to inflammatory disease: focus on the hypothalamic-pituitary-adrenal axis. Horm. Res. 43, 159\u2013161 (1995).","journal-title":"Horm. Res."},{"key":"BFnm0798808_CR9","first-page":"239","volume":"5","author":"WC Koff","year":"1986","unstructured":"Koff, W.C. Fann, A.V., Dunegan, M. A. & Lachman, L. B. Catecholamine-induced suppression of interleukin-1 production. Lymphokine Res. 5, 239\u2013247 (1986).","journal-title":"Lymphokine Res."},{"key":"BFnm0798808_CR10","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1172\/JCI118469","volume":"97","author":"T van der Poll","year":"1996","unstructured":"van der Poll, T., Coyle, S. M., Barbosa, K., Braxton, C.C. & Lowry, S. F. Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. J. Clin. Invest. 97, 713\u2013719 (1996).","journal-title":"J. Clin. Invest."},{"key":"BFnm0798808_CR11","first-page":"374","volume":"108","author":"IJ Elenkov","year":"1996","unstructured":"Elenkov, I.J., Papanicolaou, D. A., Wilder, R. L. & Chrousos, G. P. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc. Assoc. Am. Physicians. 108, 374\u2013381 (1996).","journal-title":"Proc. Assoc. Am. Physicians."},{"key":"BFnm0798808_CR12","first-page":"371","volume":"75","author":"RA Gibbons","year":"1989","unstructured":"Gibbons, R. A., Martinez, O. M., Lim, R. C., Horn, J. K. & Garovoy, M. R. Reduction in HLA-DR, HLA-DQ and HLA-DP expression by Leu-M3+ cells from the peripheral blood of patients with thermal injury. Clin. Exp. Immunol. 75, 371\u2013375 (1989).","journal-title":"Clin. Exp. Immunol."},{"key":"BFnm0798808_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0140-6736(93)92303-B","volume":"342","author":"PJ Guillou","year":"1993","unstructured":"Guillou, P. J. Biological variation in the development of sepsis after surgery or trauma. Lancet 342, 217\u2013220 (1993).","journal-title":"Lancet"},{"key":"BFnm0798808_CR14","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1001\/archsurg.1988.01400350023002","volume":"123","author":"DH Livingston","year":"1988","unstructured":"Livingston, D. H., Appel, S. H., Wellhausen, S. R., Sonnenfeld, G. & Polk, H. C. Jr. Depressed interferon gamma production and monocyte HLA-DR expression after severe injury. Arch. Surg. 123, 1309\u20131312 (1988).","journal-title":"Arch. Surg."},{"key":"BFnm0798808_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/00063110-199512000-00003","volume":"2","author":"K Asadullah","year":"1995","unstructured":"Asadullah, K. et al. Very low monocytic HLA-DR expression indicates high risk of infection - Immunomonitoring for patients after neurosurgery and patients during high dose steroid therapy. Eur. J. Emergency Med. 2, 184\u2013190 (1995).","journal-title":"Eur. J. Emergency Med."},{"key":"BFnm0798808_CR16","first-page":"293","volume-title":"4th International Congress on The Immune Consequences of Trauma, Shock and Sepsis - Mechanisms and Therapeutic Approaches.","author":"WD D\u00f6cke","year":"1997","unstructured":"D\u00f6cke, W. D. et al. in 4th International Congress on The Immune Consequences of Trauma, Shock and Sepsis - Mechanisms and Therapeutic Approaches. (eds. Faist, E., Baue, A.E. & Schildberg, F.W.) 293\u2013298 (Monduzzi Editore, Bologna, ltaly, 1997)."},{"key":"BFnm0798808_CR17","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1399-0012.1989.tb00549.x","volume":"3","author":"HD Volk","year":"1989","unstructured":"Volk, H. D. et al. Diagnostic value of an immune monitoring program for the clinical management of immunosuppressed patients with septic complications. Clin. Transplant. 3, 246\u2013252 (1989).","journal-title":"Clin. Transplant."},{"key":"BFnm0798808_CR18","doi-asserted-by":"publisher","first-page":"S474","DOI":"10.1007\/BF01743727","volume":"4","author":"HD Volk","year":"1996","unstructured":"Volk, H. D. et al. Monocyte deactivation - rationale for a new therapeutic strategy in sepsis. Intensive. Care Med. 22 Suppl 4, S474\u201381 (1996).","journal-title":"Intensive. Care Med."},{"key":"BFnm0798808_CR19","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nm0697-678","volume":"3","author":"WD D\u00f6cke","year":"1997","unstructured":"D\u00f6cke, W. D. et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nature Med 3, 678\u2013681 (1997).","journal-title":"Nature Med"},{"key":"BFnm0798808_CR20","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1084\/jem.181.5.1887","volume":"181","author":"F Randow","year":"1995","unstructured":"Randow, F. et al. Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta. J. Exp. Med. 181, 1887\u20131892 (1995).","journal-title":"J. Exp. Med."},{"key":"BFnm0798808_CR21","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","volume":"11","author":"KW Moore","year":"1993","unstructured":"Moore, K. W., O'Garra, A., de Waal Malefyt, R., Vieira, P. & Mosmann, T. R. Interleukin-10. Annu. Rev. Immunol. 11, 165\u2013190 (1993).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnm0798808_CR22","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1097\/00003246-199512000-00006","volume":"23","author":"K Asadullah","year":"1995","unstructured":"Asadullah, K. et al. Immunodepression following neurosurgical procedures. Crit. Care Med. 23, 1976\u20131983 (1995).","journal-title":"Crit. Care Med."},{"key":"BFnm0798808_CR23","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1097\/00003246-199607000-00010","volume":"24","author":"RC Bone","year":"1996","unstructured":"Bone, R. C. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit. Care Med. 24, 1125\u20131128 (1996).","journal-title":"Crit. Care Med."},{"key":"BFnm0798808_CR24","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/intimm\/7.4.517","volume":"7","author":"C Platzer","year":"1995","unstructured":"Platzer, C., Meisel, C. Vogt, K., Platzer, M. & Volk, H. D. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and CAMP elevating drugs. Int. Immunol. 7, 517\u2013523 (1995).","journal-title":"Int. Immunol."},{"key":"BFnm0798808_CR25","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.4049\/jimmunol.151.12.6853","volume":"151","author":"C Wanidworanun","year":"1993","unstructured":"Wanidworanun, C. & Strober, W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J. Immunol. 151, 6853\u20136861 (1993).","journal-title":"J. Immunol."},{"key":"BFnm0798808_CR26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/0167-5699(91)90142-G","volume":"12","author":"CA Dinarello","year":"1991","unstructured":"Dinarello, C. A. & Thompson, R. C. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today 12, 404\u2013410 (1991).","journal-title":"Immunol. Today"},{"key":"BFnm0798808_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/BF01411728","volume":"138","author":"M Heesen","year":"1996","unstructured":"Heesen, M. et al. Increase of interleukin-6 plasma levels after elective craniotomy: influence of interleukin-10 and catecholamines. Acta Neurochir. Wien. 138, 77\u201380 (1996).","journal-title":"Acta Neurochir. Wien."},{"key":"BFnm0798808_CR28","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1002\/eji.1830261110","volume":"26","author":"S Suberville","year":"1996","unstructured":"Suberville, S. et al. Regulation of interleukin-10 production by beta-adrenergic agonists. Eur. I. Immunol. 26, 2601\u20132605 (1996).","journal-title":"Eur. I. Immunol."},{"key":"BFnm0798808_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF03354243","volume":"43","author":"P Uottla","year":"1996","unstructured":"Uottla, P. The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer. Cancer Immunol. Immunother. 43, 1 \u20139 (1996).","journal-title":"Cancer Immunol. Immunother."},{"key":"BFnm0798808_CR30","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1046\/j.1365-2567.1997.00137.x","volume":"90","author":"C Szabo","year":"1997","unstructured":"Szabo, C. et al. Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia. Immunology 90, 95\u2013100 (1997).","journal-title":"Immunology"},{"key":"BFnm0798808_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/0002-8703(81)90408-7","volume":"102","author":"RP Karlsberg","year":"1981","unstructured":"Karlsberg, R. P., Cryer, P. E. & Roberts, R. Serial plasma catecholamine response early in the course of clinical acute myocardial infarction: relationship to infarct extent and mortality. Am. Heart J. 102, 24\u201329 (1981).","journal-title":"Am. Heart J."},{"key":"BFnm0798808_CR32","first-page":"A50","volume":"25","author":"WD D\u00f6cke","year":"1997","unstructured":"D\u00f6cke, W. D. et al. Rapid IL-10 release and signs for immunodepression after acute myocardial infarction. Crit. Care Med. 25, A50 (Abstract) (1997).","journal-title":"Crit. Care Med."},{"key":"BFnm0798808_CR33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/00024382-199510000-00007","volume":"4","author":"PY Hahn","year":"1995","unstructured":"Hahn, P. Y. et al. Sustained elevation in circulating catecholamine levels during polymicrobial sepsis. Shock 4, 269\u2013273 (1995).","journal-title":"Shock"},{"key":"BFnm0798808_CR34","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/00000542-199209000-00004","volume":"77","author":"Y Naito","year":"1992","unstructured":"Naito, Y. et al. Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology 77, 426\u2013431 (1992).","journal-title":"Anesthesiology"},{"key":"BFnm0798808_CR35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0039-6060(05)80011-X","volume":"118","author":"TC Fabian","year":"1995","unstructured":"Fabian, T. C. et al. Reduced tumor necrosis factor production in endotoxin-spiked whole blood after trauma: experimental results and clinical correlation. Surgery 118, 63\u201372 (1995).","journal-title":"Surgery"},{"key":"BFnm0798808_CR36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/00005373-199604000-00016","volume":"40","author":"RM Sherry","year":"1996","unstructured":"Sherry, R. M., Cue, J. I., Goddard, J. K., Parramore, J. B. & DiPiro, J. T. Interleukin-10 is associated with the development of sepsis in trauma patients. J. Trauma. 40, 613\u2013616 (1996).","journal-title":"J. Trauma."},{"key":"BFnm0798808_CR37","first-page":"226","volume":"172","author":"AJ Dunn","year":"1993","unstructured":"Dunn, A. J. Infection as a stressor: a cytokine-mediated activation of the hypothal-amopituitary-adrenal axis? Ciba. Found. Symp. 172, 226\u2013239 (1993).","journal-title":"Ciba. Found. Symp."},{"key":"BFnm0798808_CR38","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/0889-1591(90)90032-L","volume":"4","author":"GJ Cheng","year":"1990","unstructured":"Cheng, G. J., Morrow Tesch, J. L., Beller, D. I., Levy, E. M. & Black, P. H. Immunosuppression in mice induced by cold water stress. Brain Behav. Immun. 4, 278\u2013291 (1990).","journal-title":"Brain Behav. Immun."},{"key":"BFnm0798808_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1006\/brbi.1993.1003","volume":"7","author":"BS Zwilling","year":"1993","unstructured":"Zwilling, B. S., Brown, D., Feng, N., Sheridan, J. & Pearl, D. The effect of adrenalectomy on the restraint stress induced suppression of MHC class II expression by murine peritoneal macrophages. Brain Behav. lmmun. 7, 29\u201335 (1993).","journal-title":"Brain Behav. lmmun."},{"key":"BFnm0798808_CR40","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0889-1591(91)90029-A","volume":"5","author":"JP Dobbin","year":"1991","unstructured":"Dobbin, J. P., Harth, M., McCain, G. A., Martin, R. A. & Cousin, K. Cytokine production and lymphocyte transformation during stress. Brain Behav. Immun. 5, 339\u2013348 (1991).","journal-title":"Brain Behav. Immun."},{"key":"BFnm0798808_CR41","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1006\/brbi.1994.1028","volume":"8","author":"EP Zorrilla","year":"1994","unstructured":"Zorrilla, E. P., Redei, E. & DeRubeis, R. J. Reduced cytokine levels and T-cell function in healthy males: relation to individual differences in subclinical anxiety. Brain Behav. lmmun. 8, 293\u2013312 (1994).","journal-title":"Brain Behav. lmmun."},{"key":"BFnm0798808_CR42","first-page":"232","volume":"20","author":"B justice","year":"1994","unstructured":"justice, B. Critical life events and the onset of illness. Compr. Ther. 20, 232\u2013238 (1994).","journal-title":"Compr. Ther."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0798-808","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0798-808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0798-808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:30:20Z","timestamp":1734514220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0798-808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["BFnm0798808"],"URL":"https:\/\/doi.org\/10.1038\/nm0798-808","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}